KEGG   ENZYME: 2.7.11.10Help
Entry
EC 2.7.11.10                Enzyme                                 

Name
IkappaB kinase;
CHUK;
IKBKA;
IKBKB;
IKK;
IKK-1;
IKK-2;
inhibitor of NFkappaB kinase;
inhibitor of NF-kappaB kinase;
STK12;
TANK-binding kinase 1;
TBK1
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[IkappaB protein] phosphotransferase
Reaction(IUBMB)
ATP + [IkappaB protein] = ADP + [IkappaB phosphoprotein]
Reaction(KEGG)
(other) R00162
Show
Substrate
ATP [CPD:C00002];
[IkappaB protein]
Product
ADP [CPD:C00008];
[IkappaB phosphoprotein]
Comment
The enzyme phosphorylates IkappaB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IkB complex (IKK) activates NF-kappaB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably.
History
EC 2.7.11.10 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha
K05410  TANK-binding kinase 1
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta
K07211  inhibitor of nuclear factor kappa-B kinase subunit epsilon
Genes
HSA: 1147(CHUK) 29110(TBK1) 3551(IKBKB) 9641(IKBKE)
PTR: 450673(CHUK) 452047(TBK1) 472749(IKBKB) 742813(IKBKE)
PPS: 100989390(IKBKB) 100990211(TBK1) 100992569(IKBKE) 100995228(CHUK)
GGO: 101125384(IKBKE) 101137405(CHUK) 101138038(TBK1) 101141659(IKBKB) 109025098
PON: 100174735(CHUK) 100433568(TBK1) 100440586(IKBKB) 100448480(IKBKE)
NLE: 100582856(TBK1) 100588081(IKBKB) 100596225(CHUK) 100605137(IKBKE)
MCC: 695607(IKBKE) 704683(IKBKB) 709511(CHUK) 717427(TBK1)
MCF: 102115964(CHUK) 102126428(IKBKE) 102144774(TBK1) 102146604(IKBKB)
CSAB: 103215686(IKBKB) 103216382(CHUK) 103230198(IKBKE) 103238638(TBK1)
RRO: 104656469(CHUK) 104661734(IKBKE) 104666046(IKBKB) 104680828(TBK1)
RBB: 108529966(TBK1) 108535077(CHUK) 108535149(IKBKE) 108540719(IKBKB)
CJC: 100392518(IKBKE) 100393096(IKBKB) 100399701(TBK1)
SBQ: 101027871(IKBKE) 101044006(CHUK) 101052971(IKBKB) 101053608(TBK1)
MMU: 12675(Chuk) 16150(Ikbkb) 56480(Tbk1) 56489(Ikbke)
RNO: 299827(Tbk1) 309361(Chuk) 363984(Ikbke) 84351(Ikbkb)
CGE: 100750488(Ikbkb) 100754432(Chuk) 100761646(Ikbke) 100770091(Tbk1)
NGI: 103725939(Ikbke) 103726621(Ikbkb) 103730726(Tbk1) 103743976(Chuk)
HGL: 101697947(Ikbke) 101711077(Ikbkb) 101713766(Tbk1) 101719306(Chuk)
CCAN: 109681514(Chuk) 109696400(Ikbkb) 109697216(Ikbke) 109698137(Tbk1)
OCU: 100354455(IKBKE) 100355888(CHUK) 100356401(IKBKB) 100358771(TBK1)
TUP: 102467954(IKBKB) 102481203(IKBKE) 102484078(TBK1) 102501308(CHUK)
CFA: 477796(CHUK) 478950(IKBKE) 481145(TBK1) 482839(IKBKB)
AML: 100464675(CHUK) 100465112(IKBKE) 100471679(IKBKB) 100484104(TBK1)
UMR: 103656833(TBK1) 103658916(CHUK) 103671004(IKBKE) 103677059(IKBKB)
ORO: 101362394(TBK1) 101364103(CHUK) 101366827(IKBKE) 101375346(IKBKB)
FCA: 100142682(IKBKB) 101086282(IKBKE) 101091955(TBK1) 101095617(CHUK)
PTG: 102949289(CHUK) 102960158(TBK1) 102963614(IKBKE) 102963734(IKBKB)
AJU: 106966935(CHUK) 106972924(IKBKE) 106981360(TBK1) 106990012(IKBKB)
BTA: 281073(CHUK) 281854(IKBKB) 533141(TBK1) 533216(IKBKE)
BOM: 102271506(IKBKE) 102279479(TBK1) 102281443(IKBKB) 102281886(CHUK)
