KEGG   ENZYME: 2.7.1.186Help
Entry
EC 2.7.1.186                Enzyme                                 

Name
mevalonate-3-phosphate 5-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:(R)-3-phosphomevalonate 5-phosphotransferase
Reaction(IUBMB)
ATP + (R)-3-phosphomevalonate = ADP + (R)-3,5-bisphosphomevalonate [RN:R10780]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
(R)-3-phosphomevalonate [CPD:C20847]
Product
ADP [CPD:C00008];
(R)-3,5-bisphosphomevalonate [CPD:C20848]
Comment
Mevalonate 3-kinase (EC 2.7.1.185) and mevalonate-3-phosphate-5-kinase act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum.
History
EC 2.7.1.186 created 2014
Pathway
ec00900  Terpenoid backbone biosynthesis
Orthology
K18690  mevalonate-3-phosphate-5-kinase
Genes
TAC: Ta0762
TVO: TVG0885910(TVG0885910)
PTO: PTO0479
FAC: FACI_IFERC01G0924
FAI: FAD_1810(pgk2)
CDIV: CPM_0343
MARH: Mia14_0536
Taxonomy
Reference
1  [PMID:24914732]
  Authors
Vinokur JM, Korman TP, Cao Z, Bowie JU.
  Title
Evidence of a novel mevalonate pathway in archaea.
  Journal
Biochemistry 53:4161-8 (2014)
DOI:10.1021/bi500566q
  Sequence
[tac:Ta0762]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.186
IUBMB Enzyme Nomenclature: 2.7.1.186
ExPASy - ENZYME nomenclature database: 2.7.1.186
BRENDA, the Enzyme Database: 2.7.1.186

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