KEGG   ENZYME: 2.7.11.11
Entry
EC 2.7.11.11                Enzyme                                 
Name
cAMP-dependent protein kinase;
PKA;
protein kinase A;
PKA catalytic (C) subunit;
A kinase;
ATP:protein phosphotransferase (cAMP-dependent)
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:protein Ser/Thr-phosphotransferase (3',5'-cAMP-dependent)
Reaction(IUBMB)
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate [RN:R00162]
Reaction(KEGG)
R00162
Substrate
ATP [CPD:C00002];
[protein]-(L-serine/L-threonine)
Product
ADP [CPD:C00008];
[protein]-(L-serine/L-threonine) phosphate
Comment
This eukaryotic enzyme recognizes the sequence -Arg-Arg-X-Ser*/Thr*-Hpo, where * indicates the phosphorylated residue and Hpo indicates a hydrophobic residue.The inactive holoenzyme is a heterotetramer composed of two regulatory (R) subunits and two catalytic (C) subunits. Each R subunit occludes the active site of a C subunit and contains two binding sites for 3',5'-cyclic-AMP (cAMP). Binding of cAMP activates the enzyme by causing conformational changes that release two free monomeric C subunits from a dimer of the R subunits, i.e. R2C2 + 4 cAMP = R2(cAMP)4 + 2 C. Activity requires phosphorylation of a conserved Thr in the activation loop (T-loop) sequence (Thr198 in human Calpha; Thr224 in budding yeast Tpk2), installed by auto-phosphorylation or by the 3-phosphoinositide-dependent protein kinase-1 (PDPK1). Certain R2C2 combinations can be localized to particular subcellular regions by their association with diverse species of 'A Kinase-Anchoring Proteins' (AKAPs). The enzyme has been characterized from many organisms. Humans have three C units (Calpha, Cbeta, and Cgamma) encoded by the paralogous genes PRKACA, PRKACB and PRKACG, respectively, and four R subunits (R1alpha, RIbeta, RIIalpha and RIIbeta), encoded by PKRAR1A, PKRAR1B, PKRAR2A and PKRAR2B, respectively. Yeast (Saccharomyces cerevisiae) has three C subunits (Tpk1, Tpk2, and Tpk3) encoded by the paralogous genes TPK1, TPK2 and TPK3, respectively, and a single R subunit (Bcy1) encoded by the BCY1 gene. Some validated substrates of the enzyme include cAMP-response element-binding protein (CREB), phosphorylase kinase alpha subunit (PHKA), and tyrosine 3-monooxygenase (TH) in mammals; Adr1, Whi3, Nej1, and Pyk1 in yeast.
History
EC 2.7.11.11 created 2005 (EC 2.7.1.37 part-incorporated 2005), modified 2022
Orthology
K04345  protein kinase A
K19584  protein kinase X
Genes
HSA5566(PRKACA) 5567(PRKACB) 5568(PRKACG) 5613(PRKX)
PTR107966260(PRKACA) 112204126 449495(PRKY) 469367(PRKACB) 472944(PRKACG) 751063(PRKX)
PPS100968237(PRKACA) 100970917(PRKACB) 100982589(PRKACG) 100993844(PRKX)
GGO101127525(PRKX) 101134260(PRKACB) 101151469(PRKACG)
PON100174748(PRKACB) 100431906(PRKACG) 100437102(PRKACA) 100936858(PRKX)
NLE100579779(PRKACA) 100581903(PRKX) 100583577(PRKACB) 100607741(PRKACG)
HMH116458374 116458418(PRKACG) 116469844(PRKACB) 116478588(PRKACA)
MCC100270699(PRKX) 106992273 700652(PRKACG) 709728(PRKACB) 718632(PRKACA)
MCF101926461(PRKACB) 102117414(PRKACG) 102141574(PRKX) 102142443(PRKACA)
MTHB126937647 126942437 126946414 126947129 126963591
MNI105478074(PRKX) 105482741(PRKACB) 105491778(PRKACG) 105498103(PRKACA)
CSAB103219549(PRKACG) 103224540(PRKACB) 103232879(PRKX) 103234377
CATY105574760(PRKX) 105584148(PRKACG) 105593561(PRKACB) 105601580(PRKACA)
PANU101002010(PRKX) 101020553(PRKACA) 101026251(PRKACB) 101026282(PRKACG) 116271867
TGE112608183(PRKACG) 112612552(PRKACA) 112616287(PRKX) 112618864(PRKACB)
MLEU105532068(PRKACG) 105533629(PRKX) 105538055(PRKACB) 105540992(PRKACA)
RRO104661051 104662061(PRKACG) 104677489(PRKACB) 104678277(PRKX)
RBB108514761(PRKACA) 108527683(PRKACB) 108530264(PRKACG) 108540003 108545111(PRKX)
TFN117074523(PRKACA) 117078257(PRKX) 117092158(PRKACB) 117098498(PRKACG)
PTEH111523821(PRKACA) 111531371(PRKX) 111540404(PRKACB) 111542701 111543418(PRKACG) 111547124
CANG105516624(PRKACG) 105519745(PRKACA) 105521806(PRKACB) 105523263(PRKX)
CJC100392123(PRKACG) 100400737(PRKACA) 100407692(PRKACB) 100408115 100409206 100413182(PRKX) 118151333
SBQ101034152 101036705(PRKACA) 101042624(PRKX) 101043989(PRKACG) 101047300(PRKACB)
CIMI108281936(PRKACA) 108283458(PRKACB) 108284294 108298062 108309036 108314512(PRKACG)
CSYR103253311(PRKACB) 103255178(PRKX) 103266092(PRKACA)
MMUR105861780(PRKACB) 105867963(PRKACA) 105876254(PRKX)
LCAT123628277(PRKX) 123635476(PRKACB) 123637748(PRKACA)
PCOQ105807940(PRKACA) 105820340(PRKX) 105823839(PRKACB)
OGA100949582(PRKX) 100964083(PRKACA) 100966533(PRKACB)
MMU18747(Prkaca) 18749(Prkacb) 19108(Prkx)
MCAL110286537(Prkx) 110290795(Prkacb) 110300173(Prkaca)
MPAH110313433(Prkx) 110320995(Prkacb) 110337220(Prkaca)
RNO25636(Prkaca) 293508(Prkacb) 501563(Prkx)
MCOC116069698(Prkaca) 116086563(Prkx) 116093928(Prkacb)
ANU117694869(Prkx) 117706647(Prkacb) 117723055(Prkaca)
MUN110542188(Prkx) 110545842(Prkaca) 110555016(Prkacb)
CGE100756471(Prkx) 100767097(Prkacb) 100768997(Prkaca)
MAUA101831244(Prkx) 101840885(Prkaca) 101841299(Prkacb)
PROB127218263(Prkx) 127229872(Prkaca) 127229917(Prkacb)
PLEU114681379(Prkx) 114684152(Prkaca) 114698264(Prkacb)
MORG121441209 121441270 121441340 121451033(Prkacb) 121455756(Prkaca)
MFOT126487741 126492150 126512376 126512697
AAMP119800975(Prkacb) 119802004(Prkaca) 119804695(Prkx)
NGI103728095(Prkacb) 103747214(Prkx) 103751850(Prkaca)
HGL101700033(Prkx) 101707235(Prkaca) 101721558(Prkacb)
CPOC100712694(Prkacb) 100735694(Prkaca)
CCAN109681298(Prkaca) 109688701 109688706 109701357 109703305
DORD105987133(Prkacb) 105999274(Prkaca)
DSP122104508(Prkacb) 122119798(Prkaca)
PLOP125348811(Prkaca) 125355340(Prkacb)
NCAR124969119 124971872 124985819
MMMA107135580 107144974(Prkaca) 107158295(Prkacb) 107158748(Prkx)
OCU100008815(PRKACA) 100342212
OPI101516221(PRKACA) 101525119 101534210(PRKACB)
TUP102478525(PRKACA) 102496113(PRKX) 102502506(PRKACB)
