KEGG   ENZYME: 2.7.1.227
Entry
EC 2.7.1.227                Enzyme                                 
Name
inositol phosphorylceramide synthase;
AUR1 (gene name);
KEI1 (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
1-phosphatidyl-1D-myo-inositol:a very-long-chain (2'R)-2'-hydroxy-phytoceramide phosphoinositoltransferase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol + a very-long-chain (2'R)-2'-hydroxy-phytoceramide = 1,2-diacyl-sn-glycerol + a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine
Substrate
1-phosphatidyl-1D-myo-inositol [CPD:C01194];
very-long-chain (2'R)-2'-hydroxy-phytoceramide
Product
1,2-diacyl-sn-glycerol [CPD:C00641];
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine
Comment
The enzyme, characterized from yeast, attaches a phosphoinositol headgroup to alpha-hydroxyphytoceramides, generating a very-long-chain inositol phospho-alpha hydroxyphytoceramide (IPC), the simplest of the three complex sphingolipids produced by yeast.
History
EC 2.7.1.227 created 2019
Orthology
K22723  inositol phosphorylceramide synthase catalytic subunit
Genes
NVE: 5510614
EPA: 110233986
ATEN: 116307979
ADF: 107352142
AMIL: 114977687
PDAM: 113681296
SPIS: 111342333
DGT: 114529483
XEN: 124446455
HMG: 100211216
TAD: TRIADDRAFT_61536
QSU: 112014649 112037680
CME: CYME_CML255C
GSL: Gasu_20500 Gasu_51490
SCE: YKL004W(AUR1)
AGO: AGOS_ABR004C
KLA: KLLA0_B13387g
KMX: KLMA_30067(AUR1)
LTH: KLTH0D06248g
VPO: Kpol_1018p48 Kpol_1056p41
ZRO: ZYRO0B01408g
CGR: CAGL0K02805g CAGL0M10307g
NCS: NCAS_0A05620(NCAS0A05620) NCAS_0E02500(NCAS0E02500)
NDI: NDAI_0E04070(NDAI0E04070) NDAI_0K02440(NDAI0K02440)
TPF: TPHA_0G03320(TPHA0G03320)
TBL: TBLA_0B05440(TBLA0B05440) TBLA_0D05060(TBLA0D05060)
TDL: TDEL_0A02830(TDEL0A02830)
TGB: HG536_0A04380
KAF: KAFR_0D03310(KAFR0D03310)
ZMK: HG535_0D03710
PPA: PAS_chr2-2_0330
DHA: DEHA2E12848g
PIC: PICST_91106
PGU: PGUG_03354
SPAA: SPAPADRAFT_61139
LEL: LELG_03794
CAL: CAALFM_C501240WA(AUR1)
CTP: CTRG_05376
CDU: CD36_51090(IPC1)
CTEN: CANTEDRAFT_114775
YLI: YALI0E16434g
CLU: CLUG_02697
CLUS: A9F13_07g01518
CAUR: CJI97_005397
SLB: AWJ20_1930(AUR1)
PKZ: C5L36_0D06140
BNN: FOA43_002182 FOA43_004426
BBRX: BRETT_002237 BRETT_003808
NCR: NCU02282
NTE: NEUTE1DRAFT67536(NEUTE1DRAFT_67536)
SMP: SMAC_08749
PAN: PODANSg1772
TTT: THITE_2117308
MTM: MYCTH_2308679
CTHR: CTHT_0016140
TMN: UCRPA7_6474
SSCK: SPSK_00486
FGR: FGSG_00338
FPU: FPSE_07672
FVR: FVEG_00790
FOX: FOXG_00724
NHE: NECHADRAFT_65727
TRE: TRIREDRAFT_22245
TRR: M419DRAFT_141075
MAW: MAC_04621
MAJ: MAA_04600
CMT: CCM_01312
PLJ: VFPFJ_01874
VAL: VDBG_03580
VDA: VDAG_00813
CFJ: CFIO01_07093
SAPO: SAPIO_CDS3849
ELA: UCREL1_201
PFY: PFICI_14694
SSL: SS1G_11877
BFU: BCIN_02g08130(Bcaur1)
MBE: MBM_02995
PSCO: LY89DRAFT_118874
GLZ: GLAREA_11563
ANI: AN4991.2
AFM: AFUA_3G09960
ACT: ACLA_037800
NFI: NFIA_067330
AOR: AO090003000518
ANG: ANI_1_1662144(An16g03650)
AFV: AFLA_001174
ALUC: AKAW2_70313A(IPC1)
ACHE: ACHE_20945A(IPC1)
APUU: APUU_30837A(IPC1)
PCS: Pc12g15520
PDP: PDIP_76490
TMF: PMAA_025860
TRG: TRUGW13939_03289
CIM: CIMG_03953
CPW: CPC735_004060
URE: UREG_01994
PBL: PAAG_07905
PBN: PADG_08169
ABE: ARB_01217
TVE: TRV_01291
AJE: HCAG_05472
