Entry
Name
acarbose 7IV-phosphotransferase;
acarbose 7-kinase;
AcbK
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:acarbose 7IV-phosphotransferase
Reaction(IUBMB)
ATP + acarbose = ADP + acarbose 7IV-phosphate [RN:
R11184 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is specific for acarbose.
History
EC 2.7.1.187 created 2015
Pathway
ec00525 Acarbose and validamycin biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K19978 acarbose 7IV-phosphotransferase
Genes
SLE : sle_62240(sle_62240)
SSPO : DDQ41_28600 DDQ41_30790
STUI : GCM10017668_53800(rbsK)
AMAU : DSM26151_00790(acbK)
ASE : ACPL_1792 ACPL_3675(acbK)
ACTS : ACWT_1670 ACWT_3547
ACTR : Asp14428_14100(rbsK_2)
CATI : CS0771_35390 CS0771_63340(rbsK_3)
» show all
Taxonomy
Reference
Authors
Drepper A, Pape H
Title
Acarbose 7-phosphotransferase from Actinoplanes sp.: purification, properties, and possible physiological function.
Journal
Reference
Authors
Goeke K, Drepper A, Pape H
Title
Formation of acarbose phosphate by a cell-free extract from the acarbose producer Actinoplanes sp.
Journal
Reference
Authors
Zhang CS, Stratmann A, Block O, Bruckner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W
Title
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.1.187