KEGG   ENZYME: 2.7.1.211Help
Entry
EC 2.7.1.211                Enzyme                                 

Name
protein-Npi-phosphohistidine---sucrose phosphotransferase;
scrAB (gene names);
sucrose PTS permease;
EIIScr;
Enzyme IIScr
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
protein-Npi-phospho-L-histidine:sucrose Npi-phosphotransferase
Reaction(IUBMB)
[protein]-Npi-phospho-L-histidine + sucrose[side 1] = [protein]-L-histidine + sucrose 6G-phosphate[side 2] [RN:R00811]
Reaction(KEGG)
Substrate
[protein]-Npi-phospho-L-histidine;
sucrose[side 1]
Product
[protein]-L-histidine [CPD:C00615];
sucrose 6G-phosphate[side 2]
Comment
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
History
EC 2.7.1.211 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.211
Pathway
ec00500  Starch and sucrose metabolism
Orthology
K02808  PTS system, sucrose-specific IIA component
K02809  PTS system, sucrose-specific IIB component
Genes
ECG: E2348C_3041(scrA)
ECP: ECP_2752
ECM: EcSMS35_2907(scrA)
ECT: ECIAI39_2965
EOC: CE10_3197(scrA)
ESE: ECSF_2567
ENA: ECNA114_2811
ECOJ: P423_15180
ECOS: EC958_3043
STY: STY2816
STT: t0287
STM: STM2570
SENI: CY43_13705
SPT: SPA0295
SEK: SSPA0280
SEI: SPC_1079
SEC: SCH_2565(yfeV)
SHB: SU5_03166
SENS: Q786_12720
SED: SeD_A2948
SEG: SG2607
SEL: SPUL_0303
SET: SEN2550
SENA: AU38_12915
SENO: AU37_12925
SENV: AU39_12925
SENQ: AU40_14530
SENL: IY59_13270
SENE: IA1_12845
SBG: SBG_2344
SBZ: A464_2681
ECLO: ENC_37020
EEC: EcWSU1_02284(scrA) EcWSU1_03371(ybbF)
CSK: ES15_0973(scrA) ES15_3484
CTU: CTU_04470(scrA) CTU_31500(ybbF)
KPN: KPN_00514
KPU: KP1_1431
KPP: A79E_3743
KPT: VK055_2035(sacX)
KPE: KPK_4073(scrA) KPK_5352
KPR: KPR_4046(scrA)
KPJ: N559_3833
KPX: PMK1_02841(sacX)
KPNU: LI86_19645
KPNK: BN49_1557(scrA) BN49_4536
KVA: Kvar_3863
KOX: KOX_13365
KOE: A225_1489
EAE: EAE_15495
EAR: CCG30810
CKO: CKO_02945
CRO: ROD_25051(murP)
CAMA: F384_14065
RTG: NCTC13098_04057(sacX_1) NCTC13098_05538(sacX_2)
KIE: NCTC12125_00051(sacX_1) NCTC12125_00052(sacX_2)
YEN: YE0552(scrA)
YEY: Y11_37851
YEW: CH47_2924
YET: CH48_1047
YEE: YE5303_27761(scrA)
YIN: CH53_1137
YRO: CH64_3177
SRL: SOD_c35890(ybbF) SOD_c40510(scrA)
SPLY: Q5A_013190(sacX_1) Q5A_019310 Q5A_022070(sacX_2)
ECA: ECA0362(scrA)
PATR: EV46_01935
PATO: GZ59_03930
PCT: PC1_0349
PEC: W5S_0403
SOD: Sant_1108
DDD: Dda3937_01267(scrA)
