KEGG   ENZYME: 2.7.1.8
Entry
EC 2.7.1.8                  Enzyme                                 

Name
glucosamine kinase;
glucosamine kinase (phosphorylating);
ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase;
aminodeoxyglucose kinase;
ATP:D-glucosamine phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:D-glucosamine 6-phosphotransferase
Reaction(IUBMB)
ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate [RN:R01961]
Reaction(KEGG)
R01961
Substrate
ATP [CPD:C00002];
D-glucosamine [CPD:C00329]
Product
ADP [CPD:C00008];
D-glucosamine 6-phosphate [CPD:C00352]
Comment
The enzyme is specific for glucosamine and has only a minor activity with D-glucose. Two unrelated enzymes with this activity have been described. One type was studied in the bacterium Vibrio cholerae, where it participates in a chitin degradation pathway. The other type has been described from actinobacteria, where it is involved in the incorporation of environmental glucosamine into antibiotic biosynthesis pathways. cf. EC 2.7.1.147, ADP-specific glucose/glucosamine kinase.
History
EC 2.7.1.8 created 1961, modified 2014, modified 2020
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K18676  glucosamine kinase
Genes
KOR: AWR26_20120
KRD: A3780_03730
SERA: Ser39006_008770
SERQ: CWC46_08765
RAQ: Rahaq2_1676
ECA: ECA3753
PATR: EV46_18395 EV46_18400
PATO: GZ59_37490 GZ59_37500
PCT: PC1_3527 PC1_3528
PCC: PCC21_035210 PCC21_035220
EBI: EbC_09180
PAM: PANA_0315
PAJ: PAJ_3476
PVA: Pvag_3579
PSTW: DSJ_03620
VCH: VC0614
VCS: MS6_0432
VCI: O3Y_02860
VVU: VV1_1667
VVY: VV2740
VPA: VP2485
VPB: VPBB_2311
VAG: N646_1582
VSP: VS_2512
VAN: VAA_00774
VSC: VSVS12_00703(gspK)
VTA: A1619(gspK)
VFI: VF_2145
PPR: PBPRA0519(R00200)
SON: SO_3507(nagK)
SDN: Sden_2706
SBL: Sbal_1084
SLO: Shew_1116
SSE: Ssed_1212
SPL: Spea_1101
SHL: Shal_1149
SWD: Swoo_1312
SWP: swp_3703
SVO: SVI_1023
SPSW: Sps_02363
SKH: STH12_00474(gspK_1)
CPS: CPS_1026
PSM: PSM_B0132
PSEO: OM33_11650
PSPO: PSPO_a1857
PTU: PTUN_a1747(gspK)
PSEN: PNC201_07110(gspK1) PNC201_11730(gspK2)
AMAL: I607_14150
AMAO: I634_14390
AMAI: I635_14820
AMAG: I533_13975
GNI: GNIT_0638
SALH: HMF8227_01499(gspK)
FBL: Fbal_2921
CJA: CJA_1160
SDE: Sde_3036
MICC: AUP74_00061(gspK_1) AUP74_02805(gspK_3)
ALG: AQULUS_03920(gspK)
ASIP: AQUSIP_03900(gspK)
GAI: IMCC3135_01345(gspK_1)
HCH: HCH_06985
AHA: AHA_3099
ASA: ASA_3106
AVR: B565_1043
AMED: B224_1114
ASR: WL1483_83(gspK)
SALN: SALB1_0829
CVI: CV_2896
BMA: BMA2870
BMAL: DM55_909
BMAE: DM78_812
BMAQ: DM76_886
BMAI: DM57_1623
BMAF: DM51_2487
BMAZ: BM44_255
BMAB: BM45_3033
BPS: BPSL3316
BPSE: BDL_2059
BPSM: BBQ_3517
BPSU: BBN_103
BPSD: BBX_451
BPK: BBK_1548
BPSH: DR55_1185
BPSA: BBU_2223
BPSO: X996_798
BUT: X994_2817
BTE: BTH_I3192
BTQ: BTQ_3132
BTJ: BTJ_2562
BTZ: BTL_474
BTD: BTI_240
BTV: BTHA_567
BTHE: BTN_884
BTHM: BTRA_681
BTHA: DR62_1080
BTHL: BG87_691
BOK: DM82_3019
BOC: BG90_1696
BVE: AK36_595
BCN: Bcen_2861
BCJ: BCAL0119
BCEN: DM39_53
BCEW: DM40_949
BCEO: I35_0126
BAM: Bamb_0159
BMJ: BMULJ_03109(nagK)
BMU: Bmul_0155
BMK: DM80_1532
BMUL: NP80_288
BCT: GEM_0151
BCED: DM42_1582
BDL: AK34_2908
BCON: NL30_18650
BUB: BW23_1511
BLAT: WK25_01505
BTEI: WS51_11630
BSEM: WJ12_00885
BPSL: WS57_13775
BMEC: WJ16_00840
BSTG: WT74_01150
BGU: KS03_1089
BGO: BM43_1583
BUK: MYA_0168
