KEGG   ENZYME: 2.7.11.10
Entry
EC 2.7.11.10                Enzyme                                 
Name
IkappaB kinase;
CHUK;
IKBKA;
IKBKB;
IKK;
IKK-1;
IKK-2;
inhibitor of NFkappaB kinase;
inhibitor of NF-kappaB kinase;
STK12;
TANK-binding kinase 1;
TBK1
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:[IkappaB protein] phosphotransferase
Reaction(IUBMB)
ATP + [IkappaB protein] = ADP + [IkappaB phosphoprotein]
Reaction(KEGG)
(other) R00162
Substrate
ATP [CPD:C00002];
[IkappaB protein]
Product
ADP [CPD:C00008];
[IkappaB phosphoprotein]
Comment
The enzyme phosphorylates IkappaB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IkB complex (IKK) activates NF-kappaB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably.
History
EC 2.7.11.10 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha
K05410  TANK-binding kinase 1
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta
K07211  inhibitor of nuclear factor kappa-B kinase subunit epsilon
Genes
HSA1147(CHUK) 29110(TBK1) 3551(IKBKB) 9641(IKBKE)
PTR450673(CHUK) 452047(TBK1) 472749(IKBKB) 742813(IKBKE)
PPS100989390(IKBKB) 100990211(TBK1) 100992569(IKBKE) 100995228(CHUK)
GGO101125384(IKBKE) 101137405(CHUK) 101138038(TBK1) 101141659(IKBKB)
PON100174735(CHUK) 100433568(TBK1) 100440586(IKBKB) 100448480(IKBKE)
NLE100582856(TBK1) 100588081(IKBKB) 100596225(CHUK) 100605137(IKBKE)
MCC695607(IKBKE) 704683(IKBKB) 709511(CHUK) 717427(TBK1)
MCF102115964(CHUK) 102126428(IKBKE) 102144774(TBK1) 102146604(IKBKB)
CSAB103215686(IKBKB) 103216382(CHUK) 103230198(IKBKE) 103238638(TBK1)
CATY105576636(IKBKE) 105581830(CHUK) 105595759(IKBKB) 105600541(TBK1)
PANU100998877(CHUK) 100999858(TBK1) 101001355(IKBKE) 101016447(IKBKB)
TGE112606745(IKBKE) 112629970(IKBKB) 112632013(CHUK) 112635245(TBK1)
RRO104656469(CHUK) 104661734(IKBKE) 104666046(IKBKB) 104680828(TBK1)
RBB108529966(TBK1) 108535077(CHUK) 108535149(IKBKE) 108540719(IKBKB)
TFN117068535(CHUK) 117074249(IKBKE) 117089816(TBK1) 117095630(IKBKB)
PTEH111522719(IKBKE) 111538794(CHUK) 111539247 111544093(IKBKB) 111551230(TBK1)
CJC100392518(IKBKE) 100393096(IKBKB) 100399701(TBK1)
SBQ101027871(IKBKE) 101044006(CHUK) 101052971(IKBKB) 101053608(TBK1)
CSYR103256847(IKBKB) 103257998(IKBKE) 103263189(CHUK) 103271912(TBK1)
MMUR105867131 105868963(IKBKE) 105873508(CHUK) 105878144(IKBKB) 105880966(TBK1)
OGA100940759(TBK1) 100941040(IKBKE) 100946157(IKBKB) 100949554(CHUK)
MMU12675(Chuk) 16150(Ikbkb) 56480(Tbk1) 56489(Ikbke)
MCAL110285285(Chuk) 110300158(Ikbkb) 110301565(Ikbke) 110303265(Tbk1)
MPAH110321718(Ikbke) 110326206(Tbk1) 110334538(Chuk) 110336182(Ikbkb)
RNO299827(Tbk1) 309361(Chuk) 363984(Ikbke) 84351(Ikbkb)
MCOC116069014(Ikbkb) 116076589(Tbk1) 116098877(Ikbke) 116103881(Chuk)
MUN110549049(Tbk1) 110550327(Ikbke) 110552966(Chuk) 110556613(Ikbkb)
CGE100750488(Ikbkb) 100754432(Chuk) 100761646(Ikbke) 100770091
PLEU114693293(Tbk1) 114698057(Ikbke) 114705738(Ikbkb) 114706431(Chuk)