DDQ: DDI_0120
DAQ: DAQ1742_00440(scrA)
ETA: ETA_18700(scrA)
EPY: EpC_19590(scrA)
EPR: EPYR_02117(scrA)
EAM: EAMY_1616(scrA)
EAY: EAM_1596(scrA)
EBI: EbC_34040
ERJ: EJP617_27600(scrA)
EGE: EM595_p0533(scrA)
PAM: PANA_0334(scrA)
PLF: PANA5342_4080(scrA)
PAJ: PAJ_3493(scrA)
PVA: Pvag_pPag10154(scrA)
PSTW: DSJ_03530
PAY: PAU_01260(scrA)
PMR: PMI3515
HPIT: NCTC13334_00021(treB)
HAP: HAPS_1008(ptsB)
HPAZ: K756_02365
HPAS: JL26_01880
HPAK: JT17_10765
PMU: PM1846(ptsB)
PMV: PMCN06_1525(scrA)
PMP: Pmu_14880(scrA)
PMUL: DR93_89
PDAG: 4362423_01997(scrA)
PAET: NCTC13378_00174(scrA)
MSU: MS0784(ptsG)
MHAT: B824_22650
MHX: MHH_c09550(scrA)
MHAM: J450_08830
MHAQ: WC39_11840
MHAY: VK67_11845
MVI: X808_2780
MVG: X874_2900
APL: APL_1319(ptsB)
APJ: APJL_1333(ptsB)
APA: APP7_1370(ptsB)
ASU: Asuc_0914
BTO: WQG_4610
BTRE: F542_17430
BTRH: F543_19180
BTRA: F544_4890
RPNE: NCTC8284_01237(scrA)
VCH: VCA0653
VCS: MS6_A0703
VCE: Vch1786_II0337(scrA)
VCO: VC0395_0597(scrA)
VCR: VC395_A0659(scrA)
VCM: VCM66_A0611(scrA)
VAG: N646_3833
VAN: VAA_01377
PIN: Ping_0972
AHA: AHA_2979
ASA: ASA_2992(scrA)
AVR: B565_2759
AMED: B224_1311
ACAV: VI35_14310
TAU: Tola_0815
CHJ: NCTC10426_01711(bglF)
RSO: RSp1285(scrA)
RSL: RPSI07_mp1102(scrA)
RSN: RSPO_m01381(scrA)
RSM: CMR15_mp20388(scrA)
RSE: F504_4783
RSY: RSUY_42680(sacX)
BSTG: WT74_28875
MET: M446_3433
BSU: BSU01680(ybbF) BSU38050(sacP) BSU38410(sacX)
BSH: BSU6051_01680(ybbF) BSU6051_38050(sacP) BSU6051_38410(sacX)
BSUT: BSUB_00212(ybbF) BSUB_04041(sacP) BSUB_04079(sacX)
BSUL: BSUA_00212(ybbF) BSUA_04041(sacP) BSUA_04079(sacX)
BSS: BSUW23_00870(ybbF) BSUW23_18800(sacP) BSUW23_19030(sacX)
BSO: BSNT_06473(ybbF) BSNT_10462(sacP) BSNT_10503(sacX)
BSQ: B657_01680(ybbF) B657_38050(sacP) B657_38410(sacX)
BSX: C663_0167 C663_3710(sacP) C663_3752(sacX)
BLI: BL00914(sacX) BL02718(ybbF) BL03890(sacP)
BLD: BLi00189(murP) BLi00842(sacX) BLi04017(sacP)
BLH: BaLi_c02100(ybbF) BaLi_c09460(sacX) BaLi_c40310(sacP)
BAQ: BACAU_0173(ybbF) BACAU_3553(sacP)
BYA: BANAU_0172(ybbF) BANAU_3710(sacP)
BAML: BAM5036_0176(ybbF) BAM5036_3452(sacP)
BAMA: RBAU_0187(murP) RBAU_3663(sacP)
BAMN: BASU_0182(murP) BASU_3439(sacP)
BAMB: BAPNAU_0173(ybbF) BAPNAU_3725(sacP)
BAMY: V529_01770(ybbF) V529_38010(sacP)
BAO: BAMF_0172(murP) BAMF_3637(sacP)
BAZ: BAMTA208_00870(murP) BAMTA208_19250(sacP)
BQL: LL3_00171(murP) LL3_03948(sacP)
