Entry
Name
protein-Npi-phosphohistidine---lactose phosphotransferase;
lacEF (gene names);
lactose PTS permease;
EIILac;
Enzyme IILac
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
protein-Npi-phospho-L-histidine:lactose Npi-phosphotransferase
Reaction(IUBMB)
[protein]-Npi-phospho-L-histidine + lactose[side 1] = [protein]-L-histidine + lactose 6'-phosphate[side 2] [RN:
R04393 R06237 ]
Reaction(KEGG)
Substrate
[protein]-Npi-phospho-L-histidine;
lactose[side 1]
Product
[protein]-L-histidine [CPD:
C00615 ];
lactose 6'-phosphate[side 2]
Comment
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC
2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
History
EC 2.7.1.207 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.207
Pathway
Orthology
K02786 lactose PTS system EIIA component
K02788 lactose PTS system EIICB component
Genes
SDO : SD1155_00680 SD1155_00685
BAY : RBAM_012160 RBAM_012170
BAQ : BACAU_1168(lacE) BACAU_1169(lacF)
BYA : BANAU_1148(lacE) BANAU_1149(lacF)
BAMP : B938_06200 B938_06205
BQY : MUS_1295(lacE) MUS_1296(lacF)
BAML : BAM5036_1122(lacE) BAM5036_1123(lacF)
BAMA : RBAU_1170(lacE) RBAU_1171(lacF)
BAMN : BASU_1150(lacE) BASU_1151(lacF)
BAMB : BAPNAU_2575(lacF) BAPNAU_2576(lacE)
BAMT : AJ82_06820 AJ82_06825
BAMY : V529_11580(lacE) V529_11590(lacF)
BMP : NG74_01237(lacE) NG74_01238(lacF_1)
BAO : BAMF_1294(lacE) BAMF_1295(lacF)
BAZ : BAMTA208_11100(lacF) BAMTA208_11105(lacE)
BQL : LL3_01303(lacE) LL3_01304(lacF)
BXH : BAXH7_02272(lacF) BAXH7_02273(lacE)
BAMI : KSO_013490 KSO_013495
BAMC : U471_12170 U471_12180
BAMF : U722_06315 U722_06320
BSIA : CWD84_15260 CWD84_15265
BVM : B9C48_06085 B9C48_06090
BACP : SB24_03730 SB24_03735
BACB : OY17_09185 OY17_09190
BACS : AUL54_04530 AUL54_04535
TAP : GZ22_12250 GZ22_12255
SAU : SA1992(lacE) SA1993(lacF)
SAV : SAV2190(lacE) SAV2191(lacF)
SAW : SAHV_2174(lacE) SAHV_2175(lacF)
SAH : SaurJH1_2260 SaurJH1_2261
SAJ : SaurJH9_2221 SaurJH9_2222
SAM : MW2116(lacE) MW2117(lacF)
SAR : SAR2281(lacE) SAR2282(lacF)
SAC : SACOL2181(lacE) SACOL2182(lacF)
SAX : USA300HOU_2183(lacE) USA300HOU_2184(lacF)
SAA : SAUSA300_2150(lacE) SAUSA300_2151(lacF)
SAO : SAOUHSC_02450 SAOUHSC_02451
SAE : NWMN_2094(lacE) NWMN_2095(lacF)
SAD : SAAV_2251(lacE) SAAV_2252(lacF)
SUU : M013TW_2156 M013TW_2157
SUV : SAVC_09840(lacE) SAVC_09845(lacF)
SUE : SAOV_2237c SAOV_2238c
SUJ : SAA6159_02101 SAA6159_02102
SUK : SAA6008_02231 SAA6008_02232
SUC : ECTR2_2051 ECTR2_2052(lacF)
