KEGG ENZYME: 2.7.11.12

ENZYME: 2.7.11.12

Entry

EC 2.7.11.12                Enzyme

Name

cGMP-dependent protein kinase;
3':5'-cyclic GMP-dependent protein kinase;
cGMP-dependent protein kinase Ibeta;
guanosine 3':5'-cyclic monophosphate-dependent protein kinase;
PKG;
PKG 1alpha;
PKG 1beta;
PKG II;
STK23

Class

Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases

Sysname

ATP:protein phosphotransferase (cGMP-dependent)

Reaction(IUBMB)

ATP + a protein = ADP + a phosphoprotein [RN:R00162]

Reaction(KEGG)

R00162

Substrate

ATP [CPD:C00002];
protein [CPD:C00017]

Product

ADP [CPD:C00008];
phosphoprotein [CPD:C00562]

Comment

CGMP is required to activate this enzyme. The enzyme occurs as a dimer in higher eukaryotes. The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. This domain catalyses the phosphorylation by ATP to specific serine or threonine residues in protein substrates [3]. The enzyme also has two allosteric cGMP-binding sites (sites A and B). Binding of cGMP causes a conformational change that is associated with activation of the kinase [4].

History

EC 2.7.11.12 created 2005 (EC 2.7.1.37 part-incorporated 2005)

Orthology

K07376

cGMP-dependent protein kinase 1

K19477

cGMP-dependent protein kinase 2

Genes

HSA:	5592(PRKG1) 5593(PRKG2)

PTR:	461217(PRKG2) 744467(PRKG1)

PPS:	100975252(PRKG1) 100978260(PRKG2)

GGO:	101139285(PRKG2)

PON:	100437791(PRKG1) 100438589(PRKG2)

NLE:	100584834(PRKG2) 100597697(PRKG1)

HMH:	116458051(PRKG1) 116466333(PRKG2)

MCC:	696308(PRKG2) 703356(PRKG1)

MCF:	102122483(PRKG1) 102142098(PRKG2)

MTHB:

126954542 126963251

MNI:	105463319(PRKG2) 105481070(PRKG1)

CSAB:

103216192(PRKG1) 103235875(PRKG2)

CATY:

105576820(PRKG2) 105587190(PRKG1)

PANU:

101021599(PRKG2)

TGE:	112624826(PRKG2) 112631135(PRKG1)

MLEU:

105533621(PRKG2) 105546945(PRKG1)

RRO:	104654813(PRKG2) 104676729(PRKG1)

RBB:	108543451(PRKG2)

TFN:	117085403(PRKG2) 117085919(PRKG1)

PTEH:

111549391(PRKG2) 111551296(PRKG1)

CANG:

105509527(PRKG1) 105511587(PRKG2)

CJC:	100384937(PRKG2) 100388016(PRKG1)

SBQ:	101033123(PRKG2) 101043597(PRKG1)

CIMI:

108305534(PRKG2) 108309826(PRKG1)

CSYR:

103272881(PRKG2) 103275000

MMUR:

105870362(PRKG1) 105880962(PRKG2)

LCAT:

123627373(PRKG2) 123650455(PRKG1)

PCOQ:

105822725(PRKG1)

OGA:	100941256(PRKG2) 100955814(PRKG1)

MMU:	19091(Prkg1) 19092(Prkg2)

MCAL:

110285294(Prkg1) 110294464(Prkg2)

MPAH:

110313055(Prkg1) 110330505(Prkg2)

RNO:	25523(Prkg2) 54286(Prkg1)

MCOC:

116067909(Prkg2) 116103727(Prkg1)

ANU:	117699970(Prkg2) 117720082(Prkg1)

MUN:	110562188(Prkg2)

CGE:	100765312(Prkg2) 100768615(Prkg1)

MAUA:

101826743(Prkg1) 101827998(Prkg2)

PROB:

127232334(Prkg2) 127233462(Prkg1)

PLEU:

114695723(Prkg2) 114710735(Prkg1)

MORG:

121453885(Prkg1) 121460822(Prkg2)

MFOT:

126506457 126511287

AAMP:

119811553(Prkg1) 119817224(Prkg2)

NGI:	103732508(Prkg1) 103735969(Prkg2)

HGL:	101697843(Prkg2) 101708361(Prkg1)

CPOC:

100724794(Prkg2) 100734084(Prkg1)

CCAN:

109702659(Prkg2)

DORD:

105986321(Prkg1) 105988515(Prkg2)

DSP:	122106688(Prkg2) 122115721(Prkg1)

PLOP:

125346325(Prkg1) 125364578(Prkg2)

NCAR:

124984630

OCU:	100008694(PRKG1) 100008781

OPI:	101526065(PRKG1) 101534728(PRKG2)

TUP:	102489899(PRKG2)

