KEGG   ENZYME: 2.7.11.12
Entry
EC 2.7.11.12                Enzyme                                 

Name
cGMP-dependent protein kinase;
3':5'-cyclic GMP-dependent protein kinase;
cGMP-dependent protein kinase Ibeta;
guanosine 3':5'-cyclic monophosphate-dependent protein kinase;
PKG;
PKG 1alpha;
PKG 1beta;
PKG II;
STK23
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:protein phosphotransferase (cGMP-dependent)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
R00162
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
CGMP is required to activate this enzyme. The enzyme occurs as a dimer in higher eukaryotes. The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. This domain catalyses the phosphorylation by ATP to specific serine or threonine residues in protein substrates [3]. The enzyme also has two allosteric cGMP-binding sites (sites A and B). Binding of cGMP causes a conformational change that is associated with activation of the kinase [4].
History
EC 2.7.11.12 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K07376  cGMP-dependent protein kinase 1
K19477  cGMP-dependent protein kinase 2
Genes
HSA: 5592(PRKG1) 5593(PRKG2)
PTR: 461217(PRKG2) 744467(PRKG1)
PPS: 100975252(PRKG1) 100978260(PRKG2)
GGO: 101139285(PRKG2)
PON: 100437791(PRKG1) 100438589(PRKG2)
NLE: 100584834(PRKG2) 100597697(PRKG1)
MCC: 696308(PRKG2) 703356(PRKG1)
MCF: 102122483(PRKG1) 102142098(PRKG2)
CSAB: 103216192(PRKG1) 103235875(PRKG2)
RRO: 104654813(PRKG2) 104676729(PRKG1)
RBB: 108543451(PRKG2)
CJC: 100384937(PRKG2) 100388016(PRKG1)
SBQ: 101033123(PRKG2) 101043597(PRKG1)
MMU: 19091(Prkg1) 19092(Prkg2)
MCAL: 110285294(Prkg1) 110294464(Prkg2)
MPAH: 110313055(Prkg1) 110330505(Prkg2)
RNO: 25523(Prkg2) 54286(Prkg1)
MUN: 110562188(Prkg2)
CGE: 100765312(Prkg2) 100768615(Prkg1)
NGI: 103732508(Prkg1) 103735969(Prkg2)
HGL: 101697843(Prkg2) 101708361(Prkg1)
CCAN: 109702659(Prkg2)
OCU: 100008694(PRKG1) 100008781(PRKG2)
TUP: 102489899(PRKG2)
CFA: 100855930(PRKG2) 609616(PRKG1)
VVP: 112919705(PRKG2) 112931969(PRKG1)
AML: 100467892(PRKG2) 100481505(PRKG1)
UMR: 103661993(PRKG1) 103665352(PRKG2)
UAH: 113258870(PRKG1) 113263226(PRKG2)
ORO: 101381093(PRKG2)
FCA: 101091618(PRKG2) 101097420(PRKG1)
PTG: 102949245(PRKG2) 102969150(PRKG1)
PPAD: 109255410(PRKG1) 109276981(PRKG2)
AJU: 106969513(PRKG1) 106976911(PRKG2)
BTA: 282004(PRKG1) 533330(PRKG2)
BOM: 102269763(PRKG2) 102270503 102279305(PRKG1)
BIU: 109560622(PRKG2)
BBUB: 102405676(PRKG2) 102407722(PRKG1)
CHX: 102172135(PRKG2) 102182753(PRKG1)
OAS: 101113758(PRKG2) 443010(PRKG1)
SSC: 100512796(PRKG2) 733640(PRKG1)
CFR: 102509252(PRKG1) 102519263(PRKG2)
CDK: 105085256(PRKG1) 105091814(PRKG2)
BACU: 103012801(PRKG1) 103013933(PRKG2)
LVE: 103071917(PRKG1) 103091057(PRKG2)
OOR: 101279276(PRKG1) 101280012(PRKG2)
DLE: 111172539(PRKG1) 111187663(PRKG2)
PCAD: 102985621(PRKG2) 102991499(PRKG1)
ECB: 100060358(PRKG2) 100071872(PRKG1)
EPZ: 103549039(PRKG2)
EAI: 106828068(PRKG2) 106847454(PRKG1)
MYB: 102255009(PRKG1) 102258852(PRKG2)
MYD: 102770749(PRKG2)
MNA: 107537152(PRKG2) 107543282(PRKG1)
HAI: 109387521(PRKG1) 109387927(PRKG2)
DRO: 112307314(PRKG1) 112319697(PRKG2)
PALE: 102884723(PRKG1) 102894554(PRKG2)
RAY: 107515478(PRKG1) 107516479(PRKG2)
MJV: 108396587(PRKG2)
LAV: 100657163(PRKG2) 100662471(PRKG1)
TMU: 101346076
MDO: 100014568(PRKG2) 100023016(PRKG1)
SHR: 100927283(PRKG2) 100928746(PRKG1)
PCW: 110199927(PRKG1) 110209720(PRKG2)
OAA: 100073431(PRKG1) 100082499(PRKG2)
GGA: 100859181(PRKACA) 423682(PRKG1) 428753(PRKG2)
MGP: 100540173(PRKG1) 100541294(PRKG2) 100544740
CJO: 107312321 107313465(PRKG2) 107315639(PRKG1)
NMEL: 110390491(PRKG1) 110396408 110397428(PRKG2)
APLA: 101790644(PRKG2) 101802614(PRKG1)
ACYG: 106030263(PRKG1) 106041906(PRKG2)
TGU: 100229896(PRKG1) 100232260(PRKG2)
LSR: 110474019(PRKG1) 110480895(PRKG2)
SCAN: 103823826(PRKG1) 103826056(PRKG2)
