| Entry |
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| Name |
1-phosphatidylinositol-4-phosphate 5-kinase;
diphosphoinositide kinase;
PIP kinase;
phosphatidylinositol 4-phosphate kinase;
phosphatidylinositol-4-phosphate 5-kinase;
type I PIP kinase
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
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| Sysname |
ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase
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| Reaction(IUBMB) |
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [RN: R03469]
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| Reaction(KEGG) |
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| Substrate |
ATP [CPD: C00002];
1-phosphatidyl-1D-myo-inositol 4-phosphate [CPD: C01277]
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| Product |
ADP [CPD: C00008];
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD: C04637]
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| Comment |
This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known.
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| History |
EC 2.7.1.68 created 1972, modified 1980, modified 1982, modified 2002
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| Pathway |
| ec00562 | Inositol phosphate metabolism |
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| Orthology |
| K00889 | 1-phosphatidylinositol-4-phosphate 5-kinase |
| K13712 | phosphatidylinositol-4-phosphate 5-kinase-like protein 1 |
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| Genes |
» show all
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| Reference |
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| Authors |
Kai M, Salway JG, Hawthorne JN. |
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| Title |
The diphosphoinositide kinase of rat brain. |
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| Journal |
Biochem J 106:791-801 (1968) |
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| Reference |
2 |
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| Authors |
Kai, M., Salway, J.G., Michell, R.H. and Hawthorne, J.N. |
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| Title |
The biosynthesis of triphosphoinositide by rat brain in vitro. |
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| Journal |
Biochem Biophys Res Commun 22:370-375 (1966) |
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| Reference |
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| Authors |
Rameh LE, Tolias KF, Duckworth BC, Cantley LC. |
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| Title |
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.1.68 |
| ExPASy - ENZYME nomenclature database: | 2.7.1.68 |
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