KEGG ENZYME: 2.7.1.52

ENZYME: 2.7.1.52

Entry

EC 2.7.1.52                 Enzyme

Name

fucokinase;
fucokinase (phosphorylating);
fucose kinase;
L-fucose kinase;
L-fucokinase;
ATP:6-deoxy-L-galactose 1-phosphotransferase;
ATP:L-fucose 1-phosphotransferase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:beta-L-fucose 1-phosphotransferase

Reaction(IUBMB)

ATP + L-fucose = ADP + beta-L-fucose 1-phosphate [RN:R03161]

Reaction(KEGG)

R03161

Substrate

ATP [CPD:C00002];
L-fucose [CPD:C01019]

Product

ADP [CPD:C00008];
beta-L-fucose 1-phosphate [CPD:C02985]

Comment

Requires a divalent cation for activity, with Mg2+ and Fe2+ giving rise to the highest enzyme activity. Forms part of a salvage pathway for reutilization of L-fucose. Can also phosphorylate D-arabinose, but more slowly.

History

EC 2.7.1.52 created 1972, modified 2004

Pathway

ec00051

Fructose and mannose metabolism

ec00520

Amino sugar and nucleotide sugar metabolism

ec01100

Metabolic pathways

Orthology

K05305

fucokinase

K25314

fucokinase / fucose-1-phosphate guanylyltransferase

K25315

arabinokinase / fucokinase / arabinose-1-phosphate guanylyltransferase / fucose-1-phosphate guanylyltransferase

Genes

HSA:	197258(FCSK)

PTR:	468015(FUK)

PPS:	100981840(FCSK)

GGO:	101132289(FCSK)

PON:	100454490(FUK)

NLE:	100606422(FCSK)

HMH:	116471484(FCSK)

MCC:	709226(FCSK)

MCF:	102127748(FCSK)

MTHB:

126943706

MNI:	105491544(FUK)

CSAB:

103233158(FUK)

CATY:

105575740(FUK)

PANU:

101007309(FCSK)

TGE:	112613739(FUK)

MLEU:

105537219(FUK)

RRO:	104677820(FCSK)

RBB:	108527441(FUK)

TFN:	117088031(FCSK)

PTEH:

111541444(FCSK)

CANG:

105526227(FUK)

CJC:	100413891(FCSK)

SBQ:	101049340(FUK)

CIMI:

108294404(FCSK)

CSYR:

103265659(FUK)

MMUR:

105875427(FUK)

LCAT:

123625450(FCSK)

PCOQ:

105808021(FUK)

OGA:	100943770(FUK)

MMU:	234730(Fcsk)

MCAL:

110300446(Fcsk)

MPAH:

110337388(Fuk)

RNO:	307848(Fcsk)

MCOC:

116070183(Fcsk)

ANU:	117722949(Fcsk)

MUN:	110546023(Fuk)

CGE:	100752219(Fcsk)

MAUA:

101836110(Fcsk)

PROB:

127234435(Fcsk)

PLEU:

114708091(Fcsk)

MORG:

121447232(Fcsk)

MFOT:

126503037

AAMP:

119801916(Fcsk)

NGI:	103735635(Fuk)

HGL:	101722039(Fuk)

CPOC:

100717941(Fuk)

CCAN:

109684986(Fuk)

DORD:

105983169(Fuk)

DSP:	122126111(Fcsk)

PLOP:

125358199(Fcsk)

NCAR:

124966567

OCU:	100348059(FCSK)

OPI:	101520333(FCSK)

TUP:	102491737(FUK)

GVR:	103598318(FUK)

CFA:	489715(FCSK)

CLUD:

112646619(FCSK)

VVP:	112929501(FUK)

VLG:	121499799(FCSK)

NPO:	129496825(FCSK)

AML:	100481849(FCSK)

UMR:	103673574(FCSK)

UAH:	113252471(FUK)

UAR:	123800542(FCSK)

ELK:

111152994

LLV:

125089059

MPUF:

101676203(FUK)

NVS:	122911255(FCSK)

ORO:	101383814(FUK)

EJU:	114200381(FUK)

ZCA:	113936638(FCSK)

MLX:	118023586(FCSK)

NSU:	110593981(FCSK)

LWW:	102747624(FCSK)

FCA:	101094896(FCSK)

PYU:	121009773(FCSK)

PCOO:

112857406(FUK)

PBG:	122494442(FCSK)

LRUF:

124511475

PTG:	102956046(FUK)

PPAD:

109270645(FUK)

