KEGG   ENZYME: 2.7.1.3Help
Entry
EC 2.7.1.3                  Enzyme                                 

Name
ketohexokinase;
ketohexokinase (phosphorylating)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:D-fructose 1-phosphotransferase
Reaction(IUBMB)
ATP + D-fructose = ADP + D-fructose 1-phosphate [RN:R00866]
Reaction(KEGG)
R00866;
(other) R03819
Show
Substrate
ATP [CPD:C00002];
D-fructose [CPD:C00095]
Product
ADP [CPD:C00008];
D-fructose 1-phosphate [CPD:C01094]
Comment
D-Sorbose, D-tagatose and 5-dehydro-D-fructose and a number of other ketoses and their analogues can also act as substrates [4].
History
EC 2.7.1.3 created 1961
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00846  ketohexokinase
Genes
HSA: 3795(KHK)
PTR: 740614(KHK)
PPS: 100986057(KHK)
GGO: 101134632(KHK)
PON: 100447147(KHK)
NLE: 100601410(KHK)
MCC: 698328(KHK)
MCF: 102130504(KHK)
CSAB: 103220615(KHK)
RRO: 104668507(KHK)
RBB: 108532700(KHK)
CJC: 100415528(KHK)
SBQ: 101036824(KHK)
MMU: 16548(Khk)
RNO: 25659(Khk)
CGE: 100763359(Khk)
NGI: 103735676(Khk)
HGL: 101705832(Khk)
CCAN: 109679815(Khk)
OCU: 100351729(KHK)
TUP: 102484270(KHK)
CFA: 100170647(KHK)
AML: 100467138(KHK)
UMR: 103671661(KHK)
ORO: 101384115(KHK)
FCA: 101080375(KHK)
PTG: 102962169(KHK)
AJU: 106967844(KHK)
BTA: 614868(KHK)
BOM: 102268699(KHK)
BIU: 109566299(KHK)
PHD: 102339326(KHK)
CHX: 102184448(KHK)
OAS: 101113479(KHK)
SSC: 100523241(KHK)
CFR: 102511333(KHK)
CDK: 105098529(KHK)
BACU: 103010435(KHK)
LVE: 103091631(KHK)
OOR: 105747917(KHK)
ECB: 100055449(KHK)
EPZ: 103546444(KHK)
EAI: 106837028(KHK)
MYB: 102258355(KHK)
MYD: 102771838(KHK)
HAI: 109381471(KHK)
RSS: 109449257(KHK)
PALE: 102893977(KHK)
LAV: 100654223(KHK)
TMU: 101357800
MDO: 100025922(KHK)
OAA: 100078974(KHK)
GGA: 107053156(KHK)
MGP: 104915942(KHK)
CJO: 107312319(KHK)
GFR: 102041712(KHK)
FAB: 101819131(KHK)
PHI: 102102222(KHK)
PMAJ: 107198696(KHK)
FPG: 101916509(KHK)
FCH: 102052292(KHK)
CLV: 102091341(KHK)
ASN: 102372834(KHK)
AMJ: 102559964(KHK)
CMY: 102943037(KHK)
CPIC: 101931226(KHK)
ACS: 100561006(khk)
PVT: 110086983(KHK)
PBI: 103057572(KHK)
GJA: 107113758(KHK)
XLA: 447317(khk.S)
XTR: 100492918(khk)
NPR: 108803683(KHK)
DRE: 436909(khk)
SGH: 107586608(khk) 107589689
CCAR: 109062640 109106840(khk)
IPU: 108269966(khk)
AMEX: 103034968(khk)
TRU: 101064289(khk)
LCO: 104938896(khk)
OLA: 101158269(khk)
XMA: 102233542(khk)
PRET: 103460363(khk)
NFU: 107384879(khk)
CSEM: 103386816(khk)
LCF: 108890712(khk)
HCQ: 109522373(khk)
BPEC: 110170273(khk)
SASA: 100306748(khk)
ELS: 105015956(khk)
SFM: 108933631(khk)
LCM: 102364548(KHK)
CMK: 103184052(khk)
CIN: 100181324
SPU: 588197
APLC: 110986199
SKO: 100372840
DSI: Dsimw501_GD12218(Dsim_GD12218) Dsimw501_GD12219(Dsim_GD12219) Dsimw501_GD12805(Dsim_GD12805) Dsimw501_GD14306(Dsim_GD14306)
MDE: 101899690
AME: 726522(GB14491)
BIM: 100747606
BTER: 100645568
SOC: 105200104
AEC: 105146862
ACEP: 105625149
PBAR: 105429597
HST: 105189958
CFO: 105251485
LHU: 105676183
PGC: 109857528
NVI: 100115525
FCD: 110853817
TUT: 107371958
CRG: 105331023
OBI: 106876478
EPA: 110254087
ADF: 107351357
HMG: 100206260
AQU: 100637048
SLY: 101251969
NCR: NCU03742
NTE: NEUTE1DRAFT144445(NEUTE1DRAFT_144445)
MGR: MGG_15061
MAW: MAC_00511
MAJ: MAA_11256
CMT: CCM_05591
ANI: AN0344.2
ANG: ANI_1_774014(An01g06030)
PTE: PTT_11946
SPAR: SPRG_00529
TCX: Tcr_1488
MEJ: Q7A_2986
MEC: Q7C_1302
TIG: THII_2182
NOC: Noc_2848
NHL: Nhal_0504
NWA: Nwat_0240
TEE: Tel_15560
NTT: TAO_0241
HHA: Hhal_0921
TGR: Tgr7_0113
TKM: TK90_0283
TNI: TVNIR_3462(ydjH_[C])
TVR: TVD_01845
TBN: TBH_C0398
ENM: EBS_2134(khk)
MOX: DAMO_2523(KHK)
 » show all
Taxonomy
Reference
1  [PMID:14858418]
  Authors
CORI GT, OCHOA S, SLEIN MW, CORI CF.
  Title
The metabolism of fructose in liver; isolation of fructose-I-phosphate and inorganic pyrophosphate.
  Journal
Biochim Biophys Acta 7:304-17 (1951)
Reference
2  [PMID:13208667]
  Authors
HERS HG.
  Title
[Liver fructokinase.]
  Journal
Biochim Biophys Acta 8:416-23 (1952)
Reference
3  [PMID:13449068]
  Authors
PARKS RE Jr, BEN-GERSHOM E, LARDY HA.
  Title
Liver fructokinase.
  Journal
J Biol Chem 227:231-42 (1957)
Reference
4  [PMID:193556]
  Authors
Raushel FM, Cleland WW.
  Title
Bovine liver fructokinase: purification and kinetic properties.
  Journal
Biochemistry 16:2169-75 (1977)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.3
IUBMB Enzyme Nomenclature: 2.7.1.3
ExPASy - ENZYME nomenclature database: 2.7.1.3
BRENDA, the Enzyme Database: 2.7.1.3
CAS: 9030-50-6

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