NGI103725939(Ikbke) 103726621(Ikbkb) 103730726(Tbk1) 103743976(Chuk)
HGL101697947(Ikbke) 101711077(Ikbkb) 101713766(Tbk1) 101719306(Chuk)
CPOC100716187(Ikbke) 100724538(Ikbkb) 100726357(Chuk) 100731956(Tbk1)
CCAN109681514(Chuk) 109696400(Ikbkb) 109697216(Ikbke) 109698137(Tbk1)
DORD105986544(Ikbke) 105986731(Chuk) 105989073(Tbk1) 105991714(Ikbkb)
DSP122107663(Ikbkb) 122109675(Ikbke) 122115917(Chuk) 122124190(Tbk1)
OCU100354455(IKBKE) 100355888(CHUK) 100356401(IKBKB) 100358771(TBK1)
OPI101517015(IKBKB) 101524697(TBK1) 101529588(IKBKE) 101536073(CHUK)
TUP102467954(IKBKB) 102481203(IKBKE) 102484078(TBK1) 102501308(CHUK)
CFA477796(CHUK) 478950(IKBKE) 481145(TBK1) 482839(IKBKB)
VVP112914364(IKBKE) 112914804(CHUK) 112916156(IKBKB) 112922304(TBK1)
VLG121484113(CHUK) 121489510(IKBKB) 121491543(TBK1) 121501599(IKBKE)
AML100464675(CHUK) 100465112(IKBKE) 100471679(IKBKB) 100484104(TBK1)
UMR103656833(TBK1) 103658916(CHUK) 103671004(IKBKE) 103677059(IKBKB)
UAH113242466(IKBKE) 113245546(IKBKB) 113251823(CHUK) 113256330(TBK1)
UAR123780295(IKBKB) 123785662(IKBKE) 123787173(TBK1) 123795860(CHUK)
ELK111142106 111144397 111144921 111151174
LLV125084339 125085960 125094028 125106807
MPUF101676992(TBK1) 101680658(CHUK) 101686932(IKBKB) 101689805(IKBKE)
ORO101362394(TBK1) 101364103(CHUK) 101366827(IKBKE) 101375346(IKBKB)
EJU114205217(CHUK) 114214962(TBK1) 114221921(IKBKE) 114224851(IKBKB)
ZCA113921986(TBK1) 113923411(CHUK) 113924180(IKBKB) 113932728(IKBKE)
MLX118008624(TBK1) 118009921(IKBKB) 118014127(IKBKE) 118024839(CHUK)
FCA100142682(IKBKB) 101086282(IKBKE) 101091955(TBK1) 101095617(CHUK)
PYU121012848(IKBKB) 121021584(IKBKE) 121037105(CHUK) 121040822(TBK1)
PBG122472994(IKBKB) 122473944(TBK1) 122476520(IKBKE) 122493134(CHUK)
PTG102949289(CHUK) 102960158(TBK1) 102963614(IKBKE) 102963734(IKBKB)
PPAD109257640(IKBKE) 109262264(IKBKB) 109270431(TBK1) 109272766(CHUK)
AJU106966935(CHUK) 106972924(IKBKE) 106981360(TBK1) 106990012(IKBKB)
HHV120228866(IKBKE) 120233179(TBK1) 120233999(IKBKB) 120243217(CHUK)
BTA281073(CHUK) 281854(IKBKB) 533141(TBK1) 533216(IKBKE)
BOM102271506(IKBKE) 102279479(TBK1) 102281443(IKBKB) 102281886(CHUK)
BIU109553086(CHUK) 109553353(IKBKB) 109559273(TBK1) 109570721(IKBKE)
BBUB102398659(IKBKE) 102398886(IKBKB) 102399613(CHUK) 102403644(TBK1)
CHX102177406(IKBKB) 102181262(CHUK) 102181474(TBK1) 102183809(IKBKE)
OAS101110830(TBK1) 101111143(CHUK) 101116923(IKBKE) 780484(IKBKB)
ODA120857688(TBK1) 120865846(IKBKB) 120873530(CHUK) 120879941(IKBKE)
CCAD122427358(TBK1) 122432633(IKBKB) 122446045(CHUK) 122451810(IKBKE)
SSC100101471(IKBKB) 100125828(TBK1) 100135662(CHUK) 100519508(IKBKE)
CFR102503497(CHUK) 102508142(IKBKB) 102514948(TBK1) 102519234(IKBKE)
CBAI105071245(IKBKB) 105075432(IKBKE) 105081359(TBK1) 105081887(CHUK)
CDK105084316(CHUK) 105086448(IKBKB) 105089261(TBK1) 105098613(IKBKE)
VPC102528824(IKBKB) 102530199(TBK1) 102534431(CHUK) 102539212(IKBKE)
BACU103013353(TBK1) 103013616(IKBKE) 103015119(IKBKB) 103015414(CHUK)
