KEGG   ENZYME: 2.7.1.198
Entry
EC 2.7.1.198                Enzyme                                 

Name
protein-Npi-phosphohistidine---D-sorbitol phosphotransferase;
srlABE (gene names);
D-sorbitol PTS permease;
sorbitol PTS permease;
glucitol PTS permease;
EIIGut;
Enzyme IIGut
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
protein-Npi-phospho-L-histidine:D-sorbitol Npi-phosphotransferase
Reaction(IUBMB)
[protein]-Npi-phospho-L-histidine + D-sorbitol[side 1] = [protein]-L-histidine + D-sorbitol 6-phosphate[side 2] [RN:R05820]
Reaction(KEGG)
R05820
Substrate
[protein]-Npi-phospho-L-histidine [CPD:C04261];
D-sorbitol[side 1] [CPD:C00794]
Product
[protein]-L-histidine [CPD:C00615];
D-sorbitol 6-phosphate[side 2] [CPD:C01096]
Comment
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
History
EC 2.7.1.198 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.198
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K02781  glucitol/sorbitol PTS system EIIA component
K02782  glucitol/sorbitol PTS system EIIB component
Genes
ECO: b2703(srlE) b2704(srlB)
ECJ: JW2673(srlB) JW5430(srlE)
ECD: ECDH10B_2871(srlE) ECDH10B_2872(srlB)
EBW: BWG_2439(srlE) BWG_2440(srlB)
ECOK: ECMDS42_2208(srlE) ECMDS42_2209(srlB)
ECE: Z4009(srlE_2) Z4011(srlB)
ECS: ECs3560
ECF: ECH74115_3954(srlB)
ETW: ECSP_3652(srlB)
ELX: CDCO157_3320
EOI: ECO111_3421(srlE) ECO111_3422(srlB)
EOJ: ECO26_3766(srlE) ECO26_3767(srlB)
EOH: ECO103_3238(srlE) ECO103_3239(srlB)
ECOO: ECRM13514_3549(srlE) ECRM13514_3550(srlB)
ECOH: ECRM13516_3416(srlE) ECRM13516_3417(srlB)
ECK: EC55989_2965(srlE) EC55989_2966(srlB)
EOK: G2583_3351(srlE) G2583_3352(srlB)
ECW: EcE24377A_2987(srlE) EcE24377A_2988(srlB)
ENA: ECNA114_2735(srlE) ECNA114_2736(srlB)
ECOS: EC958_2969(srlE) EC958_2970(srlB)
ECV: APECO1_3822(srlB) APECO1_3823(srlE)
ECX: EcHS_A2839(srlE) EcHS_A2840(srlB)
ECM: EcSMS35_2826(srlE) EcSMS35_2827(srlB)
ECR: ECIAI1_2795(srlE) ECIAI1_2796(srlB)
ECQ: ECED1_3152(srlE) ECED1_3153(srlB)
EUM: ECUMN_2959 ECUMN_2960(srlE) ECUMN_3024(srlE) ECUMN_3025(srlB)
ECT: ECIAI39_2889(srlE) ECIAI39_2890(srlB)
EOC: CE10_3126(srlE) CE10_3127(srlB)
EBR: ECB_02553(srlE) ECB_02554(srlB)
EBL: ECD_02553(srlE) ECD_02554(srlB)
EBE: B21_02518(srlE) B21_02519(srlB)
ECI: UTI89_C3065(srlE) UTI89_C3066(srlB)
EIH: ECOK1_3075(srlE) ECOK1_3076(srlB)
ECZ: ECS88_2966(srlE) ECS88_2967(srlB)
ECC: c3257(srlE) c3258(srlB)
ELO: EC042_2896(srlE) EC042_2897(srlB)
EKF: KO11_09500(srlB) KO11_09505(srlE)
EAB: ECABU_c29730(srlE) ECABU_c29740(srlB)
ELW: ECW_m2902(srlE) ECW_m2903(srlB)
ELL: WFL_14160(srlE) WFL_14165(srlB)
ELC: i14_2988(srlE) i14_2989(srlB)
ELD: i02_2988(srlE) i02_2989(srlB)
ELP: P12B_c2804(srlE) P12B_c2805(srlB)
ELF: LF82_2171(srlB) LF82_2173(srlE)
ECOJ: P423_14810(srlE) P423_14815