BXH: BAXH7_00176(ybbF) BAXH7_03940(sacP)
BQY: MUS_0180(ybbF) MUS_4192(sacP)
BHA: BH1856(sacP) BH3574
BAN: BA_0754(scrA) BA_0823
BAR: GBAA_0754(scrA) GBAA_0823
BAI: BAA_0862(scrA) BAA_0932
BCA: BCE_0914
BCZ: BCE33L0719(scrA)
BCQ: BCQ_0910(scrA)
BCX: BCA_0821(scrA) BCA_0886
BAL: BACI_c07870(scrA1) BACI_c08610(scrA2)
BCER: BCK_04065
BTK: BT9727_0668(scrA) BT9727_0733(scrA)
BTL: BALH_0690(scrA) BALH_0746(scrA)
BTT: HD73_0957
BTHI: BTK_04760
BTM: MC28_0099
BTG: BTB_c08440(sacP) BTB_c09100(ybbF)
BTI: BTG_17075
BTW: BF38_2079
BWW: bwei_4178(murP)
BMYC: DJ92_3411
BPF: BpOF4_07340(scrA) BpOF4_17915(murP)
BMQ: BMQ_0882(sacP) BMQ_4017
BAG: Bcoa_2118
BCOA: BF29_1466
BACL: BS34A_02200(ybbF) BS34A_41230(sacP_1) BS34A_41600(sacX)
BGY: BGLY_0173(ybbF) BGLY_0865 BGLY_4421(sacP)
BKW: BkAM31D_24800(sacX_2)
BBEV: BBEV_2837(sacP)
OIH: OB0615
GKA: GK3444
GTN: GTNG_1877
GGH: GHH_c35330(sacP)
GEA: GARCT_03421(sacX)
AFL: Aflv_2785(sacP)
ANL: GFC29_482
AXL: AXY_18190(sacP)
HLI: HLI_14935
BSE: Bsel_0505
SAU: SA0186 SA2167(scrA)
SAV: SAV0192 SAV2377(scrA)
SAW: SAHV_0191 SAHV_2361(scrA)
SAM: MW0166 MW2299(scrA)
SAR: SAR0193 SAR2466(scrA)
SUC: ECTR2_155 ECTR2_2238(treP)
SAUS: SA40_0157 SA40_2127(scrA)
SAUU: SA957_0172 SA957_2211(scrA)
SAUG: SA268_0170 SA268_2284(scrA)
SAB: SAB0132 SAB2257c(scrA)
SAUB: C248_0184 C248_2425(scrA)
SAUR: SABB_01296(scrA) SABB_01651
SHA: SH0671(scrA) SH0741
SCA: SCA_2138
SDT: SPSE_0429
SSCZ: RN70_00475
MCL: MCCL_0375
LMP: MUO_08525
LMOX: AX24_05855
LMOK: CQ02_08500
LWE: lwe1676
LSG: lse_1579
GMO: NCTC11323_00334(sacX)
PPM: PPSC2_01660(scrA1) PPSC2_03915(scrA3) PPSC2_05540(scrA5)
PPO: PPM_0314(scrA1) PPM_0728(scrA3) PPM_1039(scrA5)
JEO: JMA_06400
LLA: L145238(yleD)
LLK: LLKF_0663(scrA) LLKF_1157(yleDE)
LLT: CVCAS_0602(scrA)
LLS: lilo_0573(scrA) lilo_1033(yleD)
LLC: LACR_1242
LLM: llmg_1426
LLR: llh_6250
LLW: kw2_1078(murP)
LLJ: LG36_0646(scrA) LG36_1250(yleD)
LGR: LCGT_0559
LGV: LCGL_0578
SPY: SPy_1815(scrA)
SPZ: M5005_Spy1542(scrA)
SPYM: M1GAS476_1619(scrA)
SPYA: A20_1590c
SPG: SpyM3_1569(scrA)
SPS: SPs0298
SPH: MGAS10270_Spy1609(scrA)
SPI: MGAS10750_Spy1601(scrA)
SPJ: MGAS2096_Spy1567(scrA)
SPK: MGAS9429_Spy1546(scrA)
SPF: SpyM50308(scrA)
SPB: M28_Spy1529(scrA)
STG: MGAS15252_1385(scrA)
STX: MGAS1882_1446(scrA)
SOZ: Spy49_1415c(scrA)
SPYH: L897_07410
SPN: SP_1722
SPD: SPD_1532