GVR:	103596579(PRKG2)

CFA:	100855930(PRKG2) 609616(PRKG1)

CLUD:

112646510(PRKG2) 112656199(PRKG1)

VVP:	112919705(PRKG2) 112931969(PRKG1)

VLG:	121475369(PRKG1) 121493652(PRKG2)

NPO:	129501897(PRKG2) 129507909(PRKG1)

AML:	100467892(PRKG2) 100481505(PRKG1)

UMR:	103661993(PRKG1) 103665352(PRKG2)

UAH:	113258870(PRKG1) 113263226(PRKG2)

UAR:	123787502(PRKG2) 123795560(PRKG1)

ELK:	111145213 111149130

LLV:	125085296 125093912

MPUF:

101673181(PRKG2) 101687177(PRKG1)

MNP:	132007578(PRKG2) 132016227(PRKG1)

NVS:	122889527(PRKG2) 122900680(PRKG1)

ORO:	101381093(PRKG2)

EJU:	114210308(PRKG1) 114224927(PRKG2)

ZCA:	113922106(PRKG1) 113924739(PRKG2)

MLX:	118010403(PRKG2) 118012977(PRKG1)

NSU:	110585983(PRKG1) 110591456(PRKG2)

LWW:	102747285(PRKG2)

FCA:	101091618(PRKG2) 101097420(PRKG1)

PYU:	121016604(PRKG1) 121033641(PRKG2)

PCOO:

112851475(PRKG1) 112858125(PRKG2)

PBG:	122478735(PRKG2) 122492656(PRKG1)

LRUF:

124518603 124520837

PTG:	102949245(PRKG2) 102969150(PRKG1)

PPAD:

109255410(PRKG1) 109276981(PRKG2)

PUC:	125922860 125933180

AJU:	106969513 106976911

HHV:	120222860(PRKG2) 120235955(PRKG1)

BTA:	282004(PRKG1) 533330(PRKG2)

BOM:	102269763(PRKG2) 102270503 102279305(PRKG1)

BIU:	109560622(PRKG2)

BBUB:

102405676(PRKG2) 102407722(PRKG1)

BBIS:

104982774(PRKG1) 104992909(PRKG2)

CHX:	102172135(PRKG2) 102182753(PRKG1)

OAS:	101113758(PRKG2) 443010(PRKG1)

BTAX:

128049712(PRKG2) 128068042(PRKG1)

ODA:	120861498(PRKG2) 120873771(PRKG1)

CCAD:

122428219(PRKG2) 122446215(PRKG1)

MBEZ:

129555589(PRKG1) 129561781(PRKG2)

SSC:	100512796(PRKG2) 733640(PRKG1)

CFR:	102509252(PRKG1) 102519263(PRKG2)

CBAI:

105081869(PRKG1) 105084003(PRKG2)

CDK:	105085256(PRKG1) 105091814(PRKG2)

VPC:	102525406(PRKG2) 102528698(PRKG1)

BACU:

103012801(PRKG1) 103013933(PRKG2)

LVE:	103071917(PRKG1) 103091057(PRKG2)

OOR:	101279276(PRKG1) 101280012(PRKG2)

DLE:	111172539(PRKG1) 111187663(PRKG2)

PCAD:

102985621(PRKG2) 102991499(PRKG1)

PSIU:

116741389(PRKG1) 116754313(PRKG2)

NASI:

112399588(PRKG1) 112414514(PRKG2)

ECB:	100060358(PRKG2) 100071872(PRKG1)

EPZ:	103549039(PRKG2)

EAI:	106828068(PRKG2) 106847454(PRKG1)

MYB:	102255009(PRKG1) 102258852(PRKG2)

MYD:	102770749(PRKG2)

MMYO:

118670010(PRKG1) 118670506(PRKG2)

MLF:	102423140(PRKG2)

MNA:	107537152(PRKG2) 107543282(PRKG1)

PKL:	118704664(PRKG2) 118719245(PRKG1)

EFUS:

103287900(PRKG2) 103296371(PRKG1)

HAI:	109387521(PRKG1) 109387927(PRKG2)

DRO:	112307314(PRKG1) 112319697(PRKG2)

SHON:

118990410(PRKG2) 119001529(PRKG1)

AJM:	119056901(PRKG2) 119057172

PDIC:

114493410(PRKG2) 114496021(PRKG1)

PHAS:

123828671(PRKG1) 123831363(PRKG2)

MMF:	118632751(PRKG1) 118635511(PRKG2)

RFQ:	117021894(PRKG2) 117035919(PRKG1)

PALE:

102884723(PRKG1) 102894554(PRKG2)

PGIG:

120588263(PRKG2) 120609370(PRKG1)

PVP:	105292433(PRKG2) 105293145(PRKG1)