GVR103585135(PRKACA) 103589593(PRKACB) 103598657(PRKX)
CFA403556(PRKACA) 479975(PRKACB) 610031(PRKX)
CLUD112640987(PRKACB) 112652235(PRKX) 112666620(PRKACA)
VVP112908063(PRKACA) 112908967(PRKX) 112924478(PRKACB)
VLG121483051(PRKX) 121486651(PRKACB) 121495416(PRKACA)
NPO129517689(PRKX) 129519960(PRKACB) 129521768(PRKACA)
AML100467490(PRKX) 100468252(PRKACA) 100469628(PRKACB)
UMR103662972(PRKACB) 103666338(PRKX) 103682183(PRKACA)
UAH113240773(PRKX) 113247197(PRKACA) 113254486(PRKACB)
UAR123795272(PRKACB) 123801768(PRKACA) 123802775(PRKX)
ELK111143399 111157130 111162516
LLV125083608 125091597 125097539
MPUF101681986(PRKACA) 101687865(PRKX) 101692436(PRKACB)
MNP132001064(PRKACB) 132007227(PRKX) 132011072(PRKACA)
MLK131808844(PRKACB) 131820798(PRKX) 131823635(PRKACA)
NVS122896720(PRKX) 122900129(PRKACB) 122909651(PRKACA)
ORO101367408(PRKACB) 101381462(PRKX) 101383001(PRKACA)
EJU114197723(PRKACA) 114208397(PRKACB) 114218017(PRKX)
ZCA113916866(PRKACA) 113930713(PRKX) 113931821(PRKACB)
MLX118005070(PRKACA) 118019227(PRKACB) 118026685(PRKX)
NSU110573155(PRKX) 110580659(PRKACB) 110594123(PRKACA)
LWW102729236(PRKACB) 102735449(PRKACA) 102735783(PRKX)
FCA101090494(PRKACA) 101095353(PRKACB) 111558780(PRKX)
PYU121014090(PRKACA) 121020201(PRKX) 121027378(PRKACB)
PCOO112852313(PRKACA) 112871684(PRKX) 112871920(PRKACB)
PBG122477740(PRKX) 122480698(PRKACB) 122486980(PRKACA)
LRUF124509328 124514583 124524048
PTG102948983(PRKACA) 102963584(PRKX) 102972158(PRKACB)
PPAD109246175(PRKACB) 109253991(PRKACA) 109256142(PRKX)
PUC125912461 125929088 125931453
AJU106973352 106982051 106985791
HHV120240560(PRKX) 120241649(PRKACB) 120245321(PRKACA)
BTA282322(PRKACA) 282323(PRKACB) 505773
BOM102269124(PRKACB) 102281757(PRKACA)
BIU109555327(PRKX) 109556827(PRKACB) 109561498(PRKACA)
BBUB102391266(PRKX) 102392366(PRKACA) 102413383(PRKACB)
BBIS104999887(PRKACA) 105003252(PRKACB)
CHX102168790(PRKACB) 102173379(PRKACA) 102176517(PRKX)
OAS101108785(PRKACB) 101116807 443094(PRKACA)
BTAX128044465(PRKACB) 128050339(PRKACA) 128070306(PRKX)
ODA120856949(PRKACB) 120864090(PRKACA) 120882404(PRKX)
CCAD122434595(PRKX) 122436774(PRKACB) 122440547(PRKACA)
MBEZ129540637(PRKACB) 129558401(PRKACA) 129564405(PRKX)
SSC100623628(PRKACB) 106504268(PRKX) 397652(PRKACA)
CFR102506255(PRKACB) 102508985(PRKACA) 102515891(PRKX)
CBAI105068302(PRKACA) 105075498(PRKACB) 105079524(PRKX)
CDK105095035(PRKACB) 105097368 105100776 116151032(PRKX) 116152218
VPC102528179(PRKACB) 102534902(PRKACA) 102538769(PRKX)
BACU103000011(PRKACA) 103007447(PRKX) 103008319(PRKACB)
LVE103074112(PRKACA) 103077464(PRKACB) 103081147(PRKX)
OOR101272376(PRKACA) 101273911(PRKACB) 101287527(PRKX)
DLE111166674(PRKACA) 111168285(PRKX) 111178380(PRKACB)
PCAD102981091(PRKACB) 102994338(PRKX) 102995361(PRKACA)
PSIU116748149(PRKX) 116751566(PRKACA) 116754197(PRKACB)
NASI112407118(PRKX) 112414741(PRKACA) 112415075(PRKACB)
ECB100052828(PRKACB) 100064302(PRKACA) 100064903(PRKX)
EPZ103556801(PRKX) 103557289(PRKACB) 103565953(PRKACA)
EAI106824036(PRKACB) 106844316(PRKACA) 106845885(PRKX)
MYB102244919(PRKACB) 102252927(PRKACA)
MYD102759840 102761625 102765634 102772218(PRKACA) 102773780(PRKACB)
MMYO118652717(PRKACA) 118657329(PRKX) 118675444(PRKACB)
MLF102417960(PRKACA) 102437773(PRKACB)
MNA107540415(PRKX) 107543188(PRKACB) 107544336(PRKACA)
PKL118722881(PRKACB) 118731187(PRKACA)
EFUS103284158(PRKACB) 103300989(PRKACA) 129150078(PRKX)
HAI109373333(PRKX) 109385440(PRKACB) 109394225(PRKACA)
DRO112301523(PRKACA) 112309395(PRKACB) 112313358(PRKX)
SHON118974331(PRKX) 118984085(PRKACA) 118997372(PRKACB)
AJM119045565(PRKX) 119049690(PRKACA) 119062886(PRKACB)
PDIC114489893(PRKX) 114496184(PRKACB) 114502442(PRKACA)
PHAS123816440(PRKACB) 123828245(PRKACA) 123830093(PRKX)
MMF118615793(PRKACA) 118626166(PRKACB) 118636586(PRKX)
RFQ117022375(PRKX) 117027001(PRKACB) 117037860(PRKACA)
PPAM129061554(PRKACA) 129065641(PRKACB) 129079746(PRKX)
PALE102877853(PRKACB) 102886679(PRKACA) 112483186(PRKX)
PGIG120583269(PRKACB) 120592470 120618485(PRKACA)
PVP105289063(PRKACB) 105305973 105308501(PRKACA)
RAY107505984(PRKX) 107511590(PRKACB) 107519437(PRKACA)
MJV108408343(PRKACB)
TOD119236720(PRKACB) 119241031(PRKACA) 119245754(PRKX)
SARA101539926(PRKACB) 101544489(PRKX) 101546696 101554719 101555578(PRKACA)
LAV100656966(PRKACB) 100663486 100674245(PRKACA) 111747943(PRKX)
TMU101342638 101348995 101355990
ETF101645802(PRKACA) 101649991(PRKACB)
DNM101413809 101423692(PRKACB) 101445596
MDO100009830(PRKX) 100011211(PRKACB) 100026861(PRKACA) 100032298
GAS123232104(PRKACA) 123242561(PRKX) 123246439 123247653(PRKACB) 123254019
SHR100913731 100915481(PRKACA) 100928966(PRKX) 100929360 100934183(PRKACB)
AFZ127543087 127544835 127548938 127553668 127563015
PCW110199822 110209926(PRKACB) 110212812(PRKX) 110214178(PRKACA)
OAA100078846(PRKACB) 100083943(PRKX) 100088079(PRKACA)
GGA418656(PRKX) 424542(PRKACB)
PCOC116230772(PRKX) 116233372(PRKACB) 116239748
MGP100545867(PRKX) 100548554(PRKACB)
CJO107306025(PRKX) 107317471(PRKACB)
TPAI128071718(PRKX) 128072854(PRKACB)
LMUT125694172(PRKACB) 125699770(PRKX)
NMEL110402971(PRKACB) 110405676(PRKX)
APLA101791856(PRKACB) 101792690(PRKX)
ACYG106034038(PRKACB) 106035733(PRKX)
CATA118243752(PRKACB) 118245749(PRKX)
AFUL116491750(PRKACB) 116492647(PRKX)
TGU100226105(PRKACB) 100227619(PRKX)
LSR110468859(PRKACB) 110478734(PRKX)
SCAN103812667(PRKX) 103814927(PRKACB)
PMOA120504673(PRKX) 120510816(PRKACB)
OTC121343164(PRKX) 121344945(PRKACB)
PRUF121356237(PRKX) 121361926(PRKACB)
GFR102039982(PRKACB) 102043731(PRKX)
FAB101821736(PRKACB)
OMA130256113(PRKACB) 130256975(PRKX)
PHI102112042(PRKX) 102112800(PRKACB)
PMAJ107208204(PRKACB) 107210368(PRKX)
CCAE111932863(PRKACB) 111944823(PRKX)
CCW104686329(PRKX) 104695299(PRKACB)
CBRC103612625(PRKACB) 103617624(PRKX)
ETL114064916(PRKACB) 114067027(PRKX)
ZAB102061784(PRKX) 102068791(PRKACB)