SPR: spr1566(scrA)
SPW: SPCG_1694(scrA)
SJJ: SPJ_1617
SNV: SPNINV200_15440(scrA)
SPX: SPG_1627
SNT: SPT_1660
SND: MYY_1642
SPNN: T308_07865
SNE: SPN23F17230(scrA)
SPV: SPH_1830
SPP: SPP_1738
SNI: INV104_14680(scrA)
SNP: SPAP_1727
SNX: SPNOXC15150(scrA)
SPNE: SPN034156_06020(scrA)
SPNU: SPN034183_15120(scrA)
SPNM: SPN994038_15010(scrA)
SPNO: SPN994039_15020(scrA)
SGC: A964_0290(scrA) A964_1594(scrA)
SAGG: EN73_08280
SMU: SMU_1841(scrA)
SMC: SmuNN2025_0296(scrA)
SMJ: SMULJ23_0317(scrA)
SMUA: SMUFR_1604(scrA)
STC: str1734(scrA)
STL: stu1734(scrA)
STE: STER_1710
STN: STND_1670
STU: STH8232_2000(scrA)
STW: Y1U_C1624
STHE: T303_09505
SSA: SSA_0456(scrA)
SSI: SSU1618(scrA) SSU1725
SSK: SSUD12_1782(scrA)
SSQ: SSUD9_1825(scrA)
SRP: SSUST1_1702(scrA)
SSUT: TL13_1607(scrA)
SSUI: T15_1878(scrA) T15_2001
SGO: SGO_1857
SEZ: Sez_0363(scrA)
SEQ: SZO_16150
SEZO: SeseC_00426(scrA)
SEQU: Q426_07475
SEU: SEQ_0431
SUB: SUB1543(scrA)
SDS: SDEG_1871(scrA)
SDA: GGS_1687(scrA)
SDC: SDSE_1952(scrA)
SDQ: SDSE167_1929(scrA)
SGG: SGGBAA2069_c18460(scrA)
SGT: SGGB_1876(scrA)
SMB: smi_1615
SOR: SOR_1533
STK: STP_0160(scrA)
STB: SGPB_0251(sacP) SGPB_1723(scrA)
SCF: Spaf_1682(scrA)
SSR: SALIVB_1859(scrA)
STF: Ssal_00287(scrA)
STJ: SALIVA_1804(scrA)
SSAH: HSISS4_01641(scrA2)
SMN: SMA_1804(scrA)
SIF: Sinf_1618
SIE: SCIM_0073 SCIM_1317(scrA)
SIB: SIR_0097 SIR_1503(scrA)
SIU: SII_0100 SII_1489(scrA)
SANG: SAIN_1448(scrA)
SANC: SANR_0093 SANR_1674(scrA)
SANS: DK43_02235
SCG: SCI_1598(scrA)
SCON: SCRE_1554(scrA)
SCOS: SCR2_1554(scrA)
SLU: KE3_1744
STRN: SNAG_1498(bglF)
LPL: lp_0185(pts1BCA) lp_3219(pts26BCA) lp_3522(pts32BC)
LPJ: JDM1_0175(pts1BCA) JDM1_2577(pts24BCA) JDM1_2811(pts32BC)
LPT: zj316_0392(pts1BCA) zj316_3052(pts26BCA)
LJF: FI9785_1707(scrA) FI9785_581(scrA)
LAC: LBA0401(scrA) LBA1705
LAF: SD55_0398(scrA) SD55_1708
LSA: LCA_1792(scrA)
LSL: LSL_0066(scrA)
LSI: HN6_00059(scrA)
LSJ: LSJ_0103(scrA)
LDB: Ldb1771
LDE: LDBND_1661(scrA)
LCB: LCABL_22800(pts24BCA) LCABL_22810(pts24BCA)
LCS: LCBD_2262(ptsG) LCBD_2263(treP)
LCE: LC2W_2244(ptsG) LC2W_2245(treP)
LHL: LBHH_0382(scrA) LBHH_2009(scrA3)
LHV: lhe_1682
LHH: LBH_1769(scrA1)
LFE: LAF_1578
LFR: LC40_0998
LFF: LBFF_1743
LRH: LGG_00125(pts) LGG_02103
LRL: LC705_00122(pts) LC705_02096(Span) LC705_02097(scrA)
LRA: LRHK_129(ptbA) LRHK_2101
LCR: LCRIS_00400(scrA1) LCRIS_01510(scrA2) LCRIS_01645(scrA3)
