Entry |
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Name |
acarbose 7IV-phosphotransferase;
acarbose 7-kinase;
AcbK
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Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
Sysname |
ATP:acarbose 7IV-phosphotransferase
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Reaction(IUBMB) |
ATP + acarbose = ADP + acarbose 7IV-phosphate [RN: R11184]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is specific for acarbose.
|
History |
EC 2.7.1.187 created 2015
|
Pathway |
ec00525 | Acarbose and validamycin biosynthesis |
ec01130 | Biosynthesis of antibiotics |
|
Orthology |
K19978 | acarbose 7IV-phosphotransferase |
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Genes |
» show all
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Reference |
|
Authors |
Drepper A, Pape H |
Title |
Acarbose 7-phosphotransferase from Actinoplanes sp.: purification, properties, and possible physiological function. |
Journal |
J Antibiot (Tokyo) 49:664-8 (1996) |
Reference |
|
Authors |
Goeke K, Drepper A, Pape H |
Title |
Formation of acarbose phosphate by a cell-free extract from the acarbose producer Actinoplanes sp. |
Journal |
J Antibiot (Tokyo) 49:661-3 (1996) |
Reference |
|
Authors |
Zhang CS, Stratmann A, Block O, Bruckner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W |
Title |
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.7.1.187 |
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