KEGG   ENZYME: 2.7.1.208
Entry
EC 2.7.1.208                Enzyme                                 

Name
protein-Npi-phosphohistidine---maltose phosphotransferase;
malT (gene name);
maltose PTS permease;
EIIMal;
Enzyme IIMal
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
protein-Npi-phospho-L-histidine:maltose Npi-phosphotransferase
Reaction(IUBMB)
[protein]-Npi-phospho-L-histidine + maltose[side 1] = [protein]-L-histidine + maltose 6'-phosphate[side 2] [RN:R04111 R06236]
Reaction(KEGG)
R04111 R06236(G)
Substrate
[protein]-Npi-phospho-L-histidine [CPD:C04261];
maltose[side 1] [CPD:C00208]
Product
[protein]-L-histidine [CPD:C00615];
maltose 6'-phosphate[side 2] [CPD:C02995]
Comment
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
History
EC 2.7.1.208 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.208
Pathway
ec00500  Starch and sucrose metabolism
Orthology
K02750  alpha-glucoside PTS system EIICB component
K02791  maltose/glucose PTS system EIICB component
K20108  maltose PTS system EIICB or EIICBA component
Genes
ECO: b1621(malX) b3682(glvB) b3683(glvC)
ECJ: JW1613(malX) JW3659(glvB) JW3660(glvC)
ECD: ECDH10B_1754(malX)
EBW: BWG_1435(malX)
ECOK: ECMDS42_1291(malX) ECMDS42_3118(glvB) ECMDS42_3119(glvC)
ECE: Z2626(malX) Z5178
ECS: ECs2329 ECs4623
ECF: ECH74115_2333(malX) ECH74115_5114
ETW: ECSP_2185(malX) ECSP_4734
ELX: CDCO157_2162 CDCO157_4359
EOI: ECO111_2090(malX) ECO111_4510(glvC)
EOJ: ECO26_2349(malX) ECO26_3887 ECO26_4899(glvC)
EOH: ECO103_1761(malX) ECO103_4475(glvC)
ECG: E2348C_1706(malX)
EOK: G2583_2015(malX) G2583_4477(glvC)
ECOS: EC958_1842(malX) EC958_3116
ECQ: ECED1_1821(malX) ECED1_3271 ECED1_5002(ptsG)
EOC: CE10_1894(malX) CE10_4325(glvC)
EBR: ECB_01590(malX) ECB_03566(glvBC)
EBL: ECD_01590(malX) ECD_03566(glvBC)
EBE: B21_01580(malX) B21_03509(glvB) B21_03510(glvC)
ECC: c2013(malX) c3408
ELO: EC042_1789(malX) EC042_4039(glvC)
EKF: KO11_03445(glvC) KO11_14645(malX)
ELW: ECW_m1787(malX)
ELL: WFL_08750(malX) WFL_19455(glvC)
ELC: i14_1833(malX) i14_3130
ELD: i02_1833(malX) i02_3130
ELP: P12B_c1461(malX) P12B_c3818(glvC)
ELF: LF82_1267(malX) LF82_450
ECOI: ECOPMV1_01716(ptsG_3) ECOPMV1_03102(glcB_1)
EFE: EFER_3978
SEW: SeSA_A1563(malX)
SENE: IA1_07235
SBG: SBG_1291(malX) SBG_3271
SFL: SF1645(malX) SF3780(glvB)
SFX: S1778(malX)
SFV: SFV_1638(malX) SFV_3828(glvC)
SFE: SFxv_1847(malX) SFxv_4110
SFT: NCTC1_01784(malX) NCTC1_04076(glvC)
SSN: SSON_1537(malX) SSON_3634(glvC)
SBO: SBO_1513(malX) SBO_3688(glvC)
SDY: SDY_1842(malX)
EEC: EcWSU1_00021(aglA) EcWSU1_01935(malX) EcWSU1_03337(ptsG) EcWSU1_03584(ptsG) EcWSU1_03945(malX)
CSK: ES15_0785(malX1) ES15_1007(malX2) ES15_2130(malX3) ES15_3860(glvC)
CTU: CTU_00560(aglA) CTU_20150(malX) CTU_31160 CTU_33350(ptsG)