LAM: LA2_02070
LBH: Lbuc_2330
LBN: LBUCD034_2431(pts1BCA)
LKE: WANG_0094(scrA1) WANG_0595
LRM: LRC_18780
PCE: PECL_1667
EFI: OG1RF_11317(scrA) OG1RF_11866(sacX)
EFN: DENG_01769(scrA) DENG_02392(scrA)
ENE: ENT_16480
EDU: LIU_04715
MPS: MPTP_0336
MPX: MPD5_1552
THL: TEH_24420(murP)
LME: LEUM_0288
LMM: MI1_01190
LMK: LMES_0232
LCI: LCK_01121(scrA)
LKI: LKI_09025
LGS: LEGAS_0034(scrA2) LEGAS_0777(scrA1)
CRN: CAR_c14500(ybbF) CAR_c19550(sacP)
CML: BN424_501(scrA) BN424_689(sacX)
CAE: SMB_G0432(scrA)
CAY: CEA_G0434
CPE: CPE1534
CPF: CPF_1785
CPR: CPR_1513
CBO: CBO1344
CBA: CLB_1372
CBH: CLC_1382
CBY: CLM_1521
CBL: CLK_0788
CBB: CLD_3191
CBI: CLJ_B1462
CBF: CLI_1444
CBM: CBF_1420
CLS: CXIVA_15100(NagE)
CSR: Cspa_c56620(sacP)
CPAS: Clopa_1029
CPAT: CLPA_c29830(scrA)
CPAE: CPAST_c29830(scrA)
CSB: CLSA_c44300(scrA)
RUM: CK1_30570
RUS: RBI_I00666(scrA)
FPR: FP2_28580
FPA: FPR_17460
BFI: CIY_20140
EHL: EHLA_2444
THX: Thet_0208
TTM: Tthe_2348
TSH: Tsac_0107
APR: Apre_1540
MED: MELS_0702
MHG: MHY_15750
AIN: Acin_2306(scrA)
EBM: SG0102_02240(scrA)
MPE: MYPE9680(MYPE9680)
MMY: MSC_0646(pts)
MMYM: MMS_A0706
MML: MLC_6020(scrA)
MCP: MCAP_0618
MCAI: MCCG_0703
MLC: MSB_A0625
MLH: MLEA_005900(pts)
MMO: MMOB4640(scrA)
MTAB: MTABA_v1c05650(scrA) MTABA_v1c05670(scrA)
MCOL: MCOLE_v1c00420(bglF) MCOLE_v1c05390(scrA)
ESX: ESOMN_v1c00130(scrA) ESOMN_v1c05880(bglF)
EFR: EFREU_v1c00240(scrA) EFREU_v1c01820(scrA)
STAI: STAIW_v1c07760(scrA)
SHJ: SHELI_v1c04940(scrA) SHELI_v1c09260(scrA)
SCOU: SCORR_v1c04220(scrA)
CGL: NCgl2553(Cgl2642)
CGB: cg2925(ptsS)
CGU: WA5_2553(PtsS)
CGT: cgR_2547
CGM: cgp_2925(ptsS)
CGJ: AR0_12820
CDZ: CD31A_2246(scrA)
CDB: CDBH8_2204(scrA)
CAR: cauri_0403(ptsS)
CKP: ckrop_1696(ptsS)
CSX: CSING_02325(scrA)
CKU: UL82_01690(scrA)
CMV: CMUST_02450(scrA)
CTED: CTEST_11560(scrA)
CSP: WM42_0947
CGV: CGLAU_01975(bglF1)
CMIN: NCTC10288_02130(ptsS)
SALB: XNR_2385
SMA: SAVERM_3925(scrA)
SGR: SGR_3201
SGB: WQO_19725
SFA: Sfla_2775
SVE: SVEN_4059
SDV: BN159_4892(ybbF)
STRP: F750_4022
SFI: SFUL_4127
SALU: DC74_4790
SALL: SAZ_25645
STRE: GZL_04035
SLD: T261_3408
STRM: M444_16180
SAMB: SAM23877_3406(scrA)
SLE: sle_39220(sle_39220)
SLAU: SLA_4132
SALJ: SMD11_2836
SFK: KY5_3659
PAC: PPA1142
PACC: PAC1_05975
PACH: PAGK_1012
CACN: RN83_06075
AHW: NCTC11636_00375(bglF_2)
APV: Apar_1198
