KEGG   ENZYME: 2.7.1.192
Entry
EC 2.7.1.192                Enzyme                                 

Name
protein-Npi-phosphohistidine---N-acetylmuramate phosphotransferase;
murP (gene name);
N-acetylmuramic acid PTS permease;
EIINAcMur;
Enzyme IINAcMur
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
protein-Npi-phospho-L-histidine:N-acetyl-D-muramate Npi-phosphotransferase
Reaction(IUBMB)
[protein]-Npi-phospho-L-histidine + N-acetyl-D-muramate[side 1] = [protein]-L-histidine + N-acetyl-D-muramate 6-phosphate[side 2] [RN:R08559]
Reaction(KEGG)
R08559
Substrate
[protein]-Npi-phospho-L-histidine [CPD:C04261];
N-acetyl-D_muramate[side 1] [CPD:C02713]
Product
[protein]-L-histidine [CPD:C00615];
N-acetyl-D-muramate 6-phosphate[side 2] [CPD:C16698]
Comment
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
History
EC 2.7.1.192 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.192
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
Orthology
K11192  N-acetylmuramic acid PTS system EIICB component
Genes
LCQ: 111685810
ECO: b2429(murP)
ECJ: JW2422(murP)
ECD: ECDH10B_2594(murP)
EBW: BWG_2191(murP)
ECOK: ECMDS42_1980(murP)
ECE: Z3694
ECS: ECs3300(murP)
ECF: ECH74115_3659(murP)
ETW: ECSP_3376(murP)
ELX: CDCO157_3065(murP)
EOI: ECO111_3158(murP)
EOJ: ECO26_3481(murP)
EOH: ECO103_2947(murP)
ECOO: ECRM13514_3254(murP)
ECOH: ECRM13516_3115(murP)
ESL: O3K_07260(murP)
ESO: O3O_18390(murP)
ESM: O3M_07310(murP)
ECK: EC55989_2718(murP)
ECG: E2348C_2614(murP)
EOK: G2583_2960(murP)
ELR: ECO55CA74_14650(murP)
ELH: ETEC_2542
ECW: EcE24377A_2715(murP)
ECP: ECP_2451
ECOS: EC958_2754
ECV: APECO1_4118(yfeV)
ECOA: APECO78_15875(murP)
ECX: EcHS_A2565(murP)
ECM: EcSMS35_2584(murP)
ECY: ECSE_2719
ECR: ECIAI1_2486(murP)
ECQ: ECED1_2871(murP)
EUM: ECUMN_2750(murP)
ECT: ECIAI39_2574(murP)
EOC: CE10_2812(murP)
EBR: ECB_02329(yfeV)
EBL: ECD_02329(murP)
EBE: B21_02290(murP)
EBD: ECBD_1252
EIH: ECOK1_2744(murP)
ECZ: ECS88_2617(murP)
ECC: c2962
ELO: EC042_2638(murP)
ELN: NRG857_12170(murP)
ESE: ECSF_2291
EKF: KO11_10670(murP)
EAB: ECABU_c27480(murP)
EDJ: ECDH1ME8569_2363(murP)
ELU: UM146_04485(murP)
ELW: ECW_m2657(murP)
ELL: WFL_13010(murP)
ELC: i14_2760(murP)
ELD: i02_2760(murP)
ELP: P12B_c2541(murP)
ELF: LF82_1423(murP)
ECOL: LY180_12495(murP)
ECOI: ECOPMV1_02630(murP)
ECOJ: P423_13460(murP)
EFE: EFER_0743(murP)
EAL: EAKF1_ch3573c(murP)
ESZ: FEM44_02200(murP)
SFL: SF2483(murP)
SFX: S2630
SFV: SFV_2482
SFE: SFxv_2734(murP)
SFN: SFy_3527
SFS: SFyv_3604
SFT: NCTC1_02730(murP)
SBO: SBO_2454
SBC: SbBS512_E2801(murP)
SDY: SDY_2625(murP)
SHQ: A0259_15885(murP)
ECLO: ENC_14640
ENR: H650_18505(murP)
ENF: AKI40_4348(murP)
KPN: KPN_04044
KPU: KP1_5411
KPP: A79E_0064
KPH: KPNIH24_25935(murP)
KPZ: KPNIH27_24920(murP)
KPV: KPNIH29_25880(murP)
KPW: KPNIH30_26275(murP)
KPY: KPNIH31_25350(murP)
KPG: KPNIH32_27140(murP)
KPC: KPNIH10_25905(murP)
KPQ: KPR0928_25420(murP)
KPO: KPN2242_23295(murP)
KPR: KPR_0064
KPJ: N559_0100
KPI: D364_20670(murP)
KPX: PMK1_01549(murP)
KPB: FH42_16605(murP)
KPNE: KU54_000320(murP)
KPNU: LI86_00320(murP)
KPNK: BN49_0064
KVA: Kvar_0056
KPE: KPK_0050(murP)
KPK: A593_10450(murP)
KOX: KOX_06290(murP)
KOE: A225_5731