SUT : SAT0131_02364 SAT0131_02365
SUQ : HMPREF0772_11000(lacF) HMPREF0772_11001
SUZ : MS7_2213(lacE) MS7_2214(lacF)
SUD : ST398NM01_2250 ST398NM01_2251
SUX : SAEMRSA15_20950(lacE) SAEMRSA15_20960(lacF)
SUW : SATW20_23280(lacE) SATW20_23290(lacF)
SUF : SARLGA251_19850(lacE) SARLGA251_19860(lacF)
SAUA : SAAG_00025 SAAG_00026
SAUE : RSAU_002034(lacE) RSAU_002035(lacF)
SAUN : SAKOR_02158 SAKOR_02159
SAUS : SA40_1945(lacE) SA40_1946(lacF)
SAUU : SA957_2029(lacE) SA957_2030(lacF)
SAUG : SA268_2100(lacE) SA268_2101(lacF)
SAUZ : SAZ172_2294(lacE) SAZ172_2295(lacF)
SAUT : SAI1T1_2016310(lacE)
SAUJ : SAI2T2_1016320(lacE)
SAUK : SAI3T3_1016310(lacE)
SAUQ : SAI4T8_1016320(lacE)
SAUV : SAI7S6_1016310(lacE)
SAUW : SAI5S5_1016250(lacE)
SAUX : SAI6T6_1016260(lacE)
SAUY : SAI8T7_1016290(lacE)
SAUF : X998_2178 X998_2179
SAB : SAB2071c(lacE) SAB2072c(lacF)
SUY : SA2981_2128(lacE) SA2981_2129(lacF)
SAUB : C248_2228(lacE) C248_2229(lacF)
SAUM : BN843_22320 BN843_22330
SAUC : CA347_2279(lacE) CA347_2280(lacF)
SAUR : SABB_01469(lacF) SABB_03032(lacE)
SAUI : AZ30_11590 AZ30_11595
SAUD : CH52_07990 CH52_07995
SAMS : NI36_10815 NI36_10820
SUH : SAMSHR1132_20220 SAMSHR1132_20230
SER : SERP1790(lacE) SERP1791(lacF)
SEPP : SEB_01790 SEB_01791
SEPS : DP17_734(lacE) DP17_735(lacF)
SHA : SH0846(lacF) SH0847(lacE)
SHH : ShL2_00741 ShL2_00742
SCA : SCA_0667(lacF) SCA_0668(lacE)
SLG : SLGD_00829 SLGD_00830
SSD : SPSINT_1854 SPSINT_1855
SDT : SPSE_0619(lacF) SPSE_0620(lacE)
SWA : A284_03525 A284_03530
SPAS : STP1_0619 STP1_0683 STP1_0684
SHU : SHYC_03365(lacF) SHYC_03370(lacE)
SCAP : AYP1020_1384(lacE) AYP1020_1385(lacF)
SSCH : LH95_06735 LH95_06740
SAGQ : EP23_06705 EP23_06710
SCV : A4G25_04595 A4G25_04600
SLZ : B5P37_02955 B5P37_02960
SFQ : C7J90_06160 C7J90_06165
SHOM : EGX58_07685 EGX58_07690
SCAR : DWB96_03695 DWB96_03700
SCHR : DWB92_03160 DWB92_03165
SPIC : SAMEA4384060_1896(lacE) SAMEA4384060_1897(lacF)
SSH : NCTC13712_02135(lacE) NCTC13712_02136(lacF)
SSIM : SAMEA4384339_2036(lacE) SAMEA4384339_2037(lacF)
SDB : CNQ82_05070 CNQ82_05075
SAUL : I6G39_08015 I6G39_08020
SRAI : LN051_02890 LN051_02895
STAS : HYI43_03990 HYI43_03995
SSCU : CEP64_06360 CEP64_06365
MLEN : H3V22_08280 H3V22_08285
MBOE : HT586_09330 HT586_09335
MARY : LAU42_08235 LAU42_08240
EAT : EAT1b_1051 EAT1b_1052
EAP : KB235_15115 KB235_15120
EMM : PTI97_01890 PTI97_10815 PTI97_10820
LLD : P620_14800 P620_14805
LLR : llh_14025(lacE) llh_14030(lacF)
