KEGG   ENZYME: 2.7.1.176
Entry
EC 2.7.1.176                Enzyme                                 

Name
UDP-N-acetylglucosamine kinase;
UNAG kinase;
zeta toxin;
toxin PezT;
ATP:UDP-N-acetyl-D-glucosamine 3'-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:UDP-N-acetyl-alpha-D-glucosamine 3'-phosphotransferase
Reaction(IUBMB)
ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate [RN:R09946]
Reaction(KEGG)
R09946
Substrate
ATP [CPD:C00002];
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043]
Product
ADP [CPD:C00008];
UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate [CPD:C20245]
Comment
Toxic component of a toxin-antitoxin (TA) module. The phosphorylation of UDP-N-acetyl-D-glucosamine results in the inhibition of EC 2.5.1.7, UDP-N-acetylglucosamine 1-carboxyvinyltransferase, the first committed step in cell wall synthesis, which is then blocked. The activity of this enzyme is inhibited when the enzyme binds to the cognate epsilon antitoxin.
History
EC 2.7.1.176 created 2012
Orthology
K16214  UDP-N-acetylglucosamine kinase
Genes
EOI: ECO111_4845
EOJ: ECO26_5138
EOH: ECO103_4771
ECOO: ECRM13514_5156
ECOH: ECRM13516_4893
ESL: O3K_23750
ESO: O3O_01595
ESM: O3M_23670
ECK: EC55989_4511
ECW: EcE24377A_4571
ECY: ECSE_4312
ELW: ECW_m4385
ELL: WFL_21320
EFE: EFER_4114
ADP: NCTC12871_01572(pezT)
VAN: VAA_00558
PHA: PSHAa0327
AMAI: I635_04320
FTW: FTW_0800
FTN: FTN_1502
FTX: AW25_499
FTD: AS84_1003
FTY: CH70_432
ADI: B5T_01515
AXE: P40_07015
BCJ: pBCA017
BUL: BW21_6166
PLG: NCTC10937_02741(pezT)
VEI: Veis_5016
CSPF: CSF_1644
SDP: NCTC12225_00482(pezT)
SPN: SP_1051
SPD: SPD_0931
SPR: spr0952
SJJ: SPJ_0988
SPX: SPG_1259
SPV: SPH_1263
SPNG: HMPREF1038_01132(pezT)
SAN: gbs1343
SEQU: Q426_01885
SGT: SGGB_1056
SMB: smi_1101
STB: SGPB_1117
SCF: Spaf_1102
SIU: SII_0665
SANC: SANR_1175
SANS: DK43_04825
STRN: SNAG_0768(pezT)
CSC: Csac_0067
ATE: Athe_0914
CSP: WM42_1488
PAUS: NCTC13651_02540(pezT)
BDE: BDP_1246
BDN: BBDE_1189
GVG: HMPREF0421_21171(ftsY2)
ELE: Elen_0420
GPA: GPA_16910
AEQ: AEQU_0417
COC: Coch_0360
 » show all
Reference
1  [PMID:17488720]
  Authors
Khoo SK, Loll B, Chan WT, Shoeman RL, Ngoo L, Yeo CC, Meinhart A
  Title
Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae.
  Journal
J Biol Chem 282:19606-18 (2007)
DOI:10.1074/jbc.M701703200
  Sequence
[spn:SP_1051]
Reference
2  [PMID:21445328]
  Authors
Mutschler H, Gebhardt M, Shoeman RL, Meinhart A
  Title
A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis.
  Journal
PLoS Biol 9:e1001033 (2011)
DOI:10.1371/journal.pbio.1001033
  Sequence
[spn:SP_1051]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.176
IUBMB Enzyme Nomenclature: 2.7.1.176
ExPASy - ENZYME nomenclature database: 2.7.1.176
BRENDA, the Enzyme Database: 2.7.1.176

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