LVE103080924(IKBKE) 103081814(TBK1) 103085220(CHUK) 103088633(IKBKB)
OOR101273673(IKBKE) 101281072(CHUK) 101285763(IKBKB) 101290315(TBK1)
DLE111172396(CHUK) 111173552(IKBKB) 111173795(TBK1) 111184753(IKBKE)
PCAD102976706(IKBKB) 102977668(CHUK) 102994478(IKBKE) 102994775(TBK1)
PSIU116741676(CHUK) 116743242(IKBKE) 116746707(IKBKB) 116760755(TBK1)
ECB100050167(IKBKB) 100051650(TBK1) 100055384(IKBKE) 100070393(CHUK)
EPZ103553835(IKBKE) 103557811(TBK1) 103562903(IKBKB) 103567228(CHUK)
EAI106823378(IKBKE) 106824389(TBK1) 106828957(IKBKB) 106846705(CHUK)
MYB102241250(TBK1) 102248515(IKBKE) 102261405(IKBKB) 102261467(CHUK)
MYD102760291(IKBKE) 102760888(CHUK) 102769631(TBK1) 102773824(IKBKB)
MMYO118650776(IKBKB) 118651925(TBK1) 118669852(CHUK) 118672786(IKBKE)
MLF102417312(IKBKB) 102424113(TBK1) 102425603(CHUK) 102441851(IKBKE)
MNA107523913(IKBKB) 107527094(TBK1) 107538891(IKBKE) 107542599(CHUK)
PKL118719404(CHUK) 118721500(IKBKE) 118728482(IKBKB) 118730716(TBK1)
HAI109379632(CHUK) 109381695(TBK1) 109386279(IKBKB) 109386512(IKBKE)
DRO112300474(CHUK) 112318201(IKBKE) 112319039(TBK1) 112321547(IKBKB)
SHON118993207(IKBKB) 118998723(TBK1) 118999523(CHUK) 119001656(IKBKE)
AJM119045546(TBK1) 119047140(IKBKB) 119056820(IKBKE) 119064546(CHUK)
PDIC114496345(CHUK) 114508493(IKBKB) 114512155(IKBKE) 114513223(TBK1)
PHAS123807522(IKBKB) 123812878(TBK1) 123820660(IKBKE) 123828668(CHUK)
MMF118622317(IKBKB) 118624185(TBK1) 118632312(CHUK) 118637482(IKBKE)
RFQ117014466(IKBKE) 117021384(IKBKB) 117028150(TBK1) 117036177(CHUK)
PALE102878859(TBK1) 102879469(CHUK) 102889768(IKBKE) 102893261(IKBKB)
PGIG120595665(IKBKB) 120605013(TBK1) 120609204(CHUK) 120617936(IKBKE)
PVP105300734(IKBKE) 105301022(IKBKB) 105301118(TBK1) 105304619(CHUK)
RAY107499756(CHUK) 107501353(IKBKB) 107502229(IKBKE) 107508222(TBK1)
MJV108390202(IKBKE) 108399262(TBK1) 108399795(IKBKB) 108409586(CHUK)
TOD119233588(CHUK) 119234149(IKBKE) 119248120(TBK1) 119257853(IKBKB)
SARA101538389(CHUK) 101540472(IKBKB) 101542553(TBK1) 101552901(IKBKE)
LAV100657363(IKBKB) 100661026(TBK1) 100663886(IKBKE) 100664361(CHUK)
TMU101341290 101344779 101345902 101351256
DNM101411204(IKBKB) 101413159(IKBKE) 101429772(CHUK) 101429820(TBK1)
MDO100019578(IKBKE) 100027952(CHUK) 100033031(IKBKB)
GAS123233417(IKBKB) 123236476(CHUK) 123244187(IKBKE) 123250320(TBK1)
SHR100913624(CHUK) 100915362(TBK1) 100928932(IKBKB) 100934784(IKBKE)
PCW110196387(IKBKB) 110211020(TBK1) 110213919(CHUK) 110219596(IKBKE)
OAA100076520(TBK1) 100077063(IKBKE) 100078925(IKBKB) 100082351(CHUK)
GGA417825(TBK1) 423669(CHUK) 426792(IKBKB) 430480(IKBKE)
PCOC116226617(TBK1) 116234507(IKBKB) 116234780(CHUK) 116236999(IKBKE)
MGP100542478(CHUK) 100542558(IKBKB) 100542773(TBK1) 100548215(IKBKE)
CJO107310131(TBK1) 107315625(CHUK) 107323740(IKBKB) 107324928(IKBKE)
NMEL110387184(IKBKB) 110388051(IKBKE) 110390496(CHUK) 110392745(TBK1)
APLA101790255(IKBKB) 101800085(TBK1) 101800153(IKBKE)
