KEGG   ENZYME: 2.7.1.74
Entry
EC 2.7.1.74                 Enzyme                                 

Name
deoxycytidine kinase;
deoxycytidine kinase (phosphorylating);
2'-deoxycytidine kinase;
Ara-C kinase;
arabinofuranosylcytosine kinase;
deoxycytidine-cytidine kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
NTP:deoxycytidine 5'-phosphotransferase
Reaction(IUBMB)
NTP + deoxycytidine = NDP + dCMP [RN:R02321]
Reaction(KEGG)
R02321 > R01666;
(other) R00185
Substrate
NTP [CPD:C00201];
deoxycytidine [CPD:C00881]
Product
NDP [CPD:C00454];
dCMP [CPD:C00239]
Comment
Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors.
History
EC 2.7.1.74 created 1972
Pathway
ec00230  Purine metabolism
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Orthology
K00893  deoxycitidine kinase
K15519  deoxyadenosine/deoxycytidine kinase
Genes
HSA: 1633(DCK)
PTR: 461273(DCK)
PPS: 100990892(DCK)
GGO: 101153698(DCK)
PON: 100459989(DCK)
NLE: 100580396(DCK)
MCC: 705040(DCK)
MCF: 101925611(DCK)
CSAB: 103235762(DCK)
RRO: 104678729(DCK)
RBB: 108534027(DCK)
CJC: 100395055(DCK)
SBQ: 101045176(DCK)
MMU: 13178(Dck)
MCAL: 110294384(Dck)
MPAH: 110330622(Dck)
RNO: 79127(Dck)
MUN: 110540094(Dck)
CGE: 100751299(Dck)
NGI: 103730983(Dck)
HGL: 101722212(Dck)
CCAN: 109679520(Dck)
OCU: 100348589(DCK)
TUP: 102498967(DCK)
CFA: 482188(DCK)
VVP: 112923681(DCK)
AML: 100482093(DCK)
UMR: 103665295(DCK)
UAH: 113263298(DCK)
ORO: 101384844(DCK)
ELK: 111149150
FCA: 101083845(DCK)
PTG: 102949132(DCK)
PPAD: 109278016(DCK)
AJU: 106983696(DCK)
BTA: 530642(DCK)
BOM: 102268258(DCK)
BIU: 109560557(DCK)
BBUB: 102404885(DCK)
CHX: 102175015(DCK)
OAS: 101123378(DCK)
SSC: 100517354(DCK)
CFR: 102524113(DCK)
CDK: 105091182(DCK)
BACU: 103015268(DCK)
LVE: 103071330(DCK)
OOR: 101281945(DCK)
DLE: 111187681(DCK)
PCAD: 102976054(DCK)
ECB: 100054704(DCK)
EPZ: 103560855(DCK)
EAI: 106835100(DCK)
MYB: 102246003 102261934(DCK)
MYD: 102766950(DCK)
MNA: 107532650(DCK)
HAI: 109393701(DCK)
DRO: 112320588(DCK)
PALE: 102890176(DCK)
RAY: 107504025(DCK)
MJV: 108394228(DCK)
LAV: 100667514(DCK)
TMU: 101361286
MDO: 100014536(DCK)
SHR: 100931780(DCK)
PCW: 110209808(DCK)
OAA: 100078818(DCK)
GGA: 422648(DCK) 770922(DGUOK)
MGP: 100544492(DCK) 100551225
CJO: 107313354(DCK) 107320138
NMEL: 110398815(DCK) 110405511
APLA: 101799591(DCK) 101804573
ACYG: 106032673 106043942(DCK)
TGU: 100220427 100223331(DCK)
LSR: 110470157(DCK) 110482771
SCAN: 103817288 103823424(DCK)
GFR: 102035084(DCK) 102038779
FAB: 101806066 101811376(DCK)
PHI: 102106204(DCK) 102108269
