Entry
Name
kanamycin kinase;
neomycin-kanamycin phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:kanamycin 3'-O-phosphotransferase
Reaction(IUBMB)
ATP + kanamycin = ADP + kanamycin 3'-phosphate
Reaction(KEGG)
Substrate
Product
Comment
Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. An enzyme from Pseudomonas aeruginosa also acts on butirosin.
History
EC 2.7.1.95 created 1976
Orthology
K19272 aminoglycoside 3'-phosphotransferase I
K19274 aminoglycoside 3'-phosphotransferase VI
K19299 aminoglycoside 3'-phosphotransferase III
K19300 aminoglycoside 3'-phosphotransferase II
K19315 aminoglycoside 3'-phosphotransferase XV
K19543 aminoglycoside 3'-phosphotransferase
Genes
ECLE : ECNIH2_23600 ECNIH2_26045
ECLY : LI62_013010 LI62_11650
EAX : AAHF05_04465 AAHF05_11100 AAHF05_13545 AAHF05_23470 AAHF05_24430 AAHF05_24645
KPN : KPN_pKPN5p08194(aphA)
KOK : KONIH1_14625 KONIH1_30465
KIE : NCTC12125_04789(neo)
PCOL : F1325_16150(aph(3')-I)
PCIB : F9282_16450(aph(3')-VI)
STES : MG068_09120(aph(3')-II)
SPAQ : STNY_R18290(aph(3')-II)
STEO : PEM_07065(aph(3')-II)
LUE : DCD74_02565(aph(3')-XV)
PAP : PSPA7_0973(aph) PSPA7_3721
PPAA : B7D75_04095(aph(3')-II)
PGY : AWU82_21750(aph(3')-I)
PJU : L1P09_08635 L1P09_25445(aph(3')-XV)
PPHN : HU825_15885(aph(3')-II)
PCAA : V6L78_09240 V6L78_22865
SDEG : GOM96_02975(aph(3')-II)
DCE : O6P33_04430(aph(3')-XV) O6P33_04935
ABD : ABTW07_3876(aphA1b) ABTW07_3891(aphA1b)
ADV : DJ533_01225 DJ533_07430
ACUM : C9E88_015545(aph(3')-VI)
ACHI : CDG60_00305(aph(3')-VI) CDG60_00550
AVZ : HWI77_18555(aph(3')-XV)
AEA : C2U39_23255(aph(3')-II)
AES : C2U30_02870(aph(3')-I)
NBL : GJV52_09465(aph(3')-IIIa)
PHS : C2L64_52670(aph(3')-I)
BTRM : SAMEA390648702979(neo)
JLV : G3257_21175(aph(3')-I)
MFLA : GO485_08340(aph(3')-II)
DUG : HH213_14175(aph(3')-I)
BPSN : NIK97_06495(aph(3')-IId)
OCL : GTN27_09755(aph(3'))
DEVD : GHV40_10575(aph(3'))
PSTG : E8M01_04605 E8M01_04630
BND : KWG56_14220(aph(3')-XV)
NOR : FA702_16840(aph(3')-I)
SPHF : DM480_00550 DM480_17500(aph(3')-I)
SCHY : GVO57_08575(aph(3'))
SPRR : OIM94_15090 OIM94_17430
CJY : QZ67_02800(aph(3')-IIIa)
BUY : D8S85_06000(aph(3')-IIIa)
BOU : I5818_13625 I5818_13630
PBK : Back11_32840 Back11_38870(ymdC)
PDY : QJQ58_08345 QJQ58_28650
SMEN : SAMEA4412692_1588(butA) SAMEA4412692_1589(ymdC)
SACY : O6R09_03260(aph(3')-IIIa)
EFAU : EFAU085_p3013(aphA)
EFU : HMPREF0351_12797(aphA) HMPREF0351_12830(aphA2)
ERAF : J9537_20510(aph(3')-IIIa)
SMAN : C12CBH8_05220(ymdC)
PGK : M9426_08995(aph(3')-IIIa)
MCHI : AN480_06785 AN480_29000
MBAI : MB901379_04821(neo)
MAUU : NCTC10437_05419(neo)
MFLV : NCTC10271_00197(neo)
CUA : CU7111_1481(aph(3')-Ia)
CGLU : I6J20_10650 I6J20_10660
NAD : NCTC11293_05205(neo)
SRIM : CP984_09245(aph(3')-VIII)
ARL : AFL94_01545 AFL94_17275
PROU : AB1046_11390 AB1046_11405
ATQ : GH723_07245(aph(3'))
» show all
Taxonomy
Reference
Authors
Doi O, Ogura M, Tanaka N, Umezawa H.
Title
Inactivation of kanamycin, neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginoa.
Journal
Appl Microbiol 16:1276-81 (1968)
Reference
Authors
DOLIN MI.
Title
The Streptococcus faecalis oxidases for reduced diphosphopyridine nucleotide. III. Isolation and properties of a flavin peroxidase for reduced diphosphopyridine nucleotide.
Journal
J Biol Chem 225:557-73 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.95
ExPASy - ENZYME nomenclature database: 2.7.1.95