GFR: 102041315(PRKG1) 102042278(PRKG2)
FAB: 101813345(PRKG2) 101816835(PRKG1)
PHI: 102105641(PRKG1) 102108417(PRKG2)
PMAJ: 107203574(PRKG2) 107207071(PRKG1)
CCAE: 111928808(PRKG2)
CCW: 104695105(PRKG1) 104697218(PRKG2)
ETL: 114059161(PRKG2) 114065114(PRKG1)
FPG: 101914750(PRKG1) 101916682 101918759(PRKG2)
FCH: 102051167(PRKG1) 102055004(PRKG2) 106631485
CLV: 102089346(PRKG2) 102098659(PRKG1)
EGZ: 104125151(PRKG1) 104133983(PRKG2)
NNI: 104013515(PRKG1) 104021251(PRKG2)
ACUN: 113479638(PRKG2) 113481922(PRKG1)
PADL: 103913713(PRKG2)
AAM: 106491038(PRKG2)
ASN: 102372581 102375122(PRKG2) 102385836(PRKG1)
AMJ: 102560332(PRKACA) 102570800(PRKG2) 102573015(PRKG1)
CMY: 102942713(PRKG1)
CPIC: 101953224(PRKG1) 103305918(PRKG2)
ACS: 100561246(prkg2) 103282038
PVT: 110084111(PRKG2) 110087006
PMUR: 107286453 107303184(PRKG2)
TSR: 106545902 106547680(PRKG2)
PMUA: 114595005 114597269(PRKG1) 114604385(PRKG2)
GJA: 107114871(PRKG2)
XLA: 108696071 108696263 108697216 108697357(prkg1.S) 444025(prkg2.L)
XTR: 100494278(prkg1) 100497736(prkg2) 100498055
NPR: 108789074(PRKG2) 108797031(PRKG1)
DRE: 100125912(prkg2) 326020(si:dkey-121j17.5) 394005(prkg1a) 556339 566430(prkg1b)
AMEX: 103022723 103030142(prkg2) 103041230 103047830(prkg1)
AOCE: 111565792(prkg2) 111568230 111575530(prkg1) 111586601
CSEM: 103380827 103386981 103387682(prkg1) 103397539(prkg2)
MALB: 109952723 109957341(prkg2) 109962157(prkg1)
CMK: 103180874(prkg2) 103180883(prkg1) 103181471
SPU: 589462
DME: Dmel_CG10033(for) Dmel_CG3324(Pkg21D) Dmel_CG4839(CG4839)
DSI: Dsimw501_GD22740(Dsim_GD22740) Dsimw501_GD22942(Dsim_GD22942) Dsimw501_GD23660(Dsim_GD23660)
AME: 406092(For) 551714
BIM: 100744786
BTER: 100628631
CCAL: 108631693
OBB: 114878681
SOC: 105202008
MPHA: 105835361
AEC: 105148710
ACEP: 105627059
PBAR: 105427696
VEM: 105562546
HST: 105180461
DQU: 106741445
CFO: 105255628
LHU: 105678094
PGC: 109861390
OBO: 105280702
PCF: 106784179
CSOL: 105361340
MDL: 103578414
TCA: 657149
BMOR: 692605(PKG-I)
BMAN: 114250737
PMAC: 106712155
PRAP: 110996662
HAW: 110376116
TNL: 113492093
PXY: 105381837
API: 100168151
DNX: 107170171
AGS: 114124896
RMD: 113560773
FCD: 110847879
PVM: 113813818
TUT: 107363105
CSCU: 111625343
CEL: CELE_F55A8.2(egl-4)
MYI: 110451175
NVE: 5509991
EPA: 110249033
AMIL: 114960266
PDAM: 113677276
SPIS: 111344883
HMG: 100201371(prkg1)
APRO: F751_6750
MIS: MICPUN_104866(CL-PK2)
PCB: PCHAS_100910(PC000298.03.0)
TAN: TA04955
TPV: TP03_0511
CPV: cgd8_750
SMAZ: LH19_17420
SPHU: SPPYR_2707
BBA: Bd1502
 » show all
Reference
1  [PMID:186778]
  Authors
Gill GN, Holdy KE, Walton GM, Kanstein CB.
  Title
Purification and characterization of 3':5'-cyclic GMP-dependent protein kinase.
  Journal
Proc Natl Acad Sci U S A 73:3918-22 (1976)
DOI:10.1073/pnas.73.11.3918
Reference
2  [PMID:15312978]
  Authors
Murthy KS.
  Title
Modulation of soluble guanylate cyclase activity by phosphorylation.
  Journal
Neurochem Int 45:845-51 (2004)
DOI:10.1016/j.neuint.2004.03.014
Reference
3  [PMID:12933804]
  Authors
Richie-Jannetta R, Francis SH, Corbin JD.
  Title
Dimerization of cGMP-dependent protein kinase Ibeta is mediated by an extensive amino-terminal leucine zipper motif, and dimerization modulates enzyme function.
  Journal
J Biol Chem 278:50070-9 (2003)
DOI:10.1074/jbc.M306796200
Reference
4  [PMID:9395542]
  Authors
Zhao J, Trewhella J, Corbin J, Francis S, Mitchell R, Brushia R, Walsh D.
  Title
Progressive cyclic nucleotide-induced conformational changes in the cGMP-dependent protein kinase studied by small angle X-ray scattering in solution.
  Journal
J Biol Chem 272:31929-36 (1997)
DOI:10.1074/jbc.272.50.31929
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.12
IUBMB Enzyme Nomenclature: 2.7.11.12
ExPASy - ENZYME nomenclature database: 2.7.11.12
BRENDA, the Enzyme Database: 2.7.11.12
CAS: 141588-27-4

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