LLI : uc509_p8018(lacE) uc509_p8019(lacF)
LRN : CMV25_10690 CMV25_10695
SPY : SPy_1917(lacE) SPy_1918(lacF)
SPZ : M5005_Spy1633(lacE) M5005_Spy1634(lacF)
SPYM : M1GAS476_0299(lacF) M1GAS476_0300(lacE)
SPYA : A20_1683c(lacE) A20_1684c(lacF)
SPM : spyM18_1985 spyM18_1986
SPG : SpyM3_1654(lacE) SpyM3_1655(lacF)
SPH : MGAS10270_Spy1702(lacE) MGAS10270_Spy1703(lacF)
SPI : MGAS10750_Spy1730(lacE) MGAS10750_Spy1731(lacF)
SPJ : MGAS2096_Spy1658(lacE) MGAS2096_Spy1659(lacF)
SPK : MGAS9429_Spy1636(lacE) MGAS9429_Spy1637(lacF)
SPF : SpyM51608(lacE) SpyM51609(lacF)
SPA : M6_Spy1642 M6_Spy1643
SPB : M28_Spy1623(lacE) M28_Spy1624(lacF)
STG : MGAS15252_1483(lacE) MGAS15252_1484(lacF)
STX : MGAS1882_1544(lacE) MGAS1882_1545(lacA)
SOZ : Spy49_1585c(lacE) Spy49_1586c(lacF)
STZ : SPYALAB49_001622(lacE) SPYALAB49_001623(lacF)
SPYO : STAB901_07965 STAB901_07970
SPN : SP_0476(lacF-1) SP_0478(lacE-1) SP_1185(lacE-2) SP_1186(lacF-2)
SPD : SPD_0426(lacF-1) SPD_0428(lacE-1) SPD_1047(lacE-2) SPD_1048(lacF-2)
SPR : spr0423(PTS-EII) spr0425(PTS-EII) spr1070(lacE) spr1071(lacF)
SPW : SPCG_0459 SPCG_1110 SPCG_1111
SNV : SPNINV200_04240 SPNINV200_10420(lacF) SPNINV200_10430(lacE2)
SPX : SPG_0432 SPG_0434 SPG_1082 SPG_1083
SNT : SPT_0517 SPT_0519 SPT_1038 SPT_1039
SND : MYY_0546 MYY_0548 MYY_1047 MYY_1048
SPNN : T308_02300 T308_02310 T308_04825 T308_04830
SNE : SPN23F10860(lacE2) SPN23F10870(lacF)
SPV : SPH_0588 SPH_0590 SPH_1305 SPH_1306
SNC : HMPREF0837_10774(lacF) HMPREF0837_10776 HMPREF0837_11312(lacF) HMPREF0837_11313
SNM : SP70585_0539 SP70585_0541 SP70585_1237 SP70585_1238
SPP : SPP_0501 SPP_0503 SPP_1228 SPP_1229
SNI : INV104_04040 INV104_10220(lacE2) INV104_10230(lacF)
SPNG : HMPREF1038_00512 HMPREF1038_00514 HMPREF1038_01194 HMPREF1038_01195
SNB : SP670_0555 SP670_0557 SP670_1088 SP670_1089
SNP : SPAP_0481 SPAP_0483 SPAP_1214 SPAP_1215
SNX : SPNOXC10640(lacE2) SPNOXC10650(lacF)
SPNE : SPN034156_01520(lacE2) SPN034156_01530(lacF) SPN034156_15020 SPN034156_15040
SPNU : SPN034183_10640(lacE2) SPN034183_10650(lacF)
SPNM : SPN994038_10530(lacE2) SPN994038_10540(lacF)
SPNO : SPN994039_10540(lacE2) SPN994039_10550(lacF)
SAGM : BSA_13370 BSA_13380
SAGI : MSA_13680 MSA_13690
SMU : SMU_1491(lacE) SMU_1492(lacF)
SMC : SmuNN2025_0618(lacF) SmuNN2025_0619(lacE)
SMUT : SMUGS5_06660 SMUGS5_06665
SMJ : SMULJ23_0627(lacF) SMULJ23_0628(lacE)
SMUA : SMUFR_1294 SMUFR_1295
SSA : SSA_1693(lacE) SSA_1694(lacF)