RAY:	107515478(PRKG1) 107516479(PRKG2)

MJV:	108384319(PRKG1) 108396587(PRKG2)

TOD:	119260972(PRKG2)

SARA:

101538623(PRKG1) 101542063(PRKG2)

LAV:	100657163(PRKG2) 100662471(PRKG1)

TMU:

101346076

ETF:	101643055(PRKG1) 101646984(PRKG2)

DNM:	101417452(PRKG1) 101439805(PRKG2)

MDO:	100014568(PRKG2) 100023016(PRKG1)

GAS:	123234434(PRKG1) 123252215(PRKG2)

SHR:	100927283(PRKG2) 100928746(PRKG1)

AFZ:	127540897 127552152

PCW:	110199927(PRKG1) 110209720(PRKG2)

OAA:	100073431(PRKG1) 100082499(PRKG2)

GGA:	100859181(PRKACA) 423682(PRKG1) 428753(PRKG2)

PCOC:

116230675 116231090(PRKG2) 116234759(PRKG1)

MGP:	100540173(PRKG1) 100541294(PRKG2) 100544740

CJO:	107312321 107313465(PRKG2) 107315639(PRKG1)

TPAI:

128077911(PRKG1) 128080203(PRKG2) 128080602

LMUT:

125692001(PRKG2) 125694037(PRKG1)

NMEL:

110390491(PRKG1) 110396408 110397428(PRKG2)

APLA:

101790644(PRKG2) 101802614(PRKG1)

ACYG:

106030263(PRKG1) 106041906(PRKG2) 106049906

CATA:

118243777(PRKG1) 118249551(PRKG2) 118259033

AFUL:

116488259 116489089(PRKG2) 116491070(PRKG1)

TGU:	100229896(PRKG1) 100232260(PRKG2)

LSR:	110474019(PRKG1) 110480895(PRKG2)

SCAN:

103823826(PRKG1) 103826056(PRKG2)

PMOA:

120502746(PRKG2) 120507265(PRKG1)

OTC:	121336109(PRKG1) 121339894(PRKG2)

PRUF:

121354020(PRKG2) 121357353(PRKG1)

GFR:	102041315(PRKG1) 102042278(PRKG2)

FAB:	101813345(PRKG2) 101816835(PRKG1)

OMA:	130252815(PRKG2) 130255131(PRKG1)

PHI:	102105641(PRKG1) 102108417(PRKG2)

PMAJ:

107203574(PRKG2) 107207071(PRKG1)

CCAE:

111928808(PRKG2)

CCW:	104695105(PRKG1) 104697218(PRKG2)

CBRC:

103615272(PRKG1) 103622367(PRKG2)

ETL:	114059161(PRKG2) 114065114(PRKG1)

ZAB:	102074710(PRKG2) 102075463(PRKG1)

ACHL:

103804902(PRKG2)

SVG:	106855679(PRKG2) 106856708(PRKG1)

MMEA:

130580386 130584103(PRKG2)

HRT:	120753398(PRKG2) 120755631(PRKG1)

FPG:	101914750(PRKG1) 101916682 101918759(PRKG2)

FCH:	102051167(PRKG1) 102055004(PRKG2) 106631485

CLV:	102089346(PRKG2) 102098659(PRKG1)

EGZ:	104125151(PRKG1) 104133983(PRKG2)

NNI:	104013515(PRKG1) 104021251(PRKG2)

PCRI:

104036646(CNBD2)

ACUN:

113479638(PRKG2) 113481922(PRKG1)

TALA:

104363723(PRKG2) 104364583(PRKG1) 116959621

PADL:

103913713(PRKG2)

AFOR:

103895487(PRKG1) 103897069(PRKG2)

ACHC:

115339981(PRKG2) 115348087(PRKG1) 115351043

HLE:	104829891(PRKG2) 104830771 104831216

AGEN:

126042670 126044889 126046258

GCL:	127015633 127017515

CCRI:

104163515

CSTI:

104563753(PRKG2)

CMAC:

104481119(PRKG1)

MUI:	104545609(PRKG2)

BREG:

104639710

FGA:

104080142

GSTE:

104262512

LDI:

104346921

OHA:	104330398(PRKG1)

NNT:	104400050(PRKG2)

SHAB:

115608659(PRKG1) 115610136 115610797(PRKG2)

DPUB:

104296890(PRKG2) 104308337

PGUU:

104471482(PRKG2)

ACAR:

104518127(PRKG2)

CPEA:

104397761(PRKG1)

AVIT:

104276570(PRKG1)

CVF:	104283462(PRKG1) 104288698(PRKG2)

RTD:	128907544 128910017(PRKG2) 128911094(PRKG1)

CUCA:

104065114(PRKG1)

AAM:	106491038(PRKG2)

AROW:

112973322(PRKG1) 112977374(PRKG2)

NPD:	112948419(PRKG1) 112954775(PRKG2)

TGT:	104577159(PRKG1)

DNE:	112981624(PRKG1) 112992291(PRKG2)

SCAM:

104144237(PRKG1) 104146525(PRKG2)

ASN:	102372581 102375122(PRKG2) 102385836(PRKG1)

AMJ:	102560332(PRKACA) 102570800(PRKG2) 102573015(PRKG1)

CPOO:

109309532(PRKG2) 109312524(PRKG1)

GGN:	109290935(PRKG1) 109297118(PRKG2)

CMY:	102942713(PRKG1) 114018938

CCAY:

125628886 125634824 125640557(PRKG1)

DCC:	119853911 119859497(PRKG1)

CPIC:

101953224(PRKG1) 103305918(PRKG2)

TST:	117879767(PRKG1)

MRV:	120409369(PRKG1)

ACS:	100561246(prkg2) 103282038

PVT:	110084111(PRKG2) 110087006

SUND:

121919531 121926226(PRKG1) 121931735(PRKG2)

PBI:	103050448(PRKG2) 103060529 103064237

PMUR:

107286453 107303184(PRKG2)

CTIG:

120301046(PRKG1) 120309158 120311420(PRKG2)

TSR:	106545902 106547680(PRKG2)

PGUT:

117667640 117670643(PRKG1) 117673681(PRKG2)

APRI:

131188965 131200640(PRKG1) 131203062(PRKG2)

PTEX:

113441533 113448279(PRKG2) 113449014(PRKG1)

NSS:	113414552 113417896(PRKG2) 113420266(PRKG1)

VKO:	123018460(PRKG1) 123018727 123022846(PRKG2)

PMUA:

114595005 114597269(PRKG1) 114604385(PRKG2)

PRAF:

128411526 128413988(PRKG1) 128421452(PRKG2)

ZVI:	118083662(PRKG2) 118096161(PRKG1)

HCG:	128325226 128325630(PRKG2) 128349242(PRKG1)

GJA:	107114871(PRKG2)

STOW:

125437653(PRKG1) 125440352(PRKG2) 125443595

EMC:	129332770 129334647 129336712(PRKG2)

XLA:	108696071 108696263 108697216 108697357(prkg1.S) 444025(prkg2.L)

XTR:	100494278(prkg1) 100497736(prkg2) 100498055

NPR:	108789074(PRKG2) 108797031(PRKG1)

RTEM:

120908941 120914409(PRKG2) 120947083(PRKG1)

BBUF:

120991655(PRKG2) 121003777(PRKG1) 121005082

BGAR:

122927516(PRKG2) 122940153(PRKG1) 122941006

MUO:	115465137 115470145(PRKG1) 115471206(PRKG2)

GSH:	117358256 117358630(PRKG2) 117360107(PRKG1)

DRE:	100125912(prkg2) 326020(si:dkey-121j17.5) 394005(prkg1a) 556339 566430(prkg1b)

SRX:	107708387 107708873 107719224 107727357 107731507 107744862 107746786 107747254

SANH:

107654050 107660531 107661254 107663377(prkg2) 107665604 107680302 107695529 107699307 107702750

SGH:	107554918 107557353(prkg1) 107586071 107586507 107599184 107602032

CCAR:

109078441 109090195 109090782 109106262(prkg1) 109108300

CAUA:

113049125 113056342 113057217 113063503 113077808 113111947 113112406 113112450

CGIB:

127939021 127957131 127968992 127970459 127970720 128002983 128020724 128024996 128025961

PTET:

122325243(prkg3) 122345008(prkg2) 122352830 122355530(prkg1b) 122356061 122356937(prkg1a)

LROH:

127161762(prkg3) 127164833(prkg2) 127172141 127174086(prkg1b) 127174711(prkg1a) 127174824

OMC:	131527240(prkg3) 131540163(prkg2) 131548117 131550733(prkg1b) 131552110(prkg1a) 131552271

PPRM:

120461784(prkg2) 120462257(prkg1a) 120474479(prkg1b) 120479266(prkg3) 120479323

MAMB:

125254981(prkg1b) 125266993(prkg2) 125276687 125277225(prkg1a) 125277724(prkg3)

CIDE:

127502574 127513552 127520251 127523683 127525135 127525555

MASI:

127412113 127412142 127414410 127415805 127422882 127426740 127432707 127433564 127438549

TROS:

130545645 130559144 130559642(prkg1a) 130565999(prkg3) 130569079(prkg1b) 130571236(prkg2)

MANU:

129415687(prkg1a) 129415953 129420700(prkg1b) 129440528(prkg2) 129446552

IPU:	108255985 108261320(prkg3) 108263686 108263833(prkg1a) 108274270(prkg1b)

