KEGG   ENZYME: 2.7.1.200
Entry
EC 2.7.1.200                Enzyme                                 

Name
protein-Npi-phosphohistidine---galactitol phosphotransferase;
gatABC (gene names);
galactitol PTS permease;
EIIGat;
Enzyme IIGat
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
protein-Npi-phospho-L-histidine:galactitol Npi-phosphotransferase
Reaction(IUBMB)
[protein]-Npi-phospho-L-histidine + galactitol[side 1] = [protein]-L-histidine + galactitol 1-phosphate[side 2] [RN:R05570]
Reaction(KEGG)
R05570
Substrate
[protein]-Npi-phospho-L-histidine [CPD:C04261];
galactitol[side 1] [CPD:C01697]
Product
[protein]-L-histidine [CPD:C00615];
galactitol 1-phosphate[side 2] [CPD:C06311]
Comment
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
History
EC 2.7.1.200 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.200
Pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
Orthology
K02773  galactitol PTS system EIIA component
K02774  galactitol PTS system EIIB component
Genes
ECO: b2093(gatB) b2094(gatA) b4302(sgcA) b4565(sgcB)
ECJ: JW2077(gatB) JW2078(gatA) JW4264(sgcA) JW5967(sgcB)
ECD: ECDH10B_2246(gatB) ECDH10B_2247(gatA) ECDH10B_4503(sgcA) ECDH10B_4506(sgcB)
EBW: BWG_1879(gatB) BWG_1880(gatA) BWG_3999(sgcA) BWG_4002(sgcB)
ECE: Z3256(gatB) Z3257(gatA) Z4875 Z4876
ECS: ECs2896 ECs2897 ECs4350 ECs4351
ECF: ECH74115_3072(gatB) ECH74115_3073(gatA) ECH74115_4823 ECH74115_4824
ETW: ECSP_2888(gatB) ECSP_2889(gatA) ECSP_4457 ECSP_4458
ELX: CDCO157_2673 CDCO157_2674 CDCO157_4087 CDCO157_4088
EOI: ECO111_2809(gatB) ECO111_2810(gatA)
EOJ: ECO26_3002(gatB) ECO26_3003(gatA)
ECK: EC55989_2347(gatB) EC55989_2348(gatA)
ECG: E2348C_2238(gatB) E2348C_2239(gatA)
ECW: EcE24377A_2381(gatB) EcE24377A_2382(gatA)
ECX: EcHS_A2229(gatB) EcHS_A2230(gatA)
ECR: ECIAI1_2167(gatB) ECIAI1_2168(gatA)
EBR: ECB_02019(gatB) ECB_02020(gatA) ECB_04167(sgcA) ECB_04170(sgcB)
EBL: ECD_02019(gatB) ECD_02020(gatA) ECD_04167(sgcA) ECD_04170(sgcB)
EBE: B21_01985(gatB) B21_01986(gatA) B21_04129(sgcA) B21_04132(sgcB)
ECC: c2618(gatB) c2619(gatA) c4277 c4278
EKF: KO11_12150(gatA) KO11_12155(gatB)
ELW: ECW_m2294(gatB) ECW_m2295(gatA)
ELL: WFL_11225(gatB) WFL_11230(gatA)
ELP: P12B_c2190(gatB) P12B_c2191(gatA)
ESZ: FEM44_00680(gatB) FEM44_00685(gatA)
STT: t1522 t1525 t3178(gatA) t3179(gatB) t3734 t3735
SPT: SPA1253(sgcA) SPA1256 SPA3127(gatA) SPA3128(gatB) SPA3633 SPA3634
SEC: SCH_1609(sgcB) SCH_1612(sgcA) SCH_3199(ptkA) SCH_3200(ptkB) SCH_3704(ptkB) SCH_3705
SFL: SF2155(gatB) SF2156(gatA)
SFX: S2281(gatB) S2282(gatA)
SFV: SFV_2148(gatB)
SFE: SFxv_2384(gatB) SFxv_2385(gatA)
SFT: NCTC1_02370(gatB) NCTC1_02371(gatA)