ACHL103804251 103809597(PRKX)
SVG106857393(PRKACB) 106858067(PRKX)
MMEA130578641(PRKACB) 130588949(PRKX)
HRT120748676(PRKX) 120756314(PRKACB)
FPG101915967(PRKX) 101921803(PRKACB)
FCH102052736(PRKACB) 102056586(PRKX)
CLV102093121(PRKX) 102094181(PRKACB)
EGZ104122904(PRKACB) 104127463(PRKX)
NNI104009841(PRKX) 104015461(PRKACB)
PCRI104023989(PRKX) 104025625
PLET104616667(PRKX) 104618045
EHS104506854
PCAO104040020 104044501(PRKX)
ACUN113482753(PRKACB) 113482968(PRKX)
TALA104356299(PRKACB) 104366203(PRKX)
PADL103924790 103925217(PRKACB)
AFOR103894879(PRKACB) 103900649(PRKX)
ACHC115334625(PRKX) 115349379(PRKACB)
HALD104317122 104323412(PRKX)
HLE104839892(PRKX) 104841114(PRKACB)
AGEN126042137 126043167 126053018
GCL127019058 127020157
CCRI104165890(PRKX) 104167339
CSTI104553973(PRKX) 104555809
CMAC104474549(PRKACB)
MUI104535125(PRKX) 104548588
BREG104632483(PRKX) 104633230
FGA104069331(PRKX) 104071103
GSTE104250460(PRKX) 104252377
LDI104341661(PRKX) 104345924
MNB103769579 103780925(PRKX)
OHA104333609(PRKX) 104338831(PRKACB)
NNT104404509(PRKX) 104409789
SHAB115603010 115604065(PRKX) 115612311(PRKACB)
DPUB104300085(PRKACB) 104301320(PRKX)
PGUU104466963(PRKX) 104469889
ACAR104525348 104528820(PRKX)
CPEA104391703(PRKX) 104396726(PRKACB)
AVIT104272387 104273351(PRKX)
CVF104286144(PRKACB) 104290358(PRKX)
RTD128913296(PRKACB) 128918667(PRKX)
CUCA104055210(PRKACB) 104063749(PRKX)
TEO104370618 104376026(PRKX)
BRHI104492966 104498480(PRKX)
AAM106491365(PRKX) 106499821(PRKACB)
AROW112961880(PRKACB) 112966442 112968866(PRKX)
NPD112944017(PRKX) 112946238(PRKACB)
TGT104572000(PRKACB) 104572613(PRKX)
DNE112984471(PRKX) 112993129(PRKACB)
SCAM104138705(PRKX) 104143004(PRKACB)
ASN102369602(PRKACA) 102372671(PRKX) 102373080(PRKACB)
AMJ102558584(PRKX) 102572143(PRKACB) 106737076
CPOO109306115(PRKX) 109307348(PRKACB)
GGN109286784(PRKACB) 109302970(PRKX)
PSS102454969(PRKACB) 102458631(PRKACA) 102461440(PRKX)
CMY102930962 102937534 102937758 102942980(PRKX) 102943305(PRKACB) 119564816
CCAY125627801 125627827 125627830 125627831 125640910(PRKX) 125641242(PRKACB)
DCC119845780 119845833 119845878 119849897(PRKX) 119860147(PRKACB)
CPIC101933995 101934281 101935090(PRKACB) 101940748 101943008 101949551 101951867 101953893
TST117870331(PRKX) 117881601(PRKACB) 117888473 117888475 117888815 117889034
CABI116817901 116820892(PRKX) 116825420 116835748(PRKACB)
MRV120369997(PRKACB) 120390525(PRKX) 120391063 120391064 120391216 120404799
ACS100558272(prkx) 100559138(prkacb) 103279522(prkaca)
ASAO132768719 132771649(PRKX) 132774078(PRKACB)
PVT110075586(PRKX) 110079750(PRKACB) 110082676(PRKACA)
SUND121921255(PRKACA) 121927155(PRKX) 121928556(PRKACB)
PBI103052934 103056092(PRKX) 103058343(PRKACB)
PMUR107290410(PRKX) 107291148 107294019
CTIG120297855(PRKACB) 120299877(PRKX) 120309375
TSR106544707 106551190(PRKX) 106555867
PGUT117659081(PRKACA) 117673809 117677128(PRKACB)
APRI131189981 131194596(PRKACB) 131200216(PRKX)
PTEX113433613 113436070(PRKACB) 113440833(PRKX)
NSS113411687(PRKX) 113418177 113419166(PRKACB)
VKO123024633(PRKACB) 123024649(PRKX) 123035427(PRKACA)
PMUA114590804(PRKACA) 114596314(PRKX) 114598815(PRKACB)
PRAF128407678(PRKACA) 128413234(PRKX) 128415570(PRKACB)
ZVI118079980(PRKACA) 118084747(PRKX) 118088233(PRKACB)
HCG128322263(PRKACB) 128344132(PRKACA) 128351895(PRKX)
GJA107111891(PRKX) 107117304(PRKACB) 107117579
STOW125428187(PRKACA) 125431751(PRKX) 125432825(PRKACB)
EMC129326497(PRKX) 129327293 129329909(PRKACB)
XLA100101276(prkaca.S) 108707975(prkx.L) 108711677(prkaca.L) 108714187(prkacb.L) 380388(prkacb.S)
XTR100038053(prkacb) 100488597 100494406(prkx) 101731553 105946713 108648814 116407821 116407822 116407825 116411737 549157(prkaca)
NPR108784350(PRKACB) 108790539 108793765(PRKX)
RTEM120927466(PRKX) 120933227(PRKACA) 120945982(PRKACB)
BBUF120979293(PRKACB) 120986229 120994879(PRKX)
BGAR122927346 122927350 122930563(PRKX) 122943276(PRKACB)
MUO115466106 115469435(PRKX) 115471878(PRKACB)
GSH117346542(PRKACB) 117350132(PRKACA) 117362714(PRKX)
DRE393998(prkacba) 445076(prkacab) 561941(prkx) 563147(prkacbb) 564064(prkacaa)
SRX107705125 107708581 107711144 107714121 107714303(prkx) 107728680 107742914(prkacb) 107745335 107746635 107747173
SANH107655037 107658562(prkacb) 107660409 107661836 107669012 107670487 107671753 107691607(prkx) 107694605 107703755
SGH107552224 107560415 107562862 107573599 107592581 107594309 107598753(prkx) 107599301 107600310 107602709
CCAR109052186 109053472 109054710 109054723 109063835 109072788 109090935 109102572 109105744 109107561
CAUA113039766 113044290 113046138 113051365 113053706 113054947(prkacb) 113067676 113069366 113097097 113111242
CGIB127948750 127949188 127951130 127952862 127953664 127967775 128015865 128017857 128022625 128024411
PTET122333172 122341761(prkacaa) 122344253(prkacab) 122352380(prkx) 122353933(prkacba) 122360276(prkacbb)
LROH127159391(prkacaa) 127167410(prkx) 127168154(prkacab) 127172869(prkacba) 127180703(prkacbb)
OMC131524516(prkacbb) 131536154(prkacaa) 131540829(prkacab) 131544190(prkx) 131549854(prkacba)
PPRM120460052(prkacab) 120461409(prkx) 120461561(prkacbb) 120464256(prkacba) 120491168
RKG130069143(prkacaa) 130078098(prkacba) 130087885(prkx) 130100399(prkacbb) 130105831(prkacab)
MAMB125251891(prkacbb) 125255428(prkacaa) 125256470(prkacba) 125272248(prkx) 125278182(prkacab)
CIDE127506489 127519370 127520443 127522428
MASI127426444 127428000 127440915 127442986 127444316 127444718 127445362 127450164 127451641
TROS130552373(prkx) 130553214(prkacab) 130554282(prkacbb) 130561020(prkacaa) 130571504(prkacba)
TDW130406878(prkx) 130410614(prkacba) 130413532(prkacab) 130417496(prkacbb) 130425532(prkacaa)
MANU129427096(prkacba) 129429457(prkacaa) 129443122(prkacbb) 129443123 129443886(prkacab)
IPU100528913(prkacaa) 108258341(prkacab) 108258992 108266906 108267323(prkacbb) 108270713(prkacba)
