| Entry |
|
|---|
| Name |
inositol phosphorylceramide synthase;
AUR1 (gene name);
KEI1 (gene name)
|
|---|
| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
|
|---|
| Sysname |
1-phosphatidyl-1D-myo-inositol:(2'R)-2'-hydroxy-phytoceramide phosphoinositoltransferase
|
|---|
| Reaction(IUBMB) |
1-phosphatidyl-1D-myo-inositol + a very-long-chain (2'R)-2'-hydroxyphytoceramide = 1,2-diacyl-sn-glycerol + a very-long-chain inositol phospho-(2'R)-2'-hydroxyphytoceramide
|
|---|
| Substrate |
1-phosphatidyl-1D-myo-inositol [CPD: C01194];
very-long-chain (2'R)-2'-hydroxyphytoceramide
|
|---|
| Product |
1,2-diacyl-sn-glycerol [CPD: C00641];
very-long-chain inositol phospho-(2'R)-2'-hydroxyphytoceramide [CPD: C22183]
|
|---|
| Comment |
The enzyme, characterized from yeast, attaches a phosphoinositol headgroup to alpha-hydroxyphytoceramides, generating a very-long-chain inositol phospho-alpha hydroxyphytoceramide (IPC), the simplest of the three complex sphingolipids produced by yeast.
|
|---|
| History |
EC 2.7.1.227 created 2019
|
|---|
| Orthology |
| K22723 | inositol phosphorylceramide synthase catalytic subunit |
|
|---|
| Genes |
» show all
|
|---|
| Reference |
|
|---|
| Authors |
Nagiec MM, Nagiec EE, Baltisberger JA, Wells GB, Lester RL, Dickson RC |
|---|
| Title |
Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Reference |
|
|---|
| Authors |
Levine TP, Wiggins CA, Munro S |
|---|
| Title |
Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Reference |
|
|---|
| Authors |
Sato K, Noda Y, Yoda K |
|---|
| Title |
Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.7.1.227 |
|
|---|
