KEGG ENZYME: 2.7.1.210

ENZYME: 2.7.1.210

Entry

EC 2.7.1.210                Enzyme

Name

D-erythrulose 4-kinase;
derK (gene name)

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:D-erythrulose 4-phosphotransferase

Reaction(IUBMB)

ATP + D-erythrulose = ADP + D-erythrulose 4-phosphate [RN:R11461]

Reaction(KEGG)

R11461

Substrate

ATP [CPD:C00002];
D-erythrulose [CPD:C02022]

Product

ADP [CPD:C00008];
D-erythrulose 4-phosphate [CPD:C03604]

Comment

The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of erythritol and D-threitol.

History

EC 2.7.1.210 created 2016

Orthology

K20902

D-erythrulose 4-kinase

Genes

EFE:

EFER_0430

RTG:	NCTC13098_01632(dhaK_3)

CRO:

ROD_03771

SYM:	K6K13_04225

ASUB:

NLZ15_15045

IZH:	FEM41_05120

TOE:	QMG90_21450

RBAD:

H2866_02235

RCB:	O1V66_01090

ECA:

ECA0866

PATR:

EV46_03980

PATO:

GZ59_08020

PCC:	PCC21_007710

PAQU:

DMB82_0016440

PVZ:	OA04_08690

PQU:	IG609_016205

PACB:

M9782_06380

BGJ:	AWC36_04290

EBI:

EbC_33110

EPE:	CI789_01885

ERP:	LJN55_16960

PAO:	Pat9b_4287

KLN:	LH22_13030

PANS:

FCN45_09495

TCI:	A7K98_14025

HAM:

HALO1390

HHU:	AR456_16105

HTT:	HZS52_11730

HPRO:

LMS44_16220

HBH:	E4T21_17590

HAA:	A5892_00750

KUS:	B9G99_04380

KMA:	B9H00_10765

KUY:	FY550_15060

SAJS:

QO259_02040

SALN:

SALB1_1908

NIT:	NAL212_1378

NII:	Nit79A3_1741

NUR:	ATY38_13795

SME:	SM_b20767(dak)

SMK:	Sinme_4276

SMQ:	SinmeB_4769

SMX:	SM11_pD0159(dak)

SMI:	BN406_05240

SMEG:

C770_GR4pD0158

SMEL:

SM2011_b20767(dak)

SMER:

DU99_26245

SMD:

Smed_4228

RHI:	NGR_b21080

SFH:	SFHH103_05120(dak)

SFD:	USDA257_c15770(dhaK1)

SAME:

SAMCFNEI73_pC0527(dhaK)

SINO:

SS05631_b53580

ESJ:	SJ05684_c12470

ENU:	PYH37_001201

SKM:	PZL22_000672

EAD:	OV14_a0941

EAH:	FA04_25345

ECAA:

J3R84_23055

RHL:	LPU83_pLPU83c0761(dahK)

SHZ:	shn_16395 shn_28245

SZO:	K8M09_21760

OIN:	IAR37_15565

OAN:

Oant_3102

OAH:

DR92_3401

BPSN:

NIK97_14600

OCR:	HGK82_18635

OCL:	GTN27_19230

AUA:	M673_06940

AALA:

IGS74_04070

AALM:

LUX29_03940 LUX29_04675

PARR:

EOJ32_04280

PAAK:

FIU66_16870

PLIA:

E4191_23430

PMAU:

CP157_02723(derK)

PFIS:

JHX87_07255

GOX:

GOX2222

GOH:

B932_2974

GOY:	GLS_c23710(dhaK)

GAL:	A0U94_09895

GTI:	FXF46_12685

ABG:	Asbog_01348

KBA:	A0U89_08570

NCH:	A0U93_12975

LCK:	HN018_01295 HN018_05120

MMC:

Mmcs_2560

MKM:

Mkms_2605

MJL:

Mjls_2599

MDX:	BTO20_13880

MGRO:

FZ046_21415(derK)

