KEGG   ENZYME: 2.7.1.177
Entry
EC 2.7.1.177                Enzyme                                 
Name
L-threonine kinase;
PduX
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:L-threonine O3-phosphotransferase
Reaction(IUBMB)
ATP + L-threonine = ADP + O-phospho-L-threonine [RN:R06531]
Reaction(KEGG)
R06531
Substrate
ATP [CPD:C00002];
L-threonine [CPD:C00188]
Product
ADP [CPD:C00008];
O-phospho-L-threonine [CPD:C12147]
Comment
The enzyme is involved in the de novo synthesis of adenosylcobalamin. It is specific for ATP and free L-threonine. In the bacterium Salmonella enterica the activity with CTP, GTP, or UTP is 6, 11, and 3% of the activity with ATP.
History
EC 2.7.1.177 created 2012
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
Orthology
K16651  L-threonine kinase
Genes
STY: STY2263(pduX)
STT: t0816(pduX)
SEX: STBHUCCB_8710
SENT: TY21A_04145
STM: STM2058(pduX)
SEO: STM14_2547(pduX)
SEV: STMMW_20881
SEY: SL1344_2034(pduX)
SEM: STMDT12_C20800
SEJ: STMUK_2088(pduX)
SEB: STM474_2143(pduX)
SEF: UMN798_2224(pduX)
SETU: STU288_06680
SETC: CFSAN001921_06495
SENR: STMDT2_20311(pduX)
SEND: DT104_21151(pduX)
SENI: CY43_11105
SEEN: SE451236_16500
SPT: SPA0813(pduX)
SEK: SSPA0760
SPQ: SPAB_01046
SEI: SPC_1656(pduX)
SEC: SCH_2067(pduX)
SEH: SeHA_C2281
SHB: SU5_02652
SENH: CFSAN002069_21530
SEEH: SEEH1578_19570
SEE: SNSL254_A2235
SENN: SN31241_31590
SEW: SeSA_A2228
SEA: SeAg_B2181
SENS: Q786_10160
SED: SeD_A2394
SEG: SG2087(pduX)
SEL: SPUL_0842(pduX)
SEGA: SPUCDC_0842(pduX)
SET: SEN2056(pduX)
SENA: AU38_10375
SENO: AU37_10385
SENV: AU39_10385
SENQ: AU40_11630
SENL: IY59_10670
SENJ: CFSAN001992_01145
SEEC: CFSAN002050_17250
SEEB: SEEB0189_009175
SEEP: I137_03795
SENB: BN855_21430
SENE: IA1_10270
SENC: SEET0819_17435
SES: SARI_00829
SALZ: EOS98_08720
ESH: C1N69_07935
ENR: H650_05865
ENF: AKI40_1785(pduX)
EPU: QVH39_07935
EAX: AAHF05_07690
KPN: KPN_03223(pduX)
KPU: KP1_4492(pduX)
KPM: KPHS_42860
KPP: A79E_0887
KPH: KPNIH24_07360
KPZ: KPNIH27_20770
KPV: KPNIH29_21540
KPW: KPNIH30_21560
KPY: KPNIH31_20825
KPG: KPNIH32_22420
KPC: KPNIH10_21355
KPQ: KPR0928_20845
KPT: VK055_4302
KPO: KPN2242_19065
KPR: KPR_1810(pduX)
KPJ: N559_1016
KPI: D364_16360
KPA: KPNJ1_01021
KPS: KPNJ2_01052
KPX: PMK1_00704(pduX)
KPB: FH42_12075
KPNE: KU54_005010
KPNU: LI86_05020
KPNK: BN49_0885(pduX)
KVA: Kvar_0847
KPE: KPK_0892(pduX)
KPK: A593_06245
