KEGG   ENZYME: 2.7.1.189Help
Entry
EC 2.7.1.189                Enzyme                                 

Name
autoinducer-2 kinase;
lsrK (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:(S)-4,5-dihydroxypentane-2,3-dione 5-phosphotransferase
Reaction(IUBMB)
ATP + (S)-4,5-dihydroxypentane-2,3-dione = ADP + (S)-4-hydroxypentane-2,3-dione 5-phosphate [RN:R11183]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
(S)-4,5-dihydroxypentane-2,3-dione [CPD:C11838]
Product
ADP [CPD:C00008];
(S)-4-Hydroxy-5-phosphonooxypentane-2,3-dione [CPD:C20959]
Comment
The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2.
History
EC 2.7.1.189 created 2015
Orthology
K11216  autoinducer-2 kinase
Genes
ECO: b1511(lsrK)
ECJ: JW1504(ydeV)
ECD: ECDH10B_1642(lsrK)
EBW: BWG_1330(lsrK)
ECOK: ECMDS42_1222(ydeV)
ECE: Z2194(ydeV)
ECS: ECs2118
ECF: ECH74115_2124(lsrK)
ETW: ECSP_1996(lsrK)
ELX: CDCO157_1958
EOH: ECO103_1641(lsrK)
ECOO: ECRM13514_1880(lsrK)
ECOH: ECRM13516_1876(lsrK)
EOK: G2583_1876(lsrK)
ESO: O3O_12710
ESM: O3M_12885
ESL: O3K_12925
ECW: EcE24377A_1712(lsrK)
ELH: ETEC_1581
ECX: EcHS_A1593(lsrK)
ECM: EcSMS35_1661(lsrK)
ECY: ECSE_1601
ECR: ECIAI1_1523(lsrK)
ECK: EC55989_1644(lsrK)
EOC: CE10_1700(lsrK)
EUM: ECUMN_1779(lsrK)
EKF: KO11_15610(lsrK)
EDJ: ECDH1ME8569_1454(lsrK)
ELW: ECW_m1640(lsrK)
ELL: WFL_08030(lsrK)
EFE: EFER_1566(lsrK)
STY: STY3798(ydeV)
STT: t3546(ydeV)
STM: STM4072(ydeV)
SEO: STM14_4896(ydeV)
SEY: SL1344_4021(ydeV)
SEM: STMDT12_C42190(lsrK)
SEJ: STMUK_4057(ydeV)
SEB: STM474_4254(lsrk)
SEF: UMN798_4415(ydeV)
SENR: STMDT2_39351(ydeV)
SEND: DT104_40811(ydeV)
SENI: CY43_21295
SPT: SPA3915(ydeV)
SEK: SSPA3643
SEI: SPC_4178(ydeV)
SEC: SCH_3962(ydeV)
SHB: SU5_0169
SENS: Q786_19995
SED: SeD_A4470
SEG: SG3348(ydeV)
SET: SEN3862(ydeV)
SENA: AU38_19965
SENO: AU37_19980
SENV: AU39_20000
SENQ: AU40_22305
SENL: IY59_20460
SENE: IA1_19815
SFE: SFxv_1776(lsrK)
SFN: SFy_2267
SFS: SFyv_2321
SFT: NCTC1_01714(lsrK)
ENC: ECL_04484
ECLO: ENC_33410
EEC: EcWSU1_03900(lsrK)
ECLX: LI66_19540
ECLY: LI62_21540
ENF: AKI40_0665(ydeV)
KPN: KPN_03509(ydeV)
KPU: KP1_4807(ydeV)
KPP: A79E_0608
KPT: VK055_3959(lsrK)
KPE: KPK_0603(lsrK)
KPR: KPR_4713(lsrK)
KPJ: N559_0662
KPX: PMK1_01027(lsrK)
KPNU: LI86_03205
KPNK: BN49_0598(lsrK)
KVA: Kvar_0591
KOX: KOX_03320
KOE: A225_5112
EAE: EAE_03960
EAR: CCG33200
CAMA: F384_16515
YPE: YPO0415
YPK: y3764
YPH: YPC_4186
YPA: YPA_3869
YPN: YPN_0286
YPM: YP_3766(xylB3)
YPZ: YPZ3_0407
YPD: YPD4_0359
YPX: YPD8_0361
YPW: CH59_1446(lsrK)
YPJ: CH55_2394(lsrK)
YPV: BZ15_3156(lsrK)
YPL: CH46_499(lsrK)
YPS: YPTB0554(ydeV)
YPO: BZ17_2005(lsrK)
YPY: YPK_3648
YPB: YPTS_0578
YPQ: DJ40_1813(lsrK)
YPU: BZ21_3934(lsrK)
YPR: BZ20_1539(lsrK)
YPC: BZ23_34(lsrK)
YPF: BZ19_4061(lsrK)
YEN: YE0530
YEY: Y11_37641
YEW: CH47_2946(lsrK)
YET: CH48_1068(lsrK)
YAL: AT01_3048(lsrK)
YFR: AW19_3889(lsrK)
YIN: CH53_1158(lsrK)
YKR: CH54_1901
YRO: CH64_3163(lsrK)
SPE: Spro_1382
SRL: SOD_c12740(lsrK)
