KEGG   ENZYME: 2.7.1.223Help
Entry
EC 2.7.1.223                Enzyme                                 

Name
aminoimidazole riboside kinase;
STM4066 (locus name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:5-amino-1-(beta-D-ribosyl)imidazole 5'-phosphotransferase
Reaction(IUBMB)
ATP + 5-amino-1-(beta-D-ribosyl)imidazole = ADP + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole [RN:R12245]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
5-amino-1-(beta-D-ribosyl)imidazole [CPD:C22030]
Product
ADP [CPD:C00008];
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole [CPD:C03373]
Comment
The enzyme, characterized from the bacterium Salmonella enterica, can phosphorylate exogeneously-provided 5-amino-1-(beta-D-ribosyl)imidazole to form 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole (AIR), an important intermediate in the production of both purine mononucleotides and the hydroxymethyl pyrimidine moiety of thiamine.
History
EC 2.7.1.223 created 2018
Orthology
K23147  aminoimidazole riboside kinase
Genes
STY: STY3804
STT: t3552
SEX: STBHUCCB_37350
SENT: TY21A_17945
STM: STM4066
SEO: STM14_4890
SEV: STMMW_40311
SEY: SL1344_4015
SEM: STMDT12_C42130
SEJ: STMUK_4051
SENI: CY43_21265
SPT: SPA3909
SEK: SSPA3637
SEI: SPC_4173
SEC: SCH_3957
SHB: SU5_0164
SENS: Q786_19970
SED: SeD_A4464
SEL: SPUL_3598
SET: SEN3856
SENA: AU38_19935
SENO: AU37_19950
SENV: AU39_19970
SENQ: AU40_22275
SENL: IY59_20430
SENE: IA1_19785
CAMA: F384_21510
CLAP: NCTC11466_04506(iolC_2)
AHN: NCTC12129_04848(rbsK_1) NCTC12129_04849(iolC_3)
 » show all
Taxonomy
Reference
1  [PMID:12486071]
  Authors
Dougherty M, Downs DM
  Title
The stm4066 gene product of Salmonella enterica serovar Typhimurium has aminoimidazole riboside (AIRs) kinase activity and allows AIRs to satisfy the thiamine requirement of pur mutant strains.
  Journal
J Bacteriol 185:332-9 (2003)
DOI:10.1128/JB.185.1.332-339.2003
  Sequence
[stm:STM4066]
Reference
2  [PMID:15458630]
  Authors
Zhang Y, Dougherty M, Downs DM, Ealick SE
  Title
Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica:  implications for the evolution of the ribokinase superfamily.
  Journal
Structure 12:1809-21 (2004)
DOI:10.1016/j.str.2004.07.020
  Sequence
[stm:STM4066]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.223
IUBMB Enzyme Nomenclature: 2.7.1.223
ExPASy - ENZYME nomenclature database: 2.7.1.223
BRENDA, the Enzyme Database: 2.7.1.223

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