Entry
Name
rhodopsin kinase;
cone opsin kinase;
G-protein-coupled receptor kinase 1;
GPCR kinase 1;
GRK1;
GRK7;
opsin kinase;
opsin kinase (phosphorylating);
rhodopsin kinase (phosphorylating);
RK;
STK14
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:rhodopsin phosphotransferase
Reaction(IUBMB)
ATP + rhodopsin = ADP + phosphorhodopsin [RN:
R02903 ]
Reaction(KEGG)
Substrate
Product
Comment
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the bleached or activated form of rhodopsin; also phosphorylates the beta-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC
2.7.11.15 , beta-adrenergic-receptor kinase and EC
2.7.11.16 , G-protein-coupled receptor kinase).
History
EC 2.7.11.14 created 1989 as EC 2.7.1.125 (EC 2.7.1.97 created 1978, incorporated 1992), transferred 2005 to EC 2.7.11.14
Orthology
Genes
HSA : 131890(GRK7) 6011(GRK1)
PTR : 467338(GRK1) 470950(GRK7)
PPS : 100978320(GRK7) 100991375(GRK1)
GGO : 101142226(GRK1) 101142472(GRK7)
PON : 100446305(GRK7) 100460558(GRK1)
HMH : 116461675(GRK7) 116466524(GRK1)
MCC : 714916(GRK7) 715484(GRK1)
MCF : 102131074(GRK1) 102133613(GRK7)
MTHB : 126940829 126947464
MNI : 105469988(GRK7) 105485244(GRK1)
CSAB : 103214852(GRK1) 103241564(GRK7)
CATY : 105584960(GRK1) 105586351(GRK7)
PANU : 100999299(GRK1) 101022757(GRK7)
TGE : 112611036(GRK1) 112619478(GRK7)
MLEU : 105539260(GRK1) 105555627(GRK7)
RRO : 104671367(GRK1) 104674059(GRK7)
RBB : 108521833(GRK1) 108522348(GRK7)
TFN : 117063464(GRK1) 117084096(GRK7)
PTEH : 111526431(GRK7) 111546381(GRK1)
CANG : 105505934(GRK1) 105523305(GRK7)
CJC : 100385178(GRK7) 100413609(GRK1)
SBQ : 101047234(GRK7) 101051604(GRK1)
CIMI : 108297104(GRK1) 108300820(GRK7)
CSYR : 103268592(GRK7) 103271336(GRK1)
MMUR : 105870048(GRK7) 105871942(GRK1)
LCAT : 123630112(GRK7) 123648827(GRK1)
PCOQ : 105812876(GRK7) 105825130(GRK1)
OGA : 100947659(GRK7) 100967035(GRK1)
HGL : 101697548(Grk1) 101726058(Grk7)
CPOC : 100731414(Grk1) 100735580(Grk7)
CCAN : 109686924(Grk1) 109699743(Grk7)
NCAR : 124985824 124993483
OPI : 101519737(GRK7) 101526367(GRK1)
GVR : 103590631(GRK1) 103602307(GRK7)
CFA : 485557(GRK1) 485693(GRK7)
CLUD : 112655994(GRK1) 112661018(GRK7)
VVP : 112927444(GRK1) 112934966(GRK7)
VLG : 121477034(GRK1) 121478597(GRK7)
NPO : 129507096(GRK7) 129516674(GRK1)
AML : 100464147(GRK7) 100479760(GRK1)
UMR : 103657516(GRK1) 103678440(GRK7)
UAH : 113247551(GRK1) 113254011(GRK7)
UAR : 123776755(GRK1) 123788436(GRK7)
MPUF : 101675318(GRK7) 101689672(GRK1)
NVS : 122907906(GRK1) 122910435(GRK7)
