KEGG   ENZYME: 2.7.1.204
Entry
EC 2.7.1.204                Enzyme                                 

Name
protein-Npi-phosphohistidine---D-galactose phosphotransferase;
D-galactose PTS permease;
EIIGal;
Enzyme IIGal
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
protein-Npi-phospho-L-histidine:D-galactose Npi-phosphotransferase
Reaction(IUBMB)
[protein]-Npi-phospho-L-histidine + D-galactose[side 1] = [protein]-L-histidine + D-galactose 6-phosphate[side 2] [RN:R11171]
Reaction(KEGG)
R11171
Substrate
[protein]-Npi-phospho-L-histidine [CPD:C04261];
D-galactose[side 1] [CPD:C00124]
Product
[protein]-L-histidine [CPD:C00615];
D-galactose 6-phosphate[side 2] [CPD:C01113]
Comment
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
History
EC 2.7.1.204 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.204
Orthology
K20112  galactose PTS system EIIA component
K20113  galactose PTS system EIIB component
Genes
BSON: S101395_04912 S101395_04913
VIG: BKP57_12195 BKP57_12200
VPN: A21D_01074 A21D_01075
SCA: SCA_1696
SSIF: AL483_01340
SCV: A4G25_11645
LWI: UE46_12420
SPY: SPy_1710 SPy_1711
SPZ: M5005_Spy1400 M5005_Spy1401
SPYM: M1GAS476_1479 M1GAS476_1480
SGC: A964_1793(gatB) A964_1794(gatA)
SOR: SOR_1093(sgaB) SOR_1094
SCF: Spaf_1260(gatB) Spaf_1261(gatA)
SANG: SAIN_1272
SANC: SANR_1496
LJH: LJP_0131
LAC: LBA0146
LAD: LA14_0147
LAF: SD55_0144
LDB: Ldb0199
LBU: LBUL_0173
LDL: LBU_0153
LCB: LCABL_07380(PTS-EII) LCABL_07390
LHE: lhv_0154
LHL: LBHH_0154
LHV: lhe_0161
LHH: LBH_0126
LHD: HUO_01745
LRL: LC705_00631(pts) LC705_00632(pts) LC705_02666(gatB)
LAM: LA2_00810
LKE: WANG_1702
LAE: LBAT_0166
 » show all
Reference
1  [PMID:22660715]
  Authors
Zeng L, Martino NC, Burne RA
  Title
Two gene clusters coordinate galactose and lactose metabolism in Streptococcus gordonii.
  Journal
Appl Environ Microbiol 78:5597-605 (2012)
DOI:10.1128/AEM.01393-12
  Sequence
Reference
2  [PMID:23421335]
  Authors
Zeng L, Xue P, Stanhope MJ, Burne RA
  Title
A galactose-specific sugar: phosphotransferase permease is prevalent in the non-core genome of Streptococcus mutans.
  Journal
Mol Oral Microbiol 28:292-301 (2013)
DOI:10.1111/omi.12025
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.204
IUBMB Enzyme Nomenclature: 2.7.1.204
ExPASy - ENZYME nomenclature database: 2.7.1.204
BRENDA, the Enzyme Database: 2.7.1.204

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