SSB : SSUBM407_0516(lacF2) SSUBM407_0517(lacE2) SSUBM407_0886(lacF1) SSUBM407_0887(lacE1)
SSU : SSU05_1037 SSU05_1038
SSV : SSU98_1049 SSU98_1050 SSU98_1051
SSI : SSU0892(lacE) SSU0893(lacF)
SSS : SSUSC84_0937(lacE) SSUSC84_0938(lacF)
SSF : SSUA7_0908 SSUA7_0909
SSW : SSGZ1_0916 SSGZ1_0917
SSUS : NJAUSS_0970 NJAUSS_0971
SST : SSUST3_1068 SSUST3_1069(lacF1)
SSUY : YB51_5275 YB51_5280
SSQ : SSUD9_1215 SSUD9_1216(lacF1)
SUI : SSUJS14_1017 SSUJS14_1018
SUO : SSU12_0957 SSU12_0958
SRP : SSUST1_0905 SSUST1_0906
SSUI : T15_0915(lacF) T15_0916
SGO : SGO_1513(lacE) SGO_1514(lacF)
SEZ : Sez_0459(lacF) Sez_0460(lacE)
SEQ : SZO_15230(lacE) SZO_15240(lacF)
SEZO : SeseC_00554(lacF) SeseC_00555
SEQU : Q426_06965 Q426_06970
SUB : SUB0798(lacF2) SUB0799(lacE2) SUB1451(lacF1)
SDA : GGS_0828(lacF) GGS_0829(lacE)
SDQ : SDSE167_0943 SDSE167_0944
SGA : GALLO_0187 GALLO_0188 GALLO_1047 GALLO_1048
SGG : SGGBAA2069_c02050(lacF) SGGBAA2069_c02060(lacE) SGGBAA2069_c10240(lacF1) SGGBAA2069_c10250(lacE1)
SGT : SGGB_0231(lacF) SGGB_0232(lacE) SGGB_1037 SGGB_1038
SMB : smi_1037(lacF) smi_1038(lacE)
SOR : SOR_1084(lacE) SOR_1085(lacF)
STB : SGPB_0174(lacF) SGPB_0175(lacE) SGPB_0908 SGPB_0909
SCP : HMPREF0833_10688 HMPREF0833_10689(lacF)
SCF : Spaf_1252(lacE) Spaf_1253(lacF2)
STD : SPPN_05765 SPPN_05770
SMN : SMA_0209(lacF) SMA_0210(lacE) SMA_1158(lacE) SMA_1159(lacF)
SIE : SCIM_1141(lacE) SCIM_1142(lacF)
SIB : SIR_0450(lacF) SIR_0451(lacE)
SIU : SII_0434(lacF) SII_0435(lacE)
SANG : SAIN_1265(lacE) SAIN_1266(lacF)
SANC : SANR_1490(lacE) SANR_1491(lacF)
SANS : DK43_03230 DK43_03235
SCG : SCI_1406(lacE) SCI_1407(lacF)
SCON : SCRE_1363(lacE) SCRE_1364(lacF)
SCOS : SCR2_1363(lacE) SCR2_1364(lacF)
SIG : N596_09030 N596_09035
STV : V470_05045 V470_05050
SPAT : A0O21_01305 A0O21_01310
STRA : ATM98_08455 ATM98_08460
SSOB : DK181_06575 DK181_06580
SRQ : SR187_4965 SR187_4970
SKI : D7D50_01340 D7D50_01345
SPEI : EHW89_06385 EHW89_06390
SRAT : FY406_10205 FY406_10210
SPLR : C0J00_08115 C0J00_08120
STRG : SRT_06290(lacF) SRT_06300(lacE)
SMEN : SAMEA4412692_0113(lacF_1) SAMEA4412692_0114(lacE)
SFER : NCTC12278_00093(lacF) NCTC12278_00094(lacE)
SCAI : NCTC12191_01616(lacE) NCTC12191_01617(lacF_2)
SCHJ : DDV21_009500 DDV21_009505
SLAT : J4854_08700 J4854_08705
SURN : NCTC13766_01131(lacE) NCTC13766_01132(lacF)
SACO : SAME_01409(lacE_1) SAME_01410(lacF_1) SAME_02056(lacE_2) SAME_02057(lacF_2) SAME_02061(lacF_3)
SOS : INT76_09120 INT76_09125
STOY : STYK_09460(lacF) STYK_09470(lacE)