BUL: BW21_324
BXE: Bxe_A0107
BXB: DR64_2282
BPH: Bphy_2984
BFN: OI25_1597
CABA: SBC2_02000
RTA: Rta_30025
HSE: Hsero_4554(nagK)
CFU: CFU_2609(nagK2) CFU_2985(nagK1)
CPRA: CPter91_1545(nagK1) CPter91_3368(nagK2)
LCH: Lcho_4217
PBH: AAW51_4933(gspK)
MES: Meso_2705
AMIH: CO731_00469(gspK)
SME: SMc02875
SMER: DU99_01025
SMD: Smed_3407
SIX: BSY16_656
EAD: OV14_1045
RLE: RL3360
RHL: LPU83_2787(NAGK)
RHT: NT26_4005
SHZ: shn_11305
BMR: BMI_II509
RVA: Rvan_3458
PHL: KKY_2
PLEO: OHA_1_02077(gspK_1) OHA_1_02908(gspK_2)
MMED: Mame_03626
HDI: HDIA_2827(gspK)
SIL: SPO1841
RUT: FIU92_20510(gspK)
JAN: Jann_1358
RDE: RD1_1728
PDE: Pden_2474
KVL: KVU_2002
KVU: EIO_2482
PSF: PSE_4341
PGD: Gal_00635
OTM: OSB_04490(gspK)
MALG: MALG_04280
AHT: ANTHELSMS3_01829(gspK)
MARU: FIU81_12670(gspK)
ROT: FIV09_06610(gspK)
MALU: KU6B_48680
PAMO: BAR1_11710
ZMO: ZMO1169
ZMN: Za10_0159
ZMM: Zmob_0160
ZMB: ZZ6_0162
ZMI: ZCP4_0164
GOX: GOX1475
GDI: GDI3226
GDJ: Gdia_3136
ASZ: ASN_1569
TXI: TH3_09625
PRI: PRIO_6557
LAC: LBA1511
LAD: LA14_1505
LAF: SD55_1485
LHL: LBHH_0601
LHV: lhe_1458
LHH: LBH_1314
LHD: HUO_04215
LAM: LA2_08465
LKE: WANG_0273
LAE: LBAT_0567
SAY: TPY_1382
TPR: Tpau_2047
SRW: TUE45_pSRc_0283(gspK)
STRD: NI25_36095
LXL: KDY119_03014(gspK)
MLV: CVS47_00639(murK)
MOY: CVS54_02627(murK)
ARM: ART_2817
AAU: AAur_1196
LMOI: VV02_01090
PAC: PPA1144
PACC: PAC1_05985
PACH: PAGK_1010
CACN: RN83_06085
PFRE: RM25_0434
ACIJ: JS278_00008(murK_1) JS278_00076(murK_2)
MPH: MLP_30770
KFL: Kfla_1314
TFU: Tfu_2322
NDA: Ndas_1857
NAL: B005_5056
STRR: EKD16_06010(gspK)
TCU: Tcur_4023
SEN: SACE_0495
SACC: EYD13_19245(gspK)
AOI: AORI_7371
AMYY: YIM_03220
AORI: SD37_03615
PSEA: WY02_02680
AMI: Amir_0391
SESP: BN6_04320(nagK)
ACTI: UA75_01875
ACAD: UA74_01870
ALO: CRK61230
SAQ: Sare_3210
MIL: ML5_4092
ASE: ACPL_640(nagK)
ACTN: L083_6585
ACTS: ACWT_0524
BAST: BAST_0088
PDO: PSDT_1006
SYG: sync_0326
SYNR: KR49_10370
DGE: Dgeo_2513
DFC: DFI_17575
MRB: Mrub_2466
OTE: Oter_0839
ABAS: ACPOL_5386
GAU: GAU_2004
GBA: J421_3609
PGI: PG_1100
PGN: PGN_1197
PSAC: PSM36_0401
ASH: AL1_29870
MUC: MuYL_3684
LBY: Lbys_3353
FAE: FAES_0618
HSW: Hsw_1497
FBA: FIC_02254
RAI: RA0C_1749
RAR: RIA_0739
RAG: B739_0402
RAE: G148_0083
RAT: M949_0848
TVO: TVG0204668(TVG0204668)
CDIV: CPM_0119
HBU: Hbut_1587
STO: STK_23540
SOL: Ssol_0958
SSOA: SULA_0991
SSOL: SULB_0993
SSOF: SULC_0992
MSE: Msed_1855
AHO: Ahos_2055
 » show all
Reference
1  [PMID:13242546]
  Authors
BUEDING E, MACKINNON JA.
  Title
Hexokinases of Schistosoma mansoni.
  Journal
J Biol Chem 215:495-506 (1955)
Reference
2  [PMID:11850417]
  Authors
Park JK, Wang LX, Roseman S
  Title
Isolation of a glucosamine-specific kinase, a unique enzyme of Vibrio cholerae.
  Journal
J Biol Chem 277:15573-8 (2002)
DOI:10.1074/jbc.M107953200
  Sequence
[vch:VC0614]
Reference
3  [PMID:31088917]
  Authors
Manso JA, Nunes-Costa D, Macedo-Ribeiro S, Empadinhas N, Pereira PJB.
  Title
Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity.
  Journal
mBio 10:e00239-19 (2019)
DOI:10.1128/mBio.00239-19
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.8
IUBMB Enzyme Nomenclature: 2.7.1.8
ExPASy - ENZYME nomenclature database: 2.7.1.8
BRENDA, the Enzyme Database: 2.7.1.8
CAS: 9031-90-7

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