IFU128600201(prkacaa) 128601869(prkx) 128601894(prkacab) 128609287 128610406(prkacbb) 128613629(prkacba)
PHYP113524339 113526732 113531511(prkacb) 113537420 113537575(prkx) 113546254
SMEO124376156(prkacaa) 124378325(prkx) 124378405(prkacab) 124382739 124387817(prkacbb) 124391230(prkacba)
TFD113636363(prkacab) 113642061 113650557(prkacbb) 113651591(prkacba) 113652516(prkx) 113661955(prkacaa)
TVC132837519(prkacaa) 132839455(prkx) 132839525(prkacab) 132848952(prkacbb) 132850575 132853762(prkacba)
AMEX103023241 103024963 103026199(prkx) 103029308(prkacb) 103034112 103040942
CMAO118797821(prkacab) 118803055(prkx) 118806091(prkacaa) 118811474 118818861(prkacba) 118825617(prkacbb)
EEE113577626(prkx) 113581910(prkacb) 113586730 113587857 113591278 113592026
CHAR105891269(prkacab) 105898076(prkx) 105899109(prkacbb) 105910964(prkacaa) 122130206
TRU101062935 101066292 101067856 101069822 101075373(prkx)
TFS130522600(prkx) 130527227 130528158(prkacba) 130539508(prkacbb)
TNGGSTEN00016205G001 GSTEN00019760G001 GSTEN00022860G001 GSTEN00026232G001 GSTEN00027088G001
LCO104918597 104925395(prkaca) 104931534 104931945(prkacb) 104932559(prkx)
NCC104941347(prkacb) 104951989(prkx) 104956098 104956568 104960311
TBEN117474614 117488687(prkacbb) 117493415(prkacaa) 117495553(prkacba) 117499075(prkx)
CGOB115006619(prkacb) 115011693 115018218(prkx) 115022186
PGEO117445113(prkacba) 117450679(prkacaa) 117458870(prkx) 117462185(prkacbb) 117463698
GACU117546637(prkx) 117548428 117555105(prkacba) 117558377(prkacbb) 117561581(prkacab)
ELY117250149(prkx) 117254444(prkacba) 117255397(prkacab) 117268372(prkacaa) 117271818(prkacbb)
EFO125879778(prkacaa) 125884767(prkx) 125885389(prkacab) 125895468(prkacba) 125902200(prkacbb)
PLEP121941832(prkacab) 121951289 121956428(prkacaa) 121966133(prkacba)
SLUC116042812(prkacab) 116046015(prkacbb) 116055353(prkacba) 116059452(prkacaa) 116061882(prkx)
ECRA117939519(prkx) 117950657(prkacba) 117954412(prkacbb) 117958732(prkacaa) 117959235(prkacab)
ESP116674051(prkx) 116695686(prkacb) 116698669 116703683
PFLV114551167(prkx) 114561605(prkacb) 114565306(prkaca) 114565471 114568922
GAT120816180(prkacbb) 120822146(prkx) 120823962(prkacba) 120825751 120827282(prkacaa)
PPUG119206876 119213815(prkx) 119216287(prkacba) 119217641 119220127(prkacaa)
AFB129094159(prkacba) 129095446(prkacab) 129098873(prkacaa) 129111796(prkx) 129113516(prkacbb)
CLUM117729101(prkacab) 117729746(prkacba) 117734821(prkacaa) 117741194(prkx) 117746316(prkacbb)
MSAM119896511(prkacaa) 119899469(prkacab) 119900632(prkacba) 119902028(prkacbb) 119905520(prkx)
SCHU122868669(prkacaa) 122872148(prkx) 122873333(prkacab) 122877466(prkacba) 122887397(prkacbb)
CUD121506153(prkx) 121508233(prkacab) 121512021(prkacba) 121519946(prkacbb) 121529438(prkacaa)
ALAT119011561 119014564(prkacaa) 119015519(prkx) 119018496(prkacab) 119028389(prkacba)
MZE101470440 101473852(prkacb) 101477788(prkx) 101482575 101482847(prkaca)
ONL100699977 100700452 100702736(prkaca) 100704570(prkx) 100711771(prkacb)
OAU116310623(prkacab) 116317675(prkacaa) 116318674(prkacbb) 116325158(prkx) 116333044(prkacba)
OLA101160305(prkacb) 101160964 101163742 101168847(prkx) 101170876
OML112137621 112140218(prkx) 112146515(prkacaa) 112147433(prkacbb) 112150651(prkacba)
XMA102225635(prkaca) 102230273(prkacb) 102230641 102237217 102238338(prkx)
XCO114140810(prkx) 114144649(prkaca) 114146401 114150831(prkacb) 114159753
XHE116715823(prkx) 116719583(prkaca) 116725606(prkacb) 116727897 116736298
PRET103464159(prkacb) 103468785 103477298(prkx) 103479663 103481100(prkaca)
PFOR103130823 103130850 103135793 103151985 103154167(prkaca) 103156191(prkx)
PLAI106940975 106941471 106945997(prkaca) 106946593 106955448 106959867(prkacb)
PMEI106906228 106908853(prkx) 106922057(prkaca) 106923625 106930009 106931018
GAF122821901(prkacaa) 122826927(prkx) 122829699 122838694(prkacba) 122841257(prkacbb)
PPRL129363168(prkacaa) 129365798 129366903 129371377(prkacba) 129378736(prkx)
CVG107087201(prkacb) 107090031 107093417 107094434(prkaca)
CTUL119774630(prkacba) 119794848(prkacaa) 119795697(prkacbb) 119798033
GMU124861677(prkx) 124862895 124864749 124869187 124870299(prkacbb) 124873964(prkacba)
NFU107378291 107383895 107384519(prkx) 107392711(prkacb) 107395214(prkaca)
KMR108234385(prkacba) 108239664(prkacbb) 108241350(prkacaa) 108241499(prkacab) 108241892(prkx)
ALIM106511311 106511338(prkacb) 106526233 106533807 106534672 106537320
NWH119407776(prkacba) 119415051(prkacbb) 119421717(prkacaa) 119422780(prkacab) 119429182
AOCE111573654 111577932 111579002 111581949(prkx) 111586379
MCEP124997569 125000932(prkX) 125003436 125008931 125010535
CSEM103389741(prkx) 103392208(prkacb) 103392719 103396312
POV109625861(prkacb) 109627640(prkaca) 109634223 109640063(prkx) 109642250
SSEN122764907(prkx) 122771368(prkacab) 122772674(prkacbb) 122780814(prkacba) 122785644(prkacaa)
HHIP117759920(prkacba) 117765696(prkacaa) 117777156(prkx) 117778886(prkacbb)
HSP118103311(prkx) 118117870(prkacbb) 118121305(prkacba) 118123233(prkacaa) 118123348
LCF108881271(prkacba) 108883401(prkacbb) 108885432(prkacab) 108902580 108902709(prkacaa)
SDU111220870(prkacb) 111227008 111229212(prkaca) 111232640(prkx)
SLAL111653688 111658500 111665555(prkaca) 111670358(prkx)
XGL120784329(prkacaa) 120787458(prkx) 120790764(prkacba) 120799292(prkacbb) 120800956(prkacab)
HCQ109514782(prkx) 109521323 109521456 109522036(prkacb) 109527435(prkaca)
SSCV125968895 125969625 125983880 125985301 125989384
SBIA133504134(prkacba) 133506386(prkacab) 133509190(prkx) 133510866(prkacbb) 133514435(prkacaa)
PEE133404060(prkacab) 133405584(prkx) 133405975(prkacba) 133411404(prkacbb) 133414665(prkacaa)
PTAO133465732(prkacaa) 133476315(prkacab) 133481437(prkacba) 133483259(prkx) 133488854(prkacbb)
BPEC110157202 110160084(prkacb) 110166277(prkaca) 110166288 110170888(prkx)
MALB109951873(prkx) 109952408(prkaca) 109957708 109958253 109965931
