KEGG   ENZYME: 2.7.1.72Help
Entry
EC 2.7.1.72                 Enzyme                                 

Name
streptomycin 6-kinase;
streptidine kinase;
SM 6-kinase;
streptomycin 6-kinase (phosphorylating);
streptidine kinase (phosphorylating);
streptomycin 6-O-phosphotransferase;
streptomycin 6-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:streptomycin 6-phosphotransferase
Reaction(IUBMB)
ATP + streptomycin = ADP + streptomycin 6-phosphate [RN:R02225]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
streptomycin [CPD:C00413]
Product
ADP [CPD:C00008];
streptomycin 6-phosphate [CPD:C01138]
Comment
dATP can replace ATP; and dihydrostreptomycin, streptidine and 2-deoxystreptidine can act as acceptors.
History
EC 2.7.1.72 created 1972, modified 1976
Pathway
ec00521  Streptomycin biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K04343  streptomycin 6-kinase
K12570  streptomycin 6-kinase
Genes
EOI: ECO111_p1-122
ECG: E2348_P2_03(strB)
ELR: ECO55CA74_26394
ECW: EcE24377A_B0003
ECM: EcSMS35_A0129(strB)
ELN: NRG857_30097(strB)
ESO: O3O_25230
ESM: O3M_00470
ESL: O3K_00460
EUN: pUMNK88_42(strB)
ECOO: ECRM13514_5833(strB)
STY: HCM1.224(strB)
SEY: SL1344_P3_0013(strB)
SEB: STM474_p310(strB)
SEH: SeHA_C1571(strB)
SEE: SNSL254_p_0045(strB)
SFE: SFxv_5148
SSN: SSON_PA05(strB)
CIR: C2U53_02840(aph(6)-I)
SPE: Spro_2227
SRL: SOD_c20470(str)
SPLY: Q5A_011400
SMAF: D781_2090
SMAR: SM39_1693(str)
SMAC: SMDB11_1504(str)
SERF: L085_17465
ETR: ETAE_p039(strB)
PMP: Pmu_02760(strB)
MHX: MHH_c22560(strB)
BTO: WQG_1060
BTRH: F543_22800
BTRA: F544_3120
XCV: XCV2325(strB)
SML: Smlt2336
SMT: Smal_1923
SMZ: SMD_2105
LEZ: GLE_5415
LEM: LEN_0172(strB)
DKO: I596_2002
VCE: Vch1786_I0084(strB)
PAE: PA1858(str)
PAEV: N297_1916
PAEI: N296_1916
PAU: PA14_40450(str)
PAG: PLES_34661(str)
PAF: PAM18_3184(str)
PNC: NCGM2_2775(str)
PAEB: NCGM1900_4634(str)
PAEP: PA1S_16660
PAEM: U769_16370
PAEL: T223_17715
PAEU: BN889_02007(str)
PAEG: AI22_17330
PAEC: M802_1914
PAEO: M801_1915
PPUH: B479_26874
PPUT: L483_16475
PSB: Psyr_2670
PFL: PFL_4113(str)
PPRC: PFLCHA0_c41730(str)
PPRO: PPC_4214(str)
PFO: Pfl01_3891(str)
PFC: PflA506_3107(str)
PMAN: OU5_1433
PSES: PSCI_1741(strB)
PSEM: TO66_21530
PSEC: CCOS191_3501(str)
PSOS: POS17_4213(str)
PANR: A7J50_3304
ABY: ABAYE3647(strB)
ABX: ABK1_0257
ABD: ABTW07_0268(strB)
ABH: M3Q_481
ABAU: IX87_13225
ABAA: IX88_03705
ADV: DJ533_07390(aph(6)-I)
CBD: CBUD_1665
CBC: CbuK_1661
LFA: LFA_2908
LHA: LHA_2076
TMC: LMI_1255
NSI: A6J88_09475(aph(6)-I) A6J88_09530(aph(6)-I)
KKI: KKKWG1_0921(strB) KKKWG1_2253(strB)
BCN: Bcen_5423
BCJ: BCAM2633
BCEO: I35_6530
BAM: Bamb_4780
BMU: Bmul_3331
BMK: DM80_4712
BMUL: NP80_3212
BCED: DM42_5341
BDL: AK34_3242