OLS: Olsu_0435
BRM: Bmur_0253
BPW: WESB_2283
BIP: Bint_1925
EMI: Emin_1067
SMF: Smon_0971
 » show all
Taxonomy
Reference
1  [PMID:468378]
  Authors
St Martin EJ, Wittenberger CL
  Title
Characterization of a phosphoenolpyruvate-dependent sucrose phosphotransferase system in Streptococcus mutans.
  Journal
Infect Immun 24:865-8 (1979)
Reference
2  [PMID:3009399]
  Authors
Lunsford RD, Macrina FL
  Title
Molecular cloning and characterization of scrB, the structural gene for the Streptococcus mutans phosphoenolpyruvate-dependent sucrose phosphotransferase system sucrose-6-phosphate hydrolase.
  Journal
J Bacteriol 166:426-34 (1986)
DOI:10.1128/JB.166.2.426-434.1986
Reference
3  [PMID:3122206]
  Authors
Fouet A, Arnaud M, Klier A, Rapoport G
  Title
Bacillus subtilis sucrose-specific enzyme II of the phosphotransferase system: expression in Escherichia coli and homology to enzymes II from enteric bacteria.
  Journal
Proc Natl Acad Sci U S A 84:8773-7 (1987)
DOI:10.1073/pnas.84.24.8773
  Sequence
[bsu:BSU38050]
Reference
4  [PMID:2536656]
  Authors
Sato Y, Poy F, Jacobson GR, Kuramitsu HK
  Title
Characterization and sequence analysis of the scrA gene encoding enzyme IIScr of  the Streptococcus mutans phosphoenolpyruvate-dependent sucrose phosphotransferase system.
  Journal
J Bacteriol 171:263-71 (1989)
DOI:10.1128/JB.171.1.263-271.1989
  Sequence
[smu:SMU_1841]
Reference
5  [PMID:8628219]
  Authors
Titgemeyer F, Jahreis K, Ebner R, Lengeler JW
  Title
Molecular analysis of the scrA and scrB genes from Klebsiella pneumoniae and plasmid pUR400, which encode the sucrose transport protein Enzyme II Scr of the phosphotransferase system and a sucrose-6-phosphate invertase.
  Journal
Mol Gen Genet 250:197-206 (1996)
DOI:10.1007/BF02174179
  Sequence
[kpn:KPN_00513]
Reference
6  [PMID:19726178]
  Authors
Jiang L, Cai J, Wang J, Liang S, Xu Z, Yang ST
  Title
Phosphoenolpyruvate-dependent phosphorylation of sucrose by Clostridium tyrobutyricum ZJU 8235: evidence for the phosphotransferase transport system.
  Journal
Bioresour Technol 101:304-9 (2010)
DOI:10.1016/j.biortech.2009.08.024
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.211
IUBMB Enzyme Nomenclature: 2.7.1.211
ExPASy - ENZYME nomenclature database: 2.7.1.211
BRENDA, the Enzyme Database: 2.7.1.211

DBGET integrated database retrieval system