PUC:

125916555

AJU:	106983746(FCSK)

HHV:	120223359(FCSK)

BTA:	519181(FCSK)

BOM:	102267499(FUK)

BIU:	109572530(FUK)

BBUB:

102389555(FCSK)

BBIS:

104996565(FUK)

CHX:	102173959(FUK)

OAS:	101114636(FCSK)

BTAX:

128062920(FCSK)

ODA:	120872856(FCSK)

CCAD:

122421751(FCSK)

MBEZ:

129547280(FCSK)

SSC:	100625448(FUK)

CFR:	102513917(FCSK)

CBAI:

105073650(FUK)

CDK:	105097707(FCSK)

VPC:	102538555(FCSK)

BACU:

103019486(FUK)

LVE:	103084623(FUK)

OOR:	101282658(FCSK)

DLE:	111179534(FCSK)

PCAD:

102986794(FCSK)

PSIU:

116743476(FCSK)

NASI:

112393477(FUK)

ECB:	100054844(FUK)

EPZ:	103552406(FUK)

EAI:	106823440(FCSK)

MYB:	102253257(FUK)

MYD:	102756628(FUK)

MMYO:

118674849(FCSK)

MLF:	102422485(FUK)

MNA:	107524486(FUK)

PKL:	118720764(FCSK)

EFUS:

103284653(FCSK)

HAI:	109388833(FUK)

DRO:	112300761(FUK)

SHON:

118999269(FCSK)

AJM:	119055876(FCSK)

PDIC:

114515479(FCSK)

PHAS:

123805782(FCSK)

MMF:	118638435(FCSK)

RFQ:	117034519(FCSK)

PALE:

102895323(FUK)

PGIG:

120593881(FCSK)

PVP:	105305829(FUK)

RAY:	107520544(FUK)

MJV:	108397075(FCSK)

TOD:	119249057(FCSK)

SARA:

101538149(FUK)

LAV:	100672550(FUK)

TMU:

101342284

ETF:	101653345(FCSK)

DNM:	101419623(FUK)

MDO:	100617318(FUK)

GAS:	123236719(FCSK)

SHR:	100931802(FCSK)

AFZ:

127547661

PCW:	110192405(FUK)

OAA:	100075033(FCSK)

GGA:	770049(FUK)

PCOC:

116243977(FCSK)

MGP:	100546052(FCSK)

CJO:	107319068(FCSK)

TPAI:

128081718(FCSK)

LMUT:

125699061(FCSK)

NMEL:

110404250(FUK)

APLA:

101793742(FCSK)

ACYG:

106033121(FCSK)

CATA:

118246486(FCSK)

AFUL:

116494061(FCSK)

TGU:	100228545(FCSK)

LSR:	110476215(FCSK)

SCAN:

103816829(FCSK)

PMOA:

120508114(FCSK)

OTC:	121334088(FCSK)

PRUF:

121348942(FCSK)

GFR:	102042406(FUK)

FAB:	101820082(FUK)

OMA:	130258019(FCSK)

PHI:	102104108(FUK)

PMAJ:

107209808(FCSK)

CCAE:

111934535(FUK)

CCW:	104687567(FCSK)

CBRC:

103620284(FUK)

ETL:	114063446(FUK)

ZAB:	102065902(FUK)

ACHL:

103809428(FUK)

SVG:	106855829(FUK)

MMEA:

130579571(FCSK)

FPG:	101919068(FUK)

FCH:	102046401(FUK)

CLV:	102092541(FUK)

EGZ:	104130289(FUK)

NNI:	104017497(FUK)

PCAO:

104047931(FUK)

ACUN:

113484326(FUK)

TALA:

116960326(FCSK)

AFOR:

103908470(FUK)

ACHC:

115346487(FCSK)

HLE:	104842695(FUK)

AGEN:

126040264

GCL:

127021001

SHAB:

115619585(FCSK)

DPUB:

104305084(FUK)

CPEA:

104389341(FUK)

CVF:	104284892(FUK)

CUCA:

104067258(FUK)

TEO:	104376072(FUK)

AAM:	106492724(FUK)

AROW:

112976869(FUK)

NPD:	112943208(FUK)

DNE:	112987451(FUK)

ASN:	102368059(FUK)

AMJ:	102572043(FUK)

CPOO:

109310453(FUK)

GGN:	109289669(FUK)

CMY:	102943730(FCSK)

CCAY:

125620769(FCSK)

DCC:	119841159(FCSK)

CPIC:

101941728(FCSK)

TST:	117886477(FCSK)

CABI:

116833719(FCSK)

MRV:	120384758(FCSK)

ACS:	100558701(fuk)

PVT:	110081311(FUK)

SUND:

121937553(FCSK)

PBI:	103061608(FUK)

PMUR:

107284158(FCSK)

CTIG:

120312618(FCSK)

TSR:	106547771(FUK)

PGUT:

117670471(FCSK)

APRI:

131184041(FCSK)

PTEX:

113445250(FUK)

NSS:	113422983(FUK)

VKO:	123025389(FCSK)

PMUA:

114601860(FCSK)

PRAF:

128419083(FCSK)

ZVI:	118087179(FCSK)

HCG:	128334317(FCSK)

GJA:	107117655(FUK)

STOW:

125443260(FCSK)

EMC:	129344250(FCSK)

XLA:	100137687(ffcskk.L)

XTR:	100497304(fcsk)

NPR:	108803447(FUK)

RTEM:

120917782(FCSK)

BBUF:

120980875(FCSK)

BGAR:

122920756(FCSK)

MUO:	115470432(FCSK)

GSH:	117359592(FCSK)

DRE:	100150934(fuk)

SRX:	107720764 107740890(fuk)

SANH:

107673265(fuk) 107680117

SGH:

107559996

CCAR:

109050606 109050614

CAUA:

113043695 113066689 113074844

CGIB:

127947456 128014585

PTET:

122330623

LROH:

127156382

OMC:

131534059

PPRM:

120477766

MAMB:

125247452

CIDE:

127507383

MASI:

127437669

TROS:

130551743

IPU:	108274775 108274777

PHYP:

113530125(fuk)

SMEO:

124392425

TFD:	113654016(fcsk)

AMEX:

103035161(fuk)

CMAO:

118811980

EEE:	113573662(fuk)

CHAR:

105910356(fcsk)

TRU:	101074270(fcsk)

TFS:

130536886

TNG:	GSTEN00003752G001

LCO:	104937043(fuk)

ELY:

117261974

EFO:

125888022

SLUC:

116059836

PFLV:

114560129

GAT:

120809105

PPUG:

119195810

AFB:

129108723

CLUM:

117732655

MSAM:

119893164

SCHU:

122874432

CUD:

121515235

ALAT:

119024492

MZE:	101463615(fuk)

ONL:	100689720(fuk)

OAU:

116327755

OLA:	101172159(fuk)

OML:	112151867(fcsk)

XMA:	102237071(fuk)

XCO:	114152782(fuk)

XHE:	116731393(fcsk)

PRET:

103466785(fuk)

PFOR:

103148639(fuk)

PLAI:

106955229(fuk)

PMEI:

106921953(fuk)

GAF:

122836161

CVG:	107100402(fuk)

CTUL:

119781646

GMU:

124880620

NFU:	107389126(fuk)

KMR:

108229648

ALIM:

106527958(fuk)

NWH:

119415472

AOCE:

111578064(fuk)

MCEP:

125015307

CSEM:

103379717(fuk)

POV:

109647017

HHIP:

117763271

HSP:

118109868

LCF:	108893719(fcsk)

SDU:	111231882(fuk)

SLAL:

111649731 111653431

XGL:

120793790

HCQ:	109518183(fuk)

SSCV:

125970761

BPEC:

110155087(fuk)

MALB:

109969135(fuk)

BSPL:

114856805

SASA:

106560702(fuk)

STRU:

115197198(fcsk)

OTW:	112218386(fcsk)

OMY:	110490736(fcsk)

OGO:

124040748

ONE:	115134625(fcsk)

OKI:	109867127(fcsk)

SALP:

111960937(fuk)

SNH:

120066026

CCLU:

121532005

ELS:	105026607(fcsk)

SFM:	108934685(fcsk)

PKI:	111841211(fuk)

AANG:

118215577

LOC:	102688745(fuk)

PSPA:

121296736

ARUT:

117424690

PSEX:

120535185

LCM:	102347730(FUK)

CMK:	103186660(fcsk)

RTP:	109913035(fuk)

CPLA:

122558639

LERI:

129705231

BFO:

118418081

BBEL:

109473716

CIN:

100182438

SCLV:

120338241 120339898

SPU:

100892878

LPIC:

129254270

APLC:

110975638

AJC:

117113921

SKO:

102802389

DPX:	DAPPUDRAFT_202910

DMK:

116924933

DPZ:

124342384

PVM:

113811739

PJA:

122267420

PCHN:

125044353

PMOO:

119579392

HAME:

121868856

PCLA:

123770624

PTRU:

123509882

ESN:

127007785

HAZT:

108675927

EAF:

111707340

DSV:

119445608

RSAN:

119377852

RMP:

119174164

VDE:

111249168

VJA:

111268466

CSCU:

111642164

PTEP:

107443266

UDV:

129220642

SDM:

118195782

LPOL:

106465152

PMEO:

129589244

HRO:	HELRODRAFT_181660

LGI:	LOTGIDRAFT_217536

PCAN:

112576778

BGT:

106068288

GAE:

121388594

HRF:

124113137

HRJ:

124282926

CRG:

105323794

CVN:

111135841

CANU:

128189828

OED:

125663653

MYI:

110463342

PMAX:

117338592

MCAF:

127701270

MMER:

123549440

DPOL:

127844794

OBI:

106872675

OSN:

115220697

LAK:	106156384 106169504

NVE:

5510800

EPA:

110233424

ATEN:

116306898

ADF:

107342267

AMIL:

114977194 114977201

PDAM:

113666965 113666975

SPIS:

111332602

DGT:

114517288

XEN:

124436743

HMG:

101234558

HSY:

130662471

TAD:	TRIADDRAFT_55543 TRIADDRAFT_55544

ATH:	AT1G01220(FKGP)

ALY:

9328144

CRB:

17876572

CSAT:

104738672 104754265 104759313

EUS:	EUTSA_v10006637mg

BRP:

103843778

BNA:	106352534 106377357

BOE:

106312465

RSZ:

108862914

THJ:

104815884

CPAP:

110808528

CIT:	102607405 127901096

CIC:	CICLE_v10018702mg

PVY:

116142159

MINC:

123223163

TCC:

18613941

GRA:

105763919

GHI:

121224126

GAB:

108479543

DZI:

111304857

EGR:	104445349 120286350

GMX:	100776147 100803620

GSJ:	114398035 114407822

PVU:	PHAVU_006G115200g

VRA:

106754135

VAR:

108343062

VUN:

114187899

CCAJ:

109796650

APRC:

113861369

MTR:

11435147

TPRA:

123889547

CAM:

101489062

PSAT:

127132088

LJA:	Lj1g3v5038190.1(Lj1g3v5038190.1) Lj1g3v5038190.2(Lj1g3v5038190.2)

ADU:

107491927

AIP:

107646095

AHF:	112695289 112758493

LANG:

109333340

PCIN:

129291289

FVE:

101313747

RCN:

112182084

PPER:

18785393

PMUM:

103332228

PAVI:

110757650

PDUL:

117617124

MDM:

103439376

MSYL:

126629529

PXB:

103927198

ZJU:

107423663

MNT:

21406234

CSV:

101204338

CMO:

103483166

BHJ:

120083429

MCHA:

111016303

CMAX:

111473620 111475081

CMOS:

111441674

CPEP:

111800352

RCU:

8282132

JCU:

105642816

HBR:

110632095

MESC:

110614294

POP:

7486785

PEU:

105135437

PALZ:

118041222

JRE:

109010378

CILL:

122299972

QSU:

111983257

QLO:

115955796

TWL:

120004064

VVI:

100258719

VRI:

117932264

SLY:

101258193

SPEN:

107007997

SOT:

102590041

SSTN:

125877598

CANN:

107839347

NTA:	107766622 107817245

NSY:

104228145

NTO:

104121367

NAU:

109227812

INI:

109150877

ITR:

115996628

SIND:

105173828

OEU:

111409933

EGT:

105963921

SSPL:

121795310 121798840

SMIL:

130997336

APAN:

127261313

HAN:

110937555

ECAD:

122594409

LSV:

111894586

CCAV:

112526343

DCR:

108209637

CSIN:

114290101

RVL:

131334543

BVG:

104907115

SOE:

110786573

CQI:	110713928 110731719

MOF:

131166894

NNU:

104604718

MING:

122081866

TSS:

122667273

PSOM:

113297710 113301503

OSA:

4331392

DOSA:

Os03t0115100-01(Os03g0115100)

OBR:

102713062

OGL:

127768664

BDI:

100826076

ATS:

109785929

TDC:	119292137 119304223

TAES:

123093854 123099075 123106030

TUA:

125511496

LPER:

127297502

LRD:	124701109 124701231

SBI:

8078003

ZMA:

100381824

SITA:

101773659

SVS:

