KEGG ENZYME: 2.7.1.187

ENZYME: 2.7.1.187

Entry

EC 2.7.1.187 Enzyme

Name

acarbose 7IV-phosphotransferase;
acarbose 7-kinase;
AcbK

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:acarbose 7IV-phosphotransferase

Reaction(IUBMB)

ATP + acarbose = ADP + acarbose 7IV-phosphate [RN:R11184]

Reaction(KEGG)

R11184

Substrate

ATP [CPD:C00002];
acarbose [CPD:C06802]

Product

ADP [CPD:C00008];
acarbose 7IV-phosphate [CPD:C21156]

Comment

The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is specific for acarbose.

History

EC 2.7.1.187 created 2015

Pathway

ec00525

Acarbose and validamycin biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K19978

acarbose 7IV-phosphotransferase

Genes

MSX:	AU14_17890

CJA:

CJA_3262

HCH:

HCH_06560

HAHE:

ENC22_28710

RFO:	REIFOR_01851

JAZ:	YQ44_16480

JAL:	BZG29_11390

JSV:	CNX70_11820

JAS:	FJQ89_00455

SUR:	STAUR_1373(gacK)

MBD:	MEBOL_002883

JAN:

Jann_1951

PSTE:

PSTEL_21445

CBEI:

LF65_05135

HOR:	Hore_09710

TSG:	HLK68_06310

SMA:	SAVERM_1511

SCB:	SCAB_20401

SFA:

Sfla_0297

SHY:

SHJG_7630

SHO:	SHJGH_7391

SVE:

SVEN_7113

SDV:	BN159_1685

STRP:

F750_6718

SCI:	B446_30730

SALU:

DC74_6799

SALL:

SAZ_35315

SGU:	SGLAU_01020(gacK)

STRE:

GZL_01972

SCW:	TU94_03345

SLC:	SL103_23555

SXI:	SXIM_46650

STRC:

AA958_14090

SPRI:

SPRI_1871

SCX:	AS200_09110

SRW:	TUE45_07278(kdgK_4)

SLE:	sle_62240(sle_62240)

SRN:	A4G23_05299(kdgK_4)

SGS:	AVL59_15010

SLS:	SLINC_7169

SNR:	SNOUR_08805

SPLU:

LK06_028515

SNW:	BBN63_04345

SSIA:

A7J05_03525

SPUN:

BFF78_06550

SLAU:

SLA_7384

SNZ:	DC008_29530

SRJ:

SRO_6633

SLK:	SLUN_34265

SDX:	C4B68_04950

KSK:

KSE_21730

KAU:	B6264_07090

KIT:	CFP65_4944

LXL:	KDY119_02177(rbsK)

MIM:	AKG07_06940

MIX:	AB663_003197

MIP:	AXH82_00785

MICR:

BMW26_11490

MPRT:

ET475_07120

MVD:	AWU67_13150

AGY:	ATC03_17930

AGM:	DCE93_00270

AGF:	ET445_02195

CRY:	B7495_16990

GAR:	AOZ07_07750

GLU:	F0M17_07565

BRR:	C1N80_07505

JDE:

Jden_1355

LMOI:

VV02_02970

XCE:

Xcel_1009

IVA:	Isova_0272

CET:	B8281_01830

CCEU:

CBR64_10150

CFI:

Celf_2318

CGA:	Celgi_1262

CEZ:	CBP52_06665

CEJ:	GC089_07075

CELH:

GXP71_08500

OEK:	FFI11_019090

TFL:	RPIT_10095

NDA:

NAL:

ACTW:

SRO:

NOA:	BKM31_26065

NOW:	GBF35_20075

FAL:

NML:

SESP:

SSYI:

KAL:

ALO:

STP:	Strop_4175

MAU:	Micau_4674

MIL:

MICB:

MTUA:

MICH:

MTEM:

VMA:	VAB18032_27656

ASE:	ACPL_1792 ACPL_3675(acbK)

AMS:	AMIS_22030

AFS:

ACTS:

CAI:

SNA:

HAU:

ABAT:

ABAO:

DAB:	AUC44_13735

SCD:	Spica_0068

FLS:	GLV81_14135

LUT:	Lupro_02010

KPF:	IX53_06335

MPG:	Theba_2034

MINF:

MESINF_1227

HSN:	DV733_07275

» show all

Reference

1 [PMID:8784428]

Authors

Drepper A, Pape H

Title

Acarbose 7-phosphotransferase from Actinoplanes sp.: purification, properties, and possible physiological function.

Journal

J Antibiot (Tokyo) 49:664-8 (1996)
DOI:10.7164/antibiotics.49.664

Reference

2 [PMID:8784426]

Authors

Goeke K, Drepper A, Pape H

Title

Formation of acarbose phosphate by a cell-free extract from the acarbose producer Actinoplanes sp.

Journal

J Antibiot (Tokyo) 49:661-3 (1996)
DOI:10.7164/antibiotics.49.661

Reference

3 [PMID:11937512]

Authors

Zhang CS, Stratmann A, Block O, Bruckner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W

Title

Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.

Journal

J Biol Chem 277:22853-62 (2002)
DOI:10.1074/jbc.M202375200

Sequence

[ase:ACPL_3675]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.187

IUBMB Enzyme Nomenclature:

2.7.1.187

ExPASy - ENZYME nomenclature database:

2.7.1.187

BRENDA, the Enzyme Database:

2.7.1.187

DBGET integrated database retrieval system