ORO : 101367921(GRK7) 101369670(GRK1)
EJU : 114196652(GRK1) 114205689(GRK7)
ZCA : 113918035(GRK7) 113920153(GRK1)
MLX : 118004615(GRK7) 118009109(GRK1)
NSU : 110570696(GRK7) 110585821(GRK1)
LWW : 102732786(GRK1) 102736072(GRK7)
FCA : 101089290(GRK7) 101092327(GRK1)
PYU : 121033757(GRK7) 121037672(GRK1)
PCOO : 112850345(GRK7) 112861169(GRK1)
PBG : 122485163(GRK1) 122491914(GRK7)
LRUF : 124517536 124526054
PTG : 102951583(GRK7) 102963599(GRK1)
PPAD : 109260221(GRK7) 109264025(GRK1)
HHV : 120223471(GRK1) 120242660(GRK7)
BTA : 281457(GRK1) 281802(GRK7)
BOM : 102270913(GRK7) 102276250(GRK1)
BIU : 109564588(GRK7) 109567107(GRK1)
BBUB : 102389645(GRK7) 102404183(GRK1)
BBIS : 104982198(GRK1) 105001778(GRK7)
CHX : 102176894(GRK1) 102180541(GRK7)
OAS : 101106563(GRK7) 105606083(GRK1)
BTAX : 128055905(GRK7) 128057827(GRK1)
ODA : 120858114(GRK7) 120883389(GRK1)
CCAD : 122445344(GRK7) 122447426(GRK1)
SSC : 100620646(GRK1) 397114(GRK7)
CFR : 102513037(GRK7) 102520487(GRK1)
CBAI : 105066859(GRK7) 105066912(GRK1)
CDK : 105086344(GRK7) 105095499(GRK1)
VPC : 102524859(GRK7) 102526931(GRK1)
BACU : 103002736(GRK1) 103013851(GRK7)
LVE : 103075679(GRK1) 103084736(GRK7)
OOR : 101275444(GRK1) 101277706(GRK7)
DLE : 111176312(GRK1) 111179161(GRK7)
PCAD : 102981560(GRK7) 102995100(GRK1)
PSIU : 116742978(GRK1) 116753389(GRK7)
NASI : 112404606(GRK1) 112415908(GRK7)
ECB : 100062922(GRK7) 100069151(GRK1)
EPZ : 103549665(GRK1) 103557006(GRK7)
EAI : 106838155(GRK7) 106848207(GRK1)
MYB : 102242883(GRK7) 102257754(GRK1)
MYD : 102761230(GRK1) 102772275(GRK7)
MMYO : 118659646(GRK1) 118668108(GRK7)
MLF : 102422335(GRK7) 102433720(GRK1)
MNA : 107534679(GRK7) 107536949(GRK1)
PKL : 118715742(GRK7) 118729139(GRK1)
HAI : 109383915(GRK1) 109384568(GRK7)
DRO : 112301054(GRK7) 112321528(GRK1)
SHON : 118984263(GRK1) 118990962(GRK7)
AJM : 119034610(GRK1) 119044790(GRK7)
PDIC : 114501325(GRK7) 114508889(GRK1)
PHAS : 123807779(GRK1) 123814319(GRK7)
MMF : 118622775(GRK1) 118633542(GRK7)
RFQ : 117021505(GRK1) 117036698(GRK7)
PALE : 102881273(GRK1) 102897090(GRK7)
PGIG : 120582158(GRK7) 120615632(GRK1)
PVP : 105290356(GRK7) 105305099(GRK1)
RAY : 107509393(GRK7) 107514359(GRK1)
MJV : 108389875(GRK7) 108399960(GRK1)
SARA : 101549164(GRK7) 101552242(GRK1)
LAV : 100661845(GRK7) 100663708(GRK1)
ETF : 101648357(GRK1) 101648703(GRK7)
MDO : 100013800(GRK7) 100016174(GRK1)
GAS : 123239804(GRK1) 123240191(GRK7)
SHR : 100914558(GRK1) 100931224(GRK7)
PCW : 110193377(GRK1) 110197221(GRK7)
OAA : 100078720(GRK1) 100078940(GRK7)
GGA : 395431(GRK1) 429125(GRK7)
