KEGG   ENZYME: 2.7.1.174
Entry
EC 2.7.1.174                Enzyme                                 
Name
diacylglycerol kinase (CTP);
DAG kinase;
CTP-dependent diacylglycerol kinase;
diglyceride kinase (ambiguous);
DGK1 (gene name);
diacylglycerol kinase (CTP dependent)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
CTP:1,2-diacyl-sn-glycerol 3-phosphotransferase
Reaction(IUBMB)
CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate [RN:R09944]
Reaction(KEGG)
R09944
Substrate
CTP [CPD:C00063];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
CDP [CPD:C00112];
1,2-diacyl-sn-glycerol 3-phosphate [CPD:C00416]
Comment
Requires Ca2+ or Mg2+ for activity. Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. Unlike the diacylglycerol kinases from bacteria, plants, and animals [cf. EC 2.7.1.107, diacylglycerol kinase (ATP)], the enzyme from Saccharomyces cerevisiae utilizes CTP. The enzyme can also use dCTP, but not ATP, GTP or UTP.
History
EC 2.7.1.174 created 2012, modified 2013
Pathway
ec00564  Glycerophospholipid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K16368  diacylglycerol kinase (CTP)
Genes
SCEYOR311C(DGK1)
SEUBDI49_5130
SPAOSPAR_O04210
AGOAGOS_AFR329C
ERCEcym_1490
KLAKLLA0_F08635g
KMXKLMA_20319(DGK1)
LTHKLTH0H15356g
VPOKpol_1010p4
ZROZYRO0F12540g
CGRCAGL0I09812g
NCSNCAS_0B00880(NCAS0B00880)
NDINDAI_0E00540(NDAI0E00540)
TPFTPHA_0G01150(TPHA0G01150)
TBLTBLA_0B02820(TBLA0B02820) TBLA_0D00720(TBLA0D00720)
TGBHG536_0H01130
TDLTDEL_0B01100(TDEL0B01100)
KAFKAFR_0D01590(KAFR0D01590)
KNGKNAG_0G03200(KNAG0G03200)
ZMKHG535_0F00810
PPAPAS_chr3_0072
DHADEHA2D18436g DEHA2D18502g
PICPICST_56382
PGUPGUG_05218
SPAASPAPADRAFT_60969
LELPVL30_001209(DGK1)
CALCAALFM_C200790CA(CaO19.2045)
CTPCTRG_01144
COTCORT_0A12290
CDUCD36_15730
CTENCANTEDRAFT_116161
YLIYALI0F19052g
CLUCLUG_04390
CLUSA9F13_04g01188
CAURCJI96_0001861
SLBAWJ20_3255(DGK1)
PKZC5L36_0A08970
BNNFOA43_004690
BBRXBRETT_001722
OPAHPODL_01418
SLUDSCDLUD_000729
NCRNCU03381
NTENEUTE1DRAFT84553(NEUTE1DRAFT_84553)
SMPSMAC_08256
PANPODANSg7049
TTTTHITE_2171517
MTMMYCTH_2311577
CTHRCTHT_0006610
MGRMGG_02416
PPEIPpBr36_06995
PGRIPgNI_05557
TMNUCRPA7_812
SSCKSPSK_01155
FGRFGSG_10897
FPUFPSE_09806
FPOAFPOAC1_009630
FVNFVRRES_10272
FVRFVEG_11577
FOXFOXG_12833
NHENECHADRAFT_4054
FFCNCS54_00650300
FMUJ7337_009978
TRETRIREDRAFT_77915
TRRM419DRAFT_9055
MAWMAC_03607
MAJMAA_02579
PCHMVFPPC_12955
CMTCCM_00191
AMUSLMH87_000419
PLJVFPFJ_06799
PTKZJDV02_006035(DGK1)
CFJCFIO01_08444
CLUPCLUP02_02221
CHIGCH63R_10913
PFYPFICI_09234
SSLSS1G_12219
BFUBCIN_05g05750(Bcdgk1)
MBEMBM_04096
PSCOLY89DRAFT_783476
