KEGG ENZYME: 2.7.1.188

ENZYME: 2.7.1.188

Entry

EC 2.7.1.188                Enzyme

Name

2-epi-5-epi-valiolone 7-kinase;
AcbM

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:2-epi-5-epi-valiolone 7-phosphotransferase

Reaction(IUBMB)

ATP + 2-epi-5-epi-valiolone = ADP + 2-epi-5-epi-valiolone 7-phosphate [RN:R11185]

Reaction(KEGG)

R11185

Substrate

ATP [CPD:C00002];
2-epi-5-epi-valiolone [CPD:C17691]

Product

ADP [CPD:C00008];
2-epi-5-epi-valiolone 7-phosphate [CPD:C17692]

Comment

The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is involved in the biosynthesis of the oligosaccharide acarbose.

History

EC 2.7.1.188 created 2015

Pathway

ec00525

Acarbose and validamycin biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K19979

2-epi-5-epi-valiolone 7-kinase

Genes

SERA:

Ser39006_003955

SERQ:

CWC46_03955

PEZ:	HWQ56_09185

CVC:	BKX93_19950

AVM:	JQX13_08235

MUL:

MUL_0546

MMI:

MMAR_0581

MMAE:

MMARE11_05380

NSR:	NS506_05936

NAH:	F5544_18750

NAD:	NCTC11293_02223

RER:

RER_54460

REY:

O5Y_25935

REB:	XU06_26215

RHB:

NY08_86

RHS:	A3Q41_04756(nanK_2)

RTM:	G4H71_11930

TSM:	ASU32_10300

SALS:

SLNWT_0590

SRW:	TUE45_05036(glcK)

SLE:	sle_45860(sle_45860)

SCLF:

BB341_28995

SLS:	SLINC_5102

SCYA:

EJ357_02075 EJ357_14580

SGZ:	C0216_19335

SAUH:

SU9_022205

STRH:

GXP74_28915

ARUB:

J5A65_00320

AER:	AERYTH_07145

SESP:

BN6_52650

ACTI:

UA75_21505

ACAD:

UA74_21025

ASE:	ACPL_3676(acbM) ACPL_6249

ACTS:

ACWT_3548 ACWT_6117

» show all

Reference

1 [PMID:11937512]

Authors

Zhang CS, Stratmann A, Block O, Bruckner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W

Title

Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.

Journal

J Biol Chem 277:22853-62 (2002)
DOI:10.1074/jbc.M202375200

Sequence

[ase:ACPL_3676]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.188

IUBMB Enzyme Nomenclature:

2.7.1.188

ExPASy - ENZYME nomenclature database:

2.7.1.188

BRENDA, the Enzyme Database:

2.7.1.188

DBGET integrated database retrieval system