KEGG   ENZYME: 2.7.1.81
Entry
EC 2.7.1.81                 Enzyme                                 
Name
hydroxylysine kinase;
hydroxylysine kinase (phosphorylating);
guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
GTP:5-hydroxy-L-lysine O-phosphotransferase
Reaction(IUBMB)
GTP + 5-hydroxy-L-lysine = GDP + 5-phosphooxy-L-lysine [RN:R03378]
Reaction(KEGG)
R03378
Substrate
GTP [CPD:C00044];
5-hydroxy-L-lysine [CPD:C16741]
Product
GDP [CPD:C00035];
5-phosphooxy-L-lysine [CPD:C03366]
Comment
Both the natural 5-hydroxy-L-lysine and its 5-epimer act as acceptors.
History
EC 2.7.1.81 created 1972
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K18201  hydroxylysine kinase
Genes
HSA123688(HYKK)
PTR739839(HYKK)
PPS100990244(HYKK)
GGO101138799(HYKK)
PON100455708(HYKK)
NLE100580988(HYKK)
MCC710329(HYKK)
MCF102143817(HYKK)
CSAB103245249(HYKK)
CATY105571819(HYKK)
PANU101000627(HYKK)
TGE112627842(HYKK)
RRO104677979(HYKK)
RBB108537974(HYKK)
TFN117070316(HYKK)
PTEH111528841(HYKK)
CJC100386138(HYKK)
SBQ101034398(HYKK)
CSYR103256452(HYKK)
MMUR105857204(HYKK)
LCAT123631935(HYKK)
OGA100941832(HYKK)
MMU235386(Hykk)
MCAL110301627(Hykk)
MPAH110328023(Hykk)
RNO300723(Hykk)
MCOC116073834(Hykk)
MUN110552008(Hykk)
CGE100756410(Hykk)
MAUA101839551(Hykk)
PLEU114690298(Hykk)
MORG121438306(Hykk)
AAMP119809619(Hykk)
NGI103726029(Hykk)
HGL101702212(Hykk)
CPOC100720936(Hykk)
CCAN109682392(Hykk)
DORD105982502(Hykk)
DSP122123383(Hykk)
NCAR124976988
OCU100338857(HYKK)
OPI101524587(HYKK)
TUP102477505(HYKK)
CFA475133(HYKK)
CLUD112662200(HYKK)
VVP112909881(HYKK)
VLG121483897(HYKK)
AML100484023(HYKK)
UMR103660312(HYKK)
UAH113263805(HYKK)
UAR123796869(HYKK)
ELK111152694
LLV125105409
MPUF101688302(HYKK)
ORO101366491(HYKK)
EJU114201257(HYKK)
ZCA113910405(HYKK)
MLX118023141(HYKK)
FCA101085212(HYKK)
PYU121042245(HYKK)
PBG122468152(HYKK)
PTG102965109(HYKK)
PPAD109273596(HYKK)
AJU106988498(HYKK)
HHV120220146(HYKK)
BTA530270(HYKK)
BOM102281469(HYKK)
BIU109575651(HYKK)
BBUB102393103(HYKK)
CHX102183458(HYKK)
OAS101122555(HYKK)
ODA120875495(HYKK)
CCAD122455330(HYKK)
SSC100155220(HYKK)
CFR102517400(HYKK)
CBAI105069152(HYKK)
CDK105087215(HYKK)
VPC102538867(HYKK)
BACU103015933(HYKK)
LVE103074471 103091195(HYKK)
OOR101277172(HYKK)
DLE111177871(HYKK)
PCAD102973241(HYKK)
PSIU116749947(HYKK)
ECB100060343(HYKK)
EPZ103560068(HYKK)
EAI106840831(HYKK)
MYB102242468(HYKK)
MYD102754822(HYKK)
MMYO118679030(HYKK)
MLF102442971(HYKK)
MNA107534458(HYKK)
PKL118706351(HYKK)
HAI109381512(HYKK)
DRO112306049(HYKK)
SHON118991872(HYKK)
AJM119057264(HYKK)
PDIC114488507(HYKK)
PHAS123809719(HYKK)
MMF118640995(HYKK)
RFQ117018886(HYKK)
PALE102877942(HYKK)
PGIG120599342(HYKK)
PVP105307330
RAY107500520(HYKK)
MJV108397411(HYKK)
TOD119255726(HYKK)
SARA101550341(HYKK) 105943142
LAV100659263(HYKK)
TMU101357081
MDO100025929(HYKK)
GAS123236492(HYKK)
SHR100925038(HYKK)
PCW110200621(HYKK)
OAA100082548(HYKK)
GGA415358(HYKK)
PCOC116244591(HYKK)
MGP104912798(HYKK)
CJO107318567(HYKK)
NMEL110403550(HYKK)
APLA110354194(HYKK)
ACYG106033771(HYKK)
AFUL116493319(HYKK)
SCAN103823166(HYKK)