BSPL114845099(prkacbb) 114846945(prkx) 114851831(prkacab) 114854454(prkacba) 114861092(prkacaa)
SJO128354489(prkx) 128361373(prkacba) 128368523(prkacbb) 128371365(prkacab) 128379546(prkacaa)
SASA106564260 106569146(KAPCB) 106574269 106575200 106592286 106599750(KAPCB) 106606839 106613442(prkacb)
STRU115157154 115157937(prkacb) 115169621 115171557 115178387 115179196 115181703 115196000 115204162
OTW112217412(prkacba) 112223316 112226218(prkacaa) 112227364 112253798 112260598 112266539
OMY100136597 110486718 110493397 110495894 110508616 110521954(prkacba) 110527508 110538670 118936519
OGO123994965(prkacba) 124002772 124003154 124008403 124009569 124011092 124027026 124041764
ONE115102979 115104341 115114535 115129682 115133723 115139544(prkacb)
OKI109866517(prkacb) 109871709 109874831 109880753 109886804 109890634 109898739 109906694
OKE118363730 118370196 118374464(prkacaa) 118381223 118384731 118386773(prkacba) 118394782(prkacbb) 118401987
SALP111953466 111970945(prkx) 111975986 111979502 112071492 112077218 112079295
SNH120019042 120020291 120033743(prkx) 120033914 120039714 120051263 120054595(prkacba) 120055956
CCLU121533289(prkacba) 121535328 121540386 121551300 121553820 121568086 121581015
ELS105008738 105013090 105019307 105022509(prkx) 105029732(prkaca)
SFM108919757 108920568(prkx) 108923518(prkacb) 108935274 108935762
PKI111840961 111847642 111849082(prkx) 111849218(prkaca) 111860532
AANG118214428(prkx) 118216144 118221335 118226503(prkacba) 118228903
LOC102685149(prkx) 102686951(prkaca) 102688918(prkacb)
PSPA121310175 121320668 121326749 121327676 121331016
ARUT117402119 117405251 117406624 117413096 117417322 117962254
PSEX120514851(prkacba) 120524364(prkx) 120541109
LCM102359855(PRKACB) 102362951 102363249(PRKX)
CMK103174709(prkacba) 103189096 103189206(prkx)
RTP109910402 109932689 109936811 109937447
CPLA122550925(prkx) 122552173 122554117
HOC132816545(prkx) 132819195(prkacba) 132836058
LERI129694180(prkx) 129700701 129714364
PMRN116944602 116951840 116954517 116956326
LRJ133350602 133350622 133357405(PRKX) 133359043
BFO118431338
BBEL109465737 109483558
CIN100175976 100176009 113474046
SCLV120334980
SPU583938 589947
LPIC129272120
APLC110977700 110981672
AJC117101113 117120744
SKO100369010 100370476 100374103
DMEDmel_CG12066(Pka-C2) Dmel_CG4379(Pka-C1) Dmel_CG6117(Pka-C3)
DER6540831 6543799 6555151 6555152
DSE116801188 6611839 6612901
DSIDsimw501_GD12529(Dsim_GD12529) Dsimw501_GD16880(Dsim_GD16880) Dsimw501_GD16891(Dsim_GD16891) Dsimw501_GD22345(Dsim_GD22345)
DYADyak_GE10413(Dyak_Pka-C1) Dyak_GE19804 Dyak_GE23130 Dyak_GE23365 Dyak_GE23367
DAN6493238 6504562 6505956
DSR110177889 110186878 110186879 110186881 110186882 110190217
DPO4800268 4800307 4817464 6900498
DPE113565842 6595310 6595311 6596043
DMN108153467 108157657 108157658 108163091
DWI6642862 6642967 6651177 6651178
DGR6561425 6569722
DMODmoj_GI10635 Dmoj_GI10636 Dmoj_GI11297 Dmoj_GI17571
DAZ108609131 108609133 108611513 108620567
DNV108649145 108649146 108649585 108658021
DHE111593541 111601975 111602021 111602262 115483017
DVI6629485 6634186
CCAT101449493 101453840
BOD106622438 106623618
BDR105226771 105227436
RZE108366376 108367328 108371102 108380569
TDA119669164 119669166 119670599 119689911
MDE101888109 101890817 101899324
SCAC106081723 106091523
LCQ111675374 111680287 111688016
LSQ119611823 119612853 119613641
GFS119634254 119645369
ECOE129940284 129940900
CLON129608630 129616586 129616946
HIS119648519 119648992 119657506
AGA11175914 1277913
ACOZ120953028 120955967 120959594
AARA120894194 120902222 120903749
AMER121588205 121596820 121600649
ASTE118506497 118508023 118513824
AFUN125763098 125765706 125770178
AMOU128305965 128306522 128310902
AALI118458596 118459840 118464209
AAG5569015 5573184 5575457
AALB109408802 109408804 109416633 109421435 109432573 115261557
CQUCpipJ_CPIJ000798 CpipJ_CPIJ002636 CpipJ_CPIJ018257
CPII120415840 120421152 120430429
CNS116339206 116343576
BCOO119069136 119082316 119086004
AME102653709 409791 410228
ACER107997548 108001215 108002429
ALAB122710443 122711603 122715902
ADR102675233 102679735 116186475
AFLR100866962 100867909 105734906
BIM100743941 100746977 105682024
BBIF117205168 117208338 117210935
BVK117237748 117240285 117243524
BVAN117157137 117157995 117160542
BTER100643510 100652247 110120331
BAFF126918768 126919153 126928951
BPYO122568062 122571836 122577014
BPAS132908422 132908921 132910278
FVI122527740 122534344 122536983
CCAL108623002 108624761 108632682
OBB114871912 114874896 114875037
MGEN117220103 117225072 117228417
NMEA116428640 116431884 116433162
CGIG122400346 122402300 122403099
SOC105193172 105196628 105197741
MPHA105828244 105830981 105835161
AEC105151051 105151927
ACEP105620881 105624049
PBAR105427652 105430845
VEM105558981 105563021 105567557
HST105181073 105185095 105187873
DQU106743994 106748261
CFO105249574 105254691 109610490
FEX115233294 115238440 115238441 115245822
LHU105670768 105676612 105679159
PGC109851851 109854774 109860915
OBO105277221 105284392 105286488
PCF106788900 106789515 106793541
PFUC122515668 122517596 122524853
VPS122627690 122632297 122637876
VCRB124422374 124423059 124427226
NVI100119822 100328539(Pka-C1) 103316750
CSOL105359234 105362910 105364152
TPRE106650227 106652108 106657226
LHT122503983 122504325 122511219
LBD127277729 127278505 127289143
MDL103572409 103574536 106693978
CGLO123265193 123269035 123269799
FAS105263721 105265054 105268592
DAM107035436 107035983 107036044
AGIF122852859 122856019 122858508
CINS118064164 118064754 118068156
VCAN122409957 122414321
CCIN107263245 107264403 107274724
DSM124411516 124414865
NPT124215263 124220207 124222699
NFB124179056 124183473 124185987
NLO107220864 107223876 107224070
NVG124301519 124305925 124308392
TCA655660 656552(Pka-C1) 657232 661839
DPA109537561 109538063 109540409 109543377
