KEGG ENZYME: 2.7.1.187

ENZYME: 2.7.1.187

Entry

EC 2.7.1.187                Enzyme

Name

acarbose 7IV-phosphotransferase;
acarbose 7-kinase;
AcbK

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:acarbose 7IV-phosphotransferase

Reaction(IUBMB)

ATP + acarbose = ADP + acarbose 7IV-phosphate [RN:R11184]

Reaction(KEGG)

R11184

Substrate

ATP [CPD:C00002];
acarbose [CPD:C06802]

Product

ADP [CPD:C00008];
acarbose 7IV-phosphate [CPD:C21156]

Comment

The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is specific for acarbose.

History

EC 2.7.1.187 created 2015

Pathway

ec00525

Acarbose and validamycin biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K19978

acarbose 7IV-phosphotransferase

Genes

MSX:	AU14_17890

MALL:

PBN92_19415

MSHE:

MAALD49_38210

MANP:

EHN06_15445

MNK:	RE428_33430

MAMM:

ABNF92_11185

THAT:

H3N35_23215

TVD:	SG34_025375

PAEW:

KIH87_05050

AGZ:	M0C34_15270

AGQ:	LQZ07_18255

AGAR:

OAG1_11280

CJA:

CJA_3262

HCH:

HCH_06560

HAHE:

ENC22_28710

HAHH:

O5O45_27820

RFO:	REIFOR_01851

PAGI:

ABHF91_04535

CKS:	H9L41_13925

JAZ:	YQ44_16480

JAL:	BZG29_11390

JSV:	CNX70_11820

JAS:	FJQ89_00455

JLV:	G3257_11880

JAH:	JAB4_024470(acbK)

JRI:	P9875_12160

JAE:	OPV09_11550

MVAR:

MasN3_19470

NIV:	JY500_14630

JAN:

Jann_1951

SUR:	STAUR_1373(gacK)

MBD:	MEBOL_002883

SCD:	Spica_0068

MSIL:

METEAL_07780

MSEA:

METESE_29120

FLS:	GLV81_14135

FLP:	LK994_07100

FLV:	KJS94_14640

HRS:	HER32_18960

LUT:	Lupro_02010

HWS:	RNZ46_16375

NMK:	CHR53_26640

MJO:	FOF60_11795

MSUT:

LC048_10325

PSTE:

PSTEL_21445

CCHL:

FPL14_14950

CBEI:

LF65_05135

PROQ:

P6M73_15035

KSI:	V6984_17370

LBX:

lbkm_3346

HOR:	Hore_09710

TSG:	HLK68_06310

TBK:	HF295_05705

SMA:	SAVERM_1511

SANL:

KZO11_02960

SCB:	SCAB_20401

SHY:

SHJG_7630

SHO:	SHJGH_7391

SFA:

Sfla_0297

SVE:

SVEN_7113

SDV:	BN159_1685

STRP:

F750_6718

SCI:	B446_30730

SGU:	SGLAU_01020(gacK)

STRE:

GZL_01972

SCW:	TU94_03345

SLC:	SL103_23555

SXI:	SXIM_46650

STRC:

AA958_14090

SPRI:

SPRI_1871

SCX:	AS200_09110

SRW:	TUE45_07278(kdgK_4)

SLE:	sle_62240(sle_62240)

SRN:	A4G23_05299(kdgK_4)

SGS:	AVL59_15010

SGM:	GCM10017557_11810

SCAD:

DN051_08635

SPHW:

NFX46_12550

SLS:	SLINC_7169

SNR:	SNOUR_08805

SALU:

DC74_6799

SALL:

SAZ_35315

SPLU:

LK06_028515

SNW:	BBN63_04345

SSIA:

A7J05_03525

SPUN:

BFF78_06550

SLAU:

SLA_7384

SNZ:	DC008_29530

SRJ:

SRO_6633

SLK:	SLUN_34265

SDX:	C4B68_04950

SCYA:

EJ357_02025

SAST:

CD934_07730

SNQ:	CP978_28840

STIR:

DDW44_27335

SGZ:	C0216_15315

SNK:	CP967_21885

SHAW:

CEB94_30720

SSPO:

DDQ41_28600 DDQ41_30790

SVR:	CP971_12025

SPAD:

DVK44_30925

SAQU:

EJC51_30905

SGF:	HEP81_06976

SSEO:

D0Z67_24690

SPHV:

F9278_37950

SFUG:

CNQ36_29320

SPAC:

B1H29_04410

SCHA:

CP983_06555

SGX:	H4W23_04800

SCOE:

CP976_32185

SPLA:

CP981_32500

SBRO:

GQF42_37495

STUI:

GCM10017668_53800(rbsK)

SATA:

C5746_04060

SCHF:

IPT68_31575

SHUN:

DWB77_06929(acbK)

SHAR:

HUT13_23360

SCYG:

S1361_33170(ydjH3)

SFEU:

IM697_28610

SLIA:

HA039_04205

SDW:	K7C20_31055

SAUH:

SU9_029475

SFB:	CP974_28220

SPEU:

CGZ69_28305

SROI:

IAG44_06300

SGJ:	IAG43_01740

SANU:

K7396_06165

SACT:

DMT42_32350

SINE:

KI385_36860

SDEC:

L3078_35440

SDUR:

M4V62_03095

SNIG:

HEK616_45520(kdgK)

SCAE:

IHE65_10030

SSPN:

LXH13_33225

SCIR:

STRCI_006855

SDRZ:

NEH16_01570

STUD:

STRTU_001011

SENG:

OJ254_27340

SYUN:

MOV08_08700

SARG:

HKX69_04635

SJN:	RI060_10250

SKG:	KJK29_08355

SCOA:

QU709_04815

SLAI:

P8A22_01915

SCHG:

NRO40_27745

SINN:

ABB07_05070

SPRF:

K4G22_25130

STPB:

QR97_18095

SCAJ:

O1G22_07065

STRW:

QHG49_31615

STRL:

HEP84_48450

STSD:

HEP87_49100

SCHE:

QRN89_31255

SGLY:

P8A20_01330

SCAT:

P8A18_32280

SABD:

N8I86_31290

SMOD:

POD33_33475

SPOF:

P8A21_37760

SSIR:

WAB15_33700

STRJ:

H7827_04610

KSK:

KSE_21730

KAU:	B6264_07090

KIT:	CFP65_4944

KIS:	HUT16_09340

KCH:	O1G21_14835

KCM:	ABWK59_01865 ABWK59_10050

PPOD:

AB0761_10040

STRH:

GXP74_26555

ABRY:

NYE86_13595

AGLA:

OIE69_08765

AREV:

RVR_7960

LXL:	KDY119_02177(rbsK)

PSIC:

J4E96_10105

PPHP:

VTA80_03390

MIM:	AKG07_06940

MIX:	AB663_003197

MIP:	AXH82_00785

MICR:

BMW26_11490

MPRT:

ET475_07120

MOY:	CVS54_01240(acbK)

MRN:	K8F61_08185

MPAO:

IZR02_11445

MAZA:

NFX31_05040

MELY:

L2X98_27610

MSUF:

KV394_16655

MHOT:

PU630_00295

MVD:	AWU67_13150

AGY:	ATC03_17930

AGM:	DCE93_00270

AGF:	ET445_02195

AMAU:

DSM26151_00790(acbK)

AMAV:

GCM10025877_32180

ALAV:

MTO99_15120

AIL:	FLP10_08290

CRY:	B7495_16990

GAR:	AOZ07_07750

GLU:	F0M17_07565

GMI:	NMP99_07840

GMY:

XH9_01250

GNC:	QQS42_07605

GLM:	N6V40_13350

GEY:	QMQ05_07365

BRR:	C1N80_07505

JDE:

Jden_1355

LMOI:

VV02_02970

XCE:

Xcel_1009

IVA:	Isova_0272

CET:	B8281_01830

CCEU:

CBR64_10150

CPRT:

FIC82_019755

SBIL:

SANBI_001348

CFI:

Celf_2318

CGA:	Celgi_1262

CEZ:	CBP52_06665

CEJ:	GC089_07075

CELH:

GXP71_08500

CPAL:

F1D97_13725

CELN:

CELD12_13640

OEK:	FFI11_019090

TED:	U5C87_02400

DSS:	GCM25873_05640(rbsK)