ACYG106030064(CHUK) 106041301(IKBKE) 106044397(IKBKB) 106047239(TBK1)
AFUL116491240(CHUK) 116498781(IKBKE) 116499350(IKBKB) 116501853(TBK1)
TGU100221281(CHUK) 100225072(IKBKB) 100225715(TBK1) 100228860(IKBKE) 116807244
LSR110473091(IKBKE) 110473406(IKBKB) 110474031(CHUK) 110479843(TBK1)
SCAN103814234(CHUK) 103820400(TBK1) 103822391(IKBKE) 103822735(IKBKB)
PMOA120497659(IKBKE) 120499710(CHUK) 120499842(TBK1) 120504880(IKBKB)
OTC121336198(CHUK) 121339472(TBK1) 121345534(IKBKE) 121346776(IKBKB)
PRUF121349785(IKBKE) 121352548(TBK1) 121358096(CHUK) 121359273(IKBKB)
GFR102035648(IKBKB) 102042264(CHUK) 102043917(IKBKE) 102044344(TBK1)
FAB101809300(TBK1) 101809821(IKBKB) 101812706(CHUK) 101814828(IKBKE)
PHI102100562(IKBKB) 102105384(IKBKE) 102107801(CHUK) 102112102(TBK1)
PMAJ107204371(TBK1) 107206726(CHUK) 107213912(IKBKB) 107214767(IKBKE)
CCAE111932465(TBK1) 111938770(IKBKB) 111939780(IKBKE)
CCW104692514(IKBKE) 104694916(IKBKB) 104695067(CHUK) 104698356(TBK1)
ETL114059395(TBK1) 114063148(IKBKE) 114066442(IKBKB) 114067570(CHUK)
ZAB102060602(TBK1) 102073615(IKBKB) 102074629(CHUK)
FPG101911068(TBK1) 101911668(IKBKE) 101922064(IKBKB)
FCH102050482(IKBKE) 102051211(TBK1) 102053491(CHUK) 102058892(IKBKB)
CLV102084658(CHUK) 102085310(TBK1) 102087238(IKBKB) 102088357(IKBKE)
EGZ104122201(TBK1) 104125140(CHUK) 104134342(IKBKE) 104135306(IKBKB)
NNI104011019(TBK1) 104013118(IKBKE) 104016028(IKBKB)
ACUN113481883(CHUK) 113488090(IKBKB) 113488792(IKBKE) 113491384(TBK1)
TALA104360558(IKBKB) 104362697(TBK1) 104364060(CHUK) 116965580(IKBKE)
PADL103919787(IKBKE) 103919972(TBK1) 103920554(IKBKB) 103924297(CHUK)
ACHC115335388(IKBKE) 115336293(TBK1) 115348471(CHUK) 115350500(IKBKB)
AAM106482786(IKBKE) 106487776(IKBKB) 106488940(TBK1) 106495295(CHUK)
AROW112962239(CHUK) 112968150(TBK1) 112971687(IKBKE) 112974186(IKBKB) 112977217
NPD112944634(IKBKE) 112948431(CHUK) 112953853(IKBKB) 112958829(TBK1)
DNE112978730(TBK1) 112981613 112990380(IKBKE) 112990458(IKBKB)
ASN102372815(IKBKE) 102374729(CHUK) 102377560(IKBKB) 102383892(TBK1)
AMJ102560016(IKBKE) 102561936(IKBKB) 106736873(CHUK) 106737001(TBK1)
CPOO109315543(TBK1) 109317391(IKBKB) 109317718(IKBKE) 109318435(CHUK)
GGN109293915(CHUK) 109295258(IKBKE) 109295691(TBK1)
PSS102454064(CHUK) 102454676(IKBKB) 102457979(TBK1) 102464043(IKBKE)
CMY102930512(IKBKE) 102932073(IKBKB) 102932800(CHUK) 102938424(TBK1)
CPIC101931080(CHUK) 101934458(IKBKE) 101945515(IKBKB) 101947523(TBK1)
TST117873054(IKBKB) 117875769(IKBKE) 117877447(TBK1) 117879818(CHUK)
CABI116819035(IKBKB) 116821811(TBK1) 116832079(IKBKE) 116834403(CHUK)
MRV120368653(CHUK) 120383914(TBK1) 120397038(IKBKB) 120403394(IKBKE)
ACS100551699(ikbkb) 100553575(tbk1) 100562496(ikbke) 100565922(chuk)
PVT110072148(IKBKB) 110075119(TBK1) 110087236(CHUK) 110088412(IKBKE)
SUND121925441(CHUK) 121928472(IKBKE) 121931127(TBK1) 121933447(IKBKB)
PBI103049737(TBK1) 103052688(IKBKB) 103055936(IKBKE) 103061898(CHUK)
