KEGG   ENZYME: 2.7.1.183Help
Entry
EC 2.7.1.183                Enzyme                                 

Name
glycoprotein-mannosyl O6-kinase;
SGK196;
protein O-mannose kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein] 6-phosphotransferase
Reaction(IUBMB)
ATP + O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein] = ADP + O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-(6-phospho)mannosyl]-L-threonyl/L-seryl-[protein] [RN:R11400]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein]
Product
ADP [CPD:C00008];
O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-(6-phospho)mannosyl]-L-threonyl/L-seryl-[protein]
Comment
In humans this phosphorylated trisaccharide is attached to an L-threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and is important for its activity.
History
EC 2.7.1.183 created 2014
Pathway
ec00515  Mannose type O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K17547  glycoprotein-mannosyl O6-kinase
Genes
HSA: 84197(POMK)
PTR: 464154(POMK)
PPS: 100985143(POMK)
GGO: 101148209(POMK)
PON: 100446965(POMK)
NLE: 100593922(POMK)
MCC: 706318(POMK)
MCF: 102126456(POMK)
CSAB: 103215702(POMK)
RRO: 104668311(POMK)
RBB: 108534355(POMK)
CJC: 100403123(POMK) 108590132
SBQ: 101052644(POMK)
MMU: 74653(Pomk)
RNO: 306549(Pomk)
CGE: 100771074(Pomk)
NGI: 103728518(Pomk)
HGL: 101699969(Pomk)
CCAN: 109699825(Pomk)
OCU: 100346922(POMK)
TUP: 102493452(POMK)
CFA: 482834(POMK)
AML: 100469245(POMK)
UMR: 103677043(POMK)
ORO: 101370967(POMK)
FCA: 102902090(POMK)
PTG: 102958518(POMK)
AJU: 106990023(POMK)
BTA: 514490(POMK)
BOM: 102270881(POMK)
BIU: 109553500(POMK)
PHD: 102332583(POMK)
CHX: 102191304(POMK)
OAS: 105605250(POMK)
CDK: 105094297(POMK)
BACU: 103009793(POMK)
LVE: 103085701(POMK)
OOR: 101288878(POMK)
ECB: 100053457(POMK)
EPZ: 103541353(POMK)
EAI: 106828970(POMK)
MYB: 102242789(POMK)
MYD: 102769516(POMK)
HAI: 109386257(POMK)
RSS: 109452857(POMK)
PALE: 102890250(POMK)
LAV: 100654599(POMK)
TMU: 101344402
MDO: 100030275(POMK)
SHR: 100924613(POMK)
OAA: 100082420(POMK)
GGA: 422491(POMK)
MGP: 100538885(POMK)
CJO: 107313218(POMK)
APLA: 101801929(POMK)
ACYG: 106035193(POMK)
TGU: 100231168(POMK)
GFR: 102033758(POMK)
FAB: 101811138(POMK)
PHI: 102112849(POMK)
PMAJ: 107202634(POMK)
CCW: 104697134(POMK)
FPG: 101910645(POMK)
FCH: 102059878(POMK)
CLV: 102088245(POMK)
EGZ: 104135539(POMK)
AAM: 106484357(POMK)
ASN: 102374161(POMK)
AMJ: 102567007(POMK)
PSS: 102445972(POMK)
CMY: 102947718
CPIC: 101949171(POMK)
ACS: 100560387(pomk)
PVT: 110086322(POMK)
PBI: 103068088(POMK)
GJA: 107107431(POMK)
XLA: 496338(pomk.L)
XTR: 100497421(pomk)
NPR: 108804921(POMK)
DRE: 492773(pomk)
SANH: 107678554
IPU: 108263618(pomk)
AMEX: 103039966(pomk)
TRU: 101062833
LCO: 104939320(pomk)
NCC: 104947920(pomk)
MZE: 101481202(pomk)
OLA: 101164276(pomk)
XMA: 106700026(pomk)
PRET: 103473164(pomk)
NFU: 107395076(pomk)
CSEM: 103389221(pomk)
LCF: 108877752(pomk)
HCQ: 109530012(pomk)
BPEC: 110161849(pomk)
SASA: 100306734(pomk)
ELS: 105015966(pomk)
SFM: 108920894(pomk)
LCM: 102349350(POMK)
CMK: 103191503(pomk)
APLC: 110983381
SKO: 100366379
TUT: 107367514
MYI: 110462321
OBI: 106868601
EPA: 110236958
ADF: 107334959
HMG: 100206145
 » show all
Taxonomy
Reference
1  [PMID:23929950]
  Authors
Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP
  Title
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.
  Journal
Science 341:896-9 (2013)
DOI:10.1126/science.1239951
  Sequence
[hsa:84197]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.183
IUBMB Enzyme Nomenclature: 2.7.1.183
ExPASy - ENZYME nomenclature database: 2.7.1.183
BRENDA, the Enzyme Database: 2.7.1.183

DBGET integrated database retrieval system