KEGG ENZYME: 2.7.1.176

ENZYME: 2.7.1.176

Entry

EC 2.7.1.176                Enzyme

Name

UDP-N-acetylglucosamine kinase;
UNAG kinase;
zeta toxin;
toxin PezT;
ATP:UDP-N-acetyl-D-glucosamine 3'-phosphotransferase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:UDP-N-acetyl-alpha-D-glucosamine 3'-phosphotransferase

Reaction(IUBMB)

ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate [RN:R09946]

Reaction(KEGG)

R09946

Substrate

ATP [CPD:C00002];
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043]

Product

ADP [CPD:C00008];
UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate [CPD:C20245]

Comment

Toxic component of a toxin-antitoxin (TA) module. The phosphorylation of UDP-N-acetyl-D-glucosamine results in the inhibition of EC 2.5.1.7, UDP-N-acetylglucosamine 1-carboxyvinyltransferase, the first committed step in cell wall synthesis, which is then blocked. The activity of this enzyme is inhibited when the enzyme binds to the cognate epsilon antitoxin.

History

EC 2.7.1.176 created 2012

Orthology

K16214

UDP-N-acetylglucosamine kinase

Genes

EOI:	ECO111_4845

EOJ:	ECO26_5138

EOH:	ECO103_4771

ECOO:

ECRM13514_5156

ECOH:

ECRM13516_4893

ESL:

O3K_23750

ESO:

O3O_01595

ESM:

O3M_23670

ECK:	EC55989_4511

ECW:	EcE24377A_4571

ECOA:

APECO78_00915

ECX:	EcHS_A4262

ECY:

ECSE_4312

ECR:	ECIAI1_4248

EKO:	EKO11_4299

EKF:	KO11_02260

ELW:

ECW_m4385

ELL:

WFL_21320

ECOL:

LY180_21120

EFE:

EFER_4114

PSGC:

G163CM_19690

HPAA:

E5Q53_01120

MPEG:

HV560_06980

ADP:	NCTC12871_01572(pezT)

NCZ:	NCTC10294_00446

NWD:	H3L96_04520

NMUS:

H7A79_1988

NDU:	LVJ88_11905

CHA:	CHAB381_0158

CSPF:

CSF_1644

SDP:	NCTC12225_00482(pezT)

LPK:	LACPI_2325

SPN:

SP_1051

SPD:

SPD_0931

SPR:

spr0952

SPW:	SPCG_1030 SPCG_1295

SJJ:

SPJ_0988

SNV:	SPNINV200_09690

SPX:

SPG_1259

SNE:	SPN23F09710 SPN23F12620

SPV:

SPH_1263

SNM:	SP70585_1129

SPP:	SPP_1054 SPP_1189

SPNG:

HMPREF1038_01132(pezT)

SNB:	SP670_1128 SP670_1142

SNX:	SPNOXC09500

SNU:	SPNA45_01349

SPNE:

SPN034156_00360

SPNU:

SPN034183_09480

SPNM:

SPN994038_09370

SPNO:

SPN994039_09380

SAN:

gbs1343

STU:	STH8232_0686

SSB:	SSUBM407_0967 SSUBM407_p004

SSU:	SSU05_0936

SSV:	SSU98_0943

SSS:	SSUSC84_0841

SSUS:

NJAUSS_0601

SSK:	SSUD12_1295

SSQ:	SSUD9_1039

SUI:	SSUJS14_0613

SUO:	SSU12_0865

SEZO:

SeseC_01875

SEQU:

Q426_01885

SMB:

smi_1101

STB:

SGPB_1117

SCF:

Spaf_1102

SIU:

SII_0665

SANC:

SANR_1175

SANS:

DK43_04825

SOI:	I872_04360

SIG:	N596_03355

STRN:

SNAG_0768(pezT)

SSOB:

DK181_06690

SEQI:

A6J79_10415 A6J79_11240

SGW:	D7D53_04515

SFER:

NCTC12278_00084(pezT)

SCAI:

NCTC12191_01630(pezT)

SPOC:

NCTC10925_00664(pezT)

SPAB:

KQ224_00385 KQ224_10060

SLAT:

J4854_01895

SURN:

NCTC13766_01149(pezT)

SACO:

SAME_01424(pezT)

EFL:	EF62_0807 EF62_0873

EFD:	EFD32_0431 EFD32_pA0010

EFS:	EFS1_0364 EFS1_0455

EFN:	DENG_00529

ENE:

ENT_03620

EFAU:

EFAU085_p3010

EDU:	LIU_03085 LIU_14570

EGV:	EGCR1_18660

EAV:	EH197_00415

ESG:	EsVE80_p1-00710 EsVE80_p1-00770

ERAF:

J9537_20550

EDS:	PML78_13410

VAC:	E4Z98_09650

JAR:	G7057_06460

VNK:	VEIT17_05210

VRG:	OKW85_02820

SELO:

AXE86_10640

GVG:	HMPREF0421_21171

GVH:	HMPREF9231_0367

ELE:

Elen_0420

EGD:	GS424_002425

GPA:

GPA_16910

AEQ:

AEQU_0417

AHAT:

ADCFC_19710

TSU:	Tresu_0877

FUS:	HMPREF0409_01179

FNE:	FSDG_00044 FSDG_01485

FHW:	RN87_10340 RN87_11715

FPD:	CTM68_00280

FNF:	BSQ88_04885

FPEI:

C4N17_04535

» show all

Reference

1 [PMID:17488720]

Authors

Khoo SK, Loll B, Chan WT, Shoeman RL, Ngoo L, Yeo CC, Meinhart A

Title

Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae.

Journal

J Biol Chem 282:19606-18 (2007)
DOI:10.1074/jbc.M701703200

Sequence

[spn:SP_1051]

Reference

2 [PMID:21445328]

Authors

Mutschler H, Gebhardt M, Shoeman RL, Meinhart A

Title

A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis.

Journal

PLoS Biol 9:e1001033 (2011)
DOI:10.1371/journal.pbio.1001033

Sequence

[spn:SP_1051]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.176

IUBMB Enzyme Nomenclature:

2.7.1.176

ExPASy - ENZYME nomenclature database:

2.7.1.176

BRENDA, the Enzyme Database:

2.7.1.176

DBGET integrated database retrieval system