KEGG ENZYME: 2.7.1.74

ENZYME: 2.7.1.74

Entry

EC 2.7.1.74 Enzyme

Name

deoxycytidine kinase;
deoxycytidine kinase (phosphorylating);
2'-deoxycytidine kinase;
Ara-C kinase;
arabinofuranosylcytosine kinase;
deoxycytidine-cytidine kinase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

NTP:deoxycytidine 5'-phosphotransferase

Reaction(IUBMB)

NTP + deoxycytidine = NDP + dCMP [RN:R02321]

Reaction(KEGG)

R02321 > R01666;
(other) R00185

Substrate

NTP [CPD:C00201];
deoxycytidine [CPD:C00881]

Product

NDP [CPD:C00454];
dCMP [CPD:C00239]

Comment

Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors.

History

EC 2.7.1.74 created 1972

Pathway

ec00230

Purine metabolism

ec00240

Pyrimidine metabolism

ec01100

Metabolic pathways

Orthology

K00893

deoxycitidine kinase

K15519

deoxyadenosine/deoxycytidine kinase

Genes

HSA:

1633(DCK)

PTR:	461273(DCK)

PPS:	100990892(DCK)

GGO:	101153698(DCK)

PON:	100459989(DCK)

NLE:	100580396(DCK)

MCC:	705040(DCK)

MCF:	101925611(DCK)

CSAB:

103235762(DCK)

RRO:	104678729(DCK)

RBB:	108534027(DCK)

CJC:	100395055(DCK)

SBQ:	101045176(DCK)

MMU:	13178(Dck)

MCAL:

110294384(Dck)

MPAH:

110330622(Dck)

RNO:	79127(Dck)

MUN:	110540094(Dck)

CGE:	100751299(Dck)

NGI:	103730983(Dck)

HGL:	101722212(Dck)

CCAN:

109679520(Dck)

OCU:	100348589(DCK)

TUP:	102498967(DCK)

CFA:	482188(DCK)

VVP:	112923681(DCK)

AML:	100482093(DCK)

UMR:	103665295(DCK)

UAH:	113263298(DCK)

ORO:	101384844(DCK)

ELK:

111149150

FCA:	101083845(DCK)

PTG:	102949132(DCK)

PPAD:

109278016(DCK)

AJU:	106983696(DCK)

BTA:	530642(DCK)

BOM:	102268258(DCK)

BIU:	109560557(DCK)

BBUB:

102404885(DCK)

CHX:	102175015(DCK)

OAS:	101123378(DCK)

SSC:	100517354(DCK)

CFR:	102524113(DCK)

CDK:	105091182(DCK)

BACU:

103015268(DCK)

LVE:	103071330(DCK)

OOR:	101281945(DCK)

DLE:	111187681(DCK)

PCAD:

102976054(DCK)

ECB:	100054704(DCK)

EPZ:	103560855(DCK)

EAI:	106835100(DCK)

MYB:	102246003 102261934(DCK)

MYD:	102766950(DCK)

MNA:	107532650(DCK)

HAI:	109393701(DCK)

DRO:	112320588(DCK)

PALE:

102890176(DCK)

RAY:	107504025(DCK)

MJV:	108394228(DCK)

LAV:	100667514(DCK)

TMU:

101361286

MDO:	100014536(DCK)

SHR:	100931780(DCK)

PCW:	110209808(DCK)

OAA:	100078818(DCK)

GGA:	422648(DCK) 770922(DGUOK)

MGP:	100544492(DCK) 100551225

CJO:	107313354(DCK) 107320138

NMEL:

110398815(DCK) 110405511

APLA:

101799591(DCK) 101804573

ACYG:

106032673 106043942(DCK)

TGU:	100220427 100223331(DCK)

LSR:	110470157(DCK) 110482771

SCAN:

103817288 103823424(DCK)

GFR:	102035084(DCK) 102038779

FAB:	101806066 101811376(DCK)

PHI:	102106204(DCK) 102108269

PMAJ:

107203117(DCK) 107210687

CCAE:

111929482(DCK) 111945349

CCW:	104689701 104696860(DCK)

ETL:	114060048(DCK) 114065212

FPG:	101917700(DCK) 101920025

FCH:	102055990 102056086(DCK)

CLV:	102091484 102092948(DCK)

EGZ:	104125173(DCK) 104128441

NNI:	104011376(DCK) 104018457

ACUN:

113479483(DCK) 113485095

PADL:

103915830 103916970(DCK)

AAM:	106491894(DCK) 106493434

ASN:	102381619(DCK) 102382818

AMJ:	102572880(DCK) 102575265

PSS:	102444422(DCK)

CMY:	102946796(DCK)

CPIC:

101948329(DCK)

ACS:	100554557(dck) 100557346

PVT:	110073482 110085258(DCK)

PBI:	103059568(DCK)

PMUR:

107289800(DCK)

TSR:	106550977(DCK)

PMUA:

114591328 114604270 114604356

GJA:	107123240 107123770(DCK)

XLA:	108710975 446773(dck.2.L) 494987 496391(dck.1.L)

XTR:	549546(dck.2) 594934(dck.1)

NPR:	108784695(DCK) 108797251

DRE:	474325(dck) 541538(zgc:110540)

SRX:	107715300 107720908 107752943 107756157

SANH:

107661628 107669325 107675719(dck) 107700028

SGH:	107548225 107559410 107576876 107584655 107585435

CCAR:

109057974 109061511 109074621 109109041

IPU:	108278442 108279081(dck)

PHYP:

113535609(dck) 113541634

AMEX:

103029689 103043253

EEE:	113590818(dck) 113591964

TRU:	101065882(dck)

TNG:	GSTEN00002349G001 GSTEN00014362G001 GSTEN00014659G001

LCO:	104920317(dguok) 104922470(dck) 104932480

NCC:	104941578 104952207(dck)

MZE:	101465766 101474081 101485167(dck)

ONL:	100705170 100706399(dck) 100710536

OLA:	101155710 101157232(dck) 101162762

XMA:	102219923(dck) 102220081 102221703

XCO:	114149449(dck) 114152520 114154705

PRET:

103459907 103473357(dck)

CVG:	107090340 107093354(dck) 107102290

NFU:	107373220 107394221 107395118(dck)

KMR:	108234509 108242605(dck) 108250878

ALIM:

106511806 106521660 106528779 106531323 106531498(dck)

AOCE:

111563398 111565434(dck) 111575853

CSEM:

103389988(dck) 103398651

POV:	109626045(dck) 109642212(dguok)

LCF:	108873608 108878561 108883003(dck)

SDU:	111220806(dck) 111239543

SLAL:

111648552 111648603 111649624 111666774(dck) 111671147

HCQ:	109525557(dck)

BPEC:

110157441(dck) 110175010

MALB:

109969767(dck)

SASA:

100196160(dck) 106603918

OTW:	112220161(dck) 112228262

SALP:

111950819 111961824 111964472

ELS:	105011305 105027270(dck)

SFM:	108934264 108938663 114912476(dck)

PKI:	111850184(dck)

LCM:	102355337 102355687(DCK)

CMK:	103186473(dck) 103191301

RTP:	109916942 109927964 109932976(dck)

BFO:	BRAFLDRAFT_124584

CIN:

AQU:

BRP:

CANN:

CSL:	COCSUDRAFT_19049

PTM:	GSPATT00010233001 GSPATT00033500001

GTT:	GUITHDRAFT_140223 GUITHDRAFT_57327

ASP:

AOR13_348

ASQ:	AVL57_16755

ALE:	AV939_15695

ALZ:	AV940_15450

TMB:	Thimo_0867

SDO:	SD1155_05570

MAI:

MICA_1301

BSU:	BSU00140(dck)

BSR:

I33_0020

BSL:

A7A1_1229

BSH:	BSU6051_00140(dck)

BSY:	I653_00070

BSUT:

BSUB_00020(dck)

