KEGG   ENZYME: 2.7.1.218Help
Entry
EC 2.7.1.218                Enzyme                                 

Name
fructoselysine 6-kinase;
frlD (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:D-fructosyl-L-lysine 6-phosphotransferase
Reaction(IUBMB)
ATP + N6-(D-fructosyl)-L-lysine = ADP + N6-(6-phospho-D-fructosyl)-L-lysine [RN:R08124]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
N6-(D-fructosyl)-L-lysine [CPD:C16488]
Product
ADP [CPD:C00008];
N6-(6-phospho-D-fructosyl)-L-lysine
Comment
The enzyme, characterized from the bacterium Escherichia coli, has very little activity with fructose.
History
EC 2.7.1.218 created 2017
Orthology
K10710  fructoselysine 6-kinase
Genes
ECO: b3374(frlD)
ECJ: JW3337(frlD)
ECD: ECDH10B_3549(frlD)
EBW: BWG_3065(frlD)
ECOK: ECMDS42_2820(frlD)
ECE: Z4734 Z4735
ECS: ECs4224
ELX: CDCO157_3965
EOJ: ECO26_4462(frlD)
EOI: ECO111_4183(frlD)
EOH: ECO103_4092(frlD)
ESO: O3O_23450
ESM: O3M_02245
ESL: O3K_02200
ELH: ETEC_3624
ECY: ECSE_3635
ECR: ECIAI1_3512(frlD)
ECK: EC55989_3779(frlD)
ELO: EC042_3635(frlD)
EBR: ECB_03224(yhfQ)
EBD: ECBD_0375
EKF: KO11_05930(frlD)
EDJ: ECDH1ME8569_3253(frlD)
ELW: ECW_m3629(frlD)
ELL: WFL_17725(frlD)
ELP: P12B_c3472(yhfQ)
EBL: ECD_03224(frlD)
EBE: B21_03176(frlD)
SFL: SF3392(yhfQ)
SFX: S4370(yhfQ)
SFV: SFV_3379(yhfQ)
SFE: SFxv_3703(frlD)
SFN: SFy_4820
SFS: SFyv_4895
SFT: NCTC1_03673(frlD)
SSN: SSON_3505(yhfQ)
SBO: SBO_3361(yhfQ)
ESA: ESA_04362
CSK: ES15_0289(frlD)
CTU: CTU_38900(frlD)
METY: MRY16398_04130(frlD)
AHN: NCTC12129_00401(frlD_1)
SMER: DU99_16275
SMD: Smed_2845
SFD: USDA257_c23170(frlD)
SAME: SAMCFNEI73_pC0439(frlD)
RCP: RCAP_rcp00007(frlD)
BSU: BSU32570(frlD)
BSR: I33_3361
BSL: A7A1_2473
BSH: BSU6051_32570(frlD)
BSUT: BSUB_03476(frlD)
BSUL: BSUA_03476(frlD)
BSUS: Q433_17825
BSS: BSUW23_15905(frlD)
BST: GYO_3557
BSO: BSNT_09743(yurL)
BSQ: B657_32570(frlD)
BSX: C663_3116(frlD)
BAQ: BACAU_2990(yurL)
BYA: BANAU_3149(yurL)
BAMP: B938_15170
BAML: BAM5036_2876(frlD)
BAMA: RBAU_3092(frlD)
BAMN: BASU_2880(frlD)
BAMB: BAPNAU_3140(frlD)
BAMT: AJ82_16770
BAMY: V529_32240(yurL)
BMP: NG74_03111(frlD)
BAO: BAMF_3052(frlD)
BAZ: BAMTA208_16450(frlD)
BQL: LL3_03329(frlD)
BXH: BAXH7_03356(yurL)
BQY: MUS_3551(yhfQ1)
BAMI: KSO_004340
BAMC: U471_30700
BAMF: U722_15945
BMEG: BG04_4781(frlD) BG04_614(frlD)
BJS: MY9_3292
BACP: SB24_13925
BACB: OY17_18135
BACY: QF06_14605
BACL: BS34A_35540(frlD)
BALM: BsLM_3254
BGY: BGLY_3826
PPM: PPSC2_02775(yhfQ)
PPO: PPM_0496(yhfQ)
PPQ: PPSQR21_005290(rbsK)
PPOY: RE92_09170
PMW: B2K_33630
PRI: PRIO_1384(frlD) PRIO_6652
ESR: ES1_09720
ESU: EUS_03950
RCH: RUM_11890
CCT: CC1_07220
BPRO: PMF13cell1_00269(frlD)
CSO: CLS_33560
CST: CLOST_1206(frlD)
SHY: SHJG_1054
MPH: MLP_21790
DFC: DFI_15970
EPO: Epro_0778(pfkB)
KOS: KORDIASMS9_03201(frlD)
 » show all
Taxonomy
Reference
1  [PMID:12147680]
  Authors
Wiame E, Delpierre G, Collard F, Van Schaftingen E.
  Title
Identification of a pathway for the utilization of the Amadori product fructoselysine in Escherichia coli.
  Journal
J Biol Chem 277:42523-9 (2002)
DOI:10.1074/jbc.M200863200
  Sequence
[eco:b3374]
Reference
2  [PMID:14641112]
  Authors
Wiame E, Van Schaftingen E
  Title
Fructoselysine 3-epimerase, an enzyme involved in the metabolism of the unusual Amadori compound psicoselysine in Escherichia coli.
  Journal
Biochem J 378:1047-52 (2004)
DOI:10.1042/BJ20031527
  Sequence
[eco:b3374]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.218
IUBMB Enzyme Nomenclature: 2.7.1.218
ExPASy - ENZYME nomenclature database: 2.7.1.218
BRENDA, the Enzyme Database: 2.7.1.218

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