ESZ: FEM44_03375(srlE) FEM44_03380(srlB)
STY: STY2954(srlE) STY2955(srlB)
STT: t2734(srlE) t2735(srlB)
STM: STM2751 STM2752 STM2833(srlE) STM2834(slrB)
SPT: SPA2691(srlE) SPA2692(srlB)
SEI: SPC_2874(srlE) SPC_2875(srlB)
SEC: SCH_2766(srlE) SCH_2767(slrB)
SENS: Q786_13625(srlE) Q786_13630
SED: SeD_A3142 SeD_A3143(srlB)
SEG: SG2736(srlE) SG2737(slrB)
SEL: SPUL_2827(srlE) SPUL_2828(slrB)
SEGA: SPUCDC_2813(srlE) SPUCDC_2814(slrB)
SET: SEN2674(srlE) SEN2675(slrB)
SENA: AU38_13585(srlE) AU38_13590
SENO: AU37_13595(srlE) AU37_13600
SENV: AU39_13595(srlE) AU39_13600
SENQ: AU40_15320(srlE) AU40_15325
SENL: IY59_14180(srlE) IY59_14185
SEEP: I137_13475(srlE) I137_13480
SENE: IA1_13540(srlE) IA1_13545
SBG: SBG_2453(srlE) SBG_2454(srlB)
SFL: SF2726(srlE) SF2727(srlB)
SFX: S2917(srlE) S2918(srlB)
SFV: SFV_2801(srlB)
SFE: SFxv_2990(srlE) SFxv_2991(srlB)
SFT: NCTC1_03001(srlE) NCTC1_03002(srlB)
SSN: SSON_2847(srlE) SSON_2848(srlB)
SBO: SBO_2814(srlB) SBO_2815(srlE)
SBC: SbBS512_E3173(srlB) SbBS512_E3174(srlE)
SDY: SDY_2901(srlB)
ECLO: ENC_29520
ECLX: LI66_17590(srlE) LI66_17595
ECLY: LI62_19070(srlE) LI62_19075
EEC: EcWSU1_03518(srlE) EcWSU1_03519(srlB)
ENF: AKI40_1073(srlB) AKI40_1074(srlE)
EBG: FAI37_11615(srlB) FAI37_11620(srlE)
KPNU: LI86_05910 LI86_05915(srlE)
KPNK: BN49_1089(srlB) BN49_1090(srlE) BN49_2211
KPE: KPK_1087(srlB) KPK_1088(srlE) KPK_3429
CRO: ROD_31101(srlB) ROD_31111(srlE) ROD_50571
LER: GNG29_18090(srlE) GNG29_18095(srlB)
LEA: GNG26_17480(srlE) GNG26_17485(srlB)
YEN: YE1096(gutB) YE1097(gutE)
YEW: CH47_512 CH47_513(srlE)
YET: CH48_511(srlE) CH48_512
YEE: YE5303_08491(gutB) YE5303_08501(gutE)
YAL: AT01_3567 AT01_3568(srlE)
YFR: AW19_286 AW19_287(srlE)
YIN: CH53_608(srlE) CH53_609
YRO: CH64_1442(srlE) CH64_1443
SMAR: SM39_3176(srlE) SM39_3177(srlB)
SMAC: SMDB11_2965(srlE) SMDB11_2966(srlB)
SMW: SMWW4_v1c36820(srlE) SMWW4_v1c36830(srlB)
SRL: SOD_c34920(srlE) SOD_c34930(srlB)
SERF: L085_10220 L085_10225(srlE)
PCT: PC1_0748
PEC: W5S_0876
EAM: EAMY_3074(srlB) EAMY_3075(srlE)
EAY: EAM_0522(srlE) EAM_0523(srlB)
EPY: EpC_05790(srlE) EpC_05800(srlB)
EPR: EPYR_00603(srlE) EPYR_00604(srlB)
EBI: EbC_25920(srlB) EbC_25930(srlE)
ERJ: EJP617_05220(srlB) EJP617_05230(srlE)
PAM: PANA_0836(srlB) PANA_0837(srlE)
PLF: PANA5342_3469(srlE) PANA5342_3470(srlB)
MTHI: C7M52_01829(srlB)
HSO: HS_0677(srlB) HS_0678(srlE)
PMV: PMCN06_1353(srlE) PMCN06_1354(srlB)
PMP: Pmu_13740(srlE) Pmu_13750(srlB)
PMUL: DR93_2129(srlE) DR93_2130
MHT: D648_1180(srlE) D648_1190
MHAT: B824_430 B824_440(srlE)
MHX: MHH_c06540(srlE) MHH_c06550(srlB)
MHAE: F382_07550 F382_07555(srlE)
MHAM: J450_07485(srlE) J450_07490
MHAO: J451_08415(srlE) J451_08420
MHAL: N220_00520(srlE) N220_00525
MHAQ: WC39_13540 WC39_13545(srlE)
