KEGG   ENZYME: 2.7.1.183
Entry
EC 2.7.1.183                Enzyme                                 
Name
glycoprotein-mannosyl O6-kinase;
SGK196;
protein O-mannose kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein] 6-phosphotransferase
Reaction(IUBMB)
ATP + O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein] = ADP + O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-(6-phospho)mannosyl]-L-threonyl/L-seryl-[protein] [RN:R11400 R12293]
Reaction(KEGG)
R11400 R12293(G)
Substrate
ATP [CPD:C00002];
O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein]
Product
ADP [CPD:C00008];
O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-(6-phospho)mannosyl]-L-threonyl/L-seryl-[protein]
Comment
In humans this phosphorylated trisaccharide is attached to an L-threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and is important for its activity.
History
EC 2.7.1.183 created 2014
Pathway
ec00515  Mannose type O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K17547  glycoprotein-mannosyl O6-kinase
Genes
HSA84197(POMK)
PTR464154(POMK)
PPS100985143(POMK)
GGO101148209(POMK)
PON100446965(POMK)
NLE100593922(POMK)
MCC706318(POMK)
MCF102126456(POMK)
MTHB126960764
CSAB103215702(POMK)
CATY105595742(POMK)
PANU101024701(POMK)
TGE112630262(POMK)
RRO104668311(POMK)
RBB108534355(POMK)
TFN117095885(POMK)
PTEH111544084(POMK)
CJC100403123(POMK) 108590132
SBQ101052644(POMK)
CSYR103274594
MMUR105878131(POMK)
LCAT123626595(POMK)
OGA100951684(POMK)
MMU74653(Pomk)
MCAL110299993(Pomk)
MPAH110336756(Pomk)
RNO306549(Pomk)
MCOC116069072(Pomk)
MUN110566310(Pomk)
CGE100771074(Pomk)
MAUA101844716(Pomk)
PLEU114681357(Pomk)
MORG121462112(Pomk)
MFOT126504439
AAMP119813639(Pomk)
NGI103728518(Pomk)
HGL101699969(Pomk)
CPOC100718330(Pomk)
CCAN109699825(Pomk)
DORD106002029(Pomk)
DSP122107682(Pomk)
NCAR124982626
OCU100346922(POMK)
OPI101535715(POMK)
TUP102493452(POMK)
CFA482834(POMK)
CLUD112658415(POMK)
VVP112916169(POMK)
VLG121489599(POMK)
AML100469245(POMK)
UMR103677043(POMK)
UAH113245578(POMK)
UAR123780309(POMK)
ELK111144525
LLV125092814
MPUF101690834(POMK)
ORO101370967(POMK)
EJU114224858(POMK)
ZCA113925750(POMK)
MLX118009907(POMK)
NSU110573167(POMK)
FCA102902090(POMK)
PYU121010370(POMK)
PBG122472821(POMK)
LRUF124520839
PTG102958518(POMK)
PPAD109262248(POMK)
AJU106990023(POMK)
HHV120234023(POMK)
BTA514490(POMK)
BOM102270881(POMK)
BIU109553500(POMK)
BBUB102404277(POMK)
CHX102191304(POMK)
OAS105605250(POMK)
ODA120865868(POMK)
CCAD122426731 122432247(POMK)
CFR116660062(POMK)
CBAI105071098(POMK)
VPC102525840(POMK)
BACU103009793(POMK)
LVE103085701(POMK)
OOR101288878(POMK)
DLE111173564(POMK)
PCAD102996084(POMK)
PSIU116746716(POMK)
ECB100053457(POMK)
EPZ103541353(POMK)
EAI106828970(POMK)
MYB102242789(POMK)
MYD102769516(POMK)
MMYO118651705(POMK)
MLF102436905(POMK)
MNA107523904(POMK)
PKL118729222(POMK)
HAI109386257(POMK)
DRO112321487(POMK)
SHON118993222(POMK)
AJM119063071(POMK)
PDIC114508520(POMK)
PHAS123807632(POMK)
MMF118622665(POMK)
RFQ117021646(POMK)
PALE102890250(POMK)
PGIG120595664(POMK)
PVP105300659(POMK)
RAY107501363(POMK)
MJV108396029(POMK)
TOD119257864(POMK)
LAV100654599(POMK)
TMU101344402
DNM101440148(POMK)
MDO100030275(POMK)
GAS123234842(POMK)
SHR100924613(POMK)
PCW110196409(POMK)
OAA100082420(POMK)
GGA422491(POMK)
PCOC116238088(POMK)
MGP100538885(POMK)
CJO107313218(POMK)
NMEL110397665(POMK)
APLA101801929(POMK)
ACYG106035193(POMK)
AFUL116489168(POMK)
TGU100231168(POMK)
LSR110471717(POMK)
SCAN103825994(POMK)
PMOA120502697(POMK)
OTC121331452(POMK)
PRUF121360190(POMK)
GFR102033758(POMK)
FAB101811138(POMK)
PHI102112849(POMK)
PMAJ107202634(POMK)
CCAE111927790(POMK)
CCW104697134(POMK)
CBRC103617338(POMK)
ETL114062190(POMK)
ZAB102063824(POMK)
ACHL103806002(POMK)
FPG101910645(POMK)
FCH102059878(POMK)
CLV102088245(POMK)
EGZ104135539(POMK)
NNI104021153(POMK)
PLET104627328(POMK)
PCRI104025085(POMK)
ACUN113479861(POMK)
TALA104368531(POMK)
PADL103925419(POMK)
AFOR103894248(POMK)
ACHC115339485(POMK)
HALD104317846(POMK)