SSN: SSON_2140(gatB)
SBO: SBO_0914(gatB) SBO_0915(gatA)
SBC: SbBS512_E1144(gatA) SbBS512_E1145(gatB)
CTU: CTU_04370(gatB) CTU_04380(gatA)
KPN: KPN_03548(gatA) KPN_03549(gatB)
KPU: KP1_4852(gatA) KP1_4853(gatB)
CPOT: FOB25_14250(gatB) FOB25_14255(gatA)
PSTS: E05_50930 E05_50940(gatB)
MTHI: C7M52_01852(gatB) C7M52_01855(ulaC_2)
HSO: HS_1143(gatB) HS_1144(gatA)
BHA: BH0191(gatB) BH0192(gatA)
BMQ: BMQ_3202(gatB) BMQ_3203(gatB) BMQ_3204(gatA)
VPN: A21D_00396(gatB_1) A21D_00397 A21D_01928(gatB_2) A21D_01930(fruA_7) A21D_02449(gatB_4)
LMQ: LMM7_0525(gatA-1) LMM7_0529(gatC-1) LMM7_2196(gatB) LMM7_2197(gatA) LMM7_2778(gatB-2) LMM7_2779(gatA-2)
SGC: A964_0451(gatA) A964_0452(gatB) A964_0455(gatA) A964_0457(gatB)
SDA: GGS_0293
LPL: lp_3547(pts35B) lp_3548(pts35A) lp_3599(pts36A) lp_3600(pts36B)
LPJ: JDM1_2833(pts35B) JDM1_2834(pts35A) JDM1_2880(pts36A) JDM1_2881(pts36B)
LPT: zj316_0161(pts35B) zj316_0162(pts35A)
LCB: LCABL_27620(PTS-EII) LCABL_28420(pts36B) LCABL_28430(pts36A) LCABL_29480(ptkB) LCABL_29490(fruA)
LRH: LGG_00345(gatA) LGG_00346(gatB) LGG_02574(pts) LGG_02666(gatB) LGG_02667(gatA) LGG_02754(gatB) LGG_02755(gatA)
LRL: LC705_00427(pts) LC705_00428(gatA) LC705_02582(pts) LC705_02667(gatA)
LAE: LBAT_0301
EFN: DENG_00590(gatA) DENG_00591(gatB)
ROB: CK5_19470
AWO: Awo_c00070(gatA1) Awo_c00090(gatB1)
TTE: TTE0181(PtsN) TTE0182
TOC: Toce_1446
ACIJ: JS278_00057(gatB_1) JS278_00059(gatA_1) JS278_02510 JS278_02511(gatA_3)
PCAT: Pcatena_01590 Pcatena_03040(pts36B_1) Pcatena_03070(pts35A_1) Pcatena_12360(pts36B_2) Pcatena_12370(pts35A_2)
 » show all
Reference
1  [PMID:1100608]
  Authors
Lengeler J
  Title
Nature and properties of hexitol transport systems in Escherichia coli.
  Journal
J Bacteriol 124:39-47 (1975)
DOI:10.1128/JB.124.1.39-47.1975
Reference
2  [PMID:7772602]
  Authors
Nobelmann B, Lengeler JW.
  Title
Sequence of the gat operon for galactitol utilization from a wild-type strain EC3132 of Escherichia coli.
  Journal
Biochim Biophys Acta 1262:69-72 (1995)
DOI:10.1016/0167-4781(95)00053-J
  Sequence
[eco:b2094 b2093]
Reference
3  [PMID:8955298]
  Authors
Nobelmann B, Lengeler JW
  Title
Molecular analysis of the gat genes from Escherichia coli and of their roles in galactitol transport and metabolism.
  Journal
J Bacteriol 178:6790-5 (1996)
DOI:10.1128/JB.178.23.6790-6795.1996
  Sequence
[eco:b2094 b2093]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.200
IUBMB Enzyme Nomenclature: 2.7.1.200
ExPASy - ENZYME nomenclature database: 2.7.1.200
BRENDA, the Enzyme Database: 2.7.1.200

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