KEGG   ENZYME: 2.7.11.14Help
Entry
EC 2.7.11.14                Enzyme                                 

Name
rhodopsin kinase;
cone opsin kinase;
G-protein-coupled receptor kinase 1;
GPCR kinase 1;
GRK1;
GRK7;
opsin kinase;
opsin kinase (phosphorylating);
rhodopsin kinase (phosphorylating);
RK;
STK14
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:rhodopsin phosphotransferase
Reaction(IUBMB)
ATP + rhodopsin = ADP + phosphorhodopsin [RN:R02903]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
rhodopsin [CPD:C00778]
Product
ADP [CPD:C00008];
phosphorhodopsin [CPD:C02456]
Comment
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the bleached or activated form of rhodopsin; also phosphorylates the beta-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.11.15, beta-adrenergic-receptor kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
History
EC 2.7.11.14 created 1989 as EC 2.7.1.125 (EC 2.7.1.97 created 1978, incorporated 1992), transferred 2005 to EC 2.7.11.14
Orthology
K00909  rhodopsin kinase
Genes
HSA: 131890(GRK7) 6011(GRK1)
PTR: 467338(GRK1) 470950(GRK7)
PPS: 100978320(GRK7) 100991375(GRK1)
GGO: 101142226(GRK1) 101142472(GRK7) 101152431
PON: 100446305(GRK7) 100460558(GRK1)
NLE: 100596640(GRK7) 100604187(GRK1)
MCC: 714916(GRK7) 715484(GRK1)
MCF: 102131074(GRK1) 102133613(GRK7)
CSAB: 103214852(GRK1) 103241564(GRK7)
RRO: 104671367(GRK1) 104674059(GRK7)
RBB: 108521833(GRK1) 108522348(GRK7)
CJC: 100385178(GRK7) 100413609(GRK1)
SBQ: 101047234(GRK7) 101051604(GRK1)
MMU: 24013(Grk1)
RNO: 81760(Grk1)
CGE: 100750718(Grk1)
NGI: 103746297(Grk1)
HGL: 101697548(Grk1) 101726058(Grk7)
CCAN: 109686924(Grk1) 109699743(Grk7)
OCU: 100350579(GRK7) 103347371 108176016(GRK1)
TUP: 102487091(GRK7)
CFA: 485557(GRK1) 485693(GRK7)
AML: 100464147(GRK7) 100479760(GRK1)
UMR: 103657516(GRK1) 103678440(GRK7)
ORO: 101367921(GRK7) 101369670(GRK1)
FCA: 101089290(GRK7) 101092327(GRK1)
PTG: 102951583(GRK7) 102963599(GRK1)
AJU: 106981975(GRK7) 106986706(GRK1)
BTA: 281457(GRK1) 281802(GRK7)
BOM: 102270913(GRK7) 102276250(GRK1)
BIU: 109564588(GRK7) 109567107(GRK1)
PHD: 102316540(GRK1) 102330051(GRK7)
CHX: 102176894(GRK1) 102180541(GRK7)
OAS: 101106563(GRK7) 105606083
SSC: 100620646(GRK1) 397114(GRK7)
CFR: 102513037(GRK7) 102520487(GRK1)
CDK: 105086344(GRK7) 105095499(GRK1)
BACU: 103002736(GRK1) 103013851(GRK7)
LVE: 103075679(GRK1) 103084736(GRK7)
OOR: 101275444(GRK1) 101277706(GRK7)
ECB: 100062922(GRK7) 100069151(GRK1)
EPZ: 103549665(GRK1) 103557006(GRK7)
EAI: 106838155(GRK7) 106848207(GRK1)
MYB: 102242883(GRK7) 102257754(GRK1)
MYD: 102761230(GRK1) 102772275(GRK7)
HAI: 109383915(GRK1) 109384568(GRK7)
RSS: 109452797(GRK1) 109455187(GRK7)
PALE: 102881273(GRK1) 102897090(GRK7)
LAV: 100661845(GRK7) 100663708(GRK1)
MDO: 100013800(GRK7) 100016174(GRK1)
SHR: 100914558(GRK1) 100931224(GRK7)
GGA: 395431(GRK1) 429125(GRK7)
MGP: 100540954(GRK7)
CJO: 107307752 107318088(GRK7)
APLA: 101796971(GRK7)
ACYG: 106036230(GRK7)
TGU: 100228229(GRK7)