BSUL:

BSUA_00020(dck)

BSUS:

Q433_00105

BSS:	BSUW23_00075(dck)

BST:

GYO_0019

BSO:	BSNT_06304(dck)

BSN:	BSn5_11630

BSQ:	B657_00140(dck)

BSX:	C663_0016(dck)

BSP:	U712_00075

BLI:	BL02366(dck)

BLD:	BLi00023(dck)

BLH:	BaLi_c00240(dck)

BAY:	RBAM_000190

BAQ:	BACAU_0015(dck)

BYA:	BANAU_0015(dck)

BAMP:

B938_00075

BAML:

BAM5036_0016(dck)

BAMA:

RBAU_0017(dck)

BAMN:

BASU_0017(dck)

BAMB:

BAPNAU_0015(dck)

BAMT:

AJ82_00110

BAMY:

V529_00150(dcK)

BMP:	NG74_00022(dck)

BAO:	BAMF_0015(dck)

BAZ:	BAMTA208_00070(dck)

BQL:	LL3_00015(dck)

BXH:	BAXH7_00016(dcK)

BQY:	MUS_0018(dcK)

BAMI:

KSO_019335

BAMC:

U471_00160

BAMF:

U722_00110

BAE:	BATR1942_18680

BVM:	B9C48_00105

BAN:

BA_0014

BAR:

GBAA_0014

BAT:

BAS0017

BAH:	BAMEG_0021

BAI:

BAA_0021

BAX:	H9401_0014

BANT:

BANR:

BANS:

BANH:

BANV:

DJ46_4407(dck)

BCA:

BCE_0015

BCZ:	BCE33L0015(dck)

BCR:	BCAH187_A0021

BCB:	BCB4264_A0019

BCU:	BCAH820_0019

BCG:	BCG9842_B5299

BCQ:	BCQ_0021(dck)

BCX:

BCA_0021

BAL:	BACI_c00210(dck)

BNC:

BCF:

BCER:

BCEF:

BCY:	Bcer98_0014

BTK:	BT9727_0015(dck)

BTL:	BALH_0015(dck)

BTB:	BMB171_C0014

BTT:

HD73_0015

BTHR:

YBT1520_00070

BTHI:

BTK_00095

BTC:	CT43_CH0014

BTF:	YBT020_00075

BTM:

MC28_4734

BTG:	BTB_c00200(dck)

BTI:

BTG_20810

BTN:	BTF1_26120

BTHT:

H175_ch0014

BTHU:

YBT1518_00070

BTW:	BF38_1232(dck)

BTHY:

AQ980_01715

BWE:	BcerKBAB4_0014

BWW:	bwei_5822(dck)

BMYO:

BG05_494

BTY:	Btoyo_2708

BMYC:

DJ92_2604(dck)

BBY:	CY96_26670

BWD:	CT694_00100

BCL:	ABC2890(dck)

BPU:

BPUM_0511

BPUM:

BW16_00115

BPUS:

UP12_00110

BPF:	BpOF4_04255(dck)

BMQ:	BMQ_0019(dck)

BMD:	BMD_0019(dck)

BMH:	BMWSH_4969(dck)

BMEG:

BG04_2295(dck)

BCO:	Bcell_1938

BCK:	BCO26_0075

BAG:

Bcoa_1210

BCOA:

BF29_2367(dck)

BJS:

MY9_0014

BACI:

B1NLA3E_00070

BIF:	N288_00115

BLE:	BleG1_2805

BMET:

BMMGA3_00100(dck)

BACW:

BACP:

BACB:

BACO:

BACY:

BACL:

BS34A_00220(dck)

BALM:

BsLM_0017

BEO:

BEH_00105

BSJ:	UP17_00090

BON:	A361_00115

BGY:	BGLY_0018(dck)

BFX:	BC359_00895

BGI:	BGM20_14890

BWH:	A9C19_19860

BXI:	BK049_08120

BHK:	B4U37_00105

BKW:	BkAM31D_19295(dck)