KPX: PMK1_01519(malP_3) PMK1_01593(malP_4) PMK1_03830(malX) PMK1_04016(malP_6)
CRO: ROD_14481(malX) ROD_40441(glvC)
REE: electrica_00013(malP_1) electrica_00078(malP_2) electrica_02303(malX)
CLAP: NCTC11466_02542(ptsG_1)
PSTS: E05_13220 E05_16430(malX)
YEN: YE2011(malX) YE3199(aglA)
YEE: YE5303_18601(malX) YE5303_36571(aglA)
YAL: AT01_443
YRO: CH64_557
SRL: SOD_c18400(glvC) SOD_c20930(malX) SOD_c21320(aglA)
SPLY: Q5A_010075(malP_1) Q5A_011625(malX) Q5A_011820(malP_2) Q5A_019125(malP_3)
SOF: NCTC11214_03635(ptsG_1) NCTC11214_04534(ptsG_2) NCTC11214_04887(ptsG_3) NCTC11214_05228(ptsG_6)
ECA: ECA1848(aglA) ECA3225
PATO: GZ59_27560(aglA) GZ59_32400
PCT: PC1_3019
PEC: W5S_1416
SGL: SG1913
SOD: Sant_0932 Sant_1882(malX)
ETA: ETA_14000(aglA)
EBI: EbC_19700(malX) EbC_23460(malX)
EGE: EM595_1931(malX)
PAM: PANA_2038(malX) PANA_2179(aglA)
PLF: PANA5342_1992(aglA) PANA5342_2135(malX)
PAJ: PAJ_1362(malX) PAJ_1493(aglA)
PVA: Pvag_1476(malX)
PSTW: DSJ_14410
MINT: C7M51_01404(malX)
MTHI: C7M52_01344(malX)
PLU: plu1989
PMR: PMI2982
PSI: S70_09920
PSX: DR96_1204
PRG: RB151_001740(malX)
PHEI: NCTC12003_00177(ptsG_1) NCTC12003_00555(ptsG_2)
PRJ: NCTC6933_03458(ptsG_2)
ETE: ETEE_0989(malX)
PSHI: SAMEA2665130_1351(ptsG_1)
HPIT: NCTC13334_01337(ptsEII)
ASEG: NCTC10977_01119(ptsG_1)
RPNE: NCTC8284_02380(ptsG_1) NCTC8284_02381(ptsG_2) NCTC8284_02384(ptsG_3)
VAG: N646_4018
VTA: A2460(malX)
VFI: VF_1719(malX)
VFM: VFMJ11_1846(malX)
VSA: VSAL_I1615(malX)
AHA: AHA_0116 AHA_1427(malX)
ASA: ASA_2951(malX) ASA_4276
ASR: WL1483_1649(malX)
AEL: NCTC12917_01803(ptsG_3)
TAU: Tola_2656
BSU: BSU08200(malP)
BSR: I33_0925
BSL: A7A1_0598
BSH: BSU6051_08200(malP)
BSUT: BSUB_00895(malP)
BSUL: BSUA_00895(malP)
BSUS: Q433_04610
BSS: BSUW23_04155(malP)
BST: GYO_1088
BSO: BSNT_07198(malP)
BSQ: B657_08200(malP)
BSX: C663_0842(glvC)
BLI: BL03019(malP)
BLD: BLi00857(malP)
BLH: BaLi_c09610(malP)
BAQ: BACAU_0814(malP)
BYA: BANAU_0757(glvC)
BAMP: B938_04025
BAML: BAM5036_0749(malP)
BAMA: RBAU_0813(malP)
BAMN: BASU_0789(malP)
BAMB: BAPNAU_0770(glvC)
BAMT: AJ82_04675
BAMY: V529_07810(glvC)
BMP: NG74_00835(malP_1)
BAO: BAMF_0789(malP)
BAZ: BAMTA208_03785(malP)
BQL: LL3_00845(malP)
BXH: BAXH7_00792(glvC)
BQY: MUS_0843(malP)
BAMI: KSO_015620
BAMC: U471_08220
BAMF: U722_04180
BAN: BA_0372
BAR: GBAA_0372
BAT: BAS0358
BAI: BAA_0433
BANT: A16_04130
BANR: A16R_04170
BANS: BAPAT_0351
BANV: DJ46_4811
BCE: BC0414
BCA: BCE_0482
BCZ: BCE33L0344(ptsG)
BCQ: BCQ_0446(ptsG)
BCX: BCA_0448
BAL: BACI_c04210(ptsG1)
BNC: BCN_0392
BCF: bcf_02105
BCER: BCK_05980
BTK: BT9727_0348(ptsG)
BTL: BALH_0370(ptsG)
BTT: HD73_0501
BTHI: BTK_02560
BTM: MC28_5095
BTG: BTB_c04300(exp1)
BTI: BTG_19020
BTW: BF38_1665
BWW: bwei_5197
BMYO: BG05_94
BMYC: DJ92_3000
BPU: BPUM_0660
BPUS: UP12_03645
BMQ: BMQ_5218
BMD: BMD_5204
BMEG: BG04_2212
