Entry
Name
inositol phosphorylceramide synthase;
AUR1 (gene name);
KEI1 (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
1-phosphatidyl-1D-myo-inositol:a very-long-chain (2'R)-2'-hydroxy-phytoceramide phosphoinositoltransferase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol + a very-long-chain (2'R)-2'-hydroxy-phytoceramide = 1,2-diacyl-sn-glycerol + a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine
Substrate
1-phosphatidyl-1D-myo-inositol [CPD:
C01194 ];
very-long-chain (2'R)-2'-hydroxy-phytoceramide
Product
1,2-diacyl-sn-glycerol [CPD:
C00641 ];
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine
Comment
The enzyme, characterized from yeast, attaches a phosphoinositol headgroup to alpha-hydroxyphytoceramides, generating a very-long-chain inositol phospho-alpha hydroxyphytoceramide (IPC), the simplest of the three complex sphingolipids produced by yeast.
History
EC 2.7.1.227 created 2019
Orthology
K22723 inositol phosphorylceramide synthase catalytic subunit
Genes
GSL : Gasu_20500 Gasu_51490
VPO : Kpol_1018p48 Kpol_1056p41
CGR : CAGL0K02805g CAGL0M10307g
NCS : NCAS_0A05620(NCAS0A05620) NCAS_0E02500(NCAS0E02500)
NDI : NDAI_0E04070(NDAI0E04070) NDAI_0K02440(NDAI0K02440)
TPF : TPHA_0G03320(TPHA0G03320)
TBL : TBLA_0B05440(TBLA0B05440) TBLA_0D05060(TBLA0D05060)
TDL : TDEL_0A02830(TDEL0A02830)
KAF : KAFR_0D03310(KAFR0D03310)
KNG : KNAG_0A06640(KNAG0A06640)
CAL : CAALFM_C501240WA(AUR1)
BNN : FOA43_002182 FOA43_004426
BBRX : BRETT_002237 BRETT_003808
OPA : HPODL_00639 HPODL_03692
NTE : NEUTE1DRAFT67536(NEUTE1DRAFT_67536)
BFU : BCIN_02g08130(Bcaur1)
ANG : ANI_1_1662144(An16g03650)
LBC : LACBIDRAFT_159197 LACBIDRAFT_159277 LACBIDRAFT_332565
ABP : AGABI1DRAFT78826(AGABI1DRAFT_78826)
ABV : AGABI2DRAFT188420(AGABI2DRAFT_188420)
SCM : SCHCO_02629453(SCHCODRAFT_02629453)
MRM : A7982_08742 A7982_10244
LLU : AKJ09_09990 AKJ09_10549
» show all
Taxonomy
Reference
Authors
Nagiec MM, Nagiec EE, Baltisberger JA, Wells GB, Lester RL, Dickson RC
Title
Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene.
Journal
Sequence
Reference
Authors
Levine TP, Wiggins CA, Munro S
Title
Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae.
Journal
Sequence
Reference
Authors
Sato K, Noda Y, Yoda K
Title
Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.1.227