BCON: NL30_16955
BTEI: WS51_09925
BSEM: WJ12_33070
BMEC: WJ16_31550
BUK: MYA_3264
BXE: Bxe_B0248
BXB: DR64_5591
PPUL: RO07_24270
AMIM: MIM_c08210
DAC: Daci_2795
MMS: mma_1889(str)
BBA: Bd0307(strB)
BBAT: Bdt_0303(strB)
BBAC: EP01_13480
RFE: RF_0774
RMI: RMB_04420
RMO: MCI_00855
RAM: MCE_05645
OTT: OTT_0547
MLO: mll8451
SME: SMc01228
SMX: SM11_chr2002(str)
SMEL: SM2011_c01228(str)
SMER: DU99_08190
SMD: Smed_1244
ATU: Atu1243(strB)
ARA: Arad_3150
ATF: Ach5_11510(strB)
AVI: Avi_1673(strB)
AGR: AGROH133_05578(strB)
RLE: RL3433(str)
RLG: Rleg_2987
RHL: LPU83_2884(str)
OAN: Oant_2501
OAH: DR92_1955
HDN: Hden_3500
PHL: KKY_407
FIL: BN1229_v1_1570(str)
FIY: BN1229_v1_1572(str)
MMED: Mame_03101
BMQ: BMQ_2665
BMD: BMD_2652
BMH: BMWSH_2554(strB)
BMEG: BG04_5120
MMC: Mmcs_2684
MJL: Mjls_2714
MGI: Mflv_4430
MVQ: MYVA_1766
CUR: cu1539(strB)
CSX: CSING_01985(strB)
NFA: NFA_38620(aph(6))
NSR: NS506_06662(strB)
REQ: REQ_45990
GBR: Gbro_4087
GOR: KTR9_4017
TPR: Tpau_2457
SCO: SCO4264(SCD49.05c) SCO5700(SC5H4.24c)
SMA: SAVERM_2557(aph2) SAVERM_3961(hur)
SCT: SCAT_4484(aphD) SCAT_p0366
SBH: SBI_03407(aph2)
SALS: SLNWT_1576
SPRI: SPRI_2194
SLE: sle_19810(sle_19810) sle_38880(sle_38880)
SALF: SMD44_03887(strB) SMD44_06310(strB) SMD44_p10102(strB)
SALJ: SMD11_1901(strB) SMD11_3354(strB)
KSK: KSE_53020
CMI: CMM_0891(strB)
CMS: CMS0149
CMC: CMN_00853
ART: Arth_1410
ARM: ART_4252
AAU: AAur_1555(sph)
ACH: Achl_1422
LMOI: VV02_12340
XCE: Xcel_0261
IDO: I598_1951
BLIN: BLSMQ_2547
MPH: MLP_20980
NCA: Noca_1892
NDK: I601_3820
PSIM: KR76_17555
NDA: Ndas_2219
SRO: Sros_5378
SEN: SACE_5997(hur) SACE_6537(hur)
AMD: AMED_1074
AMN: RAM_05460
AMM: AMES_1069
AMZ: B737_1070
PSEA: WY02_20550
PSEE: FRP1_26935
PSEH: XF36_00575
AMI: Amir_0803
KAL: KALB_966
MIL: ML5_3097
ASE: ACPL_6507(strB)
ACTS: ACWT_6376
SNA: Snas_4253
RCA: Rcas_3440
DRA: DR_0455
DGO: DGo_CA0977(str)
TTR: Tter_2188
SLI: Slin_6740
NJA: NSJP_3610
 » show all
Taxonomy
Reference
1  [PMID:4121456]
  Authors
Walker JB, Skorvaga M.
  Title
Phosphorylation of streptomycin and dihydrostreptomycin by Streptomyces. Enzymatic synthesis of different diphosphorylated derivatives.
  Journal
J Biol Chem 248:2435-40 (1973)
Reference
2  [PMID:6075410]
  Authors
Walker JB, Walker MS.
  Title
Streptomycin biosynthesis. Enzymatic synthesis of O-phosphorylstreptidine from streptidine and adenosinetriphosphate.
  Journal
Biochim Biophys Acta 148:335-41 (1967)
DOI:10.1016/0304-4165(67)90128-6
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.72
IUBMB Enzyme Nomenclature: 2.7.1.72
ExPASy - ENZYME nomenclature database: 2.7.1.72
BRENDA, the Enzyme Database: 2.7.1.72
CAS: 37278-11-8

DBGET integrated database retrieval system