LJF : FI9785_571(lacF) FI9785_572(lacE)
LDE : LDBND_1645(lacE) LDBND_1647(lacF)
LGA : LGAS_0342 LGAS_0343 LGAS_0500 LGAS_0501
LJE : BUE77_05050 BUE77_05060
LPW : LpgJCM5343_03380 LpgJCM5343_03390 LpgJCM5343_04920 LpgJCM5343_04930
LCS : LCBD_0732 LCBD_0734(celCD)
LCE : LC2W_0732 LC2W_0734(celCD) LC2W_p06(lacE) LC2W_p08(lacF)
LCW : BN194_07310(lacE) BN194_07330(lacF_2)
LCL : LOCK919_0655 LOCK919_0657
LPQ : AF91_01890 AF91_01900 AF91_02340 AF91_02350
LPI : LBPG_04227 LBPG_04229
LPAP : LBPC_0582 LBPC_0584
LCB : LCABL_07270(lacE) LCABL_07290(lacF)
LRH : LGG_00649(lacE) LGG_00652(lacF)
LRL : LC705_00312(lacE) LC705_00314(lacF) LC705_00622(lacE) LC705_00624(lacF) LC705_p00063(lacE) LC705_p00065(lacF)
LRA : LRHK_321(lacE) LRHK_323(lacF) LRHK_640 LRHK_642(lacF)
LRO : LOCK900_0302 LOCK900_0304 LOCK900_0591 LOCK900_0593
LRC : LOCK908_0316 LOCK908_0318 LOCK908_0633 LOCK908_0635
LCHI : KG086_02595 KG086_02605
LZE : KG087_14595 KG087_14605 KG087_14630 KG087_14640
LACA : LAC1533_0050 LAC1533_0052 LAC1533_0055
LANI : FAX13_09525 FAX13_09535
PIO : PI20285_00370 PI20285_00375
LHI : JP39_05095 JP39_05100
LCT : BI355_1201 BI355_1202 BI355_1205 BI355_1206 BI355_2122 BI355_2124
LALW : BTM29_01680 BTM29_01690 BTM29_10575 BTM29_10580 BTM29_10595 BTM29_10600
LFM : LF20184_00855 LF20184_00865 LF20184_07460 LF20184_07465 LF20184_07480 LF20184_07485
LZH : D1B17_05380 D1B17_05385
LFT : FG051_00500 FG051_00510 FG051_07120 FG051_07130 FG051_07135
CPAB : G6534_04315 G6534_04320 G6534_04335 G6534_04340 G6534_11135 G6534_11145
EFL : EF62_0868(lacE) EF62_0869(lacF)
EFD : EFD32_0427 EFD32_0428
EFN : DENG_00523(lacF) DENG_00524(lacE)
EFC : EFAU004_00040 EFAU004_00041
EFAU : EFAU085_00033 EFAU085_00034 EFAU085_p1098(lacE) EFAU085_p1099(lacF)
EFU : HMPREF0351_10031(lacF) HMPREF0351_10032(lacE)
EFM : M7W_125 M7W_126 M7W_253 M7W_254
EFT : M395_00160 M395_00165 M395_00600 M395_00605
ECAS : ECBG_02568 ECBG_02569
EMU : EMQU_1647(lacE) EMQU_1648
EGV : EGCR1_07180 EGCR1_07185
EAV : EH197_03415 EH197_03420 EH197_05655
ESG : EsVE80_18890(lacE) EsVE80_18900(lacF)
ELAC : I4Q40_00635 I4Q40_00640
ECEC : NCTC12421_00222(lacF) NCTC12421_00223(lacE)
ERAF : J9537_15900 J9537_15905 J9537_15915 J9537_15920
EDS : PML78_05225 PML78_10270 PML78_10275 PML78_11040 PML78_11045
TKR : C7K43_08975 C7K43_08985
VLU : M2919_08110 M2919_08115
AVS : AWM76_08805 AWM76_08810
CARN : FPV25_06900 FPV25_06905
CVD : LHA31_12595 LHA31_12600
DPM : FNV33_06645 FNV33_06650
