KEGG   ENZYME: 2.7.1.187Help
Entry
EC 2.7.1.187                Enzyme                                 

Name
acarbose 7IV-phosphotransferase;
acarbose 7-kinase;
AcbK
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:acarbose 7IV-phosphotransferase
Reaction(IUBMB)
ATP + acarbose = ADP + acarbose 7IV-phosphate [RN:R11184]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
acarbose [CPD:C06802]
Product
ADP [CPD:C00008];
acarbose 7IV-phosphate [CPD:C21156]
Comment
The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is specific for acarbose.
History
EC 2.7.1.187 created 2015
Pathway
ec00525  Acarbose and validamycin biosynthesis
Orthology
K19978  acarbose 7IV-phosphotransferase
Genes
SMA: SAVERM_1511
SCB: SCAB_20401
SFA: Sfla_0297
SHY: SHJG_7630
SHO: SHJGH_7391
SVE: SVEN_7113
SDV: BN159_1685
STRP: F750_6718
SCI: B446_30730
SALU: DC74_6799
SALL: SAZ_35315
SGU: SGLAU_01020(gacK)
STRE: GZL_01972
SPRI: SPRI_1871
SRW: TUE45_07278(kdgK_4)
KSK: KSE_21730
NDA: Ndas_3511
SRO: Sros_3352
KAL: KALB_6123
ASE: ACPL_1792 ACPL_3675(acbK)
AFS: AFR_34385
CAI: Caci_2113
SNA: Snas_4369
 » show all
Taxonomy
Reference
1  [PMID:8784428]
  Authors
Drepper A, Pape H
  Title
Acarbose 7-phosphotransferase from Actinoplanes sp.: purification, properties, and possible physiological function.
  Journal
J Antibiot (Tokyo) 49:664-8 (1996)
Reference
2  [PMID:8784426]
  Authors
Goeke K, Drepper A, Pape H
  Title
Formation of acarbose phosphate by a cell-free extract from the acarbose producer Actinoplanes sp.
  Journal
J Antibiot (Tokyo) 49:661-3 (1996)
Reference
3  [PMID:11937512]
  Authors
Zhang CS, Stratmann A, Block O, Bruckner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W
  Title
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.
  Journal
J Biol Chem 277:22853-62 (2002)
DOI:10.1074/jbc.M202375200
  Sequence
[ase:ACPL_3675]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.187
IUBMB Enzyme Nomenclature: 2.7.1.187
ExPASy - ENZYME nomenclature database: 2.7.1.187
BRENDA, the Enzyme Database: 2.7.1.187

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