BIU: 109553086(CHUK) 109553353(IKBKB) 109559273(TBK1) 109570721(IKBKE)
PHD: 102330768(IKBKE) 102332461(CHUK) 102337166(IKBKB) 102341504(TBK1)
CHX: 102177406(IKBKB) 102181262(CHUK) 102181474(TBK1) 102183809(IKBKE)
OAS: 101110830(TBK1) 101111143(CHUK) 101116923(IKBKE) 780484(IKBKB)
SSC: 100101471(IKBKB) 100125828(TBK1) 100135662(CHUK) 100519508(IKBKE)
CFR: 102503497(CHUK) 102508142(IKBKB) 102514948(TBK1) 102519234(IKBKE)
CDK: 105084316(CHUK) 105086448(IKBKB) 105089261(TBK1) 105098613(IKBKE)
BACU: 103013353(TBK1) 103013616(IKBKE) 103015119(IKBKB) 103015414(CHUK)
LVE: 103080924(IKBKE) 103081814(TBK1) 103085220(CHUK) 103088633(IKBKB)
OOR: 101273673(IKBKE) 101281072(CHUK) 101285763(IKBKB) 101290315(TBK1)
ECB: 100050167(IKBKB) 100051650(TBK1) 100055384(IKBKE) 100070393(CHUK)
EPZ: 103553835(IKBKE) 103557811(TBK1) 103562903(IKBKB) 103567228(CHUK)
EAI: 106823378(IKBKE) 106824389(TBK1) 106828957(IKBKB) 106846705(CHUK)
MYB: 102241250(TBK1) 102248515(IKBKE) 102261405(IKBKB) 102261467(CHUK)
MYD: 102760291(IKBKE) 102760888(CHUK) 102769631(TBK1) 102773824(IKBKB)
HAI: 109379632(CHUK) 109381695(TBK1) 109386279(IKBKB) 109386512(IKBKE)
RSS: 109443941(CHUK) 109447771(TBK1) 109452845(IKBKB) 109458660(IKBKE)
PALE: 102878859(TBK1) 102879469(CHUK) 102889768(IKBKE) 102893261(IKBKB)
LAV: 100657363(IKBKB) 100661026(TBK1) 100663886(IKBKE) 100664361(CHUK)
MDO: 100019578(IKBKE) 100027952(CHUK) 100033031(IKBKB)
SHR: 100913624(CHUK) 100915362(TBK1) 100928932(IKBKB) 100934784(IKBKE)
OAA: 100076520(TBK1) 100077063(IKBKE) 100078925(IKBKB) 100082351(CHUK)
GGA: 417825(TBK1) 423669(CHUK) 426792(IKBKB) 430480(IKBKE)
MGP: 100542478(CHUK) 100542558(IKBKB) 100542773(TBK1) 100548215(IKBKE)
CJO: 107310131(TBK1) 107315625(CHUK) 107323740(IKBKB) 107324928(IKBKE)
APLA: 101790255(IKBKB) 101800085(TBK1) 101800153(IKBKE) 101801064(CHUK)
ACYG: 106030064(CHUK) 106041301(IKBKE) 106044397(IKBKB) 106047239(TBK1)
TGU: 100221281(CHUK) 100224042 100225072(IKBKB) 100225715(TBK1) 100228860(IKBKE)
GFR: 102035648(IKBKB) 102042264(CHUK) 102043917(IKBKE) 102044344(TBK1)
FAB: 101809300(TBK1) 101809821(IKBKB) 101812706(CHUK) 101814828(IKBKE)
PHI: 102100562(IKBKB) 102105384(IKBKE) 102107801(CHUK) 102112102(TBK1)
PMAJ: 107204371(TBK1) 107206726(CHUK) 107213912(IKBKB) 107214767(IKBKE)
CCW: 104692514(IKBKE) 104694916(IKBKB) 104695067(CHUK) 104698356(TBK1)
FPG: 101911068(TBK1) 101911668(IKBKE) 101914413(CHUK) 101922064(IKBKB)
FCH: 102050482(IKBKE) 102051211(TBK1) 102053491(CHUK) 102058892(IKBKB)
CLV: 102084658(CHUK) 102085310(TBK1) 102087238(IKBKB) 102088357(IKBKE)
EGZ: 104122201(TBK1) 104125140(CHUK) 104134342(IKBKE) 104135306(IKBKB)
AAM: 106482786(IKBKE) 106487776(IKBKB) 106488940(TBK1) 106495295(CHUK)
ASN: 102372815(IKBKE) 102374729(CHUK) 102377560(IKBKB) 102383892(TBK1)
AMJ: 102560016(IKBKE) 102561936(IKBKB) 106736873(CHUK) 106737001(TBK1)
PSS: 102454064(CHUK) 102454676(IKBKB) 102457979(TBK1) 102464043(IKBKE)
CMY: 102930512(IKBKE) 102932073(IKBKB) 102932800(CHUK) 102938424(TBK1)
CPIC: 101931080(CHUK) 101934458(IKBKE) 101945515(IKBKB) 101947523(TBK1)