IFU:	128605587 128605601(prkg1a) 128616736(prkg1b) 128619504(prkg3) 128625602(prkg2)

PHYP:

113527432 113529209 113537052(prkg2) 113538666 113544135

SMEO:

124375611(prkg1a) 124380680(prkg2) 124388860(prkg1b) 124394485 124401374(prkg3)

TFD:	113637633(prkg2) 113639764 113639906(prkg1a) 113649386(prkg1b) 113654820(prkg3)

AMEX:

103022723 103030142(prkg2) 103032529 103041230 103047830(prkg1)

CMAO:

118800224(prkg3) 118809169(prkg1b) 118810379 118810389(prkg1a) 118827230(prkg2)

EEE:	113577006(prkg1) 113581636 113585394 113589804 113591915

CHAR:

105888796 105890865 105892148 105893607(prkg1b) 105902292 105906881(prkg2)

TRU:	101061256(prkg1) 101071377 101074431(prkg2) 105419048

TFS:	130515973(prkg3) 130525533(prkg2) 130533403 130533853

TNG:	GSTEN00016387G001 GSTEN00030356G001

LCO:	104921979 104927466 104929951(prkg2) 104939827

NCC:	104947339 104954051 104955830 104955882

CGOB:

115003587 115013763(prkg2) 115019815 115020192(prkg1)

ELY:	117247991 117252905(prkg2) 117270421(prkg3)

EFO:	125890075(prkg2) 125897510(prkg3) 125903270

PLEP:

121944718(prkg2) 121954433 121954489 121956012(prkg3)

SLUC:

116050373 116054106(prkg2) 116055147 116066486(prkg3)

ECRA:

117945406(prkg2) 117960504 117960788 117961240(prkg3)

ESP:	116690309(prkg2) 116705324(prkg1) 116705633 116706636

PFLV:

114555686(prkg2) 114571723 114572507

GAT:	120807891(prkg3) 120813110 120820788

PPUG:

119195391(prkg3) 119214369 119224835(prkg2)

AFB:	129092017 129092173 129100726(prkg2) 129107225(prkg3)

CLUM:

117727574(prkg3) 117735803(prkg2) 117743960 117744101

MSAM:

119892004(prkg2) 119908424(prkg3) 119917222

SCHU:

122863525(prkg3) 122876944(prkg2) 122884081

CUD:	121510051(prkg2) 121511176 121511336 121521080(prkg3)

ALAT:

119012153(prkg3) 119020289(prkg2) 119033457 119033936

MZE:	101466538 101471197(prkg2) 101479945

ONL:	100694992 100699113(prkg2) 100708987

OAU:	116310793(prkg3) 116333376(prkg2) 116333752

OLA:	100049290(prkg1) 101158535(prkg2) 101165996 101173830

OML:	112137683(prkg2) 112158429(prkg3) 112161926 112161974(prkg1b)

XMA:	102216397 102230306(prkg2) 102235247

XCO:	114138474 114153990(prkg2) 114158207

XHE:	116713518 116729132(prkg2) 116733691

PRET:

103457572 103469805(prkg2) 103476798

PFOR:

103133523 103134891(prkg2) 103134980 103138603

PLAI:

106934820(prkg2) 106935940 106947667 106957396

PMEI:

106906174 106915466 106922336(prkg2) 106928310 106929127

GAF:	122825526(prkg3) 122828661(prkg2) 122842979

CVG:	107083363 107083975(prkg2) 107098368

CTUL:

119785128(prkg3) 119785444(prkg2) 119790862

GMU:	124859212 124875514 124877400(prkg2) 124882369(prkg3)

NFU:	107375493 107376029 107377464 107386061(prkg2)

KMR:	108239119 108240136(prkg3) 108242381 108244533(prkg2)

ALIM:

106513507(prkg1) 106513735 106516936 106525434(prkg2) 106528217

NWH:	119407520 119413007 119413136(prkg2) 119418541(prkg3) 119423874

AOCE:

111565792(prkg2) 111568230 111575530(prkg1) 111586601

MCEP:

124999409(prkg3) 125012623(prkg2) 125018728 125019106

CSEM:

103380827 103386981 103387682(prkg1) 103397539(prkg2)

POV:	109629155 109632737

SSEN:

122762998(prkg2) 122764933 122782184 122783714(prkg3)

HHIP:

117758431(prkg3) 117767429(prkg2) 117775114 117775561

HSP:	118099599(prkg3) 118115516(prkg2) 118119160 118119306

LCF:	108887140 108895314 108895629(prkg3) 108897326

SDU:	111216303 111228005(prkg2) 111235208

SLAL:

111650595 111653026 111654602 111660882(prkg2) 111670023(prkg1)

XGL:	120789174(prkg3) 120796378 120796544 120805415(prkg2)