PMUR107287960(IKBKB) 107291445(CHUK) 107291767(TBK1) 114923654
TSR106548060(TBK1) 106548462(CHUK) 106550867
PGUT117655703(TBK1) 117667309(CHUK) 117676049(IKBKB)
VKO123018301(CHUK) 123019877(TBK1) 123027007(IKBKB) 123031375(IKBKE)
PMUA114596983(CHUK) 114599921(IKBKE) 114602842(IKBKB) 114605270(TBK1)
ZVI118085966(IKBKB) 118088913(IKBKE) 118091139(TBK1) 118096210(CHUK)
GJA107107812(IKBKB) 107110994(TBK1) 107115324(IKBKE) 107117758(CHUK)
XLA108709484(ikbke.S) 108712371(tbk1.S) 432200(ikbkb.L) 444556(chuk.S) 446351(tbk1.L) 734896(ikbke.L)
XTR100216212(tbk1) 100487744(ikbke) 448125(ikbkb) 549654(chuk)
NPR108791446(IKBKB) 108797654(CHUK) 108804572(TBK1)
RTEM120909050(CHUK) 120932004(TBK1) 120933164(IKBKB)
BBUF120980341(TBK1) 120986314(IKBKB) 120995009(IKBKE) 121003342(CHUK)
BGAR122927292(IKBKB) 122928028(TBK1) 122933455(IKBKE) 122939970(CHUK)
DRE393287(chuk) 437024(ikbke) 563560(ikbkb) 692289(tbk1)
SRX107707971 107710078 107722850 107726965 107728638 107739275 107743510 107754415
SANH107655432(chuk) 107655948 107658761(tbk1) 107662237 107666359 107671012 107675825(ikbke)
SGH107555619 107559325 107559596(ikbkb) 107561249 107568716 107590150 107601877
CCAR109074335(tbk1) 109087965 109092137 109095150(ikbkb) 109100658(chuk)
CAUA113048480 113052773 113056969 113064824 113106968 113111232(ikbke) 113112701
IPU108255225(ikbke) 108263650(chuk) 108265675(ikbkb) 108279669(tbk1)
PHYP113532072(tbk1) 113533569(ikbkb) 113539673(ikbke) 113542836(chuk)
SMEO124396202(chuk) 124400022(ikbkb) 124401336(tbk1) 124402582(ikbke)
AMEX103023014(tbk1) 103033415(chuk) 103040024(ikbkb) 103047687(ikbke)
EEE113579176 113582078(chuk) 113584916(ikbkb) 113586262(tbk1)
TRU101062431(ikbkb) 101068225 101069880 101071013(tbk1) 101074146(ikbke)
TNGGSTEN00005064G001 GSTEN00014007G001 GSTEN00022283G001 GSTEN00029571G001 GSTEN00030651G001
LCO104921662(ikbkb) 104925246(ikbke) 104928982 104930409 104933406(tbk1)
NCC104956687(ikbkb) 104959970(ikbke) 104960684 104961343
CGOB115008674(ikbke) 115013798(ikbkb) 115019941 115024640
ELY117247242 117247863 117249427(tbk1) 117252591(ikbkb) 117256447(ikbke)
PLEP121944151(ikbkb) 121953671(ikbke) 121954423 121958640 121961280(tbk1)
SLUC116034681(tbk1) 116053123 116054000(ikbkb) 116060936 116066925(ikbke)
ECRA117936511 117943776(ikbke) 117945478(ikbkb) 117960217
PFLV114548159 114550466(tbk1) 114554004(ikbke) 114555052(ikbkb) 114571888
GAT120817720(tbk1) 120819606 120820624 120830767(ikbkb) 120834558(ikbke)
PPUG119210711(tbk1) 119213096 119214000 119224939(ikbkb) 119229939(ikbke)
MSAM119886536(ikbke) 119891193(ikbkb) 119895285(tbk1) 119915458 119917364
CUD121505465(tbk1) 121507196(ikbke) 121510304(ikbkb) 121511183 121528381
MZE101472803(ikbkb) 101472997(ikbke) 101474803(tbk1) 101486267 101487089
ONL100692869 100695544(ikbke) 100698072(ikbkb) 100698148 100711888(tbk1)
OAU116311015(ikbkb) 116321245 116321846(tbk1) 116322782 116326446(ikbke)
OLA101159621 101168192(tbk1) 101168283(ikbke) 101170684(ikbkb) 101171857