KOY: J415_03455(murP)
KOM: HR38_04780(murP)
KMI: VW41_20585(murP)
KOK: KONIH1_28875(murP)
KOC: AB185_07600(murP)
EAE: EAE_06705(murP)
EAR: CCG32669
KLW: DA718_00195(murP)
CKO: CKO_00358
ROR: RORB6_19085(murP)
RON: TE10_01980(murP)
RTG: NCTC13098_00060(murP)
REE: electrica_00051(murP)
CNT: JT31_15375(murP)
CEM: LH23_02355(murP)
CEN: LH86_02325(murP)
CLAP: NCTC11466_00489(murP)
PGE: LG71_05845(murP)
KLE: AO703_09205(murP) AO703_21230(murP)
KOR: AWR26_21800(murP)
KRD: A3780_01960(murP)
KIE: NCTC12125_03841(murP_1) NCTC12125_03842(murP_2)
AHN: NCTC12129_02510(murP)
YRE: HEC60_17615(murP)
SGOE: A8O29_020965(murP)
EBF: D782_0038
PSTS: E05_43980(yfeV)
YEN: YE3690(murP)
YEY: Y11_25621
YEW: CH47_4109(murP)
YET: CH48_2228
YFR: AW19_2693(murP)
YIN: CH53_1387
YKR: CH54_3095
YRO: CH64_2122
SFW: WN53_14975(murP)
SFG: AV650_10565(murP)
SFO: Z042_11580(murP)
PPUJ: E2566_15135(murP)
BGJ: AWC36_11130(murP)
PAM: PANA_0295(scrA)
PAJ: PAJ_3455(scrA)
PVA: Pvag_3552(yfeV)
KLN: LH22_00510(murP)
PANT: PSNIH1_07220(murP)
PSTW: DSJ_03240
PANS: FCN45_01765(murP)
PEY: EE896_17575(murP)
PLU: plu0402
PLUM: A4R40_01965(murP)
PAY: PAU_00314
PTT: VY86_06090(murP)
XBO: XBJ1_4085(yfeV)
XBV: XBW1_0378(murP)
XNE: XNC1_4343(yfeV)
XNM: XNC2_4193(yfeV)
XDO: XDD1_3663(murP)
PSI: S70_08740(murP)
PSX: DR96_1432(murP)
PRG: RB151_003690(murP)
PHEI: NCTC12003_00368(murP)
PRQ: CYG50_14415(murP)
PRJ: NCTC6933_00416(murP)
PVC: G3341_01585(murP)
MMK: MU9_667
ANS: ArsFIN_41810(murP)
HAV: AT03_15525(murP)
OPO: DSM2777_18580(murP)
PRAG: EKN56_16795(murP)
LRI: NCTC12151_01065(murP)
PMU: PM1575
PMV: PMCN06_1839(murP)
PMP: Pmu_18430(murP)
PMUL: DR93_424
PDAG: 4362423_01860(murP)
VCH: VC0207(murP)
VCF: IR04_05965(murP)
VCS: MS6_0074
VCE: Vch1786_I2489(murP)
VCQ: EN18_17935(murP)
VCI: O3Y_00945(murP)
VVU: VV2_1142
VVY: VVA1668
VVL: VV93_v1c45280(murP)
VPA: VPA1744(murP)
VPK: M636_07475(murP)
VPF: M634_18160(murP)
VAG: N646_3456
VAN: VAA_02421
LAG: N175_01795(murP)
VAU: VANGNB10_cI2592c(murP)
VSC: VSVS12_01762(murP)
VFI: VF_1115(murP)
SALY: E8E00_13990(murP)
SCOT: HBA18_13930(murP)
PSY: PCNPT3_07835(murP)
AHA: AHA_0412(murP)
AHY: AHML_02045(murP)
AHR: V428_02180(murP)
AHP: V429_02180(murP)
AHJ: V469_21140(murP)
AHH: RY45_02355(murP)
AHI: VU14_20425(murP)
MMY: MSC_0250(pts)
MMYM: MMS_A0283
MMYI: mycmycITA_00277(murP_2)
MML: MLC_2870(scrA)
MLC: MSB_A0258
EFR: EFREU_v1c02660(murP) EFREU_v1c05890(murP)
SCR: SCHRY_v1c07140(murP)
SSYR: SSYRP_v1c07400(murP)
SDI: SDIMI_v3c05470(murP)
SMIA: P344_02190
SSAB: SSABA_v1c08840(murP)
SERI: SERIO_v1c03750(murP)
SCLA: SCLARK_001321(murP)
SPRN: S100390_v1c07960(murP)
SPIT: STU14_v1c07960(murP)
SALX: SALLE_v1c08540(murP)
 » show all
Reference
1  [PMID:15060041]
  Authors
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C
  Title
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
  Journal
J Bacteriol 186:2385-92 (2004)
DOI:10.1128/JB.186.8.2385-2392.2004
  Sequence
[eco:b2429]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.192
IUBMB Enzyme Nomenclature: 2.7.1.192
ExPASy - ENZYME nomenclature database: 2.7.1.192
BRENDA, the Enzyme Database: 2.7.1.192

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