PMOA120513309(HYKK)
OTC121348302(HYKK)
PRUF121365482(HYKK)
GFR102032372(HYKK)
FAB101812642(HYKK)
PHI102101087(HYKK)
PMAJ107209498(HYKK)
CCAE111934237(HYKK)
CCW104697460(HYKK)
CBRC103622936(HYKK)
ETL114066699(HYKK)
ZAB102073643(HYKK)
ACHL103808929(HYKK)
FPG101924119(HYKK)
FCH102057217(HYKK)
CLV102084439(HYKK)
EGZ104130741(HYKK)
NNI104016739(HYKK)
PLET104613672(HYKK)
PCRI104025327(HYKK)
ACUN113484215(HYKK)
TALA104355529(HYKK)
PADL103921999(HYKK)
ACHC115341949(HYKK)
HALD104319401(HYKK)
CCRI104155846(HYKK)
CSTI104549731(HYKK)
EHS104502631(HYKK)
CMAC104473062(HYKK)
MUI104542369(HYKK)
FGA104070748(HYKK)
GSTE104250338(HYKK)
LDI104340686(HYKK)
MNB103777343(HYKK)
AAM106496428(HYKK)
AROW112967342(HYKK)
NPD112946726(HYKK)
DNE112989223(HYKK)
ASN102385118(HYKK)
AMJ106737060(HYKK)
CPOO109308905(HYKK)
GGN109288709(HYKK)
PSS102449467(HYKK)
CMY102929726(HYKK)
CPIC101945644(HYKK)
TST117884346(HYKK)
CABI116815043(HYKK)
MRV120374138(HYKK)
PVT110086836(HYKK)
SUND121933276(HYKK)
PBI103058107(HYKK)
PGUT117661029(HYKK)
VKO123033809(HYKK)
PMUA114604490(HYKK)
ZVI118084527(HYKK)
GJA107109147(HYKK)
STOW125424564(HYKK)
XLA398833(hykk.L)
XTR549168(hykk)
NPR108792705(HYKK)
RTEM120931442(HYKK)
BBUF120985704(HYKK)
BGAR122927688(HYKK)
DRE559560(hykk.2) 559635(hykk.1)
SRX107732649 107744196
SANH107679050(hykk)
SGH107551378
CCAR109073910(hykk)
CAUA113039764(hykk)
PPRM120479942
MAMB125254632(hykk.2)
IPU108270524(hykk.2)
PHYP113536447(hykk)
SMEO124391655(hykk.2)
TFD113652460 113652633
AMEX103024473(hykk)
EEE113575413(hykk)
TRU101062646 101075649 101079621
TNGGSTEN00005111G001 GSTEN00022870G001
LCO104927806 104927817 109141606
NCC104941681(hykk)
CGOB115006964 115006965 115007143
ELY117253735 117253945 117254281
EFO125895788 125895789 125895790
PLEP121937833 121938406 121941112 121941293
SLUC116055186 116055465(hykk.2)
ECRA117950491(hykk.2)
ESP116695956 116695957
PFLV114561970(hykk)
GAT120824273 120824274(hykk.2)
PPUG119216692 119217094(hykk.2)
MSAM119900580(hykk.2)
CUD121512230 121512826 121512827 121512828 121512830
ALAT119028974 119028975
MZE101485107(hykk)
ONL100698865(hykk)
OAU116335582(hykk.2)
OLA101157673(hykk)
OML112150838(hykk.2)
XMA102234172(hykk)
XCO114150284(hykk)
XHE116726504(hykk)
PRET103463464(hykk)
PFOR103130348(hykk)
PLAI106952259(hykk)
PMEI106908687(hykk)
GAF122838534(hykk.2)
CVG107097565(hykk)
CTUL119787609(hykk.2)
GMU124874555(hykk.2)
NFU107392750(hykk)
KMR108234283(hykk.2)
ALIM106537347(hykk)
NWH119407758(hykk.2)
AOCE111575601(hykk)
MCEP125008815(hykk.2)
CSEM103394279(hykk)
POV109625440 109636588
SSEN122781172
HHIP117760401 117760402 117760403
HSP118120671 118121119 118121121
LCF108881232 108881233
SDU111221554 111221693
SLAL111650060 111650061
XGL120791041(hykk.2)
HCQ109519117(hykk) 109522092
BPEC110160020(hykk)
MALB109958363 109958364
BSPL114854536(hykk.2)
SASA106574169(hykk)
OTW112251970(hykk.2)
OMY110528925
OGO123996717(hykk.2)
ONE115109021(hykk)
SALP111952499(hykk)
SNH120053609(hykk.2)
CCLU121576502(hykk.2)
ELS105025360(hykk)
SFM108938859(hykk)
PKI111860441(hykk)
AANG118218452 118224748
LOC102690756(hykk)
PSPA121323497(hykk.2)