OML112145751(ikbke) 112148770(ikbkb) 112154264(chuk) 112157575(tbk1) 112162018
XMA102221657 102223773(ikbkb) 102226088 102227107(tbk1) 102228722
XCO114135317 114138537 114151890 114154613(ikbkb) 114160765(tbk1)
XHE116710100 116713354 116727210 116729844(ikbkb) 116737134(tbk1)
PRET103459804(tbk1) 103464875(ikbke) 103470025(ikbkb) 103476976 103481753
PFOR103129555(tbk1) 103134044 103144323(ikbke) 103145827(ikbkb) 103152473
PLAI106939540 106944810 106956804(ikbkb) 106958353(ikbke) 106960919
PMEI106915153 106915993 106917087(tbk1) 106921755(ikbkb) 106933981(ikbke)
GAF122823466 122826476(ikbkb) 122826758(tbk1) 122834259(ikbke) 122842298
CVG107083313(ikbke) 107086576 107089566 107089660(ikbkb) 107092989(tbk1)
CTUL119778144(ikbkb) 119782488 119790587(tbk1) 119790655 119791731(ikbke)
GMU124857427(ikbke) 124858595 124875252 124877211(ikbkb) 124883140(tbk1)
NFU107375593 107385596(ikbke) 107387313(chuk) 107387745(tbk1) 107394259(ikbkb)
KMR108229325(tbk1) 108233707(ikbkb) 108234021 108235567(ikbke) 108250658
ALIM106513309(ikbke) 106521989(chuk) 106529896 106533626 106536414(ikbkb)
NWH119411945(ikbke) 119413028(ikbkb) 119418051 119424196 119427971(tbk1)
AOCE111566565(ikbke) 111567460 111576738(tbk1) 111577292(ikbkb) 111581409
CSEM103382474(tbk1) 103386082(ikbke) 103387400 103397763(ikbkb) 103398848
POV109629542 109637101(ikbkb) 109643466 109644018 109645317(tbk1)
SSEN122759323 122766945(tbk1) 122768639(ikbke) 122768945(ikbkb) 122782266
HHIP117753178 117762055(ikbke) 117767714(ikbkb) 117775975
LCF108881598(ikbkb) 108882406(tbk1) 108890009(ikbke) 108891107 108892003
SDU111220255 111221468(ikbke) 111229518(tbk1) 111234378 111236497(ikbkb)
SLAL111655428 111658207 111665990(ikbkb) 111667666(ikbke) 111671054(tbk1)
XGL120783001(ikbke) 120794257 120796054 120800421(tbk1) 120805086(ikbkb)
HCQ109516272 109518553 109522194 109525796 109532591(tbk1)
BPEC110154188 110155462(ikbkb) 110156014 110157171 110161450(tbk1)
MALB109956286 109956664(ikbkb) 109961044 109962729(kctd2) 109967667(tbk1)
SASA100861582(tbk1) 106565715 106579286 106579422 106580426(ikbkb) 106589264
OTW112223622 112223895 112224128 112240934 112242097 112244673(ikbke) 112263933(ikbkb)
OMY110491527 110491813 110493262(ikbke) 110499151 110512608(tbk1) 110527112 110536185(ikbkb) 118936349
OGO124003990 124026129(tbk1) 124036437(ikbkb) 124039858 124048289 124048544
ONE115106499 115106755 115121927(ikbke) 115140184(ikbkb) 115143915
SALP111958214 111967645 111969717 111969826 111978057 111978258
SNH120029505 120039020(ikbkb) 120042517(ikbke) 120046219 120046430
ELS105006906 105010696 105014298(ikbkb) 105017402 105026533(tbk1)
SFM108920198(ikbkb) 108931981(tbk1) 108933554(chuk) 108938249(ikbke)
PKI111836749(chuk) 111847018(tbk1) 111854363(ikbkb) 111854439(ikbke)
AANG118206636(ikbkb) 118211103(ikbke) 118220615(chuk) 118232151(tbk1)
LOC102687024(tbk1) 102690045(ikbkb) 102691336(chuk) 102692331(ikbke)
PSPA121299751 121302294 121303214 121304720 121318530(tbk1) 121321809(chuk)
