KEGG   ENZYME: 2.7.1.177
Entry
EC 2.7.1.177                Enzyme                                 
Name
L-threonine kinase;
PduX
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:L-threonine O3-phosphotransferase
Reaction(IUBMB)
ATP + L-threonine = ADP + O-phospho-L-threonine [RN:R06531]
Reaction(KEGG)
R06531
Substrate
ATP [CPD:C00002];
L-threonine [CPD:C00188]
Product
ADP [CPD:C00008];
O-phospho-L-threonine [CPD:C12147]
Comment
The enzyme is involved in the de novo synthesis of adenosylcobalamin. It is specific for ATP and free L-threonine. In the bacterium Salmonella enterica the activity with CTP, GTP, or UTP is 6, 11, and 3% of the activity with ATP.
History
EC 2.7.1.177 created 2012
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
Orthology
K16651  L-threonine kinase
Genes
STY: STY2263(pduX)
STT: t0816(pduX)
SEX: STBHUCCB_8710
SENT: TY21A_04145
STM: STM2058(pduX)
SEO: STM14_2547(pduX)
SEV: STMMW_20881
SEY: SL1344_2034(pduX)
SEM: STMDT12_C20800
SEJ: STMUK_2088(pduX)
SEB: STM474_2143(pduX)
SEF: UMN798_2224(pduX)
SETU: STU288_06680
SETC: CFSAN001921_06495
SENR: STMDT2_20311(pduX)
SEND: DT104_21151(pduX)
SENI: CY43_11105
SEEN: SE451236_16500
SPT: SPA0813(pduX)
SEK: SSPA0760
SPQ: SPAB_01046
SEI: SPC_1656(pduX)
SEC: SCH_2067(pduX)
SEH: SeHA_C2281
SHB: SU5_02652
SENH: CFSAN002069_21530
SEEH: SEEH1578_19570
SEE: SNSL254_A2235
SENN: SN31241_31590
SEW: SeSA_A2228
SEA: SeAg_B2181
SENS: Q786_10160
SED: SeD_A2394
SEG: SG2087(pduX)
SEL: SPUL_0842(pduX)
SEGA: SPUCDC_0842(pduX)
SET: SEN2056(pduX)
SENA: AU38_10375
SENO: AU37_10385
SENV: AU39_10385
SENQ: AU40_11630
SENL: IY59_10670
SENJ: CFSAN001992_01145
SEEC: CFSAN002050_17250
SEEB: SEEB0189_009175
SEEP: I137_03795
SENB: BN855_21430
SENE: IA1_10270
SENC: SEET0819_17435
SES: SARI_00829
SALZ: EOS98_08720
ESH: C1N69_07935
ENR: H650_05865
ENF: AKI40_1785(pduX)
KPN: KPN_03223(pduX)
KPU: KP1_4492(pduX)
KPM: KPHS_42860
KPP: A79E_0887
KPH: KPNIH24_07360
KPZ: KPNIH27_20770
KPV: KPNIH29_21540
KPW: KPNIH30_21560
KPY: KPNIH31_20825
KPG: KPNIH32_22420
KPC: KPNIH10_21355
KPQ: KPR0928_20845
KPT: VK055_4302
KPO: KPN2242_19065
KPR: KPR_1810(pduX)
KPJ: N559_1016
KPI: D364_16360
KPA: KPNJ1_01021
KPS: KPNJ2_01052
KPX: PMK1_00704(pduX)
KPB: FH42_12075
KPNE: KU54_005010
KPNU: LI86_05020
KPNK: BN49_0885(pduX)
KVA: Kvar_0847
KPE: KPK_0892(pduX)
KPK: A593_06245
KVD: KR75_03695
KVQ: SP68_10240
KOX: KOX_01545
KOE: A225_4774
KOY: J415_08150
KOM: HR38_27680
KOK: KONIH1_23985
KOC: AB185_12405
KQU: AVR78_25865
KQV: B8P98_04940
KLL: BJF97_23815
KLW: DA718_05375
KAR: LGL98_04520
KGR: JJJ10_05395
KPAS: LUW96_01640
KLC: K7H21_05060
CRO: ROD_21441(pduX)
CKO: CKO_00778
CFD: CFNIH1_21285
CBRA: A6J81_01025
CWE: CO701_07940
CYO: CD187_09125
CPOT: FOB25_20435
CFQ: C2U38_15405
CSED: JY391_08700
CAMA: F384_10500
CAF: AL524_12180
CIF: AL515_09960
CFAR: CI104_16285
CIR: C2U53_26095
CIE: AN232_13905
CPAR: CUC49_05335
CTEL: GBC03_14195
CITZ: E4Z61_02765
CARS: E1B03_16815
EBT: EBL_c14750
PGE: LG71_20660