ARUT117423176(hykk.2)
LCM102345395(HYKK)
CMK103186056(hykk)
RTP109925457 109925458
BFO118409101 118409804 118414920 118432493
BBEL109469870 109478825 109485117
CIN100178748 100180584 100184636 100184970 101242153
SCLV120332743 120333838 120338449 120342455
SPU583471 587491 753377
APLC110974803 110975501 110977699 110986792
SKO100370444 100370558 100378277 102806377 102807082 102807546
DMEDmel_CG31751(CG31751)
DER6549175
DSE6614572
DSIDsimw501_GD24148(Dsim_GD24148)
DYADyak_GE13198
DAN6497879
DSR110187535
DPO4817340
DPE6589212
DMN108161733
DWI6644206
DGR6561871
DMODmoj_GI17173
DAZ108610532
DNV115562395
DHE111595790
DVI6627942
CCAT101458765
BOD106617658
MDE101898827
SCAC106090346
LCQ111679539
LSQ119611221
HIS119661386
AGAAgaP_AGAP004612
ACOZ120950240
AARA120895721
ASTE118507837
AAG5563704
AALB109403740 109424318
CQUCpipJ_CPIJ000646
CPII120428672
CNS116350719 116352457
BCOO119071503
AME725458
ACER107994301
ALAB122721105
BIM100745553
BBIF117204259
BVK117239865
BVAN117158241
BTER100644916
BPYO122571210
CCAL108630327
OBB114873642
MGEN117229214
NMEA116426927
CGIG122399601
SOC105199942
MPHA105829599
AEC105153719
ACEP105626660
PBAR105428025
VEM105568360
HST105182569
DQU106741046
CFO105256163
FEX115241067 115241068
LHU105669300
PGC109862498
OBO105276817
PCF106788496
PFUC122522052
VPS122637975
NVI100122924
CSOL105361410
TPRE106653523
MDL103578209
CGLO123269964
FAS105264629
DAM107038242
AGIF122853366
LHT122503041
CCIN107270514
TCA663880 663889
DPA109540663
SOY115890257
ATD109608459
CSET123307210
AGB108904692
LDC111513853
NVL108562591
APLN108742761
PPYR116168758
OTU111429167
BMOR101742724
BMAN114246868
MSEX115444616 119190758
DPLKGM_209314
BANY112047804
PMAC106717579
PPOT106110980
PXU106118710
PRAP111001363
ZCE119836718
HAW110380672
HZE124642436
TNL113499313
SLIU111364759
OFU114358385
PXY105392734 105396488
API100160754
DNX107171766
AGS114126383
RMD113555675
BTAB109038491
CLEC112126109
NLU111046383 120350039
PHUPhum_PHUM372110
FOC113207505
TPAL117644479
ZNE110828643
CSEC111866524
FCD110844701
DPXDAPPUDRAFT_306142
DMK116926154
PVM113828125
PJA122261378
PCHN125047454
HAME121864229
PCLA123745419
PTRU123499179
HAZT108669111
EAF111706489
LSM121130287
PPOI119101129
ISCIscW_ISCW011794
DSV119461884
RSAN119395684
RMP119174088
VDE111251739
VJA111266172
TUT107371095
DPTE113789212
DFR124493209
CSCU111630790
PTEP107454282
SDM118196062 118205416
NAINECAME_02928
HROHELRODRAFT_185292
LGILOTGIDRAFT_143358 LOTGIDRAFT_166513 LOTGIDRAFT_173240 LOTGIDRAFT_239161
PCAN112567105 112573837 112576306
BGT106054585 106061420
GAE121383058 121383510
HRF124113357 124134255 124141254 124141255 124141257 124141299 124141300 124141301 124147115
HRJ124253422 124267295 124267309 124267310 124271526 124285588
CRG105326602 105328928 105339342 105339343 105339360
MYI110445623 110447799 110458325 110459149
PMAX117335086 117339432 117339506 117340005 117340331
MMER123546134 123546135 123546507 123547744 123549327 123550240 123550594
OBI106870392 106884233
OSN115231386 115232336 115232374 115232465
LAK106150903 106158486 106169772
OVIT265_06043
NVE5507644 5515439 5521766
