KEGG   ENZYME: 2.7.1.178
Entry
EC 2.7.1.178                Enzyme                                 
Name
2-dehydro-3-deoxyglucono/galactono-kinase;
KDG kinase (ambiguous);
KDGK (ambiguous);
2-keto-3-deoxy-D-gluconate kinase (ambiguous)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase
Reaction(IUBMB)
(1) ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate [RN:R01541];
(2) ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-6-phospho-D-galactonate [RN:R03387]
Reaction(KEGG)
R01541 R03387
Substrate
ATP [CPD:C00002];
2-dehydro-3-deoxy-D-gluconate [CPD:C00204];
2-dehydro-3-deoxy-D-galactonate [CPD:C01216]
Product
ADP [CPD:C00008];
2-dehydro-3-deoxy-6-phospho-D-gluconate [CPD:C04442];
2-dehydro-3-deoxy-6-phospho-D-galactonate [CPD:C01286]
Comment
The enzyme from the archaeon Sulfolobus solfataricus is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It phosphorylates 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with similar catalytic efficiency. cf. EC 2.7.1.45, 2-dehydro-3-deoxygluconokinase and EC 2.7.1.58, 2-dehydro-3-deoxygalactonokinase.
History
EC 2.7.1.178 created 2013
Pathway
ec00030  Pentose phosphate pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
Orthology
K18126  2-dehydro-3-deoxygluconokinase / 2-dehydro-3-deoxygalactonokinase
Genes
KPFIX53_07975
MINFMESINF_0086
TPAFA3L08_08210
STOSTK_24780(kdgK)
SOHD1869_13565
SSOSSO3195
SOLSsol_0933
SSOASULA_0966
SSOLSULB_0968
SSOFSULC_0967
SSHIJ5U23_00302
SCASSACC_31310
SAISaci_0226(kdgK)
SACNSacN8_01095
SACRSacRon12I_01095
SACSSUSAZ_01135
SISLS215_2327
SIAM1425_2164
SIMM1627_2244
SIDM164_2167
SIYYG5714_2290
SINYN1551_0625
SIILD85_2430
SIHSiH_2109
SIRSiRe_2041
SICSiL_2016
SULABFU36_06095
SULEGFS03_11785
SULOGFS33_03595
SULLEWF20_14565
MSEMsed_1297
MCNMcup_0948
MHKDFR87_12300
MPRUDFR88_11835
MTENGWK48_00440
MJNMjAS7_2364
ABRIDFR85_14745
SACDHS1genome_1557
SAZOD1868_10840
CSTYKN1_14730
STEPIC006_2130
SAHSHS7_01550
PYRP186_1934
CMACmaq_0369
TTNTTX_1157(kdgK)
TUZTUZN_0956
VDIVdis_0996
VMOVMUT_1837
CSUCSUB_C0563
 » show all
Reference
1  [PMID:16330030]
  Authors
Lamble HJ, Theodossis A, Milburn CC, Taylor GL, Bull SD, Hough DW, Danson MJ
  Title
Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus.
  Journal
FEBS Lett 579:6865-9 (2005)
DOI:10.1016/j.febslet.2005.11.028
  Sequence
[sso:SSO3195]
Reference
2  [PMID:19018105]
  Authors
Potter JA, Kerou M, Lamble HJ, Bull SD, Hough DW, Danson MJ, Taylor GL
  Title
The structure of Sulfolobus solfataricus 2-keto-3-deoxygluconate kinase.
  Journal
Acta Crystallogr D Biol Crystallogr 64:1283-7 (2008)
DOI:10.1107/S0907444908036111
  Sequence
[sso:SSO3195]
Reference
3  [PMID:16794308]
  Authors
Kim S, Lee SB
  Title
Characterization of Sulfolobus solfataricus 2-keto-3-deoxy-D-gluconate kinase in  the modified Entner-Doudoroff pathway.
  Journal
Biosci Biotechnol Biochem 70:1308-16 (2006)
DOI:10.1271/bbb.50566
  Sequence
[sso:SSO3195]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.178
IUBMB Enzyme Nomenclature: 2.7.1.178
ExPASy - ENZYME nomenclature database: 2.7.1.178
BRENDA, the Enzyme Database: 2.7.1.178

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