KEGG   ENZYME: 2.7.1.227
Entry
EC 2.7.1.227                Enzyme                                 

Name
inositol phosphorylceramide synthase;
AUR1 (gene name);
KEI1 (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
1-phosphatidyl-1D-myo-inositol:(2'R)-2'-hydroxy-phytoceramide phosphoinositoltransferase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol + a very-long-chain (2'R)-2'-hydroxyphytoceramide = 1,2-diacyl-sn-glycerol + a very-long-chain inositol phospho-(2'R)-2'-hydroxyphytoceramide
Substrate
1-phosphatidyl-1D-myo-inositol [CPD:C01194];
very-long-chain (2'R)-2'-hydroxyphytoceramide
Product
1,2-diacyl-sn-glycerol [CPD:C00641];
very-long-chain inositol phospho-(2'R)-2'-hydroxyphytoceramide [CPD:C22183]
Comment
The enzyme, characterized from yeast, attaches a phosphoinositol headgroup to alpha-hydroxyphytoceramides, generating a very-long-chain inositol phospho-alpha hydroxyphytoceramide (IPC), the simplest of the three complex sphingolipids produced by yeast.
History
EC 2.7.1.227 created 2019
Orthology
K22723  inositol phosphorylceramide synthase catalytic subunit
Genes
NVE: 5510614
EPA: 110233986
ADF: 107352142
AMIL: 114977687
PDAM: 113681296
SPIS: 111342333
DGT: 114529483
HMG: 100211216
TAD: TRIADDRAFT_61536
QSU: 112014649 112037680
SCE: YKL004W(AUR1)
KMX: KLMA_30067(AUR1)
NCS: NCAS_0A05620(NCAS0A05620) NCAS_0E02500(NCAS0E02500)
NDI: NDAI_0E04070(NDAI0E04070) NDAI_0K02440(NDAI0K02440)
TPF: TPHA_0G03320(TPHA0G03320)
TBL: TBLA_0B05440(TBLA0B05440) TBLA_0D05060(TBLA0D05060)
TDL: TDEL_0A02830(TDEL0A02830)
KAF: KAFR_0D03310(KAFR0D03310)
CAL: CAALFM_C501240WA(AUR1)
CDU: CD36_51090(IPC1)
SLB: AWJ20_1930(AUR1)
NCR: NCU02282
NTE: NEUTE1DRAFT67536(NEUTE1DRAFT_67536)
SSCK: SPSK_00486
MAW: MAC_04621
MAJ: MAA_04600
CMT: CCM_01312
BFU: BCIN_02g08130(Bcaur1)
MBE: MBM_02995
ANI: AN4991.2
ANG: ANI_1_1662144(An16g03650)
ABE: ARB_01217
TVE: TRV_01291
PTE: PTT_15997
SPO: SPAC3H8.06(aur1)
CNE: CNI01040
CNB: CNBH0990
TASA: A1Q1_02708
ABP: AGABI1DRAFT78826(AGABI1DRAFT_78826)
ABV: AGABI2DRAFT188420(AGABI2DRAFT_188420)
MGL: MGL_3111
MRT: MRET_1369
MXA: MXAN_0451
BXY: BXY_45390
CPI: Cpin_2406
FLN: FLA_4762
MUC: MuYL_2030
SLI: Slin_1527
 » show all
Reference
1  [PMID:9092515]
  Authors
Nagiec MM, Nagiec EE, Baltisberger JA, Wells GB, Lester RL, Dickson RC
  Title
Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene.
  Journal
J Biol Chem 272:9809-17 (1997)
DOI:10.1074/jbc.272.15.9809
  Sequence
[sce:YKL004W]
Reference
2  [PMID:10888667]
  Authors
Levine TP, Wiggins CA, Munro S
  Title
Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae.
  Journal
Mol Biol Cell 11:2267-81 (2000)
DOI:10.1091/mbc.11.7.2267
  Sequence
[sce:YKL004W]
Reference
3  [PMID:19726565]
  Authors
Sato K, Noda Y, Yoda K
  Title
Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization.
  Journal
Mol Biol Cell 20:4444-57 (2009)
DOI:10.1091/mbc.E09-03-0235
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.227
IUBMB Enzyme Nomenclature: 2.7.1.227
ExPASy - ENZYME nomenclature database: 2.7.1.227
BRENDA, the Enzyme Database: 2.7.1.227

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