KEGG   ENZYME: 2.7.1.227
Entry
EC 2.7.1.227                Enzyme                                 
Name
inositol phosphorylceramide synthase;
AUR1 (gene name);
KEI1 (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
1-phosphatidyl-1D-myo-inositol:a very-long-chain (2'R)-2'-hydroxy-phytoceramide phosphoinositoltransferase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol + a very-long-chain (2'R)-2'-hydroxy-phytoceramide = 1,2-diacyl-sn-glycerol + a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine
Substrate
1-phosphatidyl-1D-myo-inositol [CPD:C01194];
very-long-chain (2'R)-2'-hydroxy-phytoceramide
Product
1,2-diacyl-sn-glycerol [CPD:C00641];
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine
Comment
The enzyme, characterized from yeast, attaches a phosphoinositol headgroup to alpha-hydroxyphytoceramides, generating a very-long-chain inositol phospho-alpha hydroxyphytoceramide (IPC), the simplest of the three complex sphingolipids produced by yeast.
History
EC 2.7.1.227 created 2019
Orthology
K22723  inositol phosphorylceramide synthase catalytic subunit
Genes
NVE5510614
EPA110233986
ATEN116307979
ADF107352142
AMIL114977687
PDAM113681296
SPIS111342333
DGT114529483
XEN124446455
HMG100211216
TADTRIADDRAFT_61536
QSU112014649 112037680
CMECYME_CML255C
GSLGasu_20500 Gasu_51490
SCEYKL004W(AUR1)
AGOAGOS_ABR004C
KLAKLLA0_B13387g
KMXKLMA_30067(AUR1)
LTHKLTH0D06248g
VPOKpol_1018p48 Kpol_1056p41
ZROZYRO0B01408g
CGRCAGL0K02805g CAGL0M10307g
NCSNCAS_0A05620(NCAS0A05620) NCAS_0E02500(NCAS0E02500)
NDINDAI_0E04070(NDAI0E04070) NDAI_0K02440(NDAI0K02440)
TPFTPHA_0G03320(TPHA0G03320)
TBLTBLA_0B05440(TBLA0B05440) TBLA_0D05060(TBLA0D05060)
TDLTDEL_0A02830(TDEL0A02830)
TGBHG536_0A04380
KAFKAFR_0D03310(KAFR0D03310)
ZMKHG535_0D03710
PPAPAS_chr2-2_0330
DHADEHA2E12848g
PICPICST_91106
PGUPGUG_03354
SPAASPAPADRAFT_61139
LELLELG_03794
CALCAALFM_C501240WA(AUR1)
CTPCTRG_05376
CDUCD36_51090(IPC1)
CTENCANTEDRAFT_114775
YLIYALI0E16434g
CLUCLUG_02697
CLUSA9F13_07g01518
CAURCJI97_005397
SLBAWJ20_1930(AUR1)
PKZC5L36_0D06140
BNNFOA43_002182 FOA43_004426
BBRXBRETT_002237 BRETT_003808
NCRNCU02282
NTENEUTE1DRAFT67536(NEUTE1DRAFT_67536)
SMPSMAC_08749
PANPODANSg1772
TTTTHITE_2117308
MTMMYCTH_2308679
CTHRCTHT_0016140
TMNUCRPA7_6474
SSCKSPSK_00486
FGRFGSG_00338
FPUFPSE_07672
FVRFVEG_00790
FOXFOXG_00724
NHENECHADRAFT_65727
TRETRIREDRAFT_22245
TRRM419DRAFT_141075
MAWMAC_04621
MAJMAA_04600
CMTCCM_01312
PLJVFPFJ_01874
VALVDBG_03580
VDAVDAG_00813
CFJCFIO01_07093
SAPOSAPIO_CDS3849
ELAUCREL1_201
PFYPFICI_14694
SSLSS1G_11877
BFUBCIN_02g08130(Bcaur1)
MBEMBM_02995
PSCOLY89DRAFT_118874
GLZGLAREA_11563
ANIAN4991.2
AFMAFUA_3G09960
ACTACLA_037800
NFINFIA_067330
AORAO090003000518
ANGANI_1_1662144(An16g03650)
AFVAFLA_001174
ALUCAKAW2_70313A(IPC1)
ACHEACHE_20945A(IPC1)
APUUAPUU_30837A(IPC1)
PCSPc12g15520
PDPPDIP_76490
TMFPMAA_025860