BBEV:

BBEV_1505(dck)

BKO:	CKF48_10750

BALT:

BACS:

BMUR:

BSAF:

BIT:	BIS30_10455

BACQ:

DOE78_00105

OIH:

OB0015

OCN:	CUC15_00080

GWC:	GWCH70_0015

GMC:	GY4MC1_0014

GTH:	Geoth_0035

PTL:	AOT13_02975

AFL:	Aflv_0014(dck)

AGN:	AFK25_00105

ANM:	GFC28_2670

AAMY:

GFC30_183

ANL:	GFC29_2765

LSP:

Bsph_0031

LGY:	T479_00150

LFU:	HR49_23710

LYS:	LBYS11_00275

LYB:	C3943_00300

LYZ:	DCE79_00120

LYG:	C1N55_00125

HHD:	HBHAL_1016

HMN:	HM131_01085

HLI:

HLI_11885

TAP:	GZ22_11640

VIR:	X953_00125

VHL:	BME96_00120

VIG:	BKP57_10615

VIL:	CFK37_06045

VNE:	CFK40_01550

VPN:	A21D_01450(dck)

LAO:	AOX59_13630

FPN:	ABE65_000060

FAR:	ABE41_000070

SJE:	AAV35_013645

AQT:	FN924_00095

PSYH:

D0S48_12220

PRD:	F7984_00085

STEA:

BSE:

SAV:

SAW:

SAH:	SaurJH1_0593

SAJ:	SaurJH9_0579

SAM:

SAS:

SAR:

SAC:

SAX:	USA300HOU_0550

SAA:	SAUSA300_0541

SAO:	SAOUHSC_00539

SAE:

NWMN_0518

SAD:

SAAV_0519

SUU:	M013TW_0543

SUV:	SAVC_02375

SUE:	SAOV_0591c

SUJ:	SAA6159_00510

SUK:	SAA6008_00563

SUC:

ECTR2_510

SUT:	SAT0131_00610

SUQ:	HMPREF0772_12633

SUZ:	MS7_0546(dck)

SUD:	ST398NM01_0631

SUX:	SAEMRSA15_04830

SUW:	SATW20_06260

SUG:

SAPIG0631

SUF:	SARLGA251_04920

SAUA:

SAUE:

SAUN:

SAUS:

SAUU:

SAUG:

SAUZ:

SAUT:

SAUJ:

SAUK:

SAUQ:

SAUV:

SAUW:

SAUX:

SAUY:

SAUF:

SAB:

SUY:	SA2981_0533

SAUB:

C248_0631

SAUM:

BN843_5500

SAUC:

CA347_572(dck)

SAUR:

SABB_00607(dck)

SAUI:

AZ30_02815

SAUD:

CH52_02975

SAMS:

NI36_02765

SUH:	SAMSHR1132_05000

SEP:

SER:

SEPP:

SEPS:

SHA:

SHH:	ShL2_02226

SSP:

SSP2158

SCA:

SCA_0220

SLG:	SLGD_02327

SLN:	SLUG_22460

SSD:	SPSINT_0236

SDT:	SPSE_2226(dak)

SWA:	A284_10520

SPAS:

STP1_1645

SXY:	BE24_00535

SXL:	SXYLSMQ121_2148

SXO:	SXYL_02302

SHU:	SHYC_10855(dck)

SCAP:

AYP1020_2308(dck)

SSCH:

SSCZ:

SAGQ:

SEQO:

SCV:	A4G25_06580

SPET:

CEP67_09820

SLZ:	B5P37_07205

SSCU:

CEP64_11485

SNL:	BJD96_12090

SKL:	C7J89_12655

SFQ:	C7J90_01860

SHOM:

EGX58_03380

SMUS:

C7J88_08230

MCL:

MCCL_1852

MCAK:

MCCS_23990(dck)

MACR:

BHM04_11465

SBAC:

BVH56_07840

ESI:

Exig_0015

EAT:	EAT1b_1714

EAN:	Eab7_0016(dck)