CCRI104161231(POMK)
CSTI104549119(POMK)
EHS104503411(POMK)
CMAC104472956(POMK)
MUI104546321(POMK)
FGA104074713(POMK)
GSTE104256305(POMK)
LDI104352380(POMK)
MNB103775806(POMK)
OHA104329196(POMK)
NNT104413156(POMK)
DPUB104304152(POMK)
PGUU104465858(POMK)
ACAR104521295(POMK)
AVIT104266994(POMK)
CVF104282997(POMK)
AAM106484357(POMK)
AROW112972166(POMK)
NPD112953460(POMK)
TGT104564852(POMK)
DNE112993247(POMK)
SCAM104152069(POMK)
ASN102374161(POMK)
AMJ102567007(POMK)
CPOO109309428(POMK)
GGN109301227(POMK)
PSS102445972(POMK)
CMY102947718(POMK)
CPIC101949171(POMK)
TST117877944(POMK)
CABI116834477(POMK)
MRV120406732(POMK)
ACS100560387(pomk)
PVT110086322(POMK)
SUND121917884 121932988(POMK)
PBI103068088(POMK)
PMUR107302375(POMK)
CTIG120302759(POMK)
TSR106550224(POMK)
PGUT117664778(POMK)
VKO123031849(POMK)
PMUA114581527 114581529
ZVI118079270 118094855(POMK)
GJA107107431(POMK)
XLA496338(pomk.L)
XTR100497421(pomk)
NPR108804921(POMK)
RTEM120914558(POMK)
BBUF120989665(POMK)
BGAR122945703(POMK)
DRE492773(pomk)
SRX107708470 107733691
SANH107678554
SGH107567859 107582561
CCAR109061611 109065618
CAUA113057034 113078215
PPRM120479678(pomk)
MAMB125276601(pomk)
IPU108263618(pomk)
PHYP113542784(pomk)
SMEO124394813(pomk)
TFD113639743(pomk)
AMEX103039966(pomk)
EEE113585802(pomk)
TRU101062833(pomk)
TNGGSTEN00000504G001 GSTEN00013652G001
NCC104947920(pomk)
ELY117269211(pomk)
EFO125905840(pomk)
PLEP121960031(pomk)
SLUC116041376(pomk)
ECRA117958862(pomk)
PFLV114571045(pomk)
GAT120831507(pomk)
PPUG119226242(pomk)
MSAM119914310(pomk)
CUD121525343(pomk)
ALAT119030297(pomk)
MZE101481202(pomk)
ONL100700536(pomk)
OAU116319162(pomk)
OLA101164276(pomk)
OML112140349(pomk)
XMA106700026(pomk)
XCO114150255(pomk)
XHE116724754(pomk)
PRET103473164(pomk)
PFOR103152298(pomk)
PLAI106947027(pomk)
PMEI106922492(pomk)
GAF122847279(pomk)
CVG107098491(pomk)
CTUL119797753(pomk)
GMU124872308(pomk)
NFU107395076(pomk)
KMR108246453(pomk)
ALIM106522200(pomk)
NWH119424393(pomk)
AOCE111579159(pomk)
MCEP124996365(pomk)
CSEM103389221(pomk)
POV109637637(pomk)
SSEN122761047(pomk)
HHIP117771427(pomk)
HSP118098074(pomk)
LCF108877752
SDU111221209(pomk)
SLAL111659623(pomk)
XGL120806638(pomk)
HCQ109530012(pomk)
BPEC110161849(pomk)
MALB109960745(pomk)
BSPL114867242(pomk)
SASA100306734(pomk)
STRU115172928(pomk)
OTW112262119(pomk)
OMY110498207(pomk)
OGO124001569(pomk)
ONE115146469(pomk)
SALP111968961(pomk)
SNH120059807(pomk)
CCLU121538738(pomk)
ELS105015966(pomk)
SFM108920894(pomk)
PKI111833170(pomk)
AANG118226785(pomk)
LOC102694538(pomk)
PSPA121294710(pomk)
ARUT117408772(pomk) 117420431
LCM102349350(POMK)
CMK103191503(pomk)
RTP109935288(pomk)
BFO118412857 118413332 118426113
BBEL109462232 109462249 109462276 109463158 109463207 109466369 109469120 109475484 109475485
CIN100180020 100180094
SCLV120335512 120336072 120336720
APLC110983381
SKO100366379
BTAB109043533
NLU111056326 120350971
FOC113213134
TPAL117647322
PVM113825371
PJA122253449
PCHN125026273
HAME121859183
PPOI119107979
ISCIscW_ISCW021504
DSV119459675
RSAN119379176
RMP119175867
VDE111249089
VJA111265098
TUT107367514
DPTE113799300
DFR124496257
PTEP107438133
SDM118198420
LGILOTGIDRAFT_123453
PCAN112563976
BGT106072675
GAE121384009
CRG105333495 105333837 105333838 105343841 117690447
MYI110462321
PMAX117340008
OBI106868601
OSN115219475
LAK106159752 106164523
NVE5520898
EPA110236958
ATEN116292519
ADF107334959
AMIL114953313 114976608
PDAM113681644
SPIS111329972
DGT114515738
XEN124443858
HMG100206145
TADTRIADDRAFT_32494
SREPTSG_04862
 » show all
Reference
1  [PMID:23929950]
  Authors
Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP
  Title
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.
  Journal
Science 341:896-9 (2013)
DOI:10.1126/science.1239951
  Sequence
[hsa:84197]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.183
IUBMB Enzyme Nomenclature: 2.7.1.183
ExPASy - ENZYME nomenclature database: 2.7.1.183
BRENDA, the Enzyme Database: 2.7.1.183

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