KEGG   ENZYME: 2.7.1.91Help
Entry
EC 2.7.1.91                 Enzyme                                 

Name
sphingosine kinase;
SPHK1 (gene name);
SPHK2 (gene name);
dihydrosphingosine kinase;
dihydrosphingosine kinase (phosphorylating);
sphingosine kinase (phosphorylating);
sphingoid base kinase;
sphinganine kinase;
ATP:sphinganine 1-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:sphingoid base 1-phosphotransferase
Reaction(IUBMB)
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate
Reaction(KEGG)
(other) R01926 R02976
Show
Substrate
ATP [CPD:C00002];
sphingoid base
Product
ADP [CPD:C00008];
sphingoid base 1-phosphate
Comment
The enzyme is involved in the production of sphingolipid metabolites. It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo-dihydrosphingosine. The exact substrate range depends on the species.
History
EC 2.7.1.91 created 1976, modified 1980, modified 2016
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K04718  sphingosine kinase
Genes
HSA: 56848(SPHK2) 8877(SPHK1)
PTR: 468943(SPHK2) 738821(SPHK1)
PPS: 100977890(SPHK1) 100992056(SPHK2)
GGO: 101127850(SPHK1) 101130021(SPHK2)
PON: 100172513(SPHK2) 100433232(SPHK1)
NLE: 100592000(SPHK2) 100598765(SPHK1)
MCC: 710441(SPHK1) 718088(SPHK2)
MCF: 101926057(SPHK1) 102116114(SPHK2)
CSAB: 103234983(SPHK2) 103242988(SPHK1)
RRO: 104666560(SPHK2) 104681274(SPHK1)
RBB: 108523630(SPHK2) 108537441(SPHK1)
CJC: 100387720(SPHK2) 100406587(SPHK1)
SBQ: 101029043(SPHK1) 101044895(SPHK2)
MMU: 20698(Sphk1) 56632(Sphk2)
RNO: 170897(Sphk1) 308589(Sphk2)
CGE: 100762053(Sphk1) 100774790(Sphk2)
NGI: 103732783(Sphk1) 103742305 103743619(Sphk2)
HGL: 101711606(Sphk1) 101720879(Sphk2)
CCAN: 109682695(Sphk2) 109685588(Sphk1)
OCU: 100357790(SPHK1)
TUP: 102471518(SPHK1) 102476140(SPHK2)
CFA: 483329(SPHK1) 484401(SPHK2)
AML: 100473787(SPHK1) 100479407(SPHK2)
UMR: 103657238(SPHK2) 103665951(SPHK1)
ORO: 101375807(SPHK1) 101376404(SPHK2)
FCA: 101081345(SPHK2) 101084918(SPHK1)
PTG: 102961449(SPHK2) 102966392(SPHK1)
AJU: 106987762(SPHK1) 106988651(SPHK2)
BTA: 533103(SPHK2) 618605(SPHK1)
BOM: 102284142(SPHK2) 102285123(SPHK1)
BIU: 109572468(SPHK2) 109573990(SPHK1)
PHD: 102317875(SPHK2) 102337092(SPHK1)
CHX: 102168201(SPHK1) 102184187(SPHK2)
OAS: 101105263(SPHK1) 101106964(SPHK2)
SSC: 100519210(SPHK1) 100738292(SPHK2)
CFR: 102523205(SPHK1) 102524512(SPHK2)
CDK: 105092188(SPHK1) 105102906(SPHK2)
BACU: 103003972(SPHK1) 103010420(SPHK2)
LVE: 103072023(SPHK1) 103079519(SPHK2)
OOR: 101286291(SPHK1) 101289072(SPHK2)
ECB: 100054066(SPHK2) 100058875(SPHK1)
EPZ: 103540021(SPHK2) 103541302(SPHK1)
EAI: 106830329(SPHK1) 106838247(SPHK2)
MYB: 102254173(SPHK1) 102255740(SPHK2)
MYD: 102762504(SPHK1) 102766668(SPHK2)
HAI: 109383749(SPHK1) 109391059(SPHK2)
RSS: 109452525(SPHK2) 109454675(SPHK1)
PALE: 102887299(SPHK2) 102892759(SPHK1)