GFR: 102042191(GRK7) 102043674(GRK1)
FAB: 101807639(GRK7)
PHI: 102101127(GRK1) 102108762(GRK7)
PMAJ: 107208859(GRK7)
CCW: 104693451(GRK7)
FPG: 101912507(GRK7)
FCH: 102054411(GRK7)
CLV: 102097157(GRK7)
EGZ: 104127107(GRK7)
AAM: 106485856(GRK7)
ASN: 102377543(GRK1) 102379208(GRK7)
AMJ: 102559313(GRK7) 102572840(GRK1)
PSS: 102453105(GRK1) 102457262(GRK7)
CPIC: 101943692(GRK7) 101945480
ACS: 100557153(grk7) 100562054(grk1)
PVT: 110078433(GRK7) 110087761(GRK1)
PBI: 103049908(GRK7)
GJA: 107112349(GRK7) 107121051(GRK1)
XLA: 100192358(grk7.L) 100192359(grk7.S) 443726(grk1.L) 733223(grk1.S)
XTR: 100145727(grk7) 100486335(grk1)
NPR: 108790153(GRK7) 108801185(GRK1)
DRE: 373871(grk7b) 550406(grk1b) 564152(grk1a) 566120(grk7a)
IPU: 108258333(grk1) 108260147 108280312(grk7)
SFM: 108918707 108926834(grk7) 108937888(grk1)
LCM: 102348929(GRK7) 102357257(GRK1) 102362932
CMK: 103177456(grk1) 103178747(grk7)
 » show all
Taxonomy
Reference
1  [PMID:3014340]
  Authors
Benovic JL, Mayor F Jr, Somers RL, Caron MG, Lefkowitz RJ.
  Title
Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase.
  Journal
Nature 321:869-72 (1986)
DOI:10.1038/321869a0
Reference
2  [PMID:690139]
  Authors
Shichi H, Somers RL.
  Title
Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase.
  Journal
J Biol Chem 253:7040-6 (1978)
Reference
3  [PMID:2844754]
  Authors
Palczewski K, McDowell JH, Hargrave PA.
  Title
Purification and characterization of rhodopsin kinase.
  Journal
J Biol Chem 263:14067-73 (1988)
Reference
4  [PMID:164024]
  Authors
Weller M, Virmaux N, Mandel P.
  Title
Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin.
  Journal
Proc Natl Acad Sci U S A 72:381-5 (1975)
DOI:10.1073/pnas.72.1.381
Reference
5  [PMID:9380677]
  Authors
Cha K, Bruel C, Inglese J, Khorana HG.
  Title
Rhodopsin kinase: expression in baculovirus-infected insect cells, and characterization of post-translational modifications.
  Journal
Proc Natl Acad Sci U S A 94:10577-82 (1997)
DOI:10.1073/pnas.94.20.10577
Reference
6  [PMID:8812493]
  Authors
Khani SC, Abitbol M, Yamamoto S, Maravic-Magovcevic I, Dryja TP.
  Title
Characterization and chromosomal localization of the gene for human rhodopsin kinase.
  Journal
Genomics 35:571-6 (1996)
DOI:10.1006/geno.1996.0399
  Sequence
[hsa:6011]
Reference
7  [PMID:11754336]
  Authors
Chen CK, Zhang K, Church-Kopish J, Huang W, Zhang H, Chen YJ, Frederick JM, Baehr W.
  Title
Characterization of human GRK7 as a potential cone opsin kinase.
  Journal
Mol Vis 7:305-13 (2001)
  Sequence
[hsa:131890]
Reference
8  [PMID:14654303]
  Authors
Willets JM, Challiss RA, Nahorski SR.
  Title
Non-visual GRKs: are we seeing the whole picture?
  Journal
Trends Pharmacol Sci 24:626-33 (2003)
DOI:10.1016/j.tips.2003.10.003
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.14
IUBMB Enzyme Nomenclature: 2.7.11.14
ExPASy - ENZYME nomenclature database: 2.7.11.14
BRENDA, the Enzyme Database: 2.7.11.14
CAS: 54004-64-7

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