KEGG   ENZYME: 2.7.1.179Help
Entry
EC 2.7.1.179                Enzyme                                 

Name
kanosamine kinase;
rifN (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:kanosamine 6-phosphotransferase
Reaction(IUBMB)
ATP + kanosamine = ADP + kanosamine 6-phosphate [RN:R06588]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
kanosamine [CPD:C12212]
Product
ADP [CPD:C00008];
kanosamine 6-phosphate [CPD:C12213]
Comment
The enzyme from the bacterium Amycolatopsis mediterranei is specific for kanosamine.
History
EC 2.7.1.179 created 2013
Pathway
ec01051  Biosynthesis of ansamycins
ec01130  Biosynthesis of antibiotics
Orthology
K16018  kanosamine 6-kinase
Genes
SVL: Strvi_5366
FRA: Francci3_0432
FRE: Franean1_1662
FAL: FRAAL0917
SEN: SACE_2869(rifN)
AMD: AMED_0630(rifN)
AMN: RAM_03220
AMM: AMES_0628(rifN)
AMZ: B737_0629(rifN)
AMI: Amir_3285
SAQ: Sare_1275
MIL: ML5_5917
 » show all
Taxonomy
Reference
1  [PMID:12207505]
  Authors
Arakawa K, Muller R, Mahmud T, Yu TW, Floss HG.
  Title
Characterization of the early stage aminoshikimate pathway in the formation of 3-amino-5-hydroxybenzoic acid: the RifN protein specifically converts kanosamine into kanosamine 6-phosphate.
  Journal
J Am Chem Soc 124:10644-5 (2002)
DOI:10.1021/ja0206339
  Sequence
[amn:RAM_03220]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.179
IUBMB Enzyme Nomenclature: 2.7.1.179
ExPASy - ENZYME nomenclature database: 2.7.1.179
BRENDA, the Enzyme Database: 2.7.1.179

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