LAV: 100668199(SPHK1) 100676401(SPHK2)
MDO: 100026664(SPHK1)
SHR: 100914991(SPHK1)
OAA: 100076678(SPHK1)
GGA: 427803(SPHK1)
MGP: 100539320(SPHK1)
CJO: 107322120(SPHK1)
APLA: 101798369(SPHK1)
ACYG: 106034629(SPHK1)
TGU: 100222679(SPHK1) 100227204
GFR: 102044859(SPHK1)
FAB: 101818075(SPHK1)
PHI: 102106754(SPHK1)
PMAJ: 107212638(SPHK1)
CCW: 104694392(SPHK1)
FPG: 101921272(SPHK1)
FCH: 102060119(SPHK1)
CLV: 102093489(SPHK1)
EGZ: 104125307(SPHK1)
AAM: 106486052
ASN: 102374989(SPHK2) 102385258(SPHK1)
AMJ: 102558563(SPHK1) 102566845(SPHK2)
PSS: 102454103(SPHK1)
CMY: 102935501(SPHK1) 102947921(SPHK2)
CPIC: 101949496(SPHK1) 101953391(SPHK2)
ACS: 100553167(sphk1) 100553460(sphk2)
PVT: 110081807(SPHK2) 110085912(SPHK1)
PBI: 103057563(SPHK2) 103060065(SPHK1)
GJA: 107111139(SPHK2) 107121147(SPHK1) 107125344
XLA: 108696679(sphk2.L) 108697745(sphk2.S) 495437(sphk1.L)
XTR: 100494664(sphk2) 549672(sphk1)
NPR: 108796856(SPHK1) 108804675(SPHK2)
DRE: 100150090(sphk2) 100331840(sphk1)
IPU: 108264213(sphk2) 108272828 108273191(sphk1)
TRU: 101062830 101078125(sphk2)
NCC: 104960464 104966924(sphk1)
MZE: 101473156(sphk1) 101482860(sphk2) 101483399
XMA: 102227445 102228021(sphk1) 106699615(sphk2)
PRET: 103469144 103469685(sphk1) 103478094(sphk2)
NFU: 107374236 107379707(sphk2) 107382243(sphk1)
HCQ: 109514836 109515289(sphk2) 109519880(sphk1)
BPEC: 110160669 110162977(sphk2) 110166231(sphk1)
SFM: 108925996 108940136(sphk1)
LCM: 102350955(SPHK1) 102367258(SPHK2)
CIN: 100183047
SPU: 580005
APLC: 110981818
SKO: 100377659
DME: Dmel_CG1747(Sk1) Dmel_CG32484(Sk2)
DSI: Dsimw501_GD13722(Dsim_GD13722) Dsimw501_GD17022(Dsim_GD17022)
AAG: 5570737
AME: 411349
BIM: 100746202
BTER: 100643842
SOC: 105202025
AEC: 105146244
ACEP: 105627044
PBAR: 105422757
HST: 105181133
CFO: 105251817
LHU: 105675851
PGC: 109859854
NVI: 100123187
TCA: 658654
DPA: 109534481
NVL: 108562198
BMOR: 101742466
PMAC: 106718321
PRAP: 111003444
API: 100168375
DNX: 107173358
ZNE: 110833981
TUT: 107362739
CEL: CELE_C34C6.5(sphk-1)
CBR: CBG11121(Cbr-tag-274)
CRG: 105343802
MYI: 110446543
OBI: 106875475
LAK: 106164905
SHX: MS3_09568
EGL: EGR_07693
ADF: 107345603
HMG: 100197951
ATH: AT4G21534(SPHK2) AT4G21540(SPHK1)
THJ: 104806277
CPAP: 110812605
CIT: 102626139
TCC: 18596946
DZI: 111275101
CAM: 101499291
LJA: Lj6g3v2081330.1(Lj6g3v2081330.1)
ADU: 107468660
AIP: 107623332
FVE: 101311446
PPER: 18779554
PMUM: 103324637
PAVI: 110758004
PXB: 103964944
ZJU: 107422974
CSV: 101206190
CMO: 103484546
MCHA: 111012384
CMAX: 111478387
CMOS: 111453022
CPEP: 111804471
RCU: 8289825
JCU: 105649467
HBR: 110664617
POP: 7495267
JRE: 109013735
VVI: 100248229
INI: 109158937
SIND: 105175465
BVG: 104909115
SOE: 110793434
DOSA: Os01t0782200-01(Os01g0782200)
ATS: 109731823(LOC109731823) 109751945(LOC109751945) 109764430(LOC109764430)
PDA: 103719340
ATR: 18431601