EPA110241127 110248711 110251071 110251859 110251922
ATEN116293263 116301468 116306748
ADF107331345 107332204
AMIL114946784 114959541 114959542
PDAM113666571 113673267 113685805
SPIS111319147 111322409 111322473 111335215 111339381
DGT114521296 114524241 114532849
XEN124445061 124445079 124445209
HMG101240165
TADTRIADDRAFT_54795 TRIADDRAFT_56165 TRIADDRAFT_56166 TRIADDRAFT_56167 TRIADDRAFT_56170
AQU105312566 105314496
VCNVOLCADRAFT_98508
MNGMNEG_1285
OLUOSTLU_27007
OTAOT_ostta13g00340
BPGBathy02g06050
MISMICPUN_63558
MPPMICPUCDRAFT_59381
SREPTSG_07237
ACANACA1_037770
FCYFRACYDRAFT_247871
NGDNGA_0689900
AAFAURANDRAFT_3563
EHXEMIHUDRAFT_363286
GTTGUITHDRAFT_111600
RACEJHW33_25605
RAQRahaq2_4715
ROXBV494_23585
GQUAWC35_06825
BGJAWC36_10295
BIZHC231_14875
PAMPANA_1813
PLFPANA5342_2390(atrB)
PAJPAJ_1149
PAQPAGR_g2297
PSTWDSJ_13320
TPTYNCTC11468_00653
PFUWKF707C_40650
PCQPcP3B5_14680
PPUTL483_16525
PFVPsefu_1001
PSYRN018_14220
PPZH045_06460
PMANOU5_P0250
PDRH681_07415
PKCPKB_1499
PLALFXN65_20400
PVKEPZ47_10885
PTRTHU722_0016205
WOCBA177_15320
HTXEKK97_16760
HAAA5892_01130 A5892_09545
THINCRN91_00400
VITADP71_12760
AMAHDLM_1713
AQSDKK66_17740
RPJN234_36855
COXE0W60_33505
BOCBG90_2879
BCENDM39_6993
BPSLWS57_15345
BSTLBBJ41_32925
BPYBphyt_5904
PPULRO07_00250
AXONH44784_059951
AXNAX27061_4232
AXXERS451415_04253
AISBUW96_19460
ACHRC2U31_24690
PACRFXN63_00345 FXN63_04270
RHYRD110_03240 RD110_24450
VAPVapar_5226
VPEVarpa_0623
VPDVAPA_1c54350
VAMC4F17_01265
HRBHrubri_0244
HEEhmeg3_03815
HFRG5S34_01140
XYKGT347_03140
MLNA9174_33740
MESMEJ066_01325
AAKAA2016_6209
RHINGR_b06580
SFHSFHH103_06611
SFDUSDA257_c02260
SINOSS05631_c28210
ESJSJ05684_b53200
EAKEKH55_4217
ARAArad_9341
REPIE4803_PC00591
REIIE4771_PD00602
RLURLEG12_09795
RTRRTCIAT899_PC06515
RHKKim5_PC00528
RHIDFFM81_025660
RLSHB780_06415
NENNCHU2750_32300
OCHCES85_3005
TRBHB776_00625 HB776_17865
BOIBLM15_17660
BOFFQV39_29835
STARG3545_15575
LNEFZC33_14685
ANCGBB76_18165
MRDMrad2831_3215
MIVC4E04_14300
PPHRAPZ00_22820
SUAMBOO69_14270
ROMEI983_16935
PARSDRW48_11250
PAEDG5B38_12490
NPPPP1Y_Mpl8030
NPNJI59_19550
SYBTZ53_01940
SBARH5V43_11085
SMICSmB9_17490
GXLH845_1614
KNAB0W47_15785
KEUS101446_00222
RMUCFOB66_03055
KHAIFJ82_11115
MDXBTO20_33700
MNED174_16745 D174_16755
MYNMyAD_16425 MyAD_16430
MVQMYVA_5926
MLLB1R94_04130
MAUUNCTC10437_01583
MTYMTOK_15560
MARZMARA_25130 MARA_35920
MANYMANY_47470
MPOFMPOR_02440
SLSSLINC_1409
SCYAEJ357_45860
SHAWCEB94_38780
SCOECP976_06705
SFEUIM697_30505
MOOBWL13_02888(srkA)
HEAHL652_07325
GLNF1C58_05995
ARHAHiyo8_pI68240
ARQBWQ92_21310
BLUTEW640_10160
AMYBBKN51_09170
BSUEBS3272_07515
 » show all
Reference
1  [PMID:4621658]
  Authors
Hiles RA, Henderson LM.
  Title
The partial purification and properties of hydroxylysine kinase from rat liver.
  Journal
J Biol Chem 247:646-51 (1972)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.81
IUBMB Enzyme Nomenclature: 2.7.1.81
ExPASy - ENZYME nomenclature database: 2.7.1.81
BRENDA, the Enzyme Database: 2.7.1.81
CAS: 9073-58-9

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