SOY115883194 115883954 115891254 115891884
AGRG126734537 126740291 126741533 126747848 126748005
ATD109596258 109597410 109600504 109601683 109606501
CSET123312329 123312387 123315259 123319410
AGB108904298 108906362 108908120 108914153
LDC111502815 111504140 111507225 111517643
NVL108561304 108568556 108568850
APLN108739084 108739259 108739707
PPYR116166240 116171378 116171386 116181392
OTU111421356 111426589 111428422 111429006
BMOR100101210 101736275 101736413 101736532 101740078
BMAN114245956 114251882 114251883 114251884 114253107
MSEX115440352 115441026 115442624 115442625 115442626 115456253
DPLKGM_207641 KGM_211896 KGM_213835 KGM_214228
BANY112048100 112051470 112051480 112058233 112058524
MJU123865867 123866021 123866022 123869019 123869057 123870342
NIQ126768172 126768174 126772374 126780523 126781278
VCD124531095 124531421 124543569 124544491 124544492 124544493
MCIX123658454 123669322 123669374 123670104 123670105
PMAC106708555 106708556 106708557 106708672 106714263 106714444
PPOT106099629 106099720 106100031 106100771 106100773
PXU106122150 106123518 106123519 106127669 106127701
PRAP110992558 110992559 110992560 110992626 110994192 111002248
PBX123708105 123712156 123715450 123715451 123715452 123719790
PNAP125050890 125052544 125056730 125061431 125061433 125061434
ZCE119831666 119833609 119833610 119834143 119840477
CCRC123690738 123692024 123692027 123696640 123705810
LSIN126970653 126970654 126970655 126972682 126975082 126979912
HAW110371034 110373248 110377317 110377318 110379404 126056703
HZE124632488 124632490 124632491 124633709 124645976 124646065
TNL113500979 113501206 113501435 113505229 113506804 113506877 113508440
SLIU111352510 111357413 111358509 111361917
OFU114355132 114364095 114365156 114365157 114365158 114366783
PXY105391055 105397916 105398425
PGW126366072 126366074 126366096 126368268 126369123 126371494
CFEL113363198 113373438 113374373 113375309 113375748 113376505 113388549
CCRN123290497 123291515 123292845 123301774
API100159120 100161173 100163418
DNX107166458 107166698 107173985
AGS114125323 114126142 114126495 114128736 114129426
RMD113547873 113548979 113555692 113557762 113558957
ACOO126839382 126843555 126845430 126846259
DVT126897927 126901900 126902019 126910436
BTAB109040726 109041123
DCI103510949 103517463
CLEC106666812 106667912 106667914 106667915 106667989 106673119
HHAL106678700 106682178 106683818 106687088 106687089 106688150 106691678 112209999
NLU111044963 111045698 111046365 111046843 111053035 120349442
HVI124357992 124359486 124361488 124361489 124361531 124365247 124365289 124367210 124367211
MQU128983100 128986983 128987402 128987425 128987960 128991561 128993350 128993351 128995204 128995513 128999730 128999806 129000080 129005472 129005665
PHUPhum_PHUM090820 Phum_PHUM137480 Phum_PHUM318270 Phum_PHUM488810
FOC113206939 113214931 113217618
TPAL117639225 117651580 117652315
ZNE110838038 110841066
CSEC111869107 111873749
SGRE126297585 126335384 126335729
IEL124155769 124167743 124171922
FCD110844940 110844941 110846262 110848737 110851054 110854456 110862845
DPXDAPPUDRAFT_229422 DAPPUDRAFT_319998
DMK116922447 116922544 116925088
DPZ124311350 124313834 124342762
PVM113827838 113829323
PJA122256393 122256594
PCHN125027951 125047245
PMOO119573113 119592871
HAME121853595 121867056 121868593
PCLA123762980 123766943
CQD128695067 128704238
PTRU123507929 123517467
ESN126998185 127009280
HAZT108673971 108679431
EAF111701604 111703250
LSM121115590 121121510
TCF131887280
PPOI119091343 119107483 119109653
ISC8026095 8042156
DSV119433476 119442498
RSAN119404686
RMP119159451 119180549
VDE111243462 111243861 111251053 111251096 111251139 111251176 111251746 111254502
VJA111259458 111260158 111262933 111262989 111264204 111267695 111268598 111273072
TUT107366684
DPTE113790477 113796751
DFR124489850
CSCU111620732 111620733 111623977 111629525 111631689 111631697 111632894 111637750 111639828
PTEP107451496 107454703 107456224
UDV129216119 129216986 129231789
SDM118193804 118197998 118203290
LPOL106459645 106459871 106461573 106462361 106462606 106462862 106462941 106471467 106472109 106473550
PMEO129580782 129584249 129586975 129592035 129593583
CELCELE_F47F2.1(F47F2.1) CELE_ZK909.2(kin-1)
CBRCBG_14305 CBG_19814(Cbr-kin-1)
CRQGCK72_003564 GCK72_024172 GCK72_025067
NAINECAME_02475 NECAME_02713 NECAME_14910 NECAME_17311
BMYBM_BM4184(Bm4184) BM_BM7586(Bma-kin-1)
LOALOAG_17642 LOAG_18601
TSPTsp_00967 Tsp_00969 Tsp_03463 Tsp_10990 Tsp_10991
HROHELRODRAFT_110749 HELRODRAFT_156571 HELRODRAFT_158167 HELRODRAFT_169068 HELRODRAFT_187486 HELRODRAFT_65617 HELRODRAFT_67692 HELRODRAFT_67852 HELRODRAFT_70625 HELRODRAFT_80468 HELRODRAFT_84000 HELRODRAFT_88726 HELRODRAFT_94328 HELRODRAFT_98699
LGILOTGIDRAFT_116148 LOTGIDRAFT_190501
PVUL126813077 126819468
PCAN112555942 112573234
BGT106055829 106059263 106064116
GAE121371770 121382109
HRF124120538 124139561
HRJ124254967 124273263
CRG105336635 105346669
CVN111118497 111135327
CANU128165887 128179974
OED125658506 125667891
MYI110454697 110458440
PMAX117325503 117342015
MCAF127727728 127737258
MMER123525237 123554167
RPHI132714270 132730947 132739805
DPOL127833250 127874137
OBI106874074 106882854
OSN115227417 115229611
LAK106160230 106173017 106177254
SMMSmp_085690 Smp_147450 Smp_152330 Smp_164380 Smp_194610
SHXMS3_00002636(PKA-C1_1) MS3_00003633 MS3_00004156(PKAC3) MS3_00008673(PKA1_5) MS3_00008682
OVIT265_06662 T265_09755 T265_10587 T265_13709 T265_14825
EGLEGR_04421 EGR_06851 EGR_06877
NVE116614813 5498360 5506610
EPA110236331 110237972
ATEN116293512 116307117
ADF107328942 107339178 107358053
AMIL114953416 114962654
PDAM113683021 113686107
SPIS111331523 111338664
DGT114536138 114536258
XEN124437082 124446710
HMG100198292 100205790
HSY130629238 130629435 130636695
AQU100640804 100641589
NCOL116268091
SMOSELMODRAFT_110120 SELMODRAFT_124622 SELMODRAFT_137987