BAG: Bcoa_1807
BJS: MY9_0910
BACW: QR42_03435
BACP: SB24_05725
BACB: OY17_06840
BACY: QF06_02970
BACL: BS34A_09170(malP)
BALM: BsLM_0856
BGY: BGLY_0876(malP)
BCL: ABC0713 ABC2087 ABC3580(malP)
BPF: BpOF4_07425(ptsG)
BKW: BkAM31D_01110(ptsG_1)
GEA: GARCT_02747(ptsG_3)
VPN: A21D_00894(ptsG_1) A21D_01444(malP_1) A21D_01816(malP_2) A21D_02583(glcB_2)
SAU: SA0233 SA2114(glvC)
SAV: SAV0242 SAV2323(glvC)
SAW: SAHV_0241 SAHV_2307(glvC)
SAM: MW0218 MW2244(glvC)
SUE: SAOV_0180
SAUR: SABB_01351(glvC) SABB_06019
SER: SERP1909
SEP: SE1897
SEPP: SEB_01911
SEPS: DP17_850
SHA: SH0358(ptsG) SH0732(glvC)
SPAS: STP1_0807
SCAP: AYP1020_1503(malP)
SAGQ: EP23_11350
SDP: NCTC12225_02423(ptsG_2) NCTC12225_02582(glcB_2)
MCL: MCCL_0278
MCAK: MCCS_04190(glcB)
LSG: lse_0100(malP)
LIV: LIV_1056
ESI: Exig_2910
EAN: Eab7_2722
GMO: NCTC11323_01252(ptsG)
BLR: BRLA_c026300(ptsG_2) BRLA_c041980(ptsG_4)
PPY: PPE_00251
PPM: PPSC2_01530(ptsG1)
PPO: PPM_0287(ptsG1)
PPOL: X809_01000
PPQ: PPSQR21_002520(ptsG)
PPOY: RE92_10375
PLV: ERIC2_c19170(ptsG2) ERIC2_c31450(malX2)
PSAB: PSAB_18825
JEO: JMA_31330
LGR: LCGT_0603
LGV: LCGL_0622
SPY: SPy_1986
SPYA: A20_1737c(ptbA)
SPM: spyM18_2050(ptsG)
SPS: SPs1708
SPF: SpyM51662
STZ: SPYALAB49_001678(ptbA)
SPYH: L897_08465
SPN: SP_0758
SPD: SPD_0661(exp5)
SPR: spr0668(ptsG)
SPW: SPCG_0708(ptsG)
SJJ: SPJ_0696
SPX: SPG_0690
SNT: SPT_0772
SND: MYY_0792
SPNN: T308_03545
SPV: SPH_0859
SPP: SPP_0769
SNP: SPAP_0733
SAG: SAG1959
SAN: gbs1946
SAK: SAK_1920
SGC: A964_1824(crr)
SAGM: BSA_19820
SAGI: MSA_20560
SAGR: SAIL_19900
SAGP: V193_08605
SAGC: DN94_08605
SAGE: EN72_10275
SAGG: EN73_09360
SAGN: W903_1896(ptbA)
SMU: SMU_2047(ptsG)
SMC: SmuNN2025_1792(ptsG)
SMJ: SMULJ23_1793(ptsG)
SMUA: SMUFR_1780(crr)
STC: str0191
STL: stu0191
STN: STND_0192
STU: STH8232_0283(exp5)
STW: Y1U_C0180
SSA: SSA_1809(ptsG)
SSI: SSU0357
SUP: YYK_01695
SSUY: YB51_1945
SSUT: TL13_0422(ulaA)
SSUI: T15_0389(crr)
SGO: SGO_0505
SEZ: Sez_1783
SEQ: SZO_01860
SEZO: SeseC_02421(gamP)
SEQU: Q426_10235
SEU: SEQ_2021
SUB: SUB0236
SDS: SDEG_0222
SDA: GGS_0205
SDC: SDSE_0228
SGG: SGGBAA2069_c01660(ptsG)
SGT: SGGB_0193
SMB: smi_1404(ptsG)
SOR: SOR_1368(ptsG)
STK: STP_1502
STB: SGPB_0138
SCF: Spaf_1615(ptsG)
SSR: SALIVB_0208(exp5)
STF: Ssal_01989(ptsG)
STJ: SALIVA_0189(PTSG)
SMN: SMA_0173
SIF: Sinf_0162
SIE: SCIM_1234(ptsG) SCIM_1566
SANG: SAIN_1369
SANS: DK43_02705
SIK: K710_0279
SLU: KE3_0101
STRN: SNAG_1342(ptsG)
LPJ: JDM1_2889(pts18CBA) JDM1_2893(pts18CBA)
LJO: LJ_0636
LJH: LJP_1571c
LAC: LBA0606
LAD: LA14_0635
LAF: SD55_0629
LCA: LSEI_0370
LCS: LCBD_2901(malX)
LCE: LC2W_2875(malX)
LCW: BN194_28190(malX)
LHL: LBHH_1511
LRH: LGG_02702(glvC)
LRG: LRHM_2595
LRL: LC705_00438(glvC) LC705_00456(glvC) LC705_02704(glvC)
LCR: LCRIS_00606(malX)
LAM: LA2_03145
LRM: LRC_18820