TFL:	RPIT_10095

NRN:	SHK17_10210

KQI:	F1D05_22850

KSL:	OG809_14125

KRI:	OX958_34265

NDA:

Ndas_3511

NAL:

B005_4335

NCG:	KGD84_22195

SNAH:

OUQ99_21855

SAIU:

J4H86_24555

ACTW:

F7P10_40580

SRO:

Sros_3352

NOA:	BKM31_26065

NOW:	GBF35_20075

NCX:	Nocox_24910(kdgK4)

NGN:	LCN96_20515

NFS:	OIE67_25935

MHAI:

OHB01_32985

FAL:

FRAAL2349

NML:

Namu_1114

SESP:

BN6_77270

SSYI:

EKG83_24095

KAL:

KALB_6123

ALO:

CRK60158

UME:	RM788_07370

STP:	Strop_4175

MAU:	Micau_4674

MIL:

ML5_3626

MICB:

MicB006_3678

MTUA:

CSH63_01235

MICH:

FJK98_24800

MTEM:

GCE86_17735

MSAG:

GCM10017556_09000

VMA:	VAB18032_27656

MCRA:

ID554_23100

VER:	HUT12_25325

MENO:

Jiend_43990

MCHL:

PVK74_13490

MFEU:

H1D33_28925

MHAW:

RMN56_19700

MCAY:

PVK37_29705

MICF:

QQG74_24415

ASE:	ACPL_1792 ACPL_3675(acbK)

AMS:	AMIS_22030

ACTS:

ACWT_1670 ACWT_3547

AIH:	Aiant_61270

ACTR:

Asp14428_14100(rbsK_2)

ACTL:

L3i22_017450

ASIC:

Q0Z83_071710

AOU:	ACTOB_001750

ACTE:

ACTI_42100

AFS:

AFR_34385

ATL:	Athai_20450(rbsK_2)

PRY:	Prubr_33530

CATI:

CS0771_35390 CS0771_63340(rbsK_3)

DVC:	Dvina_39925

DFU:	Dfulv_30315

DAUR:

Daura_15825

DMAT:

Dmats_34810

DACT:

KZZ52_19865 KZZ52_23045

CAI:

Caci_2113

SNA:

Snas_4369

NAV:	JQS30_11260

GLY:	K3N28_04365

PHON:

BH719_03455

HAU:

Haur_0148

CALL:

OZ401_004026

ABAT:

CFX1CAM_1639

ABAO:

BEQ56_01045

DAB:	AUC44_13735

DEID:

HLB42_20275

KPF:	IX53_06335

MPG:	Theba_2034

MINF:

MESINF_1227

LTE:	JMUB4039_1104

HSN:	DV733_07275

HDS:	HSR122_2987(rbsK4)

» show all

Reference

1 [PMID:8784428]

Authors

Drepper A, Pape H

Title

Acarbose 7-phosphotransferase from Actinoplanes sp.: purification, properties, and possible physiological function.

Journal

J Antibiot (Tokyo) 49:664-8 (1996)
DOI:10.7164/antibiotics.49.664

Reference

2 [PMID:8784426]

Authors

Goeke K, Drepper A, Pape H

Title

Formation of acarbose phosphate by a cell-free extract from the acarbose producer Actinoplanes sp.

Journal

J Antibiot (Tokyo) 49:661-3 (1996)
DOI:10.7164/antibiotics.49.661

Reference

3 [PMID:11937512]

Authors

Zhang CS, Stratmann A, Block O, Bruckner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W

Title

Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.

Journal

J Biol Chem 277:22853-62 (2002)
DOI:10.1074/jbc.M202375200

Sequence

[ase:ACPL_3675]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.187

IUBMB Enzyme Nomenclature:

2.7.1.187

ExPASy - ENZYME nomenclature database:

2.7.1.187

BRENDA, the Enzyme Database:

2.7.1.187

All links

Gene (196)   
   MGENES (194)   
   RefGene (2)   
Protein sequence (21)   
   UniProt (16)   
   SWISS-PROT (1)   
   PDBSTR (4)   
DNA sequence (18)   
   GenBank (10)   
   EMBL (8)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   InterPro (3)   
All databases (239)   

Download RDF

DBGET integrated database retrieval system