KEGG   ENZYME: 2.7.1.203
Entry
EC 2.7.1.203                Enzyme                                 

Name
protein-Npi-phosphohistidine---D-glucosaminate phosphotransferase;
dgaABCD (gene names);
2-amino-2-deoxy-D-gluconate PTS permease
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
protein-Npi-phospho-L-histidine:2-amino-2-deoxy-D-gluconate Npi-phosphotransferase
Reaction(IUBMB)
[protein]-Npi-phospho-L-histidine + 2-amino-2-deoxy-D-gluconate[side 1] = [protein]-L-histidine + 2-amino-2-deoxy-D-gluconate 6-phosphate[side 2] [RN:R10407]
Reaction(KEGG)
R10407
Substrate
[protein]-Npi-phospho-L-histidine [CPD:C04261];
2-amino-2-deoxy-D-gluconate[side 1] [CPD:C03752]
Product
[protein]-L-histidine [CPD:C00615];
2-amino-2-deoxy-D-gluconate 6-phosphate[side 2] [CPD:C20589]
Comment
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
History
EC 2.7.1.203 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.203
Pathway
ec00030  Pentose phosphate pathway
ec01120  Microbial metabolism in diverse environments
Orthology
K17464  D-glucosaminate PTS system EIIA component
K17465  D-glucosaminate PTS system EIIB component
Genes
EOI: ECO111_3681 ECO111_3682
EOJ: ECO26_4032 ECO26_4033
ECW: EcE24377A_3276 EcE24377A_3277
ECV: APECO1_2997 APECO1_2998
ECR: ECIAI1_3066 ECIAI1_3067
ECI: UTI89_C3970 UTI89_C3971
EIH: ECOK1_3884
ECZ: ECS88_3858 ECS88_3859
ELU: UM146_17400 UM146_17405
ECOI: ECOPMV1_03775(manX_5) ECOPMV1_03776(manX_6)
STT: t3746 t3747
SEC: SCH_3691(ptfB) SCH_3692
DMA: DMR_25820
LCB: LCABL_04120(ptnA) LCABL_04130(ptfB)
LCW: BN194_03940 BN194_04200(manX) BN194_04210(manX_2) BN194_28660(levE_5)
EFL: EF62_0065(mopB) EF62_0066(mopA)
EFN: DENG_02865(manX) DENG_02866(manX)
TTE: TTE0193
THX: Thet_0171
TIT: Thit_0168
TSH: Tsac_2503
PUF: UFO1_0311
 » show all
Reference
1  [PMID:23836865]
  Authors
Miller KA, Phillips RS, Mrazek J, Hoover TR.
  Title
Salmonella utilizes D-glucosaminate via a mannose family phosphotransferase system permease and associated enzymes.
  Journal
J Bacteriol (2013)
DOI:10.1128/JB.00290-13
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.203
IUBMB Enzyme Nomenclature: 2.7.1.203
ExPASy - ENZYME nomenclature database: 2.7.1.203
BRENDA, the Enzyme Database: 2.7.1.203

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