PPP112291827
CRECHLRE_16g669800v5
VCNVOLCADRAFT_45332 VOLCADRAFT_81085
MNGMNEG_7075
CSLCOCSUDRAFT_11750 COCSUDRAFT_65594
CVRCHLNCDRAFT_27424 CHLNCDRAFT_50248
APROF751_6210
OLUOSTLU_36971 OSTLU_41532 OSTLU_4415
MISMICPUN_70257 MICPUN_70519 MICPUN_82505 MICPUN_87816
MPPMICPUCDRAFT_31393(JGI:MicpuC2_31393) MICPUCDRAFT_3181(JGI:MicpuC2_3181) MICPUCDRAFT_44677(JGI:MicpuC2_44677) MICPUCDRAFT_5053(JGI:MicpuC2_5053)
SCEYJL164C(TPK1) YKL166C(TPK3) YPL203W(TPK2)
SEUBDI49_2863 DI49_3214 DI49_5264
SPAOSPAR_J00500 SPAR_K00530 SPAR_P00720
AGOAGOS_AEL115C AGOS_AFL090W
ERCEcym_2203 Ecym_8095
KLAKLLA0_B07205g KLLA0_D03190g
KMXKLMA_10642(TPK2) KLMA_50248(TPK1)
LTHKLTH0F04840g KLTH0H04180g
VPOKpol_1033p50 Kpol_2002p75
ZROZYRO0G08844g ZYRO0G18502g
CGRCAGL0G09020g CAGL0M08404g
NCSNCAS_0A01100(NCAS0A01100) NCAS_0B08280(NCAS0B08280) NCAS_0I02840(NCAS0I02840)
NDINDAI_0A00960(NDAI0A00960) NDAI_0B00210(NDAI0B00210) NDAI_0F01650(NDAI0F01650)
TPFTPHA_0E02840(TPHA0E02840) TPHA_0E03300(TPHA0E03300)
TBLTBLA_0A02030(TBLA0A02030) TBLA_0C05830(TBLA0C05830)
TGBHG536_0B03490 HG536_0E05320
TDLTDEL_0C03710(TDEL0C03710) TDEL_0E05220(TDEL0E05220)
KAFKAFR_0F01800(KAFR0F01800) KAFR_0G00480(KAFR0G00480) KAFR_0K00330(KAFR0K00330)
KNGKNAG_0C01060(KNAG0C01060) KNAG_0C02440(KNAG0C02440) KNAG_0D01140(KNAG0D01140)
ZMKHG535_0B00820 HG535_0B04680
PPAPAS_chr1-4_0357 PAS_chr3_0964
DHADEHA2B12386g DEHA2F23782g
PICPICST_68202(TPK2) PICST_70266
PGUPGUG_00446 PGUG_01778
SPAASPAPADRAFT_136577 SPAPADRAFT_61383
LELPVL30_000539(PKA1) PVL30_003298(TPK2_3)
CALCAALFM_C110220CA(TPK1) CAALFM_C207210CA(TPK2)
CTPCTRG_01736 CTRG_03315
COTCORT_0A04970 CORT_0C05890
CDUCD36_09610 CD36_21480(CaTPK2)
CTENCANTEDRAFT_113649 CANTEDRAFT_116383
YLIYALI0C08305g
CLUCLUG_00572 CLUG_05816
CLUSA9F13_05g01353 A9F13_15g00605
CAURCJI96_0000627 CJI96_0002448
SLBAWJ20_3189(TPK2)
PKZC5L36_0B01960 C5L36_0D01850
BNNFOA43_003686(TPK2_1) FOA43_004515(TPK2_2)
BBRXBRETT_000744(TPK2_1) BRETT_003464(TPK2_2)
OPAHPODL_04021 HPODL_04656
SLUDSCDLUD_001102 SCDLUD_002414
NCRNCU00682(pkac-2) NCU06240(pkac-1)
NTENEUTE1DRAFT149564(NEUTE1DRAFT_149564) NEUTE1DRAFT81394(NEUTE1DRAFT_81394)
SMPSMAC_01361 SMAC_07080
PANPODANSg4388 PODANSg5290
TTTTHITE_2112048 THITE_2119633
MTMMYCTH_2297709 MYCTH_2304075
CTHRCTHT_0007920 CTHT_0023760
MGRMGG_02832 MGG_06368
PPEIPpBr36_05955 PpBr36_09231
PGRIPgNI_09868 PgNI_10544
TMNUCRPA7_354 UCRPA7_4863
SSCKSPSK_02377 SPSK_03064
FGRFGSG_07251 FGSG_08729
FPUFPSE_00184(PKAC) FPSE_07713
FPOAFPOAC1_004858 FPOAC1_011027
FVNFVRRES_05373 FVRRES_12047
FVRFVEG_01931 FVEG_05331
FOXFOXG_02166 FOXG_03067
NHENECHADRAFT_59012 NECHADRAFT_68629
FFCNCS54_00398400 NCS54_00588000
FKRNCS57_00403300 NCS57_00625700
FMUJ7337_002434 J7337_008285
TRETRIREDRAFT_57399(pkac1) TRIREDRAFT_65873(pkac2)
TRRM419DRAFT_10156 M419DRAFT_127143
MAWMAC_00809 MAC_08643
MAJMAA_05976 MAA_07427
PCHMVFPPC_02718 VFPPC_04662
CMTCCM_01778 CCM_03352
AMUSLMH87_002251 LMH87_003535
PLJVFPFJ_00264 VFPFJ_05669
PTKZJDV02_000817(TPK2_1) JDV02_009880(PKA4)
VALVDBG_02174 VDBG_08817
VDAVDAG_02641 VDAG_06474
CFJCFIO01_02933
CLUPCLUP02_03633 CLUP02_09122
CHIGCH63R_02689 CH63R_07193
SAPOSAPIO_CDS5866 SAPIO_CDS7430
ELAUCREL1_10709 UCREL1_8801
PFYPFICI_07536 PFICI_09912
SSLSS1G_03171 SS1G_13577
BFUBCIN_08g03910(Bcpka2) BCIN_16g01130(Bcpka1)
MBEMBM_00355 MBM_07529
PSCOLY89DRAFT_743093 LY89DRAFT_743916
GLZGLAREA_07832 GLAREA_10700
ANIAN4717.2 AN6305.2
AFMAFUA_2G12200 AFUA_5G08570
ACTACLA_011960 ACLA_071080
NFINFIA_078710 NFIA_087380
AORAO090026000426 AO090120000207
ANGAn02g04270(pkaC) An07g05060
AFVAFLA_005857 AFLA_009425
ALUCAKAW2_11711S(PKA2) AKAW2_21256S(PKA1)
ACHEACHE_40879S(PKA1) ACHE_50550S(PKA2)
APUUAPUU_51174A(PKA1) APUU_71013A(PKA2)
PCSN7525_004738 N7525_009823
PDPPDIP_51730 PDIP_89420
POUPOX_a00183 POX_e07239
TMFEYB26_004025 EYB26_007318
TRGTRUGW13939_07035 TRUGW13939_10717
CIMCIMG_06775 CIMG_13464(CIMG05383)
CPWCPC735_032030 CPC735_065510
UREUREG_03689 UREG_06328
PBLPAAG_00108 PAAG_04050
PBNPADG_07154 PADG_07326
ABEARB_00580 ARB_06644
TVETRV_02144 TRV_02424
AJEHCAG_00714 HCAG_03889
BGHBDBG_01144 BDBG_05661
PNOSNOG_09577 SNOG_13001
PTEPTT_11769 PTT_12790
BZECOCCADRAFT_108052 COCCADRAFT_2530
BSCCOCSADRAFT_172148 COCSADRAFT_37514
BORCOCMIDRAFT_37135 COCMIDRAFT_88178
AALTCC77DRAFT_1003989 CC77DRAFT_1021959
ARABEKO05_0000111 EKO05_0011501
ZTRMYCGRDRAFT_38697(MgTpk1) MYCGRDRAFT_99725(Tpk2)
PFJMYCFIDRAFT_152751 MYCFIDRAFT_41888
FFUCLAFUR5_05816 CLAFUR5_06570
CBETCB0940_08502 CB0940_08565
BCOMBAUCODRAFT_75293 BAUCODRAFT_84800
NPAUCRNP2_3832 UCRNP2_6376
TMLGSTUM_00000085001 GSTUM_00000447001
SPOSPBC106.10(pka1)
SOMSOMG_05052(pka1)
CNECNA03840 CNI02980
CNBCNBA3650 CNBH2850
CNGCNAG_00396 CNAG_04162
CGICGB_A3580C CGB_H5240W
TMSTREMEDRAFT_13278 TREMEDRAFT_14150 TREMEDRAFT_73469
TASAA1Q1_02702 A1Q1_04065
CCACCcaHIS019_0302110(PKA4) CcaHIS019_0509740(TPK2)
PPLPOSPLDRAFT_112798 POSPLDRAFT_59912
TVSTRAVEDRAFT_164933 TRAVEDRAFT_31211 TRAVEDRAFT_76086 TRAVEDRAFT_83458
DSQDICSQDRAFT_70031 DICSQDRAFT_97125
PCOPHACADRAFT_48045 PHACADRAFT_83533 PHACADRAFT_98884
SHSSTEHIDRAFT_105104 STEHIDRAFT_137461 STEHIDRAFT_172406 STEHIDRAFT_74820
HIRHETIRDRAFT_454663 HETIRDRAFT_68091
PSQPUNSTDRAFT_144259 PUNSTDRAFT_72873
ADLAURDEDRAFT_187081 AURDEDRAFT_97402
FMEFOMMEDRAFT_73172
GTRGLOTRDRAFT_21770 GLOTRDRAFT_35435 GLOTRDRAFT_61216
RSXRhiXN_02584
LBCLACBIDRAFT_189547 LACBIDRAFT_255253 LACBIDRAFT_322262
CCICC1G_01089 CC1G_04466
ABPAGABI1DRAFT34901(AGABI1DRAFT_34901) AGABI1DRAFT84160(AGABI1DRAFT_84160)
ABVAGABI2DRAFT136405(AGABI2DRAFT_136405) AGABI2DRAFT64256(AGABI2DRAFT_64256)
PCUBJR316_0002578 JR316_0003652
MRRMoror_17903
MOREE1B28_003264 E1B28_007116 E1B28_010303(TPK2)
SCMSCHCO_02588966(SCHCODRAFT_02588966) SCHCO_02630814(SCHCODRAFT_02630814)
CPUTCONPUDRAFT_57022 CONPUDRAFT_98382
SLASERLADRAFT_362898 SERLADRAFT_463302 SERLADRAFT_475953
WSEWALSEDRAFT_33262(PkaC)
WICJ056_001233
UMAUMAG_04456 UMAG_11860