SPLY: Q5A_006945(lsrK)
SMAF: D781_1308
SMW: SMWW4_v1c13610(lsrK)
SMAR: SM39_0819(lsrK)
SMAC: SMDB11_0647(lsrK)
SERF: L085_21655
RAA: Q7S_12885
SOD: Sant_3797(lsrK)
PLU: plu3141
PAY: PAU_01471
XBO: XBJ1_4109(ydeV)
XBV: XBW1_0353(lsrK)
XNE: XNC1_4323(ydeV)
XNM: XNC2_4172(ydeV)
XDO: XDD1_3684(lsrK)
MMK: MU9_2083
HIA: H733_1673(lsrK)
HIC: NTHIC486_00200(lsrK)
HSO: HS_0049
HSM: HSM_1942
PMU: PM1272
PMV: PMCN06_1937(lsrK)
PMP: Pmu_19330(lsrK)
PMUL: DR93_516(lsrK)
AAT: D11S_1398
AAN: D7S_00013
AACN: AANUM_1694(lsrK)
SWD: Swoo_3745
SVO: SVI_3479
SPSW: Sps_04498
SUA: Saut_1517
SULR: B649_11025
SUN: SUN_0119
SME: SM_b21022
SMI: BN406_06009(lsrK)
SMER: DU99_30215
RSP: RSP_3506
CID: P73_1373
BSR: I33_2078
BSL: A7A1_2441
BSH: BSU6051_18550(yoaC)
BSUT: BSUB_01994(yoaC)
BSUL: BSUA_01994(yoaC)
BSUS: Q433_10970
BSS: BSUW23_09895(yoaC)
BST: GYO_2233
BSQ: B657_18550(yoaC)
BSX: C663_1918(yoaC)
BAY: RBAM_018750(yoaC)
BAQ: BACAU_1875(yoaC)
BYA: BANAU_1996(yoaC)
BAMP: B938_09695
BAML: BAM5036_1806(yoaC)
BAMA: RBAU_1842(yoaC)
BAMN: BASU_1824(yoaC)
BAMB: BAPNAU_1873(yoaC)
BAMT: AJ82_10635
BAMY: V529_19000(yoaC)
BMP: NG74_01947(yoaC)
BAO: BAMF_1970(yoaC)
BAZ: BAMTA208_07675(yoaC)
BQL: LL3_02065(yoaC)
BXH: BAXH7_01563(yoaC)
BQY: MUS_2235(xylB1)
BAMI: KSO_010010
BAMC: U471_19270
BAMF: U722_10215
BATR: TD68_07385
BANS: BAPAT_2858
BANV: DJ46_1742
BCE: BC2965
BCA: BCE_3017
BCQ: BCQ_2801(ydeV)
BCX: BCA_3051
BAL: BACI_c29350(ydeV)
BNC: BCN_2825
BCF: bcf_14535
BCER: BCK_20020
BTK: BT9727_2718(ydeV)
BTL: BALH_2666
BTT: HD73_3008
BTHI: BTK_14895
BTM: MC28_2165
BTG: BTB_c30940(lsrK)
BTI: BTG_04510
BTW: BF38_4133(lsrK)
BWW: bwei_2047(lsrK)
BMYC: DJ92_62(lsrK)
BMYO: BG05_3047
BJS: MY9_2024
BACP: SB24_00045
BACB: OY17_12495
BACY: QF06_08375
BACL: BS34A_20540(yoaC)
BALM: BsLM_1973
CSB: CLSA_c21380(lsrK)
TPYO: X956_00445
PHE: Phep_3504
SMIZ: 4412673_01035(lsrK)
DFE: Dfer_3131
LBY: Lbys_0365
 » show all
Taxonomy
Reference
1  [PMID:17274596]
  Authors
Xavier KB, Miller ST, Lu W, Kim JH, Rabinowitz J, Pelczer I, Semmelhack MF, Bassler BL
  Title
Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria.
  Journal
ACS Chem Biol 2:128-36 (2007)
DOI:10.1021/cb600444h
  Sequence
[stm:STM4072]
Reference
2  [PMID:20025244]
  Authors
Roy V, Fernandes R, Tsao CY, Bentley WE
  Title
Cross species quorum quenching using a native AI-2 processing enzyme.
  Journal
ACS Chem Biol 5:223-32 (2010)
DOI:10.1021/cb9002738
  Sequence
[eco:b1511]
Reference
3  [PMID:23672516]
  Authors
Zhu J, Hixon MS, Globisch D, Kaufmann GF, Janda KD
  Title
Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation.
  Journal
J Am Chem Soc 135:7827-30 (2013)
DOI:10.1021/ja4024989
  Sequence
[stm:STM4072]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.189
IUBMB Enzyme Nomenclature: 2.7.1.189
ExPASy - ENZYME nomenclature database: 2.7.1.189
BRENDA, the Enzyme Database: 2.7.1.189

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