EFL: EF62_0417 EF62_1331(malT)
EFI: OG1RF_10026(malX) OG1RF_10684(exp5)
EFS: EFS1_0025(malX) EFS1_0782
EFN: DENG_00027(malX) DENG_01016(crr)
EFQ: DR75_11(ptbA) DR75_2076
EFU: HMPREF0351_10419(ptsG)
EFM: M7W_584
EHR: EHR_03425
EDU: LIU_04200
CRN: CAR_c17800(ptsG2) CAR_c18320 CAR_c19350(malP)
CML: BN424_364(malX) BN424_721(glvC)
JDA: BW727_101151(malX)
CAC: CA_C0532 CA_C3425(glvC)
CAE: SMB_G0544(glvC) SMB_G3463(malX)
CAY: CEA_G0545 CEA_G3429(glvC)
CPF: CPF_0422
CPR: CPR_0418
CBK: CLL_A0331
CBT: CLH_0316
CPAT: CLPA_c18890(aglA) CLPA_c32010(malP)
CPAE: CPAST_c18890(aglA) CPAST_c32010(malP)
CSB: CLSA_c41610(malP)
CLT: CM240_0581(exp5) CM240_0583(exp6)
CBV: U729_886
CLD: CLSPO_c03050(malP) CLSPO_c03160(malX) CLSPO_c16590(exp)
FPA: FPR_08870
CSO: CLS_10310
BPRL: CL2_19740
EHL: EHLA_0193
CDC: CD196_1199(malX) CD196_2355 CD196_2818(malX) CD196_2848(glvC)
ELM: ELI_1178
APR: Apre_0453
MED: MELS_0382
MHG: MHY_25800
PUF: UFO1_3579
PFT: JBW_03106
ERH: ERH_0020(ptsG.1)
EBM: SG0102_27860(ptsG)
MCAP: MCCPF38_00184(glcB_2) MCCPF38_00185(malX_1) MCCPF38_00917(malP_3) MCCPF38_00918(malX_2) MCCPF38_00924(malX_3)
SAPI: SAPIS_v1c08270(malX)
SSAB: SSABA_v1c07950(ptsG2)
SERI: SERIO_v1c08940(malX)
SFZ: SFLOR_v1c05110(malX)
SCO: SCO0434(malX)
SFA: Sfla_5687
STRP: F750_0909
SLV: SLIV_35775(malX)
SAMB: SAM23877_7057(malX)
RDN: HMPREF0733_10217(glvC)
BBP: BBPR_0239
BBI: BBIF_0261(crr)
BBF: BBB_0221(exp5)
BBRE: B12L_1684
BBRV: B689b_1782
BBRC: B7019_1920
BBRN: B2258_1774
BBRD: BBBR_1755
BSCA: BBSC_0342
OLS: Olsu_1211
BGA: BG0117(malX) BG0668(ptsG) BGB26(malX)
BAF: BAPKO_0117(malX-1) BAPKO_0689(ptsG) BAPKO_5027(malX-2)
BAFH: BafHLJ01_0121(malX-1) BafHLJ01_0712(ptsG)
BDU: BDU_119(malX) BDU_13011(malX) BDU_648(ptsG)
BRE: BRE_6010(malX) BRE_651(ptsG)
BPO: BP951000_0254(glvC)
BIP: Bint_2168(glvC)
LBA: Lebu_1527
LHF: JCM16775_1652(glvC2)
LSZ: JCM16776_1311(glvC)
LGO: JCM16774_1066(glvC2) JCM16774_1067(glvC1)
 » show all
Reference
1  [PMID:8195080]
  Authors
Robrish SA, Fales HM, Gentry-Weeks C, Thompson J
  Title
Phosphoenolpyruvate-dependent maltose:phosphotransferase activity in Fusobacterium mortiferum ATCC 25557: specificity, inducibility, and product analysis.
  Journal
J Bacteriol 176:3250-6 (1994)
DOI:10.1128/JB.176.11.3250-3256.1994
Reference
2  [PMID:17277067]
  Authors
Webb AJ, Homer KA, Hosie AH
  Title
A phosphoenolpyruvate-dependent phosphotransferase system is the principal maltose transporter in Streptococcus mutans.
  Journal
J Bacteriol 189:3322-7 (2007)
DOI:10.1128/JB.01633-06
  Sequence
[smu:SMU_2047]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.208
IUBMB Enzyme Nomenclature: 2.7.1.208
ExPASy - ENZYME nomenclature database: 2.7.1.208
BRENDA, the Enzyme Database: 2.7.1.208

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