KEGG   ENZYME: 2.7.1.188Help
Entry
EC 2.7.1.188                Enzyme                                 

Name
2-epi-5-epi-valiolone 7-kinase;
AcbM
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:2-epi-5-epi-valiolone 7-phosphotransferase
Reaction(IUBMB)
ATP + 2-epi-5-epi-valiolone = ADP + 2-epi-5-epi-valiolone 7-phosphate [RN:R11185]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
2-epi-5-epi-valiolone [CPD:C17691]
Product
ADP [CPD:C00008];
2-epi-5-epi-valiolone 7-phosphate [CPD:C17692]
Comment
The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is involved in the biosynthesis of the oligosaccharide acarbose.
History
EC 2.7.1.188 created 2015
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K19979  2-epi-5-epi-valiolone 7-kinase
Genes
MUL: MUL_0546
MMI: MMAR_0581
RER: RER_54460
REY: O5Y_25935
REB: XU06_26215
RHB: NY08_86
SALS: SLNWT_0590
SRW: TUE45_05036(glcK)
AER: AERYTH_07145
SESP: BN6_52650
ASE: ACPL_3676(acbM) ACPL_6249
 » show all
Taxonomy
Reference
1  [PMID:11937512]
  Authors
Zhang CS, Stratmann A, Block O, Bruckner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W
  Title
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.
  Journal
J Biol Chem 277:22853-62 (2002)
DOI:10.1074/jbc.M202375200
  Sequence
[ase:ACPL_3676]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.188
IUBMB Enzyme Nomenclature: 2.7.1.188
ExPASy - ENZYME nomenclature database: 2.7.1.188
BRENDA, the Enzyme Database: 2.7.1.188

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