CRE: CHLREDRAFT_147241(KDG2)
APRO: F751_3234
SCE: YLR260W(LCB5) YOR171C(LCB4)
ERC: Ecym_3138
KMX: KLMA_40194(LCB5)
NCS: NCAS_0D02510(NCAS0D02510) NCAS_0F00230(NCAS0F00230)
NDI: NDAI_0I02370(NDAI0I02370) NDAI_0K02870(NDAI0K02870)
TPF: TPHA_0F02490(TPHA0F02490) TPHA_0J00530(TPHA0J00530)
TBL: TBLA_0E03180(TBLA0E03180) TBLA_0G00430(TBLA0G00430)
TDL: TDEL_0G04220(TDEL0G04220)
KAF: KAFR_0A05250(KAFR0A05250) KAFR_0G02620(KAFR0G02620)
PIC: PICST_54239(SPH1)
CAL: CAALFM_C112080WA(LCB4)
CAUR: QG37_02457
SLB: AWJ20_3638(LCB4)
NCR: NCU07937
NTE: NEUTE1DRAFT120743(NEUTE1DRAFT_120743)
MGR: MGG_05147
SSCK: SPSK_07175
MAW: MAC_09644
MAJ: MAA_00275
CMT: CCM_00739
MBE: MBM_05749
ANI: AN1176.2
ANG: ANI_1_458074(An08g03280)
ABE: ARB_02821
TVE: TRV_04958
PTE: PTT_06596
CNE: CND02910
CNB: CNBD3450
ABP: AGABI1DRAFT104558(AGABI1DRAFT_104558)
ABV: AGABI2DRAFT176573(AGABI2DRAFT_176573)
MGL: MGL_3927
DDI: DDB_G0272522(sgkA) DDB_G0284545(sgkB)
DFA: DFA_12044(sgkA)
EHI: EHI_023410(25.t00015)
SMIN: v1.2.011198.t1(symbB.v1.2.011198.t1)
AMR: AM1_1694
 » show all
Taxonomy
Reference
1  [PMID:4372149]
  Authors
Stoffel W, Heimann G, Hellenbroich B.
  Title
Sphingosine kinase in blood platelets.
  Journal
Hoppe Seylers Z Physiol Chem 354:562-6 (1973)
Reference
2  [PMID:4373374]
  Authors
Stoffel W, Bauer E, Stahl J.
  Title
The metabolism of sphingosine bases in Tetrahymena pyriformis. Sphingosine kinase and sphingosine-1-phosphate lyase.
  Journal
Hoppe Seylers Z Physiol Chem 355:61-74 (1974)
Reference
3  [PMID:9677363]
  Authors
Nagiec MM, Skrzypek M, Nagiec EE, Lester RL, Dickson RC
  Title
The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases.
  Journal
J Biol Chem 273:19437-42 (1998)
DOI:10.1074/jbc.273.31.19437
  Sequence
Reference
4  [PMID:9726979]
  Authors
Kohama T, Olivera A, Edsall L, Nagiec MM, Dickson R, Spiegel S
  Title
Molecular cloning and functional characterization of murine sphingosine kinase.
  Journal
J Biol Chem 273:23722-8 (1998)
DOI:10.1074/jbc.273.37.23722
  Sequence
[mmu:20698]
Reference
5  [PMID:10751414]
  Authors
Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S
  Title
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.
  Journal
J Biol Chem 275:19513-20 (2000)
DOI:10.1074/jbc.M002759200
  Sequence
[hsa:56848] [mmu:56632]
Reference
6  [PMID:18557834]
  Authors
Worrall D, Liang YK, Alvarez S, Holroyd GH, Spiegel S, Panagopulos M, Gray JE, Hetherington AM
  Title
Involvement of sphingosine kinase in plant cell signalling.
  Journal
Plant J 56:64-72 (2008)
DOI:10.1111/j.1365-313X.2008.03579.x
  Sequence
[ath:AT4G21540]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.91
IUBMB Enzyme Nomenclature: 2.7.1.91
ExPASy - ENZYME nomenclature database: 2.7.1.91
BRENDA, the Enzyme Database: 2.7.1.91
CAS: 50864-48-7

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