KEGG   ENZYME: 2.7.1.176Help
Entry
EC 2.7.1.176                Enzyme                                 

Name
UDP-N-acetylglucosamine kinase;
UNAG kinase;
zeta toxin;
toxin PezT;
ATP:UDP-N-acetyl-D-glucosamine 3'-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:UDP-N-acetyl-alpha-D-glucosamine 3'-phosphotransferase
Reaction(IUBMB)
ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate [RN:R09946]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043]
Product
ADP [CPD:C00008];
UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate [CPD:C20245]
Comment
Toxic component of a toxin-antitoxin (TA) module. The phosphorylation of UDP-N-acetyl-D-glucosamine results in the inhibition of EC 2.5.1.7, UDP-N-acetylglucosamine 1-carboxyvinyltransferase, the first committed step in cell wall synthesis, which is then blocked. The activity of this enzyme is inhibited when the enzyme binds to the cognate epsilon antitoxin.
History
EC 2.7.1.176 created 2012
Orthology
K16214  UDP-N-acetylglucosamine kinase
Genes
CSPF: CSF_1644
LPK: LACPI_2325
SPN: SP_1051
SPD: SPD_0931
SPR: spr0952
SPW: SPCG_1030 SPCG_1295
SJJ: SPJ_0988
SNV: SPNINV200_09690
SPX: SPG_1259
SNE: SPN23F09710 SPN23F12620
SPV: SPH_1263
SPNG: HMPREF1038_01132(pezT)
SAN: gbs1343
SEQU: Q426_01885
SMB: smi_1101
STB: SGPB_1117
SCF: Spaf_1102
SIU: SII_0665
SANC: SANR_1175
SANS: DK43_04825
GVG: HMPREF0421_21171(ftsY2)
ELE: Elen_0420
GPA: GPA_16910
AEQ: AEQU_0417
 » show all
Taxonomy
Reference
1  [PMID:17488720]
  Authors
Khoo SK, Loll B, Chan WT, Shoeman RL, Ngoo L, Yeo CC, Meinhart A
  Title
Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae.
  Journal
J Biol Chem 282:19606-18 (2007)
DOI:10.1074/jbc.M701703200
  Sequence
[spn:SP_1051]
Reference
2  [PMID:21445328]
  Authors
Mutschler H, Gebhardt M, Shoeman RL, Meinhart A
  Title
A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis.
  Journal
PLoS Biol 9:e1001033 (2011)
DOI:10.1371/journal.pbio.1001033
  Sequence
[spn:SP_1051]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.176
IUBMB Enzyme Nomenclature: 2.7.1.176
ExPASy - ENZYME nomenclature database: 2.7.1.176
BRENDA, the Enzyme Database: 2.7.1.176

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