KEGG   ENZYME: 2.7.1.206
Entry
EC 2.7.1.206                Enzyme                                 

Name
protein-Npi-phosphohistidine---L-sorbose phosphotransferase;
sorABFM (gene names);
L-sorbose PTS permease;
EIISor;
Enzyme IISor
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
protein-Npi-phospho-L-histidine:L-sorbose Npi-phosphotransferase
Reaction(IUBMB)
[protein]-Npi-phospho-L-histidine + L-sorbose[side 1] = [protein]-L-histidine + L-sorbose 1-phosphate[side 2] [RN:R04076]
Reaction(KEGG)
R04076
Substrate
[protein]-Npi-phospho-L-histidine [CPD:C04261];
L-sorbose[side 1] [CPD:C00247]
Product
[protein]-L-histidine [CPD:C00615];
L-sorbose 1-phosphate[side 2] [CPD:C02888]
Comment
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
History
EC 2.7.1.206 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.206
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K02812  sorbose PTS system EIIA component
K02813  sorbose PTS system EIIB component
Genes
ECE: Z5616 Z5617
ECS: ECs5001 ECs5002
ECF: ECH74115_5497
ETW: ECSP_5094 ECSP_5095
ELX: CDCO157_4684 CDCO157_4685
EOI: ECO111_4837 ECO111_4838
EOJ: ECO26_5130 ECO26_5131
ECOO: ECRM13514_5147 ECRM13514_5148
ECOH: ECRM13516_4884 ECRM13516_4885
ECG: E2348C_4333 E2348C_4334
EOK: G2583_4843(sorB) G2583_4844(sorF)
EOC: CE10_4707(sorB) CE10_4708
ECC: c4984 c4985
ELO: EC042_4387(sorB) EC042_4388(sorF)
ECOI: ECOPMV1_04398(sorB) ECOPMV1_04399(manX_7)
SFL: SF4091(sorB) SF4092(sorF)
SFX: S3638(sorF) S3639(sorB)
SFV: SFV_4096(sorB) SFV_4097(sorF)
SFT: NCTC1_04447(sorB) NCTC1_04448(manX_4)
SSN: SSON_4197(sorF)
SBO: SBO_4046(sorB) SBO_4047(sorF)
KPN: KPN_04405(manX) KPN_04406(manX)
KPT: VK055_3068 VK055_3069(manX2)
KPR: KPR_0387(sorA)
KPNK: BN49_5027(sorF) BN49_5028(sorB)
KPE: KPK_5268(sorF) KPK_5269(sorB)
RTG: NCTC13098_06890(manX_11) NCTC13098_06892(sorB_2)
REE: electrica_04781(manX_4) electrica_04782(sorB)
YEN: YE0813(sorB) YE0814(sorF)
YEW: CH47_2673 CH47_2674(sorB)
YET: CH48_2517(sorB) CH48_2518
YEE: YE5303_25211(sorF) YE5303_25221(sorB)
YFR: AW19_13(sorB) AW19_14
YIN: CH53_867 CH53_868(sorB)
DVM: DvMF_0422
STK: STP_1527
LCS: LCBD_0429
LCE: LC2W_0424
LCB: LCABL_04250(sorA) LCABL_04260(sorB)
LCW: BN194_04340(sorB)
LRL: LC705_00408(sorA) LC705_00409(sorB)
LRA: LRHK_422(sorB)
CBK: CLL_A3359
CBEI: LF65_05130
STH: STH1939
APR: Apre_0157
 » show all
Reference
1  [PMID:7700234]
  Authors
Wehmeier UF, Wohrl BM, Lengeler JW
  Title
Molecular analysis of the phosphoenolpyruvate-dependent L-sorbose: phosphotransferase system from Klebsiella pneumoniae and of its multidomain structure.
  Journal
Mol Gen Genet 246:610-8 (1995)
DOI:10.1007/bf00298968
  Sequence
Reference
2  [PMID:10613875]
  Authors
Yebra MJ, Veyrat A, Santos MA, Perez-Martinez G
  Title
Genetics of L-sorbose transport and metabolism in Lactobacillus casei.
  Journal
J Bacteriol 182:155-63 (2000)
DOI:10.1128/JB.182.1.155-163.2000
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.206
IUBMB Enzyme Nomenclature: 2.7.1.206
ExPASy - ENZYME nomenclature database: 2.7.1.206
BRENDA, the Enzyme Database: 2.7.1.206

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