PMAJ: 107203117(DCK) 107210687
CCAE: 111929482(DCK) 111945349
CCW: 104689701 104696860(DCK)
ETL: 114060048(DCK) 114065212
FPG: 101917700(DCK) 101920025
FCH: 102055990 102056086(DCK)
CLV: 102091484 102092948(DCK)
EGZ: 104125173(DCK) 104128441
NNI: 104011376(DCK) 104018457
ACUN: 113479483(DCK) 113485095
PADL: 103915830 103916970(DCK)
AAM: 106491894(DCK) 106493434
ASN: 102381619(DCK) 102382818
AMJ: 102572880(DCK) 102575265
PSS: 102444422(DCK)
CMY: 102946796(DCK)
CPIC: 101948329(DCK)
ACS: 100554557(dck) 100557346
PVT: 110073482 110085258(DCK)
PBI: 103059568(DCK)
PMUR: 107289800(DCK)
TSR: 106550977(DCK)
GJA: 107123240 107123770(DCK)
XLA: 108710975 446773(dck.2.L) 494987 496391(dck.1.L)
XTR: 549546(dck.2) 594934(dck.1)
NPR: 108784695(DCK) 108797251
DRE: 474325(dck) 541538(zgc:110540)
IPU: 108278442 108279081(dck)
PHYP: 113535609(dck) 113541634
EEE: 113590818(dck) 113591964
TRU: 101065882(dck)
LCO: 104920317(dguok) 104922470(dck) 104932480
NCC: 104941578 104952207(dck)
MZE: 101465766 101485167(dck)
PRET: 103459907 103473357(dck)
CSEM: 103389988(dck) 103398651
POV: 109626045(dck) 109642212(dguok)
SDU: 111220806(dck) 111239543
HCQ: 109525557(dck)
BPEC: 110157441(dck) 110175010
MALB: 109969767(dck)
SASA: 100196160(dck) 106603918
OTW: 112220161(dck) 112228262
ELS: 105011305 105027270(dck)
PKI: 111850184(dck)
LCM: 102355337 102355687(DCK)
CMK: 103186473(dck) 103191301
BFO: 118411425
CIN: 100184470
AQU: 100634027
CSK: ES15_0182
PAY: PAU_01229(DAK)
VCI: O3Y_07175
ASP: AOR13_348
CCX: COCOR_03075(dck) COCOR_05454(dck1)
BSU: BSU00140(dck)
BSR: I33_0020
BSL: A7A1_1229
BSH: BSU6051_00140(dck)
BSUT: BSUB_00020(dck)
BSUL: BSUA_00020(dck)
BSUS: Q433_00105
BSS: BSUW23_00075(dck)
BST: GYO_0019
BSO: BSNT_06304(dck)
BSQ: B657_00140(dck)
BSX: C663_0016(dck)
BLI: BL02366(dck)
BLD: BLi00023(dck)
BLH: BaLi_c00240(dck)
BAQ: BACAU_0015(dck)
BYA: BANAU_0015(dck)
BAMP: B938_00075
BAML: BAM5036_0016(dck)
BAMA: RBAU_0017(dck)
BAMN: BASU_0017(dck)
BAMB: BAPNAU_0015(dck)
BAMT: AJ82_00110
BAMY: V529_00150(dcK)
BMP: NG74_00022(dck)
BAO: BAMF_0015(dck)
BAZ: BAMTA208_00070(dck)
BQL: LL3_00015(dck)
BXH: BAXH7_00016(dcK)
BQY: MUS_0018(dcK)
BAMI: KSO_019335
BAMC: U471_00160
BAMF: U722_00110
BAN: BA_0014
BAR: GBAA_0014
BAT: BAS0017
BAI: BAA_0021
BANT: A16_00180
BANR: A16R_00190
BANS: BAPAT_0015
BANV: DJ46_4407(dck)
BCA: BCE_0015
BCZ: BCE33L0015(dck)
BCQ: BCQ_0021(dck)
BCX: BCA_0021
BAL: BACI_c00210(dck)
BNC: BCN_0015
BCF: bcf_00105
BCER: BCK_07780
BTK: BT9727_0015(dck)
BTL: BALH_0015(dck)
BTT: HD73_0015
BTHI: BTK_00095
