| Entry |
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| Name |
kanamycin kinase;
neomycin-kanamycin phosphotransferase
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
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| Sysname |
ATP:kanamycin 3'-O-phosphotransferase
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| Reaction(IUBMB) |
ATP + kanamycin = ADP + kanamycin 3'-phosphate
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. An enzyme from Pseudomonas aeruginosa also acts on butirosin.
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| History |
EC 2.7.1.95 created 1976
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| Orthology |
| K19272 | aminoglycoside 3'-phosphotransferase I |
| K19274 | aminoglycoside 3'-phosphotransferase VI |
| K19299 | aminoglycoside 3'-phosphotransferase III |
| K19300 | aminoglycoside 3'-phosphotransferase II |
| K19315 | aminoglycoside 3'-phosphotransferase XV |
| K19543 | aminoglycoside 3'-phosphotransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Doi O, Ogura M, Tanaka N, Umezawa H. |
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| Title |
Inactivation of kanamycin, neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginoa. |
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| Journal |
Appl Microbiol 16:1276-81 (1968) |
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| Reference |
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| Authors |
DOLIN MI. |
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| Title |
The Streptococcus faecalis oxidases for reduced diphosphopyridine nucleotide. III. Isolation and properties of a flavin peroxidase for reduced diphosphopyridine nucleotide. |
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| Journal |
J Biol Chem 225:557-73 (1957) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.1.95 |
| ExPASy - ENZYME nomenclature database: | 2.7.1.95 |
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