ESC: Entcl_1739
KLE: AO703_13250
KSA: C813_00150
KOR: AWR26_09165
KRD: A3780_14810
KPSE: IP581_14425
KOO: O9K67_08815
KIE: NCTC12125_04859
KAS: KATP_08810(pduX)
KLU: K7B04_09720
BUF: D8682_20820
BAGE: BADSM9389_15260
BFT: MNO13_05040
METY: MRY16398_18390(pduX)
YRE: HEC60_23150
KIN: AB182_08045
PDZ: HHA33_11170
PSGC: G163CM_06120(pduX)
EBF: D782_1619
EBC: C2U52_18630
EBU: CUC76_20195
YEN: YE2750(pduX) YE4039(pduX)
YEP: YE105_C1535 YE105_C3759
YEY: Y11_16371 Y11_31561
YEL: LC20_00186 LC20_02014
YEW: CH47_2099 CH47_3692
YET: CH48_1491 CH48_3131
YEF: FORC2_0155 FORC2_2731
YEE: YE5303_31831(pduX) YE5303_38731(pduX)
YAL: AT01_1094 AT01_4013
YFR: AW19_699
YIN: CH53_309 CH53_3347
YKR: CH54_963
YRO: CH64_1336
YAK: ACZ76_01765
YMA: DA391_08040
YHI: D5F51_11610 D5F51_21340
YCA: F0T03_14080 F0T03_21025
YMO: HRD69_13055
YAS: N0H69_09510 N0H69_17190
YKI: HRD70_18730
BGJ: AWC36_11470
BRB: EH207_06450
BNG: EH206_15130
BIZ: HC231_16080
SLIG: GTU79_14995
PLU: plu2966
PLUM: A4R40_14825
PAY: PAU_01636(pduX)
PTT: VY86_16855
PAKH: B0X70_15185
PLUI: CE143_15180
XBO: XBJ1_0855
XBV: XBW1_1555
XNE: XNC1_1145
XNM: XNC2_1124
XBU: HGO23_10425
MMK: MU9_1018
EIC: NT01EI_2195
ETR: ETAE_2006
ETD: ETAF_1814
ETE: ETEE_4061(pduX)
ETC: ETAC_09175
EDW: QY76_10250
EDL: AAZ33_10195
EHO: A9798_07130
HAV: AT03_05625 AT03_08670
HPAR: AL518_16430
OPO: DSM2777_13880
VTU: IX91_24675
VEU: IXK98_24740
VZI: G5S32_07770
VOS: KNV97_01220
GAI: IMCC3135_05635(pduX)
TAU: Tola_1706
BTM: MC28_E122
BTN: BTF1_32006
BWD: CT694_33810
BTRO: FJR70_30735
MVT: I6J10_02965
LMO: lmo1170
LMN: LM5578_1243
LMY: LM5923_1196
LMT: LMRG_00613
LMOC: LMOSLCC5850_1159(pduX)
LMOE: BN418_1373
LMOB: BN419_1371
LMOD: LMON_1163
LMOW: AX10_14355
LMOQ: LM6179_1477
LMR: LMR479A_1191
LMOM: IJ09_04485
LMF: LMOf2365_1178
LMC: Lm4b_01175
LMOG: BN389_11890
LMP: MUO_06045
LMOL: LMOL312_1157(pduX)
LMOJ: LM220_17107
LMOZ: LM1816_08278
LMOX: AX24_03220
LMH: LMHCC_1480
LMQ: LMM7_1176(pduX)
LML: lmo4a_1153(pduX)
LMG: LMKG_01764
LMS: LMLG_1094
LMJ: LMOG_00559
LMW: LMOSLCC2755_1162(pduX)
LMX: LMOSLCC2372_1165(pduX)
LMZ: LMOSLCC2482_1209(pduX)
LMON: LMOSLCC2376_1121(pduX)
LMOS: LMOSLCC7179_1137(pduX)
LMOO: LMOSLCC2378_1175(pduX)
LMOY: LMOSLCC2479_1166(pduX)
LMOT: LMOSLCC2540_1148(pduX)
LMOA: LMOATCC19117_1170(pduX)
LMOK: CQ02_06015
LMV: Y193_09885
LIN: lin1134
LWE: lwe1128
LSG: lse_1048(pduX)
LIV: LIV_1102
LII: JL52_05845
LIW: AX25_05950
LIA: JL58_05970
LIO: JL53_06500
LMAR: LAX80_005430
SSA: SSA_0511(pduX)
SIP: N597_05170
SMEN: SAMEA4412692_0330(pduX)
EAV: EH197_13935
ERAF: J9537_06315
VCP: H9L18_11620
VHY: G7082_09040
ABAE: CL176_08765
CAC: CA_C1371
CAE: SMB_G1394
CAY: CEA_G1385
CTC: CTC_00786
CTET: BN906_00826
CBO: CBO0953(pduX)
CBA: CLB_0995
CBH: CLC_1009
CBY: CLM_1104
CBL: CLK_0391
CBB: CLD_3607
CBI: CLJ_B1004
CBF: CLI_1043
CBM: CBF_1012
CBJ: H04402_01022
CKL: CKL_0717
CKR: CKR_0639
CLJ: CLJU_c31830
CPAS: Clopa_1225
CPAT: CLPA_c12730(pduX)
CPAE: CPAST_c12730(pduX)
CAH: CAETHG_1111