BTM: MC28_4734
BTG: BTB_c00200(dck)
BTI: BTG_20810
BTW: BF38_1232(dck)
BWW: bwei_5822(dck)
BMYO: BG05_494
BMYC: DJ92_2604(dck)
BPU: BPUM_0511
BPUM: BW16_00115
BPUS: UP12_00110
BMQ: BMQ_0019(dck)
BMD: BMD_0019(dck)
BMH: BMWSH_4969(dck)
BMEG: BG04_2295(dck)
BAG: Bcoa_1210
BCOA: BF29_2367(dck)
BJS: MY9_0014
BMET: BMMGA3_00100(dck)
BACW: QR42_00110
BACP: SB24_09640
BACB: OY17_02840
BACO: OXB_0988
BACL: BS34A_00220(dck)
BALM: BsLM_0017
BEO: BEH_00105
BGY: BGLY_0018(dck)
BBEV: BBEV_1505(dck)
BCL: ABC2890(dck)
BPF: BpOF4_04255(dck)
BKW: BkAM31D_19295(dck)
OIH: OB0015
AFL: Aflv_0014(dck)
AAMY: GFC30_183
LSP: Bsph_0031
HLI: HLI_11885
VPN: A21D_01450(dck)
PSYO: PB01_00105
BSE: Bsel_2067
SAU: SA0514
SAV: SAV0556
SAW: SAHV_0554
SAM: MW0511
SAS: SAS0514
SAR: SAR0561
SAC: SACOL0603
SAE: NWMN_0518
SAD: SAAV_0519
SUC: ECTR2_510
SUZ: MS7_0546(dck)
SUG: SAPIG0631
SAUA: SAAG_00974
SAUS: SA40_0496
SAUU: SA957_0511
SAUG: SA268_0509
SAUF: X998_0598
SAB: SAB0507c
SAUB: C248_0631
SAUM: BN843_5500
SAUC: CA347_572(dck)
SAUR: SABB_00607(dck)
SAUI: AZ30_02815
SAUD: CH52_02975
SAMS: NI36_02765
SER: SERP0202
SEP: SE0325
SEPP: SEB_00248
SEPS: DP17_1635
SHA: SH2436
SSP: SSP2158
SCA: SCA_0220
SDT: SPSE_2226(dak)
SPAS: STP1_1645
SHU: SHYC_10855(dck)
SCAP: AYP1020_2308(dck)
SSCH: LH95_10445
SSCZ: RN70_11180
SAGQ: EP23_11305
SDP: NCTC12225_02431(dak)
SARL: SAP2_22050
MCL: MCCL_1852
MCAK: MCCS_23990(dck)
ESI: Exig_0015
EAN: Eab7_0016(dck)
BBE: BBR47_21290(dck)
PPY: PPE_00889
PPM: PPSC2_04615(dck)
PPO: PPM_0865(dck)
PPOL: X809_04240
PPOY: RE92_07350
PSAB: PSAB_09380
PRI: PRIO_2447(dck)
SIV: SSIL_0077
JEO: JMA_00270
KZO: NCTC404_00752(dck)
AMT: Amet_4076
SALQ: SYNTR_2269
MPM: MPNA3860
MPJ: MPNE_0447
MPB: C985_0389
MMYI: mycmycITA_00352(dck_1) mycmycITA_00484(dck_2)
MML: MLC_4190
MCP: MCAP_0527
MCAP: MCCPF38_00623(dck)
MCAR: MCCPILRI181_00626(dck)
MCAI: MCCG_0616
MLC: MSB_A0803
MSY: MS53_0141
MAA: MAG0180(dgk)
MPF: MPUT_0364
MHE: MHC_02825
MCY: MCYN_0417(MCYN0417)
MYT: MYE_01720
MGLY: NCTC10194_00252(MCYN0418_2)
UUR: UU086(dgk)
UPA: UPA3_0086
UPR: UP3_c0051
HCR: X271_00459(dck_1) X271_00461(dck_2)
MTAB: MTABA_v1c05990(dck)
ELJ: ELUMI_v1c07360(dck)
EML: EMELA_v1c07530(dck)
SCR: SCHRY_v1c03710(dck)
SSYR: SSYRP_v1c03790(dck)
SDI: SDIMI_v3c02370(dck)
STAI: STAIW_v1c02830(dck)
SAPI: SAPIS_v1c02880(dck)
SMIR: SMM_0435
SMIA: P344_02610
SCQ: SCULI_v1c03070(dck)
SATR: SATRI_v1c04920(dck)
SERI: SERIO_v1c04650(dck)
SCJ: SCANT_v1c02510(dck)
SHJ: SHELI_v1c02440(dck)
SFZ: SFLOR_v1c03090(dck)
SCLA: SCLARK_001545(dck)