BGH: BDBG_02491
PNO: SNOG_02767
PTE: PTT_15997
BZE: COCCADRAFT_84150
BSC: COCSADRAFT_85211
BOR: COCMIDRAFT_84205
AALT: CC77DRAFT_943703
ZTR: MYCGRDRAFT_109911
PFJ: MYCFIDRAFT_204117
BCOM: BAUCODRAFT_499183
NPA: UCRNP2_4267
TML: GSTUM_00007464001
SPO: SPAC3H8.06(aur1)
CNE: CNI01040
CNB: CNBH0990
CGI: CGB_H1570W
TMS: TREMEDRAFT_22906
TASA: A1Q1_02708
TVS: TRAVEDRAFT_31948
DSQ: DICSQDRAFT_137064
PCO: PHACADRAFT_263101
SHS: STEHIDRAFT_99651
HIR: HETIRDRAFT_460872
PSQ: PUNSTDRAFT_108718
ADL: AURDEDRAFT_112723
FME: FOMMEDRAFT_127026
GTR: GLOTRDRAFT_79423
LBC: LACBIDRAFT_159197 LACBIDRAFT_159277 LACBIDRAFT_332565
MRR: Moror_17785
CCI: CC1G_07984
SCM: SCHCODRAFT_85343
ABP: AGABI1DRAFT78826(AGABI1DRAFT_78826)
ABV: AGABI2DRAFT188420(AGABI2DRAFT_188420)
CPUT: CONPUDRAFT_128967
SLA: SERLADRAFT_450689
WSE: WALSEDRAFT_60865
WIC: J056_000972
UMA: UMAG_01613
PFP: PFL1_03729
MGL: MGL_3111
MRT: MRET_1369
MSYM: MSY001_2874
PGR: PGTG_15186
MLR: MELLADRAFT_50745
MXA: MXAN_0451
MSD: MYSTI_00469
MYM: A176_006545
MFB: MFUL124B02_02700
CCX: COCOR_00420
MFU: LILAB_06445
MMAS: MYMAC_000492
SUR: STAUR_7983
SCU: SCE1572_23115
CCRO: CMC5_045470
LLU: AKJ09_09990 AKJ09_10549
MRM: A7982_08742 A7982_10244
PCAY: FRD00_09210
PHR: C6569_01075
PSTG: E8M01_18705
VBA: IMCC26134_14845
BHL: Bache_2976
BCEL: BcellWH2_01061
BIS: DXK01_019920
BUN: Bun01g_21030
PPN: Palpr_2423
DUN: FDZ78_07280
PRO: HMPREF0669_00349
CPI: Cpin_2406
CHIH: GWR21_27385
NKO: Niako_1285
FGG: FSB75_05880
ARB: A9P82_14940
ARAC: E0W69_001835
FLN: FLA_4762
PSEG: D3H65_09925
PEK: FFJ24_013920
PROE: H9L23_13370
MUP: A0256_14965
MUC: MuYL_2030
MGOT: MgSA37_02611
MUH: HYN43_004615
MGIN: FRZ54_19135
MGK: FSB76_21425
MRUB: DEO27_004830
MGOS: DIU38_004600
MMAB: HQ865_14480
MGIK: GO620_007660
SBX: CA265_13540
SLI: Slin_1527
SRD: SD10_19875
SPIR: CWM47_05410
SPIK: EXU85_32910
FIB: A6C57_03535
HYP: A0257_01685
HYZ: AXW84_15715
HNV: DDQ68_10530
PKO: PKOR_15480
PACT: CA264_06990
CHK: D4L85_19585
PDL: Pyrde_1542
 » show all
Reference
1  [PMID:9092515]
  Authors
Nagiec MM, Nagiec EE, Baltisberger JA, Wells GB, Lester RL, Dickson RC
  Title
Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene.
  Journal
J Biol Chem 272:9809-17 (1997)
DOI:10.1074/jbc.272.15.9809
  Sequence
[sce:YKL004W]
Reference
2  [PMID:10888667]
  Authors
Levine TP, Wiggins CA, Munro S
  Title
Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae.
  Journal
Mol Biol Cell 11:2267-81 (2000)
DOI:10.1091/mbc.11.7.2267
  Sequence
[sce:YKL004W]
Reference
3  [PMID:19726565]
  Authors
Sato K, Noda Y, Yoda K
  Title
Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization.
  Journal
Mol Biol Cell 20:4444-57 (2009)
DOI:10.1091/mbc.E09-03-0235
  Sequence
[sce:YKL004W YDR367W]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.227
IUBMB Enzyme Nomenclature: 2.7.1.227
ExPASy - ENZYME nomenclature database: 2.7.1.227
BRENDA, the Enzyme Database: 2.7.1.227

  All links  
Gene (1907)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (214)   
   KEGG MGENES (1692)   
Protein sequence (6)   
   UniProt (3)   
   SWISS-PROT (3)   
Protein domain (6)   
   InterPro (6)   
All databases (1919)   

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