KEGG   ENZYME: 2.7.1.228
Entry
EC 2.7.1.228                Enzyme                                 

Name
mannosyl-inositol-phosphoceramide inositolphosphotransferase;
IPT1 (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
1-phosphatidyl-1D-myo-inositol:mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide phosphoinositoltransferase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol + a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide = 1,2-diacyl-sn-glycerol + a very-long-chain mannosyl-diphosphoinositol-(2'R)-2'-hydroxyphytoceramide
Substrate
1-phosphatidyl-1D-myo-inositol [CPD:C01194];
very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide [CPD:C22184]
Product
1,2-diacyl-sn-glycerol [CPD:C00641];
very-long-chain mannosyl-diphosphoinositol-(2'R)-2'-hydroxyphytoceramide
Comment
This enzyme catalyses the ultimate reaction in the yeast sphingolipid biosynthesis pathway. It transfers a second phosphoinositol group to mannosyl-inositol-phospho-alpha-hydroxyphytoceramide (MIPC), forming the final and most abundant yeast sphingolipid, mannosyl-diphosphoinositol-ceramide (MIP2C).
History
EC 2.7.1.228 created 2019
Orthology
K22725  mannosyl-inositol-phosphoceramide inositolphosphotransferase
Genes
SCE: YDR072C(IPT1)
ERC: Ecym_5553
KLA: KLLA0_E10187g
KMX: KLMA_20024(IPT1)
LTH: KLTH0H07590g
VPO: Kpol_1032p31
ZRO: ZYRO0G14718g
CGR: CAGL0G05313g
NCS: NCAS_0B04230(NCAS0B04230)
NDI: NDAI_0A03650(NDAI0A03650)
TPF: TPHA_0A02150(TPHA0A02150)
TBL: TBLA_0F03590(TBLA0F03590)
TDL: TDEL_0B04170(TDEL0B04170)
KAF: KAFR_0C02620(KAFR0C02620)
CAL: CAALFM_C109120WA(IPT1)
BFU: BCIN_13g02520(Bcipt1)
MBE: MBM_07403
 » show all
Reference
1  [PMID:9368028]
  Authors
Dickson RC, Nagiec EE, Wells GB, Nagiec MM, Lester RL
  Title
Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene.
  Journal
J Biol Chem 272:29620-5 (1997)
DOI:10.1074/jbc.272.47.29620
  Sequence
[sce:YDR072C]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.228
IUBMB Enzyme Nomenclature: 2.7.1.228
ExPASy - ENZYME nomenclature database: 2.7.1.228
BRENDA, the Enzyme Database: 2.7.1.228

DBGET integrated database retrieval system