SMOO: SMONO_v1c02310(dck)
SGQ: SGLAD_v1c02930(dck)
RCA: Rcas_0030
DGO: DGo_CA0181(dnk)
DFC: DFI_13090
TRA: Trad_2827
TAQ: TO73_1517
TBC: A0O31_00515(dck)
MRB: Mrub_2584
BGB: KK9_0243(dck)
BGN: BgCN_0241
BDU: BDU_239(dck)
BRE: BRE_238(dck)
BPAK: X966_01185
BANE: N187_01150
GBA: J421_0262
POC: NCTC13071_02384(dck_1) NCTC13071_02385(dck_2)
AFD: Alfi_0145
ASH: AL1_13560
BACC: BRDCF_p199(dck)
DORI: FH5T_03570
BLQ: L21SP5_01839(dck)
SRM: SRM_01454
RMR: Rmar_2346
CPI: Cpin_6885
FLN: FLA_4613
SGN: SGRA_3733
PHE: Phep_2581
SMIZ: 4412673_02023(dck)
SDJ: NCTC13534_02906(dck)
STHA: NCTC11429_04693(dck)
MUC: MuYL_1906
MGOT: MgSA37_03401(dck)
DFE: Dfer_0477
SLI: Slin_1672
LBY: Lbys_0233
FAE: FAES_3316
HSW: Hsw_0956
GFL: GRFL_2090
FJO: Fjoh_1482
FJG: BB050_01136(dck)
FIN: KQS_02285
FSN: GS03_01021(dck)
COC: Coch_1627
ZPR: ZPR_3651
MARM: YQ22_04325
CBAL: M667_08080
CBAT: M666_08115
DDO: I597_0232(dck)
ZGA: ZOBELLIA_859(dgkA1)
MLT: VC82_2042
NDO: DDD_1496(dnk)
MYR: MYRA21_1858(dck)
MPW: MPR_0650
WIN: WPG_0753
TMAR: MARIT_2639(dck)
AALG: AREALGSMS7_00371(dck)
KOS: KORDIASMS9_01945(dck)
KAN: IMCC3317_37060(dck)
MARF: CJ739_528
MESQ: C7H62_1517
FBA: FIC_01532
RAI: RA0C_0343
RAR: RIA_0003
RAG: B739_1939
RAE: G148_1492
RAT: M949_0144
EAO: BD94_2664
ELB: VO54_00049(dck)
CHZ: CHSO_3185
CTAK: 4412677_00781(dck)
CJG: NCTC13459_00907(dck)
CANT: NCTC13489_00955(dck)
CPRV: CYPRO_2287
TLE: Tlet_2047
MARN: LN42_01030
ASAC: ATHSA_0328
CABY: Cabys_937
 » show all
Reference
1  [PMID:5442271]
  Authors
Durham JP, Ives DH.
  Title
Deoxycytidine kinase. II. Purification and general properties of the calf thymus enzyme.
  Journal
J Biol Chem 245:2276-84 (1970)
Reference
2  [PMID:5462538]
  Authors
Ives DH, Durham JP.
  Title
Deoxycytidine kinase. 3. Kinetics and allosteric regulation of the calf thymus enzyme.
  Journal
J Biol Chem 245:2285-94 (1970)
Reference
3  [PMID:5687717]
  Authors
Kessel D.
  Title
Properties of deoxycytidine kinase partially purified from L1210 cells.
  Journal
J Biol Chem 243:4739-44 (1968)
Reference
4  [PMID:5684726]
  Authors
Momparler RL, Fischer GA.
  Title
Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase: purification, properties, and kinetic studies with cytosine arabinoside.
  Journal
J Biol Chem 243:4298-304 (1968)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.74
IUBMB Enzyme Nomenclature: 2.7.1.74
ExPASy - ENZYME nomenclature database: 2.7.1.74
BRENDA, the Enzyme Database: 2.7.1.74
CAS: 9039-45-6

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