KEGG   ENZYME: 2.7.1.206Help
Entry
EC 2.7.1.206                Enzyme                                 

Name
protein-Npi-phosphohistidine---L-sorbose phosphotransferase;
sorABFM (gene names);
L-sorbose PTS permease;
EIISor;
Enzyme IISor
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
protein-Npi-phospho-L-histidine:L-sorbose Npi-phosphotransferase
Reaction(IUBMB)
[protein]-Npi-phospho-L-histidine + L-sorbose[side 1] = [protein]-L-histidine + L-sorbose 1-phosphate[side 2] [RN:R04076]
Reaction(KEGG)
Substrate
[protein]-Npi-phospho-L-histidine [CPD:C04261];
L-sorbose[side 1] [CPD:C00247]
Product
[protein]-L-histidine [CPD:C00615];
L-sorbose 1-phosphate[side 2] [CPD:C02888]
Comment
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
History
EC 2.7.1.206 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.206
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K02812  PTS system, sorbose-specific IIA component
K02813  PTS system, sorbose-specific IIB component
Genes
ECE: Z5616 Z5617
ECS: ECs5001 ECs5002
ECF: ECH74115_5497
ETW: ECSP_5094 ECSP_5095
ELX: CDCO157_4684
EOJ: ECO26_5130 ECO26_5131
EOI: ECO111_4837 ECO111_4838
ECOO: ECRM13514_5147
ECOH: ECRM13516_4884
ECG: E2348C_4333 E2348C_4334
EOK: G2583_4843(sorB) G2583_4844(sorF)
ECC: c4984 c4985
EOC: CE10_4707(sorB)
ELO: EC042_4387(sorB)
ESE: ECSF_3875
ELC: i14_4573
ELD: i02_4573
ELF: LF82_635
ECOI: ECOPMV1_04398(sorB)
ECOJ: P423_22300
ECOS: EC958_4473
EAL: EAKF1_ch1895(manX)
SFL: SF4091(sorB) SF4092(sorF)
SFX: S3638(sorF) S3639(sorB)
SFV: SFV_4096(sorB) SFV_4097(sorF)
SFE: SFxv_4461
SFN: SFy_5869
SFS: SFyv_5936
SFT: NCTC1_04447(sorB)
SSN: SSON_4197(sorF)
SBO: SBO_4046(sorB) SBO_4047(sorF)
KPN: KPN_04405(manX) KPN_04406(manX)
KPT: VK055_3069(manX2)
KPE: KPK_5268(sorF) KPK_5269(sorB)
KPR: KPR_0387(sorA)
KPJ: N559_4896
KPNU: LI86_25230
KPNK: BN49_5028(sorB)
KOE: A225_0286
CAMA: F384_22140
RTG: NCTC13098_06891(sorB_1) NCTC13098_06892(sorB_2)
EBF: D782_4248
YEN: YE0813(sorB) YE0814(sorF)
YEY: Y11_22391
YEW: CH47_2674(sorB)
YET: CH48_2517(sorB)
YEE: YE5303_25221(sorB)
YFR: AW19_13(sorB)
YIN: CH53_868(sorB)
YKR: CH54_1649
STK: STP_1527
LCB: LCABL_04250(sorA) LCABL_04260(sorB)
LCS: LCBD_0429
LCE: LC2W_0424
LCW: BN194_04340(sorB)
LRL: LC705_00408(sorA) LC705_00409(sorB)
LRA: LRHK_422(sorB)
 » show all
Taxonomy
Reference
1  [PMID:7700234]
  Authors
Wehmeier UF, Wohrl BM, Lengeler JW
  Title
Molecular analysis of the phosphoenolpyruvate-dependent L-sorbose: phosphotransferase system from Klebsiella pneumoniae and of its multidomain structure.
  Journal
Mol Gen Genet 246:610-8 (1995)
  Sequence
Reference
2  [PMID:10613875]
  Authors
Yebra MJ, Veyrat A, Santos MA, Perez-Martinez G
  Title
Genetics of L-sorbose transport and metabolism in Lactobacillus casei.
  Journal
J Bacteriol 182:155-63 (2000)
DOI:10.1128/JB.182.1.155-163.2000
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.206
IUBMB Enzyme Nomenclature: 2.7.1.206
ExPASy - ENZYME nomenclature database: 2.7.1.206
BRENDA, the Enzyme Database: 2.7.1.206

DBGET integrated database retrieval system