Entry
Name
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:L-threonine O3-phosphotransferase
Reaction(IUBMB)
ATP + L-threonine = ADP + O-phospho-L-threonine [RN:
R06531 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme is involved in the de novo synthesis of adenosylcobalamin. It is specific for ATP and free L-threonine. In the bacterium Salmonella enterica the activity with CTP, GTP, or UTP is 6, 11, and 3% of the activity with ATP.
History
EC 2.7.1.177 created 2012
Pathway
Orthology
Genes
METY : MRY16398_18390(pduX)
YEN : YE2750(pduX) YE4039(pduX)
YEP : YE105_C1535 YE105_C3759
YEF : FORC2_0155 FORC2_2731
YEE : YE5303_31831(pduX) YE5303_38731(pduX)
YHI : D5F51_11610 D5F51_21340
YEL : LC20_00186 LC20_02014
YCA : F0T03_14080 F0T03_21025
YAS : N0H69_09510 N0H69_17190
HAV : AT03_05625 AT03_08670
GAI : IMCC3135_05635(pduX)
LMOC : LMOSLCC5850_1159(pduX)
LMW : LMOSLCC2755_1162(pduX)
LMX : LMOSLCC2372_1165(pduX)
LMZ : LMOSLCC2482_1209(pduX)
LMON : LMOSLCC2376_1121(pduX)
LMOS : LMOSLCC7179_1137(pduX)
LMOO : LMOSLCC2378_1175(pduX)
LMOY : LMOSLCC2479_1166(pduX)
LMOT : LMOSLCC2540_1148(pduX)
LMOA : LMOATCC19117_1170(pduX)
SMEN : SAMEA4412692_0330(pduX)
PHX : KGNDJEFE_00479(pduX)
MANA : MAMMFC1_03994(pduX)
» show all
Taxonomy
Reference
Authors
Fan C, Bobik TA.
Title
The PduX enzyme of Salmonella enterica is an L-threonine kinase used for coenzyme B12 synthesis.
Journal
Sequence
Reference
Authors
Fan C, Fromm HJ, Bobik TA
Title
Kinetic and functional analysis of L-threonine kinase, the PduX enzyme of Salmonella enterica.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.1.177