GLZGLAREA_05179
ANIAN3177.2
AFMAFUA_3G13270
ACTACLA_040980
NFINFIA_064080
AORAO090012000806
ANGAn02g09160
AFVAFLA_002520
ALUCAKAW2_10782A AKAW2_80531A
ACHEACHE_20191S
APUUAPUU_30355S
PCSN7525_002587
PDPPDIP_23570
POUPOX_b02834
TMFEYB26_000413
TRGTRUGW13939_04470
CIMCIMG_03494
CPWCPC735_007490
UREUREG_07293
PBLPAAG_02107
PBNPADG_00789
ABEARB_05368
TVETRV_01710
BGHBDBG_03109
PNOSNOG_06468
PTEPTT_18596
BZECOCCADRAFT_3592
BSCCOCSADRAFT_178032
BORCOCMIDRAFT_109291
ARABEKO05_0005731
ZTRMYCGRDRAFT_34966
PFJMYCFIDRAFT_203374
FFUCLAFUR5_04245
CBETCB0940_11816
BCOMBAUCODRAFT_28994
NPAUCRNP2_7212
TMLGSTUM_00010292001
SPOSPBC3D6.05(ptp4)
SOMSOMG_01296(ptp4)
CNECNA08270
CNBCNBA8100
CNGCNAG_00852
CGICGB_A9630W
TMSTREMEDRAFT_73615
TASAA1Q1_01060
CCACCcaHIS019_0109300(DGK1)
TVSTRAVEDRAFT_155258
DSQDICSQDRAFT_89106
PCOPHACADRAFT_254155
SHSSTEHIDRAFT_121170
HIRHETIRDRAFT_446249
PSQPUNSTDRAFT_57981
ADLAURDEDRAFT_56616
FMEFOMMEDRAFT_124258
GTRGLOTRDRAFT_50706
RSXRhiXN_10847
LBCLACBIDRAFT_303651 LACBIDRAFT_307204 LACBIDRAFT_316889 LACBIDRAFT_317349
CCICC1G_11851
ABPAGABI1DRAFT116813(AGABI1DRAFT_116813)
ABVAGABI2DRAFT195012(AGABI2DRAFT_195012)
PCUBJR316_0013368
MPRMPER_10629
MRRMoror_15923
MOREE1B28_006263
SCMSCHCO_02702080(SCHCODRAFT_02702080)
CPUTCONPUDRAFT_86032
SLASERLADRAFT_414556
WSEWALSEDRAFT_60470
WICJ056_002927
UMAUMAG_04898
PFPPFL1_02740
SGRAEX895_005769
MGLMGL_1278
MRTMRET_2866
MSYMMSY001_0629
PGRPGTG_20746
PTRCPtA15_10A511
PSTRPst134EA_019480
MLRMELLADRAFT_29397
 » show all
Reference
1  [PMID:18458075]
  Authors
Han GS, O'Hara L, Carman GM, Siniossoglou S
  Title
An unconventional diacylglycerol kinase that regulates phospholipid synthesis and nuclear membrane growth.
  Journal
J Biol Chem 283:20433-42 (2008)
DOI:10.1074/jbc.M802903200
  Sequence
[sce:YOR311C]
Reference
2  [PMID:18458076]
  Authors
Han GS, O'Hara L, Siniossoglou S, Carman GM
  Title
Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase.
  Journal
J Biol Chem 283:20443-53 (2008)
DOI:10.1074/jbc.M802866200
  Sequence
[sce:YOR311C]
Reference
3  [PMID:21071438]
  Authors
Fakas S, Konstantinou C, Carman GM
  Title
DGK1-encoded diacylglycerol kinase activity is required for phospholipid synthesis during growth resumption from stationary phase in Saccharomyces cerevisiae.
  Journal
J Biol Chem 286:1464-74 (2011)
DOI:10.1074/jbc.M110.194308
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.174
IUBMB Enzyme Nomenclature: 2.7.1.174
ExPASy - ENZYME nomenclature database: 2.7.1.174
BRENDA, the Enzyme Database: 2.7.1.174

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