KVD: KR75_03695
KVQ: SP68_10240
KQU: AVR78_25865
KQV: B8P98_04940
KOX: KOX_01545
KOE: A225_4774
KOY: J415_08150
KOM: HR38_27680
KOK: KONIH1_23985
KOC: AB185_12405
KLL: BJF97_23815
KLW: DA718_05375
KAR: LGL98_04520
KGR: JJJ10_05395
KPAS: LUW96_01640
KLC: K7H21_05060
KLM: BWI76_23205
KLP: GUC22_04630
CRO: ROD_21441(pduX)
CKO: CKO_00778
CFD: CFNIH1_21285
CBRA: A6J81_01025
CWE: CO701_07940
CYO: CD187_09125
CPOT: FOB25_20435
CFQ: C2U38_15405
CSED: JY391_08700
CAMA: F384_10500
CAF: AL524_12180
CIF: AL515_09960
CFAR: CI104_16285
CIR: C2U53_26095
CIE: AN232_13905
CPAR: CUC49_05335
CTEL: GBC03_14195
CITZ: E4Z61_02765
CARS: E1B03_16815
CIX: M4I31_09050
CIB: HF677_009300
CITR: GUC46_08990
CIQ: FD428_08200
CIY: HAP28_16025
EBT: EBL_c14750
PGE: LG71_20660
ESC: Entcl_1739
KLE: AO703_13250
KSA: C813_00150
KOR: AWR26_09165
KRD: A3780_14810
KPSE: IP581_14425
KOO: O9K67_08815
KOU: C0557_16265
KCA: AAEY27_08425
KIE: NCTC12125_04859
KAS: KATP_08810(pduX)
KLU: K7B04_09720
KCY: RIN60_04480
BUF: D8682_20820
BAGE: BADSM9389_15260
BFT: MNO13_05040
BSEL: RHD99_04845
YRE: HEC60_23150
KIN: AB182_08045
PDZ: HHA33_11170
METY: MRY16398_18390(pduX)
PSGC: G163CM_06120(pduX)
MPHG: MPHASIOC01_002258
EBF: D782_1619
EBC: C2U52_18630
EBU: CUC76_20195
EBB: F652_940
YEN: YE2750(pduX) YE4039(pduX)
YEP: YE105_C1535 YE105_C3759
YEY: Y11_16371 Y11_31561
YEW: CH47_2099 CH47_3692
YET: CH48_1491 CH48_3131
YEF: FORC2_0155 FORC2_2731
YEE: YE5303_31831(pduX) YE5303_38731(pduX)
YAL: AT01_1094 AT01_4013
YFR: AW19_699
YIN: CH53_309 CH53_3347
YKR: CH54_963
YRO: CH64_1336
YAK: ACZ76_01765
YMA: DA391_08040
YHI: D5F51_11610 D5F51_21340
YEL: LC20_00186 LC20_02014
YCA: F0T03_14080 F0T03_21025
YMO: HRD69_13055
YAS: N0H69_09510 N0H69_17190
YKI: HRD70_18730
BGJ: AWC36_11470
BRB: EH207_06450
BNG: EH206_15130
BIZ: HC231_16080
SLIG: GTU79_14995
PLU: plu2966
PLUM: A4R40_14825
PAY: PAU_01636(pduX)
PTT: VY86_16855
PAKH: B0X70_15185
PLUI: CE143_15180
XBO: XBJ1_0855
XBV: XBW1_1555
XNE: XNC1_1145
XNM: XNC2_1124
XBU: HGO23_10425
XGR: QL128_04815
MMK: MU9_1018
EIC: NT01EI_2195
ETD: ETAF_1814
ETE: ETEE_4061(pduX)
ETR: ETAE_2006
ETC: ETAC_09175
EDW: QY76_10250
EDL: AAZ33_10195
EHO: A9798_07130
HAV: AT03_05625 AT03_08670
HPAR: AL518_16430
OPO: DSM2777_13880
VTU: IX91_24675
VEU: IXK98_24740
VZI: G5S32_07770
VOS: KNV97_01220
GAI: IMCC3135_05635(pduX)
TAU: Tola_1706
PAGI: ABHF91_07915
MASH: LP419_10660