ARUT117397675 117397678 117416037(chuk) 117419798(tbk1) 117431931
LCM102356087(TBK1) 102358966(IKBKB) 102361819(CHUK) 102364129(IKBKE)
CMK103179820(tbk1) 103181859(chuk) 103182410(ikbke)
RTP109918795(chuk) 109927975(ikbkb) 109935579
BFO118406958 118411310 118428072
BBEL109463591 109477818 109478257
CIN778650(ikk-epsilon) 778921
SCLV120338723 120347579
SPU579073 590620
APLC110974001 110983129
SKO100372702 100375591 102806810
DMEDmel_CG2615(IKKepsilon) Dmel_CG4201(IKKbeta)
DER6548886 6553147
DSE6606172 6618180
DSIDsimw501_GD20310(Dsim_ird5) Dsimw501_GD24274(Dsim_GD24274)
DYADyak_GE12340 Dyak_GE26340(Dyak_ird5)
DAN6494177 6498161
DSR110184957 110191738
DPODpse_GA15402 Dpse_GA18025
DPE6589367 6594219
DMN108156166 108163389
DWI26529178 6642105
DGR6562287 6563402
DMODmoj_GI10102 Dmoj_GI18250
DAZ108611159 108621533
DNV108649817 108659762
DHE111594743 111604649
DVI6627493 6631291
CCAT101448706 101451363
BOD106620316 106622227
MDE101888056 101896529
SCAC106083076 106088471
LCQ111681682 111684045 111689869
AGAAgaP_AGAP009166(IKK1) AgaP_AGAP009565
ACOZ120957464 120959579
AARA120900916 120902673
AAG5566387 5577620
AALB109419873 109420658 115271052
CQUCpipJ_CPIJ006852 CpipJ_CPIJ015672
CPII120416603 120430182
CNS116338941 116341159
AME413493 726760
ACER107999416 108004488
ALAB122716694 122717408
BIM100744732 100748635
BBIF117209723 117210395
BVK117235088 117237830
BVAN117157967 117158702
BTER100642917 100644806
BPYO122569381 122577593 122577651
CCAL108629605 108632449
OBB114871063 114871896
MGEN117221678 117222822
NMEA116433124 116434059
CGIG122396699 122402233
SOC105197895 105203581
MPHA105828924 105831917
AEC105147535 105151453
ACEP105620284 105623150
PBAR105426672
VEM105561849 105563455
HST105186757 105187659
DQU106748819 106749034
CFO105250722 105251219
FEX115240033 115243813
LHU105677180 105679052
PGC109853369 109861528
OBO105277074 105288233
PCF106785497 106789451
PFUC122513736 122522607
VPS122633754 122637965
NVI100116284 100122336
CSOL105359082 105359204
TPRE106659803
MDL103578013 103579561
CGLO123265625 123266235
FAS105269079 105272072
DAM107039787 107048976
AGIF122850683 122856282
CCIN107267072 107267930
TCA100141977 655324 658218(ik2) 658393(ikkb)
DPA109540103 109540487 109544994
SOY115884520 115887944
ATD109595698
CSET123308519 123312891
AGB108904664 108913950 108914110
LDC111504248 111508410
NVL108561216 108569535
APLN108739858
PPYR116164253 116176703 116176759 116182984
OTU111417278 111424559
BMOR101737865 101747125
BMAN114243763 114244430
MSEX115450784 115452801
DPLKGM_202564 KGM_209901
BANY112046106 112055005
PMAC106711966 106715712
PPOT106101605 106102154
PXU106113861 106114462
PRAP110994808 111001847
ZCE119831974
HAW110372140 110376308
TNL113503695 113505335
OFU114357143 114361757
PXY105395113 105396222
API100168269
DNX107165510
AGS114121351
RMD113555489
BTAB109033611 109041626
DCI103512606
CLEC106666211 106666374
HHAL106681274 106688729