CAC : CA_C2964(lacE) CA_C2965(lacF)
CAE : SMB_G3000(lacE) SMB_G3001(lacF)
CAY : CEA_G2971(lacE) CEA_G2972(lacF)
CSB : CLSA_c41090(lacE) CLSA_c41100(lacF)
CBV : U729_2187(lacF) U729_2188(lacE)
CRW : CROST_038410(lacE) CROST_038420(lacF)
CFB : CLFE_009430(lacF) CLFE_009440(lacE)
CAUN : CLAUR_036850(lacF_2) CLAUR_036860(lacE)
SARJ : HH195_03315 HH195_03320
ROC : HF520_11835 HF520_11840
SRI : SELR_04240(lacE) SELR_04320(lacF)
FRO : AALO17_03140 AALO17_03150
FIT : Fi14EGH31_18970(lacE1) Fi14EGH31_18980(lacF)
EBM : SG0102_04400(lacF) SG0102_04410
ERM : EYR00_14535 EYR00_14540
CMIT : NQ499_00155 NQ499_00160
ELJ : ELUMI_v1c08110(lacF) ELUMI_v1c08130(celB)
STAI : STAIW_v1c07630(celC)
SERI : SERIO_v1c00550(lacF)
SLL : SLITO_v1c06870(lacF) SLITO_v1c06890(lacE)
SCLA : SCLARK_00209(celC) SCLARK_00215(celC) SCLARK_00223(celC)
CAER : CSV91_06185 CSV91_06195 CSV91_06210
LOT : AXF11_06470 AXF11_06475
LEQ : BCB68_02660 BCB68_02665
LHF : JCM16775_1974(lacE) JCM16775_1975
LSZ : JCM16776_0562(lacF) JCM16776_0563(lacE)
LTE : JMUB4039_1771(lacE) JMUB4039_1772
STR : Sterm_1616 Sterm_3457 Sterm_3458
» show all
Taxonomy
Reference
Authors
Hengstenberg W
Title
Solubilization of the membrane bound lactose specific component of the staphylococcal PEP dependant phosphotransferase system.
Journal
Reference
Authors
Vadeboncoeur C, Proulx M
Title
Lactose transport in Streptococcus mutans: isolation and characterization of factor IIIlac, a specific protein component of the phosphoenolpyruvate-lactose phosphotransferase system.
Journal
Reference
Authors
Breidt F Jr, Hengstenberg W, Finkeldei U, Stewart GC
Title
Identification of the genes for the lactose-specific components of the phosphotransferase system in the lac operon of Staphylococcus aureus.
Journal
J Biol Chem 262:16444-9 (1987)
Sequence
Reference
Authors
de Vos WM, Boerrigter I, van Rooyen RJ, Reiche B, Hengstenberg W
Title
Characterization of the lactose-specific enzymes of the phosphotransferase system in Lactococcus lactis.
Journal
J Biol Chem 265:22554-60 (1990)
Sequence
Reference
Authors
Peters D, Frank R, Hengstenberg W
Title
Lactose-specific enzyme II of the phosphoenolpyruvate-dependent phosphotransferase system of Staphylococcus aureus. Purification of the histidine-tagged transmembrane component IICBLac and its hydrophilic IIB domain by metal-affinity chromatography, and functional characterization.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.1.207