Entry |
|
Name |
glycoprotein-mannosyl O6-kinase;
SGK196;
protein O-mannose kinase
|
Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
Sysname |
ATP:O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein] 6-phosphotransferase
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Reaction(IUBMB) |
ATP + O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein] = ADP + O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-(6-phospho)mannosyl]-L-threonyl/L-seryl-[protein] [RN: R11400 R12293]
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Reaction(KEGG) |
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Substrate |
ATP [CPD: C00002];
O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein]
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Product |
ADP [CPD: C00008];
O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-(6-phospho)mannosyl]-L-threonyl/L-seryl-[protein]
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Comment |
In humans this phosphorylated trisaccharide is attached to an L-threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and is important for its activity.
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History |
EC 2.7.1.183 created 2014
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Pathway |
ec00515 | Mannose type O-glycan biosynthesis |
|
Orthology |
K17547 | glycoprotein-mannosyl O6-kinase |
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Genes |
» show all
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Reference |
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Authors |
Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP |
Title |
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.7.1.183 |
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