NLU111048096 111048243
PHUPhum_PHUM387680 Phum_PHUM605130
FOC113205975 113214861
ZNE110836419 110838212
CSEC111863609 111866549
FCD110842355 110852083
DPXDAPPUDRAFT_300170 DAPPUDRAFT_317376
DMK116919393 116928976
PVM113819389 113828454
PJA122243754 122247284 122257869
HAME121859114 121874198
PCLA123766496 123773107
PTRU123511842 123515125
HAZT108669188 108677742
EAF111704300 111706894
ISCIscW_ISCW002130 IscW_ISCW020049
DSV119436697
RSAN119372539 119396275
RMP119161269 119163178
VDE111248886 111250664 111253047
VJA111262983 111270277 111272552
TUT107368313
DPTE113792695 113796829
DFR124490353 124499075
CSCU111620135 111632902
PTEP107440477 107450450
SDM118183469 118199832
BMYBM_BM9065(Bm9065)
LOALOAG_07487
HROHELRODRAFT_191565 HELRODRAFT_191604 HELRODRAFT_193700
LGILOTGIDRAFT_105441 LOTGIDRAFT_168021 LOTGIDRAFT_171984 LOTGIDRAFT_175137
PCAN112557750 112571698 112572643
BGT106052993 106068715
GAE121366834 121368213 121369054 121369116 121369172 121379525
HRF124120668 124121979 124122574 124128458 124132163 124135613 124136281
HRJ124254714 124270148 124278769 124282002 124286378 124286694
CRG105318588 105318591 105333842 105343370 105343371 105347601
MYI110443334 110454975 110454999 110456994 110460618
PMAX117328789 117330376 117330617 117331565
MMER123528572 123528633 123528692 123528795 123529751 123563603
OBI106867230 106868427 106873186 106883543
OSN115209342 115210407 115211871
LAK106167428 106170753 106176722
NVE116618481 5516342
EPA110254140
ATEN116301657 116302916
ADF107358025
AMIL114963622 114966040
PDAM113678513
SPIS111325021
DGT114531073 114533538
XEN124433847 124434860 124452742
HMG100201666 100207607
TADTRIADDRAFT_62259
AQU100636688
MING122065657 122091966
 » show all
Reference
1  [PMID:9244310]
  Authors
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M
  Title
Identification and characterization of an IkappaB kinase.
  Journal
Cell 90:373-83 (1997)
DOI:10.1016/S0092-8674(00)80344-X
  Sequence
[hsa:1147]
Reference
2  [PMID:9346484]
  Authors
Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, Young DB, Barbosa M, Mann M, Manning A, Rao A.
  Title
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.
  Journal
Science 278:860-6 (1997)
DOI:10.1126/science.278.5339.860
  Sequence
[hsa:1147 3551]
Reference
3  [PMID:9346241]
  Authors
Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M.
  Title
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.
  Journal
Cell 91:243-52 (1997)
DOI:10.1016/S0092-8674(00)80406-7
Reference
4  [PMID:15653325]
  Authors
Viatour P, Merville MP, Bours V, Chariot A.
  Title
Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation.
  Journal
Trends Biochem Sci 30:43-52 (2005)
DOI:10.1016/j.tibs.2004.11.009
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.10
IUBMB Enzyme Nomenclature: 2.7.11.10
ExPASy - ENZYME nomenclature database: 2.7.11.10
BRENDA, the Enzyme Database: 2.7.11.10

DBGET integrated database retrieval system