HCQ:	109516694 109520050 109526918(prkg2) 109528789

SSCV:

125978372 125978603 125989832 125994013

BPEC:

110155390 110157105 110158150 110160457

MALB:

109952723 109957341(prkg2) 109962157(prkg1)

BSPL:

114850179(prkg3) 114862959(prkg2) 114870401

SASA:

106571758 106576682 106577002 106607187 106607930 106608672

STRU:

115153151 115153218 115157023 115174456 115189308 115193760 115193847 115201173

OTW:	112217699 112232971 112253028 112253523 112253870 112254522

OMY:	110491369 110498977 110502406 110502467 110522345 110527939 110528926 110529892

OGO:	123991020 123995194 124037210 124038255 124040042(prkg1b) 124040785 124041256 124048150

ONE:	115106350 115108024 115113223 115113268 115135103 115135178 115139298 115144061

OKI:	109865573 109866123 109870242 109888778 109889943 109899093 109899108 109900319

OKE:	118357463(prkg1b) 118361806 118368484 118369645 118369715 118387011 118398382 118400205

SALP:

111951584 111951933 111954366 111973400 111977420

SNH:	120017414 120017651 120024381 120029745(prkg1b) 120045630 120045866 120046129

CCLU:

121532297 121541537 121547345 121548817(prkg3) 121553393 121553733 121570914 121580925 121583510 121584826 121587383

ELS:	105006031 105007647(prkg2) 105010645 105010732

SFM:	108924066 108932765 108938469(prkg2) 108939676(prkg1) 108942712

PKI:	111839266 111841262 111853690(prkg1)

AANG:

118217691 118217808 118221272(prkg1b) 118229259(prkg3) 118237345(prkg2)

LOC:	102684201(prkg1) 102689239 102694398(prkg2) 102697784 102698203

PSPA:

121300010(prkg2) 121303213 121317145(prkg3) 121318794 121321863 121325426 121325521

ARUT:

117397688 117410442(prkg3) 117414972 117417630 117418513 117962943

PSEX:

120525826(prkg3) 120532132(prkg2) 120538748

LCM:	102345412 102357627 102361824(PRKG2)

CMK:	103180874(prkg2) 103180883(prkg1b) 103181471 103190998

RTP:	109923944 109924169 109927508

CPLA:

122541939 122543167 122552933(prkg2) 122561042(prkg1b)

LERI:

129693307(prkg2) 129704248(prkg1b) 129712974 129713372

BFO:	118411480 118412576 118412578

BBEL:

109466828 109478278 109478342

CIN:	100176673 100179064 100184124

SCLV:

120329981 120336876 120347122 120347480

SPU:

589462

LPIC:

129281775 129282276

APLC:

110973758 110982046

AJC:	117103168 117109840

DME:	Dmel_CG10033(for) Dmel_CG3324(Pkg21D) Dmel_CG4839(CG4839)

DER:	6540897 6541099 6542539

DSE:	6611919 6613265 6617296

DSI:	Dsimw501_GD22740(Dsim_GD22740) Dsimw501_GD22942(Dsim_GD22942) Dsimw501_GD23660(Dsim_GD23660)

DYA:	Dyak_GE14825 Dyak_GE15942 Dyak_GE18902

DAN:	6497481 6497690 6498550

DSR:	110178188 110182603 110187360

DPO:	4816859 4817047 4817545

DPE:	6588824 6589026 6595699

DMN:	108162046 108162419 108163582

DWI:	6642441 6644123 6651863

DGR:	6561993 6562037 6566754

DMO:	Dmoj_GI17596 Dmoj_GI17764 Dmoj_GI18016

DAZ:	108609997 108611585 108611824

DNV:	115562010 115563626 115563805

DHE:	111599114 111601364 111603971

DVI:	116651565 6628026 6628367 6634199

CCAT:

101451635 101452607

BOD:	106615054 106617651

RZE:	108359674 108366307 108377343

TDA:	119662733 119687868 119689482

MDE:	101889819 101891319 101900584

SCAC:

106085521 106093532

LCQ:	111677667 111679265 111681972

LSQ:	119603018 119610902

ECOE:

129938363 129940306 129952097

HIS:	119646149 119651059 119651726

AGA:	AgaP_AGAP008585 AgaP_AGAP008863 AgaP_AGAP009798

ACOZ:

120955578 120956569 120959490

AARA:

120899642 120900505 120902572

AMER:

121595242 121595627 121598054

ASTE:

118512489 118513432 118513550

AFUN:

125761957 125762127 125765543

AALI:

118456370 118457380 118457804

AAG:	5567008 5569682 5577470

AALB:

109397574 109433057 109621380 109621502 115268590

CQU:	CpipJ_CPIJ006121 CpipJ_CPIJ015653

CPII:

120414069 120418422 120420968 120431661

CNS:	116337020 116338275

BCOO:

119075651 119077031 119082106

AME:	406092(For)

ACER:

107997323 108004011

ALAB:

122712172 122712332

ADR:	102670636 102671412

AFLR:

100865705 105736922

BIM:

100744786

BBIF:

117213509

BVK:

117233582

BVAN:

117154791

BTER:

100628631

BAFF:

126915969 126922811

BPYO:

122574299 122577979

FVI:	122536436 122536437 122538673

CCAL:

108631693

OBB:

114878681

MGEN:

117221657

NMEA:

116428630

CGIG:

122400917 122403435

SOC:

105202008

MPHA:

105835361

AEC:

105148710

ACEP:

105627059

PBAR:

105427696

VEM:

105562546

HST:

105180461

DQU:

106741445

CFO:

105255628

FEX:	115234366 115240325

LHU:

105678094

PGC:

109861390

OBO:

105280702

PCF:

106784179

PFUC:

122516023 122522834

VPS:	122628887 122632580

VCRB:

124424566 124427562

NVI:	100117965 100119839

CSOL:

105361340

TPRE:

106649867 106657344

LHT:	122501787 122504809

LBD:	127278983 127278984 127287656

MDL:

103578414

CGLO:

123265708 123265709 123268458

FAS:	105265589 105269094 105269097

DAM:	107037098 107039744 107039745

AGIF:

122849834 122857197

CINS:

118068663 118072177

VCAN:

122414097 122414476 122414919

CCIN:

107265986 107267830 107267842

DSM:

124416370

NPT:	124210689 124219831

NFB:	124183192 124188173

NLO:	107219420 107225029

NVG:	124304709 124310509

TCA:

657149

DPA:	109536702 109546365

SOY:	115877055 115877063 115883044 115883833

AGRG:

126735140 126735154 126735312 126740790 126750239

ATD:	109603865 109608223

CSET:

123311494 123312035 123312094 123315992 123317286 123317590

AGB:	108903623 108908291 108909709 108916198

LDC:	111508658 111508661 111508668 111509749 111511298

NVL:	108561083 108561485

APLN:

108737706 108738730 108739815 108743355

PPYR:

116170816 116180394 116181607

OTU:	111424894 111426555 111427377 111427906

BMOR:

692605(PKG-I)

BMAN:

114250737

MSEX:

115443172 115455815

DPL:	KGM_205085 KGM_208453

BANY:

112046535 112049408

MJU:	123873603 123880929

NIQ:	126769856 126771824

VCD:	124533834 124536810

MCIX:

123653832 123660590

PMAC:

106710807 106712155

PPOT:

106105142 106109172

PXU:	106126670 106128323

PRAP:

110996423 110996662

PBX:	123711265 123713838

PNAP:

125053378 125060938

ZCE:	119834783 119839976

CCRC:

123691418 123698143

LSIN:

126965933 126970575

HAW:	110369981 110376116

HZE:	124631326 124639070

TNL:	113492093 113504464

SLIU:

111351847 111353670 111362670

OFU:	114351338 114353143

PXY:

105381837

PGW:	126367934 126374063

CFEL:

113382888 113383447 113384965

CCRN:

123298579 123299186 123300984 123305060 123305170

API:

100168151

DNX:

107170171

AGS:

114124896

RMD:

113560773

ACOO:

126836122 126846412

BTAB:

109030563 109043112

DCI:	103507911 103516942

CLEC:

106662224 106663991

HHAL:

106678864 106681618

NLU:	111048384 111048592

HVI:	124359728 124362545

PHU:	Phum_PHUM189890 Phum_PHUM596920

FOC:	113202771 113212626

TPAL:

117648659 117650290

ZNE:	110836511 110837257

CSEC:

111867470 111868652

SGRE:

126273200 126320482 126355586

IEL:	124161496 124170531

FCD:

110847879

DPX:	DAPPUDRAFT_194528 DAPPUDRAFT_207381

DMK:	116930926 116932040 116932149

DPZ:	124348848 124349495

PVM:

113813818

PJA:	122247724 122249836 122251530 122261895

PCHN:

125041886 125042756

PMOO:

119581792 119590013

HAME:

121864608 121880177

PCLA:

123757902 123758453

CQD:	128688561 128689229

PTRU:

123499641 123520209

ESN:	126980970 127004637

HAZT:

108666480 108679848

EAF:	111700247 111700258 111701474 111713529

LSM:

121126665

PPOI:

119097726 119101854 119101965 119102078

DSV:	119436380 119445576

RSAN:

119389391 119401322

RMP:	119161615 119161732

VDE:

111243669

VJA:

111266620

TUT:

107363105

DPTE:

113790699

DFR:	124490296 124496655

CSCU:

111625343

PTEP:

107436702 107446305

UDV:	129217009 129225504 129234104 129234493 129235107

SDM:	118180849 118183323 118186346 118201394 118202144

LPOL:

106460031 106461395 106466460 106472797 106474380

PMEO:

129584165 129593823

CEL:	CELE_F55A8.2(egl-4)

CBR:	CBG_08401(Cbr-pkg-1)

CRQ:	GCK72_016302

LGI:	LOTGIDRAFT_127769 LOTGIDRAFT_210612

PCAN:

112565934 112573499

BGT:	106065352 106067606

GAE:	121378627 121378889

HRF:	124132484 124139612

HRJ:	124277971 124285481

CRG:	105335784 105345094

CVN:	111118725 111120773

CANU:

128166073 128166844

OED:	125668069 125668763

MYI:	110449619 110451175

PMAX:

117328060 117334498

MCAF:

127707469 127710214

MMER:

123563923 123564110

DPOL:

127857618 127866058 127866575

OBI:

106880808

OSN:

115214224

LAK:	106156342 106181988

SMM:	Smp_168670

NVE:

5509991

EPA:

110249033

ATEN:

116288998 116289897

AMIL:

114960266

PDAM:

113677276

SPIS:

111344883

XEN:	124438049 124439048

HMG:

100201371

HSY:	130622095 130655722

TAD:	TRIADDRAFT_30166

VCN:	VOLCADRAFT_81219 VOLCADRAFT_97912

CSL:	COCSUDRAFT_35741

CVR:	CHLNCDRAFT_49225

APRO:

F751_6750

OTA:	OT_ostta13g01130

BPG:	Bathy04g01910

MIS:	MICPUN_104866(CL-PK2)

MPP:	MICPUCDRAFT_33413

PFA:	PF3D7_1436600

PFD:	PFDG_01207 PFDG_03615

PFH:	PFHG_00276 PFHG_04513

PREI:

PRSY57_1435900

PGAB:

PGSY75_1436600

PYO:	PY17X_1009800

PCB:	PCHAS_1009100

PBE:	PBANKA_1008200

PVV:	PVVCY_0800870

PKN:	PKNH_0423200

PVX:	PVX_084705

PCY:	PCYB_132230

PMAL:

PMUG01_13023700(PKG)

PREL:

PRELSG_1314500(PKG)

TAN:

TA04955

TPV:

TP03_0511

BBIG:

BBBOND_0406010

CPV:

cgd8_750

CHO:	Chro.80094

TET:	TTHERM_00013270 TTHERM_00105520 TTHERM_00193700 TTHERM_00442770

PTM:	GSPATT00017822001 GSPATT00038158001

FCY:	FRACYDRAFT_263989

TPS:	THAPSDRAFT_1553 THAPSDRAFT_21108

AAF:	AURANDRAFT_19287 AURANDRAFT_63526

PIF:	PITG_11102

SMAG:

AN936_03545

SMAZ:

LH19_17420

SPHU:

SPPYR_2707

» show all

Reference

1 [PMID:186778]

Authors

Gill GN, Holdy KE, Walton GM, Kanstein CB.

Title

Purification and characterization of 3':5'-cyclic GMP-dependent protein kinase.

Journal

Proc Natl Acad Sci U S A 73:3918-22 (1976)
DOI:10.1073/pnas.73.11.3918

Reference

2 [PMID:15312978]

Authors

Murthy KS.

Title

Modulation of soluble guanylate cyclase activity by phosphorylation.

Journal

Neurochem Int 45:845-51 (2004)
DOI:10.1016/j.neuint.2004.03.014

Reference

3 [PMID:12933804]

Authors

Richie-Jannetta R, Francis SH, Corbin JD.

Title

Dimerization of cGMP-dependent protein kinase Ibeta is mediated by an extensive amino-terminal leucine zipper motif, and dimerization modulates enzyme function.

Journal

J Biol Chem 278:50070-9 (2003)
DOI:10.1074/jbc.M306796200

Reference

4 [PMID:9395542]

Authors

Zhao J, Trewhella J, Corbin J, Francis S, Mitchell R, Brushia R, Walsh D.

Title

Progressive cyclic nucleotide-induced conformational changes in the cGMP-dependent protein kinase studied by small angle X-ray scattering in solution.

Journal

J Biol Chem 272:31929-36 (1997)
DOI:10.1074/jbc.272.50.31929

Other DBs

ExplorEnz - The Enzyme Database:

2.7.11.12

IUBMB Enzyme Nomenclature:

2.7.11.12

ExPASy - ENZYME nomenclature database:

2.7.11.12

BRENDA, the Enzyme Database:

2.7.11.12

CAS:	141588-27-4

DBGET integrated database retrieval system