MHAY: VK67_13545 VK67_13550(srlE)
ASA: ASA_3581(srlB) ASA_3582(srlE)
BSON: S101395_00524(srlE) S101395_00525(srlB)
LMOW: AX10_11230 AX10_11235(srlE)
LMF: LMOf2365_0571(srlB) LMOf2365_0572(srlE)
LMOG: BN389_05790(srlB) BN389_05800(srlE)
LMQ: LMM7_0572(srlB) LMM7_0573(srlE)
LWE: lwe0512(srlB) lwe0513(srlE)
LPK: LACPI_0327(srlE) LACPI_0328(srlB)
SMJ: SMULJ23_1655(srlB) SMULJ23_1656(srlE)
SMUA: SMUFR_0264(srlE) SMUFR_0265(srlB)
SEZ: Sez_0208(srlE) Sez_0209(srlB)
SEZO: SeseC_00242(srlE) SeseC_00243(srlB)
SEQU: Q426_08235(srlE)
SUB: SUB1700(srlB) SUB1701(srlE)
STK: STP_1719(srlB) STP_1720(srlE)
LPL: lp_2218(pts17A) lp_3618(pts37A) lp_3619(pts37BC) lp_3652(pts38A) lp_3653(pts38BC)
LPJ: JDM1_1855(pts17A) JDM1_2920(pts38A) JDM1_2921(pts38BC)
LPT: zj316_0191(pts38A) zj316_0192(pts38BC) zj316_2204(pts17A)
LJO: LJ_0829
LJH: LJP_1324c
LAC: LBA0655(pthA)
LAD: LA14_0683
LAF: SD55_0679(pthA)
LSA: LCA_0471
LSI: HN6_01637
LDB: Ldb0589
LBU: LBUL_0525
LDL: LBU_0492
LCB: LCABL_10220(pthA) LCABL_29010(pts38A) LCABL_29020(pts37BC)
LCW: BN194_09940 BN194_28450(pts38A) BN194_28460(srlE)
LGA: LGAS_1348
LHL: LBHH_1457(pthA)
LHH: LBH_0561(pthA)
LRH: LGG_00872(pts) LGG_02717(srlB) LGG_02718(srlE)
LRL: LC705_00922(pts) LC705_02720(srlB) LC705_02721(srlE)
LCR: LCRIS_00664(srlB)
LAM: LA2_03385
LRM: LRC_07750(srlB)
LAE: LBAT_1196
PPE: PEPE_1197
PPEN: T256_05900
PCE: PECL_795
EFL: EF62_0364(gutA) EF62_0365(gutB) EF62_2770
EFN: DENG_02540(srlB) DENG_03196(v) DENG_03197(srlE)
EDU: LIU_03995
ESG: EsVE80_04080(srlB)
MPS: MPTP_1560
MPX: MPD5_0488
THL: TEH_05560
CML: BN424_761(ptsA)
CARC: NY10_1105
CBO: CBO3414(gutB) CBO3415(gutE)
CBK: CLL_A0400
CDC: CD196_0712(srlE) CD196_0713(srlE') CD196_0714(srlB) CD196_2258(srlB) CD196_2261(srlE)
AWO: Awo_c29450(gutB) Awo_c29460(gutE)
MMI: MMAR_4062
PAW: PAZ_c03730 PAZ_c15710(srlE) PAZ_c15720(srlB)
ACIJ: JS278_01313(srlB_1) JS278_01314(srlE_1) JS278_02505(srlB_2) JS278_02506(srlE_2)
AMYY: YIM_33055(srlE) YIM_33060
PBF: CFX0092_A1873(srlB)
LBJ: LBJ_2844
LBL: LBL_0227
 » show all
Reference
1  [PMID:1100608]
  Authors
Lengeler J
  Title
Nature and properties of hexitol transport systems in Escherichia coli.
  Journal
J Bacteriol 124:39-47 (1975)
DOI:10.1128/JB.124.1.39-47.1975
Reference
2  [PMID:8875915]
  Authors
Reizer J, Mitchell WJ, Minton N, Brehm J, Reizer A, Saier MH Jr
  Title
Proposed topology of the glucitol permeases of Escherichia coli and Clostridium acetobutylicum.
  Journal
Curr Microbiol 33:331-3 (1996)
DOI:10.1007/s002849900123
  Sequence
[eco:b2703 b2704]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.198
IUBMB Enzyme Nomenclature: 2.7.1.198
ExPASy - ENZYME nomenclature database: 2.7.1.198
BRENDA, the Enzyme Database: 2.7.1.198

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