KEGG   ENZYME: 2.7.1.215
Entry
EC 2.7.1.215                Enzyme                                 

Name
erythritol kinase (D-erythritol 1-phosphate-forming);
eryA (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:erythritol 1-phosphotransferase
Reaction(IUBMB)
ATP + erythritol = ADP + D-erythritol 1-phosphate [RN:R11536]
Reaction(KEGG)
R11536
Substrate
ATP [CPD:C00002];
erythritol [CPD:C00503]
Product
ADP [CPD:C00008];
D-erythritol 1-phosphate [CPD:C21294]
Comment
The enzyme, characterized from the pathogenic bacterium Brucella abortus, which causes brucellosis in livestock, participates in erythritol catabolism. cf. EC 2.7.1.27, erythritol kinase (D-erythritol 4-phosphate-forming).
History
EC 2.7.1.215 created 2016
Orthology
K00862  erythritol kinase (D-erythritol 1-phosphate-forming)
Genes
EFE: EFER_0338(eryA)
KOX: KOX_14070
KOE: A225_1632
KOY: J415_23470
KOM: HR38_12805
KOK: KONIH1_08010
KOC: AB185_28110
KLL: BJF97_08390
KLW: DA718_20265
GQU: AWC35_02410
RTG: NCTC13098_05403(lyx_2)
BUL: BW21_6384
VEI: Veis_2016
MLO: mlr7268
MHUA: MCHK_0787
SME: SMc01623(eriA)
SMX: SM11_chr1024(eryA)
SMI: BN406_02059(eriA)
SMEL: SM2011_c01623(eryA)
SMER: DU99_12530
SMD: Smed_2159
SFD: USDA257_c12970(xylB1)
SAME: SAMCFNEI73_pC1169(eryA)
EAD: OV14_3647
ARA: Arad_7460(lyxX)
RLE: pRL120204(eryA)
RLG: Rleg_5323
SHZ: shn_16425
BME: BMEII0430
BMEL: DK63_2809
BMEE: DK62_2589
BMF: BAB2_0372(eryA)
BMB: BruAb2_0368(eryA)
BABO: DK55_2362
BABR: DO74_2782
BABT: DK49_2870
BABB: DK48_2329
BABU: DK53_2372
BABS: DK51_2951
BABC: DO78_2688
BMS: BRA0864(eryA)
BSI: BS1330_II0857(eryA)
BSF: BSS2_II0819(eryA)
BSZ: DK67_2818
BSV: BSVBI22_B0856(eryA)
BOL: BCOUA_II0864(eryA)
BCAR: DK60_2555
BCAS: DA85_14605
BMR: BMI_II858(eryA)
BPP: BPI_II920(eryA)
BPV: DK65_2785
BCET: V910_200428(eryA)
OAN: Oant_2911
OAH: DR92_3594
OCH: CES85_5819(eryA)
BRA: BRADO4795
BBT: BBta_3230
AOL: S58_28790
BRO: BRAD285_2448(eryA)
BBAR: RHAL1_00624(eryA)
MMED: Mame_00678(eryA)
RDE: RD1_3634
PDE: Pden_4595
LABT: FIU93_29490(eryA2)
SPSE: SULPSESMR1_04461(eryA)
MALU: KU6B_05470
ACR: Acry_2571
SHUM: STHU_34070(eriA)
ROB: CK5_09680
ASD: AS9A_2886
RHB: NY08_872
SGR: SGR_224
SGB: WQO_33390
SBH: SBI_04000
SALU: DC74_6901
SALL: SAZ_35840
STRE: GZL_01855
SLD: T261_1073
SRW: TUE45_01264(lyx) TUE45_03247(eryA_10)
SALJ: SMD11_6891(xylB)
SFK: KY5_0774c
SGE: DWG14_05498(eryA_2)
CACN: RN83_00270
ACIJ: JS278_00483(eryA)
KFL: Kfla_6645
STRR: EKD16_11325(eryA1)
SRO: Sros_8242
NML: Namu_3325
SEN: SACE_5218(eryA) SACE_6531(eryA)
AOI: AORI_7453
AMQ: AMETH_6522(eryA)
AMYY: YIM_41180(eryA12)
SNA: Snas_4068
CAP: CLDAP_16690(xylB) CLDAP_24770(xylB)
TTR: Tter_2480
 » show all
Reference
1  [PMID:163226]
  Authors
Sperry JF, Robertson DC
  Title
Erythritol catabolism by Brucella abortus.
  Journal
J Bacteriol 121:619-30 (1975)
DOI:10.1128/JB.121.2.619-630.1975
Reference
2  [PMID:12639570]
  Authors
Lillo AM, Tetzlaff CN, Sangari FJ, Cane DE
  Title
Functional expression and characterization of EryA, the erythritol kinase of Brucella abortus, and enzymatic synthesis of L-erythritol-4-phosphate.
  Journal
Bioorg Med Chem Lett 13:737-9 (2003)
DOI:10.1016/S0960-894X(02)01032-6
  Sequence
[bmf:BAB2_0372]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.215
IUBMB Enzyme Nomenclature: 2.7.1.215
ExPASy - ENZYME nomenclature database: 2.7.1.215
BRENDA, the Enzyme Database: 2.7.1.215

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