KEGG   ENZYME: 2.7.1.195
Entry
EC 2.7.1.195                Enzyme                                 
Name
protein-Npi-phosphohistidine---2-O-alpha-mannosyl-D-glycerate phosphotransferase;
mngA (gene names);
2-O-alpha-mannosyl-D-glycerate PTS permease;
EIIMngA;
Enzyme IIMngA;
Enzyme IIHrsA;
EIImannosylglycerate;
Frx
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
protein-Npi-phospho-L-histidine:2-O-alpha-mannopyranosyl-D-glycerate Npi-phosphotransferase
Reaction(IUBMB)
[protein]-Npi-phospho-L-histidine + 2-O-(alpha-D-mannopyranosyl)-D-glycerate [side 1] = [protein]-L-histidine + 2-O-(6-phospho-alpha-D-mannopyranosyl)-D-glycerate [side 2] [RN:R11169]
Reaction(KEGG)
R11169
Substrate
[protein]-Npi-phospho-L-histidine [CPD:C04261];
2-O-(alpha-D-mannopyranosyl)-D-glycerate[side 1] [CPD:C11544]
Product
[protein]-L-histidine [CPD:C00615];
2-O-(6-phospho-alpha-D-mannopyranosyl)-D-glycerate[side 2] [CPD:C16699]
Comment
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
History
EC 2.7.1.195 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.195
Orthology
K11200  2-O-A-mannosyl-D-glycerate PTS system EIIABC component
Genes
ECOb0731(mngA)
ECJJW0720(mngA)
ECDECDH10B_0797(mngA)
EBWBWG_0589(mngA)
ECOKECMDS42_0580(mngA)
EOIECO111_0747(mngA)
EOJECO26_0791(mngA)
ESLO3K_17990
ESOO3O_07300
ESMO3M_17970
ECKEC55989_0714(mngA)
ELHETEC_0741
ECWEcE24377A_0757
EUNUMNK88_767(hrsA)
ENAECNA114_0666(mngA)
ECOSEC958_0845
ECOAAPECO78_07180
ECXEcHS_A0778
ECYECSE_0790
ECRECIAI1_0704(mngA)
EBRECB_00690(hrsA)
EBLECD_00690(mngA)
EBEB21_00679(mngA)
EBDECBD_2930
ESEECSF_0663
ECLEcolC_2925
EKOEKO11_3149
EKFKO11_20100(mngA)
EDHEcDH1_2905
EDJECDH1ME8569_0689(mngA)
ELWECW_m0785(mngA)
ELLWFL_03830(mngA)
ELPP12B_c0701(mngA)
ECOLLY180_03855
ECOJP423_03595
EFEEFER_2373(mngA)
SBGSBG_0634(mngA)
SBZA464_709
SFLSF0566(hrsA)
SFXS0579(hrsA)
SFESFxv_0624(mngA)
SFNSFy_0752
SFSSFyv_0793
SFTNCTC1_00601(hrsA)
SSNSSON_0682(hrsA)
SBOSBO_0589(hrsA)
SBCSbBS512_E0650
SHQA0259_07360
ENCECL_03001
ECLGEC036_12600
ECLEECNIH2_07330
ECLNECNIH4_16040
ECLIECNIH5_06405
ECLXLI66_06280
ECLYLI62_07180
ECLOENC_20070
EHMAB284_18580
EXFBFV63_06425
ECLAECNIH3_06425
ECLCECR091_06405
EAUDI57_12295
EKBBFV64_06300
ENOECENHK_06640
EECEcWSU1_01279(hrsA)
ELGBH714_02515
ECANCWI88_15795
ERNBFV67_06065
ECLSLI67_007325
EASEntas_1209
LNICWR52_05825
EBGFAI37_00135(mngA)
ENDA4308_10380
ENZG0034_06420(mngA)
ENSHWQ15_14895(mngA)
ENKLOC22_17165(mngA)
EHUD5067_0016265(mngA)
EMORL6Y89_06275(mngA)
ESAESA_02617
CSKES15_2699(mngA)
CSZCSSP291_12365
CSJCSK29544_03912
CTUCTU_13370(hrsA)
CKOCKO_02414
CSEDJY391_14725(mngA)
CAFAL524_18975
CIRC2U53_17260
ESCEntcl_3091
KLEAO703_06855
LAXAPT61_16080
LEHC3F35_05070
LAZA8A57_06540
LEWDAI21_20185
BUFD8682_22805
BAGEBADSM9389_12890
BFTMNO13_07065(mngA)
ASUBNLZ15_07210(mngA)
SGOEA8O29_016025(mngA)
PSGCG163CM_21180(mngA)
EBFD782_3124
SFGAV650_06685
RACEJHW33_20485(mngA)
RAQRahaq2_0807
RVCJ9880_11425(mngA)
EHOA9798_10015
HPARAL518_00115
VHRAL538_26375
VOWA9237_23280
VSPVS_II0605
VEJVEJY3_09110
VFUvfu_B01212
VCTJV59_22285
VFLAL536_06575
VBRA6E01_08690
VAFD1115_08080
VCCFAZ90_21110(mngA)
VSLLTQ54_20150(mngA)
AVRB565_2243
AVOAMS64_10975
AJDI6H43_20200(mngA)
CFIRNAF01_22805(mngA)
GYCGYMC61_2235
GYAGYMC52_1363
GSEGT50_00835
GSRGS3922_09400
PCALBV455_00337(hrsA)
ACAIISX45_04980(mngA)
HMNHM131_05200
HLIHLI_15290
VNECFK40_04440
MDGK8L98_15320(mngA)
PDGBCM40_12800
LACTD7I46_05370
LACKFLP15_10585(mngA)
LARGLPA65_15025
TOOC7K38_02105
CBUTATN24_18810
CDFCD630_30860(mngA)
PDCCDIF630_03369(mngA)
CDCCD196_2878(hrsA)
CDLCDR20291_2925(hrsA)
PDFCD630DERM_30860(mngA)
ERMEYR00_02900(mngA)
ESXESOMN_v1c03240(mngA)
SMIRSMM_0331
SMIAP344_01970
SPRNS100390_v1c09020(mngA)
SPITSTU14_v1c09020(mngA)
SALXSALLE_v1c11100(mngA)
SMEISRED_002819
IPOIlyop_0751
STRSterm_3592
 » show all
Reference
1  [PMID:14645248]
  Authors
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
  Title
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
  Journal
J Biol Chem 279:5537-48 (2004)
DOI:10.1074/jbc.M310980200
  Sequence
[eco:b0731]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.195
IUBMB Enzyme Nomenclature: 2.7.1.195
ExPASy - ENZYME nomenclature database: 2.7.1.195
BRENDA, the Enzyme Database: 2.7.1.195

DBGET integrated database retrieval system