ACS: 100551699(ikbkb) 100553575(tbk1) 100562496(ikbke) 100565922(chuk)
PVT: 110072148(IKBKB) 110075119(TBK1) 110087236(CHUK) 110088412(IKBKE)
PBI: 103049737(TBK1) 103052688(IKBKB) 103055936(IKBKE) 103061898(CHUK)
GJA: 107107812(IKBKB) 107110994(TBK1) 107115324(IKBKE) 107117758(CHUK)
XLA: 108709484(ikbke.S) 108712371(tbk1.S) 432200(ikbkb.L) 444556(chuk.S) 446351(tbk1.L) 734896(ikbke.L)
XTR: 100216212(tbk1) 100487744(ikbke) 101732839 448125(ikbkb) 549654(chuk)
NPR: 108791446(IKBKB) 108797654(CHUK) 108804572(TBK1)
DRE: 393287(chuk) 437024(ikbke) 563560(ikbkb) 692289(tbk1)
IPU: 108255225(ikbke) 108263650(chuk) 108265675(ikbkb) 108279669(tbk1)
AMEX: 103023014(tbk1) 103033415(chuk) 103040024(ikbkb) 103047687(ikbke)
MZE: 101472803(ikbkb) 101472997(ikbke) 101474803(tbk1) 101486267 101487089
OLA: 101159621 101168192(tbk1) 101168283(ikbke) 101170684(ikbkb) 101171857
PRET: 103459804(tbk1) 103464875(ikbke) 103470025(ikbkb) 103476976 103481753
NFU: 107375593 107385596(ikbke) 107387313(chuk) 107387745(tbk1) 107394259(ikbkb) 107396601
CSEM: 103382474(tbk1) 103386082(ikbke) 103387400 103397763(ikbkb) 103398848
LCF: 108881598(ikbkb) 108882406(tbk1) 108890009(ikbke) 108891107 108892003
SFM: 108920198(ikbkb) 108931981(tbk1) 108933554(chuk) 108938249(ikbke)
LCM: 102349717 102356087(TBK1) 102358966(IKBKB) 102361819(CHUK) 102364129(IKBKE)
CMK: 103172650 103179820(tbk1) 103181859(chuk)
CIN: 778650(ikk-epsilon) 778921(ikk-alpha/beta) 780713(ikk-epsilon)
SPU: 579073
DME: Dmel_CG2615(IKKepsilon) Dmel_CG4201(IKKbeta)
DSI: Dsimw501_GD20310(Dsim_ird5) Dsimw501_GD24274(Dsim_GD24274)
DYA: Dyak_GE12340 Dyak_GE26340(Dyak_ird5)
AME: 413493(Mik2) 726760(GB18611)
PBAR: 105426672
TCA: 100141977 655324 658218(ik2) 658393(ikkb)
API: 100168269
DNX: 107165510
TUT: 107368313
BMY: Bm1_21030
AQU: 100636688
 » show all
Taxonomy
Reference
1  [PMID:9244310]
  Authors
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M.
  Title
Identification and characterization of an IkappaB kinase.
  Journal
Cell 90:373-83 (1997)
DOI:10.1016/S0092-8674(00)80344-X
  Sequence
[hsa:1147]
Reference
2  [PMID:9346484]
  Authors
Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, Young DB, Barbosa M, Mann M, Manning A, Rao A.
  Title
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.
  Journal
Science 278:860-6 (1997)
DOI:10.1126/science.278.5339.860
  Sequence
[hsa:1147 3551]
Reference
3  [PMID:9346241]
  Authors
Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M.
  Title
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.
  Journal
Cell 91:243-52 (1997)
DOI:10.1016/S0092-8674(00)80406-7
Reference
4  [PMID:15653325]
  Authors
Viatour P, Merville MP, Bours V, Chariot A.
  Title
Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation.
  Journal
Trends Biochem Sci 30:43-52 (2005)
DOI:10.1016/j.tibs.2004.11.009
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.10
IUBMB Enzyme Nomenclature: 2.7.11.10
ExPASy - ENZYME nomenclature database: 2.7.11.10
BRENDA, the Enzyme Database: 2.7.11.10

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