TRGTRUGW13939_03289
CIMCIMG_03953
CPWCPC735_004060
UREUREG_01994
PBLPAAG_07905
PBNPADG_08169
ABEARB_01217
TVETRV_01291
AJEHCAG_05472
BGHBDBG_02491
PNOSNOG_02767
PTEPTT_15997
BZECOCCADRAFT_84150
BSCCOCSADRAFT_85211
BORCOCMIDRAFT_84205
AALTCC77DRAFT_943703
ZTRMYCGRDRAFT_109911
PFJMYCFIDRAFT_204117
BCOMBAUCODRAFT_499183
NPAUCRNP2_4267
TMLGSTUM_00007464001
SPOSPAC3H8.06(aur1)
CNECNI01040
CNBCNBH0990
CGICGB_H1570W
TMSTREMEDRAFT_22906
TASAA1Q1_02708
TVSTRAVEDRAFT_31948
DSQDICSQDRAFT_137064
PCOPHACADRAFT_263101
SHSSTEHIDRAFT_99651
HIRHETIRDRAFT_460872
PSQPUNSTDRAFT_108718
ADLAURDEDRAFT_112723
FMEFOMMEDRAFT_127026
GTRGLOTRDRAFT_79423
LBCLACBIDRAFT_159197 LACBIDRAFT_159277 LACBIDRAFT_332565
MRRMoror_17785
CCICC1G_07984
SCMSCHCODRAFT_85343
ABPAGABI1DRAFT78826(AGABI1DRAFT_78826)
ABVAGABI2DRAFT188420(AGABI2DRAFT_188420)
CPUTCONPUDRAFT_128967
SLASERLADRAFT_450689
WSEWALSEDRAFT_60865
WICJ056_000972
UMAUMAG_01613
PFPPFL1_03729
MGLMGL_3111
MRTMRET_1369
MSYMMSY001_2874
PGRPGTG_15186
MLRMELLADRAFT_50745
MXAMXAN_0451
MSDMYSTI_00469
MYMA176_006545
MFBMFUL124B02_02700
CCXCOCOR_00420
MFULILAB_06445
MMASMYMAC_000492
SURSTAUR_7983
SCUSCE1572_23115
CCROCMC5_045470
LLUAKJ09_09990 AKJ09_10549
MRMA7982_08742 A7982_10244
PCAYFRD00_09210
PHRC6569_01075
PSTGE8M01_18705
VBAIMCC26134_14845
BHLBache_2976
BCELBcellWH2_01061
BISDXK01_019920
BUNBun01g_21030
PPNPalpr_2423
DUNFDZ78_07280
PROHMPREF0669_00349
CPICpin_2406
CHIHGWR21_27385
NKONiako_1285
FGGFSB75_05880
ARBA9P82_14940
ARACE0W69_001835
FLNFLA_4762
PSEGD3H65_09925
PEKFFJ24_013920
PROEH9L23_13370
MUPA0256_14965
MUCMuYL_2030
MGOTMgSA37_02611
MUHHYN43_004615
MGINFRZ54_19135
MGKFSB76_21425
MRUBDEO27_004830
MGOSDIU38_004600
MMABHQ865_14480
MGIKGO620_007660
SBXCA265_13540
SLISlin_1527
SRDSD10_19875
SPIRCWM47_05410
SPIKEXU85_32910
FIBA6C57_03535
HYPA0257_01685
HYZAXW84_15715
HNVDDQ68_10530
PKOPKOR_15480
PACTCA264_06990
CHKD4L85_19585
PDLPyrde_1542
 » show all
Reference
1  [PMID:9092515]
  Authors
Nagiec MM, Nagiec EE, Baltisberger JA, Wells GB, Lester RL, Dickson RC
  Title
Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene.
  Journal
J Biol Chem 272:9809-17 (1997)
DOI:10.1074/jbc.272.15.9809
  Sequence
[sce:YKL004W]
Reference
2  [PMID:10888667]
  Authors
Levine TP, Wiggins CA, Munro S
  Title
Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae.
  Journal
Mol Biol Cell 11:2267-81 (2000)
DOI:10.1091/mbc.11.7.2267
  Sequence
[sce:YKL004W]
Reference
3  [PMID:19726565]
  Authors
Sato K, Noda Y, Yoda K
  Title
Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization.
  Journal
Mol Biol Cell 20:4444-57 (2009)
DOI:10.1091/mbc.E09-03-0235
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.227
IUBMB Enzyme Nomenclature: 2.7.1.227
ExPASy - ENZYME nomenclature database: 2.7.1.227
BRENDA, the Enzyme Database: 2.7.1.227

DBGET integrated database retrieval system