EXM:	U719_16645

EXU:	ESP131_02295

BBE:	BBR47_21290(dck)

BLR:	BRLA_c014730

BFM:	BP422_05860

BAGR:

BA6348_18440

PJD:	Pjdr2_1278

PPY:

PPE_00889

PPM:	PPSC2_04615(dck)

PPO:	PPM_0865(dck)

PPOL:

X809_04240

PPQ:	PPSQR21_009210

PPOY:

RE92_07350

PTA:	HPL003_12345

PSAB:

PSAB_09380

PDU:	PDUR_10585

PBD:	PBOR_12490

PGM:	PGRAT_11510

POD:	PODO_09905

PAEN:

PAEF:

PAEQ:

PSTE:

PAEA:

PAEE:

PAEH:

PAEJ:

PIH:	UB51_15450

PRI:	PRIO_2447(dck)

PPEO:

ABE82_04395

PBV:	AR543_06775

PXL:	BS614_08245

PYG:	AWM70_16910

PDH:	B9T62_06595

PKB:	B4V02_20640

PAIH:

ASL14_07135

SACA:

FFV09_15070

TUM:	CBW65_07275

TAB:	CIG75_00125

SIV:

SSIL_0077

SSIL:

SOLI23_18445

SOB:	CSE16_00100

PLN:	Plano_3037

PKU:	AUO94_00140

PRT:	AUC31_10205

PLL:	I858_007730

PANA:

BBH88_02980

PDG:	BCM40_16035

PHC:	BBI08_12595

PMAR:

B0X71_00100

PPLA:

BBI15_11760

PFAE:

AJGP001_00105

PLX:	CW734_01280

JEO:

JMA_00270

KUR:	ASO14_2878

KZO:	NCTC404_00752(dck)

SPSY:

SPOR:

SPOP:

SURE:

SPOS:

SPAE:

RST:	ATY39_15215

PAEK:

D3873_00160 D3873_13275

PANC:

E2636_18150

AMT:

Amet_4076

PSOR:

RSJ16_16670

HCR:	X271_00459(dck_1) X271_00461(dck_2)

ELJ:	ELUMI_v1c07360(dck)

SDI:	SDIMI_v3c02370(dck)

STAI:

STAIW_v1c02830(dck)

SMIR:

SMM_0435

SMIA:

P344_02610

SCQ:	SCULI_v1c03070(dck)

SSAB:

SSABA_v1c05500

SATR:

SATRI_v1c04920(dck)

SCJ:	SCANT_v1c02510(dck)

SHJ:	SHELI_v1c02440(dck)

SCLA:

SCLARK_001545(dck)

BGA:	BG0242(dck)

GBA:

J421_0262

KPF:	IX53_10000

MPG:	Theba_0964

MINF:

MESINF_0198(dck)

» show all

Reference

1 [PMID:5442271]

Authors

Durham JP, Ives DH.

Title

Deoxycytidine kinase. II. Purification and general properties of the calf thymus enzyme.

Journal

J Biol Chem 245:2276-84 (1970)

Reference

2 [PMID:5462538]

Authors

Ives DH, Durham JP.

Title

Deoxycytidine kinase. 3. Kinetics and allosteric regulation of the calf thymus enzyme.

Journal

J Biol Chem 245:2285-94 (1970)

Reference

3 [PMID:5687717]

Authors

Kessel D.

Title

Properties of deoxycytidine kinase partially purified from L1210 cells.

Journal

J Biol Chem 243:4739-44 (1968)

Reference

4 [PMID:5684726]

Authors

Momparler RL, Fischer GA.

Title

Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase: purification, properties, and kinetic studies with cytosine arabinoside.

Journal

J Biol Chem 243:4298-304 (1968)

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.74

IUBMB Enzyme Nomenclature:

2.7.1.74

ExPASy - ENZYME nomenclature database:

2.7.1.74

BRENDA, the Enzyme Database:

2.7.1.74

CAS:

9039-45-6

DBGET integrated database retrieval system