PIJ: QEJ31_04890
ALAM: RT761_00796(pduX)
TVX: QBE54_10540
ATHO: M15_00100
BTM: MC28_E122
BTN: BTF1_32006
BWD: CT694_33810
BTRO: FJR70_30735
MVT: I6J10_02965
LMO: lmo1170
LMN: LM5578_1243
LMY: LM5923_1196
LMT: LMRG_00613
LMOC: LMOSLCC5850_1159(pduX)
LMOE: BN418_1373
LMOB: BN419_1371
LMOD: LMON_1163
LMOW: AX10_14355
LMOQ: LM6179_01477
LMR: LMR479A_1191
LMOM: IJ09_04485
LMF: LMOf2365_1178
LMC: Lm4b_01175
LMOG: BN389_11890
LMP: MUO_06045
LMOL: LMOL312_1157(pduX)
LMOJ: LM220_17107
LMOZ: LM1816_08278
LMOX: AX24_03220
LMH: LMHCC_1480
LMQ: LMM7_1176(pduX)
LML: lmo4a_1153(pduX)
LMG: LMKG_01764
LMS: LMLG_1094
LMJ: LMOG_00559
LMW: LMOSLCC2755_1162(pduX)
LMX: LMOSLCC2372_1165(pduX)
LMZ: LMOSLCC2482_1209(pduX)
LMON: LMOSLCC2376_1121(pduX)
LMOS: LMOSLCC7179_1137(pduX)
LMOO: LMOSLCC2378_1175(pduX)
LMOY: LMOSLCC2479_1166(pduX)
LMOT: LMOSLCC2540_1148(pduX)
LMOA: LMOATCC19117_1170(pduX)
LMOK: CQ02_06015
LMV: Y193_09885
LIN: lin1134
LWE: lwe1128
LSG: lse_1048(pduX)
LIV: LIV_1102
LII: JL52_05845
LIW: AX25_05950
LIA: JL58_05970
LIO: JL53_06500
LMAR: LAX80_005430
SSA: SSA_0511(pduX)
SIP: N597_05170
SMEN: SAMEA4412692_0330(pduX)
EAV: EH197_13935
ERAF: J9537_06315
VCP: H9L18_11620
VHY: G7082_09040
ABAE: CL176_08765
FCT: NRE15_10590
CAC: CA_C1371
CAE: SMB_G1394
CAY: CEA_G1385
CTC: CTC_00786
CTET: BN906_00826
CBO: CBO0953(pduX)
CBA: CLB_0995
CBH: CLC_1009
CBY: CLM_1104
CBL: CLK_0391
CBB: CLD_3607
CBI: CLJ_B1004
CBF: CLI_1043
CBM: CBF_1012
CBJ: H04402_01022
CKL: CKL_0717
CKR: CKR_0639
CLJ: CLJU_c31830
CPAS: Clopa_1225
CPAT: CLPA_c12730(pduX)
CPAE: CPAST_c12730(pduX)
CAH: CAETHG_1111
CSQ: CSCA_5077
CLD: CLSPO_c09520
CACE: CACET_c00560(pduX)
CCK: Ccar_15380
CTYK: CTK_C09530
CFM: BJL90_05860
CDRK: B9W14_19425
CCOH: SAMEA4530647_0646
CFER: D4Z93_11015
CLOS: DMR38_15940
CRW: CROST_019380(pduX)
CFB: CLFE_019350(pduX)
CAUN: CLAUR_010520(pduX)
CRS: FQB35_05195
CPRF: K7H06_10805
CRAS: KVH43_09740
CMIC: caldi_06890
DSY: DSY4058
DHD: Dhaf_1308
DDH: Desde_1240
DDL: Desdi_1031
DMT: DESME_03945
DOR: Desor_2797
DAI: Desaci_2446
DMI: Desmer_2199
DCA: Desca_0591
DRM: Dred_2702
DRU: Desru_0911
DFG: B0537_13895
TFR: BR63_04680
AACX: DEACI_2584
TJR: TherJR_1311
HMO: HM1_2403
HCV: FTV88_0710
ELM: ELI_0756
EMT: CPZ25_016720
ELIM: B2M23_11480
AWO: Awo_c30510
AWI: CHL1_000434
AMT: Amet_0068
GFE: Gferi_24220
CSPO: QNI18_11980
PBIF: KXZ80_14525
PSOR: RSJ16_16285
CDF: CD630_34310