MSM:	MSMEG_3271

MSG:	MSMEI_3187

MSB:	LJ00_16260

MSN:	LI99_16265

MSH:	LI98_16270

MCB:	Mycch_3017

MNE:	D174_03540

MYN:	MyAD_03455

MPHL:

MPHLCCUG_02595(dhaK_1)

MVQ:

MYVA_3227

MAUU:

NCTC10437_04726(dhaK_1)

MMAG:

MMAD_20660(derK)

MAIC:

MAIC_17830(derK)

MTY:	MTOK_15430(lerK_1) MTOK_45770(derK)

MPSC:

MPSYJ_33240(derK)

MARZ:

MARA_06810(derK)

MHEV:

MHEL_19770(derK)

MANY:

MANY_46180(derK)

MMAT:

MMAGJ_25120(dak) MMAGJ_63080(derK)

MBOK:

MBOE_19520(derK)

MFG:	K6L26_27865

MSEI:

MSEDJ_44920(derK)

MMON:

EWR22_13000

MGO:	AFA91_23525

MSEN:

K3U95_03920

MRF:	MJO55_15415(derK)

CCYC:

SCMU_34600 SCMU_35420(derK) SCMU_39240

NTP:	CRH09_14745

GBR:

Gbro_4222

GPO:	GPOL_c10030

SCO:	SCO0580(SCF55.04c)

SGRF:

SGFS_001210

SVL:	Strvi_6130

SRC:	M271_41675

SMAL:

SMALA_1062 SMALA_4772

SSOI:

I1A49_08805

SFA:

Sfla_3629

SBH:	SBI_04330(dak2)

STRP:

F750_3088

SLV:	SLIV_35045

SXI:	SXIM_40180

SCZ:	ABE83_02065

SGM:	GCM10017557_02980

SNR:	SNOUR_13940

SALU:

DC74_5668

SALL:

SAZ_29940

STRD:

NI25_01455

SAUO:

BV401_09105 BV401_27720

SGD:	ELQ87_37465

SPAD:

DVK44_35070

SRIM:

CP984_11440

SFUG:

CNQ36_25895

SHAR:

HUT13_20050

STUB:

MMF93_19230

LEIF:

HF024_07195

CMI:	CMM_0788(dakA)

CMS:

CMS2383

CMH:	VO01_12435

CMC:	CMN_00743(dakA)

CCAP:

AES38_03475

CZH:	H9X71_03570

CPHA:

FGI33_09415

CCAF:

FGD68_05980

MTS:

MTES_2016

MPAL:

BO218_08360 BO218_09875

MHOS:

CXR34_02915

MLV:	CVS47_02771(lerK_1) CVS47_02889(lerK_2)

MWA:	E4K62_02420

MPRT:

ET475_09045

MOY:	CVS54_00536(lerK)

MCAW:

F6J84_13150

MLZ:	F6J85_02225

MICS:

C1N74_01110 C1N74_02600

RFS:	C1I64_09325 C1I64_14760 C1I64_17115

ROE:	Q0F99_09575 Q0F99_16095

CUM:	NI26_00150 NI26_11815

CUB:	BJK06_01765 BJK06_07760 BJK06_13000

CUG:	C1N91_12000

CCIT:

QPK07_12190

FRP:	AX769_17340

FSB:	GCM10025867_24940

AARC:

G127AT_01565

AMAU:

DSM26151_02390(lerK)

AMAV:

GCM10025877_18510

MYL:	C3E77_02125

MSPO:

KXZ72_03860 KXZ72_07175 KXZ72_09175

SALA:

ESZ53_08620

LYD:	D7I47_03140

PLAP:

EAO79_00920 EAO79_04805

AGG:	C1N71_10440

FRN:	F1C15_12620

NAEI:

GCM126_14470

ART:	Arth_0884 Arth_3953

ARR:	ARUE_c10550 ARUE_c18640 ARUE_c42630

ARM:	ART_2219 ART_3795

ARW:	MB46_01290 MB46_13980

ARH:	AHiyo8_20760 AHiyo8_30930 AHiyo8_42860

ARZ:	AUT26_04885 AUT26_20025

ARQ:	BWQ92_05660 BWQ92_11385 BWQ92_12020 BWQ92_14545

ARN:	CGK93_05735(dhaL) CGK93_09920

ARX:	ARZXY2_2903 ARZXY2_3962

ACRY:

AC20117_09275

ARTH:

C3B78_01670 C3B78_10715(dhaL)

ARTP:

E5206_00475

AOD:	Q8Z05_06865 Q8Z05_12395(dhaL)

AAU:	AAur_1102 AAur_4135

PUE:	FV140_05670(dhaL)

PNV:	JMY29_05195(dhaL) JMY29_19760

ACH:

Achl_0411

APN:	Asphe3_20060

PSUL:

AU252_20960

PSNI:

NIBR502771_00645(dhaL) NIBR502771_03590

PSEY:

GU243_03925 GU243_05120

PDEL:

JCQ34_03965(dhaL)

GMI:	NMP99_15390(dhaL)

KPL:	KPaMU14_00720

SATK:

SA2016_3408 SA2016_3485

DAY:	FV141_00325

CFL:

Cfla_0184

CELZ:

E5225_16145

CIRA:

LFM56_17085

CELC:

K5O09_04550

CDON:

KKR89_00875

CWAN:

KG103_00865

CWN:	NP075_00885

CXIE:

NP048_01075

PSEI:

GCE65_00435

BCAU:

I6G59_05010

HALT:

IM660_02370

RHAL:

LQF10_02100

RSUA:

LQF12_01540

PPC:	HMPREF9154_0653

ARUB:

J5A65_00840

MPH:

MLP_03260

MIK:	FOE78_12725

MICG:

GJV80_08715

RAIN:

Rai3103_05085 Rai3103_07410

NPS:	KRR39_22280

TFU:

Tfu_1716

STRR:

EKD16_11340(dhaK2)

SNAH:

OUQ99_29860

ACTW:

F7P10_39075

KRA:

Krad_1919

SEN:	SACE_4765(dak) SACE_5217(dak)

SACG:

FDZ84_01155

AOI:

AORI_7456

AJA:	AJAP_38995

AMQ:	AMETH_2242(dak) AMETH_6525(dak)

AMYC:

CU254_36090

AAB:	A4R43_36890

AMYY:

YIM_41195(dhaK2)

AROO:

NQK81_22470

ATHM:

L1857_13970 L1857_34730(dhaL)

PSEA:

WY02_03005 WY02_18480

PSEE:

FRP1_24315

PSEH:

XF36_22925

PSEQ:

AD006_03505

PECQ:

AD017_11320

PHH:	AFB00_09160

PAUT:

Pdca_04900(derK) Pdca_32710

APRE:

CNX65_13430

AMI:

Amir_2647

ACTI:

UA75_20470

ACAD:

UA74_19970

ACTA:

C1701_04345 C1701_24260

PMAD:

BAY61_13425 BAY61_13440

ATL:	Athai_12400

ACTT:

DDD63_00090

FSL:	EJO69_06475

FLH:	EJ997_08765

AEY:	CDG81_00540

RRD:	RradSPS_3028

RMAR:

GBA65_01610(dhaL)

OLS:

Olsu_0402

ATB:	J4859_15790

LCAL:

ATTO_00510(derK)

CAP:	CLDAP_27030

MICA:

P0L94_11550

» show all

Reference

1 [PMID:26560079]

Authors

Huang H, Carter MS, Vetting MW, Al-Obaidi N, Patskovsky Y, Almo SC, Gerlt JA

Title

A General Strategy for the Discovery of Metabolic Pathways: d-Threitol, l-Threitol, and Erythritol Utilization in Mycobacterium smegmatis.

Journal

J Am Chem Soc 137:14570-3 (2015)
DOI:10.1021/jacs.5b08968

Sequence

[msm:MSMEG_3271]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.210

IUBMB Enzyme Nomenclature:

2.7.1.210

ExPASy - ENZYME nomenclature database:

2.7.1.210

BRENDA, the Enzyme Database:

2.7.1.210

DBGET integrated database retrieval system