PFPPFL1_02359 PFL1_05723
SGRAEX895_002409
MGLMGL_3248
MRTMRET_2447
PGRPGTG_01034 PGTG_17146
PTRCPtA15_16A392 PtA15_4A202
PSTRPst134EA_011463 Pst134EA_013387 Pst134EA_029472
MLRMELLADRAFT_103532 MELLADRAFT_25984 MELLADRAFT_35870 MELLADRAFT_40213 MELLADRAFT_41186 MELLADRAFT_78487 MELLADRAFT_87329 MELLADRAFT_94122 MELLADRAFT_94151
ECUECU07_0520
EINEint_100510
EROEROM_100440
NCENCER_100362 NCER_101539
MBRMONBRDRAFT_12960 MONBRDRAFT_31027
SREPTSG_03113 PTSG_04201
DDIDDB_G0283907(pkaC) DDB_G0284029
DPPDICPUDRAFT_100116 DICPUDRAFT_42383(PKAC) DICPUDRAFT_8174
DFADFA_05748 DFA_06591(pkaC)
EHIEHI_053040(4.t00093)
ACANACA1_095580 ACA1_267000
PFAPF3D7_0934800
PFDPFDG_02360
PFHPFHG_02233
PREIPRSY57_0932800
PGABPGSY75_0934800
PYOPY17X_0839000
PCBPCHAS_0835900
PBEPBANKA_0835600
PVVPVVCY_0803320
PKNPKNH_0733500
PVXPVX_086975
PCYPCYB_074210
PMALPMUG01_07046600(PKAc)
PRELPRELSG_0732800(PKAc)
TANTA12860 TA14790
TPVTP02_0378 TP02_0727
TOTTOT_020000373 TOT_020000659
BEQBEWA_021200 BEWA_025590 BEWA_034980
BBOBBOV_I004190 BBOV_III005740
BMICBMR1_03g00225 BmR1_04g07710
BBIGBBBOND_0308680 BBBOND_0402050
CPVcgd3_3040
CHOChro.30344
TGOTGME49_226030 TGME49_228420
TETTTHERM_00215950 TTHERM_00290770 TTHERM_00369640 TTHERM_00433420 TTHERM_00445970 TTHERM_00474370 TTHERM_00658860 TTHERM_00825310 TTHERM_00992710 TTHERM_01020820
PTMGSPATT00000190001 GSPATT00001592001 GSPATT00002480001 GSPATT00003674001 GSPATT00004442001 GSPATT00006690001 GSPATT00007458001 GSPATT00007679001 GSPATT00008150001 GSPATT00010342001 GSPATT00011454001 GSPATT00012047001 GSPATT00013898001 GSPATT00014958001 GSPATT00015257001 GSPATT00015479001 GSPATT00015830001 GSPATT00017350001 GSPATT00018263001 GSPATT00019142001 GSPATT00019371001 GSPATT00020056001 GSPATT00020328001 GSPATT00020450001 GSPATT00020732001 GSPATT00021416001 GSPATT00021511001 GSPATT00021701001 GSPATT00022666001 GSPATT00022772001 GSPATT00023383001 GSPATT00023569001 GSPATT00023676001 GSPATT00024539001 GSPATT00024731001 GSPATT00025035001 GSPATT00026208001 GSPATT00026309001 GSPATT00027506001 GSPATT00028413001 GSPATT00029259001 GSPATT00029731001 GSPATT00029909001 GSPATT00030166001 GSPATT00030654001 GSPATT00030705001 GSPATT00031053001 GSPATT00031698001 GSPATT00032920001 GSPATT00033165001 GSPATT00033399001 GSPATT00033832001 GSPATT00034329001 GSPATT00035001001 GSPATT00039519001 PTMB.308
SMINv1.2.001047.t1(symbB.v1.2.001047.t1) v1.2.002962.t1(symbB.v1.2.002962.t1) v1.2.007634.t1(symbB.v1.2.007634.t1) v1.2.016451.t1(symbB.v1.2.016451.t1) v1.2.025734.t1(symbB.v1.2.025734.t1) v1.2.025734.t2(symbB.v1.2.025734.t2) v1.2.027542.t1(symbB.v1.2.027542.t1) v1.2.028498.t1(symbB.v1.2.028498.t1) v1.2.030862.t1(symbB.v1.2.030862.t1) v1.2.040763.t1(symbB.v1.2.040763.t1)
PTIPHATRDRAFT_9413
FCYFRACYDRAFT_141063 FRACYDRAFT_157927 FRACYDRAFT_174300 FRACYDRAFT_185896 FRACYDRAFT_186625 FRACYDRAFT_188553 FRACYDRAFT_188721 FRACYDRAFT_194547
TPSTHAPSDRAFT_261973 THAPSDRAFT_30963(PKA) THAPS_16501
AAFAURANDRAFT_11973 AURANDRAFT_13121 AURANDRAFT_18403 AURANDRAFT_19529 AURANDRAFT_21481 AURANDRAFT_22299 AURANDRAFT_25675 AURANDRAFT_30383 AURANDRAFT_30857 AURANDRAFT_34678 AURANDRAFT_36271 AURANDRAFT_3822 AURANDRAFT_54763
PIFPITG_02429 PITG_03049 PITG_14968 PITG_20156 PITG_21854
PSOJPHYSODRAFT_263935 PHYSODRAFT_293527 PHYSODRAFT_329149 PHYSODRAFT_547376 PHYSODRAFT_559273
SPARSPRG_00666 SPRG_05964 SPRG_06118 SPRG_08767
EHXEMIHUDRAFT_118282 EMIHUDRAFT_414406 EMIHUDRAFT_419469 EMIHUDRAFT_425794 EMIHUDRAFT_43649 EMIHUDRAFT_69772
GTTGUITHDRAFT_118235 GUITHDRAFT_145000 GUITHDRAFT_160289 GUITHDRAFT_164805 GUITHDRAFT_44039 GUITHDRAFT_55340
TBRTb09.211.2360 Tb09.211.2410 Tb10.389.0490
TCR508461.310 511269.50
LMALMJF_18_1080(PKAC1) LMJF_35_3960 LMJF_35_4010
LIFLINJ_35_4010 LINJ_35_4060
LDOLDBPK_354010
LMILMXM_34_3960 LMXM_34_4010
LBZLBRM_34_3990
LPANLPMP_343880
NGRNAEGRDRAFT_31357
TVATVAG_2v0538290 TVAG_2v1058180
 » show all
Reference
1  [PMID:2550680]
  Authors
Krebs EG.
  Title
The Albert Lasker Medical Awards. Role of the cyclic AMP-dependent protein kinase in signal transduction.
  Journal
JAMA 262:1815-8 (1989)
DOI:10.1001/jama.262.13.1815
Reference
2  [PMID:11705384]
  Authors
Technikova-Dobrova Z, Sardanelli AM, Speranza F, Scacco S, Signorile A, Lorusso V, Papa S.
  Title
Cyclic adenosine monophosphate-dependent phosphorylation of mammalian mitochondrial proteins: enzyme and substrate characterization and functional role.
  Journal
Biochemistry 40:13941-7 (2001)
DOI:10.1021/bi011066p
Reference
3  [PMID:21644927]
  Authors
Smith FD, Samelson BK, Scott JD.
  Title
Discovery of cellular substrates for protein kinase A using a peptide array screening protocol.
  Journal
Biochem J 438:103-10 (2011)
DOI:10.1042/BJ20110720
Reference
4  [PMID:22964838]
  Authors
Broach JR.
  Title
Nutritional control of growth and development in yeast.
  Journal
Genetics 192:73-105 (2012)
DOI:10.1534/genetics.111.135731
Reference
5  [PMID:27860220]
  Authors
Embogama DM, Pflum MK.
  Title
K-BILDS: A Kinase Substrate Discovery Tool.
  Journal
Chembiochem 18:136-141 (2017)
DOI:10.1002/cbic.201600511
Reference
6  [PMID:33957122]
  Authors
Taylor SS, Wu J, Bruystens JGH, Del Rio JC, Lu TW, Kornev AP, Ten Eyck LF.
  Title
From structure to the dynamic regulation of a molecular switch: A journey over 3 decades.
  Journal
J Biol Chem 296:100746 (2021)
DOI:10.1016/j.jbc.2021.100746
Reference
7  [PMID:34663687]
  Authors
Ramms DJ, Raimondi F, Arang N, Herberg FW, Taylor SS, Gutkind JS.
  Title
Galphas-Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Galphas-PKA Signaling.
  Journal
Pharmacol Rev 73:155-197 (2021)
DOI:10.1124/pharmrev.120.000269
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.11
IUBMB Enzyme Nomenclature: 2.7.11.11
ExPASy - ENZYME nomenclature database: 2.7.11.11
BRENDA, the Enzyme Database: 2.7.11.11
CAS: 142008-29-5

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