CSQ: CSCA_5077
CLD: CLSPO_c09520
CACE: CACET_c00560(pduX)
CCK: Ccar_15380
CTYK: CTK_C09530
CFM: BJL90_05860
CDRK: B9W14_19425
CCOH: SAMEA4530647_0646
CFER: D4Z93_11015
CLOS: DMR38_15940
CRW: CROST_019380(pduX)
CFB: CLFE_019350(pduX)
CAUN: CLAUR_010520(pduX)
AMT: Amet_0068
GFE: Gferi_24220
CRS: FQB35_05195
CPRF: K7H06_10805
CRAS: KVH43_09740
PBIF: KXZ80_14525
CDF: CD630_34310
PDC: CDIF630_03739(pduX)
CDC: CD196_3207
CDL: CDR20291_3253
PDF: CD630DERM_34310
EAC: EAL2_808p00980
CST: CLOST_0986(pduX)
PSOR: RSJ16_16285
ROC: HF520_12005
PHX: KGNDJEFE_00479(pduX)
TEM: JW646_05960
TGC: L0P85_02375
TEB: T8CH_0255(pduX)
IBR: NQ514_13840
PEB: O0R46_01200
CMIC: caldi_06890
DSY: DSY4058
DHD: Dhaf_1308
DDH: Desde_1240
DDL: Desdi_1031
DMT: DESME_03945
DOR: Desor_2797
DAI: Desaci_2446
DMI: Desmer_2199
DCA: Desca_0591
DRM: Dred_2702
DRU: Desru_0911
DFG: B0537_13895
TFR: BR63_04680
AACX: DEACI_2584
TJR: TherJR_1311
HMO: HM1_2403
HCV: FTV88_0710
ELM: ELI_0756
EMT: CPZ25_016720
ELIM: B2M23_11480
AWO: Awo_c30510
AWI: CHL1_000434
TKI: TKV_c19670(pduX)
CHY: CHY_0772
MTA: Moth_1103
MTHO: MOTHE_c10630(pduX)
MTHZ: MOTHA_c11520(pduX)
TPZ: Tph_c05150(pduX)
MAS: Mahau_0759
TEP: TepRe1_1002
TAE: TepiRe1_1099
TOC: Toce_1423
NCD: ACONDI_00699(pduX)
HAS: Halsa_2192
HPK: Hprae_1518
HALS: D7D81_15695
IFN: GM661_12830
AAR: Acear_0846
HHL: Halha_1700
KME: H0A61_01981(pduX)
VPR: Vpar_0909
VAT: B7L28_04410
VRM: 44547418_00926
VDN: NCTC11831_01037
VNK: VEIT17_09200
MED: MELS_1829
MHW: ACT01_09715
MEG: DKB62_00150
MMAX: LCQ47_01760
DHO: Dia5BBH33_09490
SRI: SELR_20710
SELE: ADJ74_00245
SELO: AXE86_10020
SELT: BCS37_04990
MFUN: GXM21_03750
PUF: UFO1_2208
PFT: JBW_02349
MANA: MAMMFC1_03994(pduX)
STED: SPTER_16900(pduX)
TAI: Taci_0066
TLI: Tlie_0163
ARAM: KAR29_13755
ALAM: RT761_00796(pduX)
 » show all
Reference
1  [PMID:18308727]
  Authors
Fan C, Bobik TA.
  Title
The PduX enzyme of Salmonella enterica is an L-threonine kinase used for coenzyme B12 synthesis.
  Journal
J Biol Chem 283:11322-9 (2008)
DOI:10.1074/jbc.M800287200
  Sequence
[stm:STM2058]
Reference
2  [PMID:19509296]
  Authors
Fan C, Fromm HJ, Bobik TA
  Title
Kinetic and functional analysis of L-threonine kinase, the PduX enzyme of Salmonella enterica.
  Journal
J Biol Chem 284:20240-8 (2009)
DOI:10.1074/jbc.M109.027425
  Sequence
[stm:STM2058]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.177
IUBMB Enzyme Nomenclature: 2.7.1.177
ExPASy - ENZYME nomenclature database: 2.7.1.177
BRENDA, the Enzyme Database: 2.7.1.177

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (2214)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (386)   
   KEGG MGENES (1702)   
   RefGene (125)   
Protein sequence (520)   
   UniProt (411)   
   SWISS-PROT (2)   
   RefSeq(pep) (107)   
DNA sequence (3014)   
   RefSeq(nuc) (1026)   
   GenBank (1276)   
   EMBL (712)   
Protein domain (4)   
   InterPro (4)   
All databases (5763)   

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