117840567

PVIR:

120647567 120687885

PHAI:

112878344

PDA:

103719462

EGU:

105043452

MUS:

103970309

ZOF:	121967564 122052800

DCT:

110094703

PEQ:

110030506

AOF:

109825030

NCOL:

116263426

ATR:

18447674

PPP:

112278448

OTA:	OT_ostta07g01230

MPP:	MICPUCDRAFT_57613

MBR:	MONBRDRAFT_15021

SRE:	PTSG_11727

DDI:	DDB_G0269678

DPP:	DICPUDRAFT_49164

DFA:

DFA_01669

ACAN:

ACA1_232880

PTI:	PHATRDRAFT_bd1431

FCY:	FRACYDRAFT_232262(FUK1)

TPS:	THAPSDRAFT_11189

EHX:	EMIHUDRAFT_453358

GTT:	GUITHDRAFT_146616

TCR:

508379.10

LMA:	LMJF_16_0440 LMJF_16_0480

LIF:	LINJ_16_0450 LINJ_16_0490

LDO:	LDBPK_160450

LMI:	LMXM_16_0440 LMXM_16_0480

LBZ:	LBRM_16_0500

LPAN:

LPMP_160480

ROB:

CK5_28240

BLAB:

EYS05_17015

RTO:

RTO_22660

RGN:	RGna_00050

SGY:

Sgly_1597

FGI:	OP10G_0382

SUS:

Acid_0569

PFER:

IRI77_32210

BTH:

BT_2128

BTHO:

Btheta7330_00915(hddA_1)

BFR:

BF2586

BFS:	BF9343_2526

BFG:	BF638R_2601

BFB:	VU15_11545(fkp)

BHL:	Bache_1982

BXY:

BXY_11610

BOA:	Bovatus_02192(hddA_1)

BCEL:

BcellWH2_05118(hddA)

BCAC:

CGC64_18450(fkp)

BCAE:

A4V03_13765(fkp)

BIS:	DXK01_014525(fkp)

BUN:	Bun01g_30610

BFE:	K6V30_25045(fkp)

BNO:	K8P02_12605(fkp)

BFC:	BacF7301_25665(fkp)

BSAL:

K6V25_19695(fkp)

BVU:

BVU_1606

BSA:	Bacsa_0234

BDO:	EL88_02950(fkp)

BDH:	GV66_08320(fkp)

PCOP:

I6J50_07580(fkp)

PBT:	ING2E5B_0495

PMUC:

ING2E5A_2839(FUK)

PET:	PEIBARAKI_4442

PSAC:

PSM36_0195

PROJ:

KDN43_10215(fkp)

PDI:

BDI_1573

PARC:

CI960_12140(fkp)

PMER:

INE87_01603

PGOL:

K6V26_04000(fkp)

PJO:	LK449_10460(fkp)

DUN:	FDZ78_02420(fkp)

PII:	NF347_05955

PRU:

PRU_0129

PDT:	Prede_2699

PCOU:

L6468_12135(fkp)

PEO:	AS203_09210(fkp)

ALQ:	C7Y71_002115(fkp)

PCLR:

PC1C4_28300

AIT:	AI2BBH_01730

MCOS:

GM418_23895(fkp)

ASX:	CDL62_10010(fkp)

MGK:	FSB76_14330(fkp)

FBE:	FF125_11410(fkp)

» show all

Reference

1 [PMID:5646161]

Authors

Ishihara H, Massaro DJ, Heath EC.

Title

The metabolism of L-fucose. 3. The enzymatic synthesis of beta-L-fucose 1-phosphate.

Journal

J Biol Chem 243:1103-9 (1968)

Reference

2 [PMID:2986701]

Authors

Butler W, Serif GS.

Title

Fucokinase, its anomeric specificity and mechanism of phosphate group transfer.

Journal

Biochim Biophys Acta 829:238-43 (1985)
DOI:10.1016/0167-4838(85)90193-1

Reference

3 [PMID:9488699]

Authors

Park SH, Pastuszak I, Drake R, Elbein AD.

Title

Purification to apparent homogeneity and properties of pig kidney L-fucose kinase.

Journal

J Biol Chem 273:5685-91 (1998)
DOI:10.1074/jbc.273.10.5685

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.52

IUBMB Enzyme Nomenclature:

2.7.1.52

ExPASy - ENZYME nomenclature database:

2.7.1.52

BRENDA, the Enzyme Database:

2.7.1.52

CAS:	37278-00-5

DBGET integrated database retrieval system