KEGG ENZYME: 2.7.1.225

ENZYME: 2.7.1.225

Entry

EC 2.7.1.225                Enzyme

Name

L-serine kinase (ATP);
sbnI (gene name)

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:L-serine 3-phosphotransferase

Reaction(IUBMB)

ATP + L-serine = ADP + O-phospho-L-serine [RN:R12344]

Reaction(KEGG)

R12344

Substrate

ATP [CPD:C00002];
L-serine [CPD:C00065]

Product

ADP [CPD:C00008];
O-phospho-L-serine [CPD:C01005]

Comment

The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of L-2,3-diaminopropanoate, which is used by that organism as a precursor for the biosynthesis of the siderophore staphyloferrin B.

History

EC 2.7.1.225 created 2019

Pathway

ec00997

Biosynthesis of various other secondary metabolites

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K23371

L-serine kinase (ATP) / ParB family transcriptional regulator, heme-responsive regulator

Genes

BTHR:

YBT1520_29789

BTHI:

BTK_29574

BTHT:

H175_233p021 H175_328p222 H175_328p225

BBY:	CY96_29570

BBAD:

K7T73_21420

PCAL:

BV455_03916

SAU:	SA0120(sbnI)

SAV:

SAV0124

SAW:

SAHV_0123

SAH:	SaurJH1_0115

SAJ:	SaurJH9_0111

SAM:	MW0097(sbnI)

SAS:

SAS0098

SAR:

SAR0127

SAC:

SACOL0108

SAX:	USA300HOU_0135

SAA:	SAUSA300_0126

SAO:	SAOUHSC_00083

SAE:	NWMN_0068(sbnI)

SAD:

SAAV_0092

SUU:	M013TW_0114(sbnI)

SUV:	SAVC_00360

SUE:

SAOV_0071

SUJ:	SAA6159_00107(sbnI)

SUK:	SAA6008_00102(sbnl)

SUC:

ECTR2_80

SUT:	SAT0131_00110

SUQ:	HMPREF0772_10373

SUZ:

MS7_0116

SUD:	ST398NM01_0136

SUX:	SAEMRSA15_00900

SUW:	SATW20_01360(sbnI)

SUG:

SAPIG0136

SUF:	SARLGA251_00990(sbnI)

SAUA:

SAAG_00608

SAUE:

RSAU_000078

SAUN:

SAKOR_00098

SAUS:

SA40_0091

SAUU:

SA957_0106

SAUG:

SA268_0103(sbnI)

SAUZ:

SAZ172_0135(sbnI)

SAUT:

SAI1T1_2000800(sbnl)

SAUJ:

SAI2T2_1000800(sbnl)

SAUK:

SAI3T3_1000800(sbnl)

SAUQ:

SAI4T8_1000800(sbnl)

SAUV:

SAI7S6_1000800

SAUW:

SAI5S5_1000800

SAUX:

SAI6T6_1000800

SAUY:

SAI8T7_1000800

SAUF:

X998_0103

SAB:

SAB0063

SUY:	SA2981_0125(sbnI)

SAUB:

C248_0112

SAUM:

BN843_1260

SAUC:

CA347_135

SAUR:

SABB_01716(sbnI)

SAUI:

AZ30_00645

SAUD:

CH52_05100

SAMS:

NI36_00540

SUH:	SAMSHR1132_01000

SSD:	SPSINT_0342

SDT:

SPSE_2116

SDP:	NCTC12225_02333

SHU:	SHYC_00395(sbnI)

SSCH:

LH95_00395

SSCZ:

RN70_00615

SAGQ:

EP23_09730(sbnI)

SEQO:

SE1039_25030

SLZ:	B5P37_07630

SARL:

SAP2_02110

SSH:	NCTC13712_00077

SRAI:

LN051_00270(sbnI)

SFF:	FOB90_07395(sbnI)

BBE:	BBR47_31880

BLR:	BRLA_c008290

BFM:	BP422_11075

BAGR:

BA6348_15315

BRW:	GOP56_19895

BCHS:

JNE38_14390

PLV:	ERIC2_c18230

ANX:	ACH33_02530

ATHE:

K3F53_16420

TUM:	CBW65_11360

TAB:	CIG75_02750 CIG75_02875

LFB:	C1X05_04270

KPUL:

GXN76_14205

PABS:

JIR001_05160(sbnI)

PAC:

PPA1292

PAV:	TIA2EST22_06440

PAX:	TIA2EST36_06410

PAZ:	TIA2EST2_06345

PAW:	PAZ_c13530

PAD:	TIIST44_08130

PCN:	TIB1ST10_06650

PACC:

PAC1_06780

RXY:

Rxyl_0989

RRD:	RradSPS_0901

RUB:	GBA63_07300

RMAR:

GBA65_09075

THUG:

KNN16_05245

PMET:

G4Y79_15610

» show all

Reference

1 [PMID:29483190]

Authors

Verstraete MM, Perez-Borrajero C, Brown KL, Heinrichs DE, Murphy MEP

Title

SbnI is a free serine kinase that generates O -phospho-l-serine for staphyloferrin B biosynthesis in Staphylococcus aureus.

Journal

J Biol Chem 293:6147-6160 (2018)
DOI:10.1074/jbc.RA118.001875

Sequence

[saa:SAUSA300_0126]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.225

IUBMB Enzyme Nomenclature:

2.7.1.225

ExPASy - ENZYME nomenclature database:

2.7.1.225

BRENDA, the Enzyme Database:

2.7.1.225

DBGET integrated database retrieval system