PDC: CDIF630_03739(pduX)
CDC: CD196_3207
CDL: CDR20291_3253
PDF: CD630DERM_34310
ROC: HF520_12005
RIL: CRIB_2257
RHOM: FRIFI_2588
PHX: KGNDJEFE_00479(pduX)
TEM: JW646_05960
TGC: L0P85_02375
TMY: TEMA_36580(pduX)
TPET: TPHSE_06710(pduX)
TEB: T8CH_0255(pduX)
THYR: P4S50_16245
IBR: NQ514_13840
PEB: O0R46_01200
EAC: EAL2_808p00980
CST: CLOST_0986(pduX)
TKI: TKV_c19670(pduX)
CHY: CHY_0772
TPZ: Tph_c05150(pduX)
MAS: Mahau_0759
MTA: Moth_1103
MTHO: MOTHE_c10630(pduX)
MTHZ: MOTHA_c11520(pduX)
TEP: TepRe1_1002
TAE: TepiRe1_1099
BACG: D2962_09950
TOC: Toce_1423
NCD: ACONDI_00699(pduX)
HAS: Halsa_2192
HPK: Hprae_1518
HALS: D7D81_15695
IFN: GM661_12830
AAR: Acear_0846
HHL: Halha_1700
KME: H0A61_01981(pduX)
HPRF: HLPR_10450
VPR: Vpar_0909
VAT: B7L28_04410
VRM: 44547418_00926
VDN: NCTC11831_01037
VNK: VEIT17_09200
VOR: VEIS_06580
MED: MELS_1829
MHW: ACT01_09715
MEG: DKB62_00150
MMAX: LCQ47_01760
DHO: Dia5BBH33_09490
SRI: SELR_20710
SELE: ADJ74_00245
SELO: AXE86_10020
SELT: BCS37_04990
SDIA: QU667_05225
STIM: H1B31_09555
MFUN: GXM21_03750
SGBI: P3F81_06310
PUF: UFO1_2208
PFT: JBW_02349
MANA: MAMMFC1_03994(pduX)
STED: SPTER_16900(pduX)
SSPH: SPSPH_016220(pduX)
SOVA: SOV_16410(pduX)
SSID: SPSIL_021300(pduX)
SACV: SPACI_020980(pduX)
TAI: Taci_0066
TLI: Tlie_0163
ARAM: KAR29_13755
 » show all
Reference
1  [PMID:18308727]
  Authors
Fan C, Bobik TA.
  Title
The PduX enzyme of Salmonella enterica is an L-threonine kinase used for coenzyme B12 synthesis.
  Journal
J Biol Chem 283:11322-9 (2008)
DOI:10.1074/jbc.M800287200
  Sequence
[stm:STM2058]
Reference
2  [PMID:19509296]
  Authors
Fan C, Fromm HJ, Bobik TA
  Title
Kinetic and functional analysis of L-threonine kinase, the PduX enzyme of Salmonella enterica.
  Journal
J Biol Chem 284:20240-8 (2009)
DOI:10.1074/jbc.M109.027425
  Sequence
[stm:STM2058]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.177
IUBMB Enzyme Nomenclature: 2.7.1.177
ExPASy - ENZYME nomenclature database: 2.7.1.177
BRENDA, the Enzyme Database: 2.7.1.177

  All links  
Gene (1865)   
   MGENES (1740)   
   RefGene (125)   
Protein sequence (504)   
   UniProt (404)   
   SWISS-PROT (2)   
   RefSeq(pep) (98)   
DNA sequence (4209)   
   RefSeq(nuc) (234)   
   GenBank (2003)   
   EMBL (1972)   
Protein domain (4)   
   InterPro (4)   
All databases (6582)   

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