PCOC : 116230895(GRK7) 116232969
CJO : 107307752 107318088(GRK7)
LSR : 110467780(GRK1) 110473944(GRK7) 110480313
PMOA : 120507209(GRK1) 120508566(GRK7)
OTC : 121341101(GRK7) 121347835
PRUF : 121354065(GRK1) 121357933(GRK7)
GFR : 102042191(GRK7) 102043674(GRK1)
PHI : 102101127(GRK1) 102108762(GRK7)
CBRC : 103621812 103624830(GRK7)
ACHC : 115338260(GRK1) 115346977(GRK7)
HLE : 104832247(GRK7) 104834075(GRK1)
AGEN : 126034671 126039317
SHAB : 115602930(GRK1) 115612043(GRK7)
DPUB : 104300639(GRK7) 104308959(GRK1)
CVF : 104290376 104290843(GRK7)
ASN : 102377543(GRK1) 102379208(GRK7)
AMJ : 102559313(GRK7) 102572840(GRK1)
PSS : 102453105(GRK1) 102457262(GRK7)
CMY : 102935951(GRK7) 102942787(GRK1)
CABI : 116816433(GRK7) 116833195
MRV : 120372669(GRK7) 120381865(GRK1)
ACS : 100557153(grk7) 100562054(grk1)
PVT : 110078433(GRK7) 110087761(GRK1)
SUND : 121926933(GRK7) 121933941(GRK1)
VKO : 123016680(GRK1) 123024774(GRK7)
PMUA : 114597833(GRK7) 114608093(GRK1)
ZVI : 118093643(GRK7) 118094752(GRK1)
HCG : 128330363(GRK1) 128350679(GRK7)
GJA : 107112349(GRK7) 107121051(GRK1)
STOW : 125438160(GRK7) 125445233(GRK1)
XLA : 100192358(grk7.L) 100192359(grk7.S) 443726(grk1.L) 733223(grk1.S)
XTR : 100145727(grk7) 100486335(grk1)
NPR : 108790153(GRK7) 108801185(GRK1)
RTEM : 120926396(GRK1) 120936453(GRK7)
BBUF : 120993480(GRK1) 120997623(GRK7)
BGAR : 122931459(GRK1) 122935590(GRK7)
DRE : 373871(grk7b) 550406(grk1b) 564152(grk1a) 566120(grk7a)
SRX : 107710616 107713316 107730351 107732950 107748333 107751068
SANH : 107654472(grk1) 107677726 107684366 107692039 107694475 107700560
SGH : 107553262 107563306 107563518 107571983(grk1) 107577152 107595985
CCAR : 109063155 109067355 109081031 109082762(grk1) 109090907 109109566 109110704 109112542
CAUA : 113044685 113045782 113083413 113084744(grk1) 113115522 113118830
CGIB : 127948898 127950545 127965813 127977708 127989220 128027001
PTET : 122322891(grk7b) 122324930(grk7a) 122345746(grk1b) 122350375(grk1a)
LROH : 127161399(grk1a) 127164674(grk1b) 127172979(grk7a) 127180913(grk7b)
PPRM : 120459072(grk1a) 120460023(grk7b) 120472285(grk1b) 120483236(grk7a)
MAMB : 125251663(grk7a) 125254749(grk7b) 125267991(grk1b) 125273010(grk1a)
CIDE : 127500078 127501833 127513026 127513371
MASI : 127416754 127433959 127440504 127442273 127443440 127444925
IPU : 108258333(grk1a) 108260147(grk1b) 108280312(grk7a)
PHYP : 113528872 113537539(grk1) 113546327(grk7)
SMEO : 124378648(grk1a) 124402899(grk7a)
TFD : 113638503(grk7a) 113648879(grk1a)
AMEX : 103024262(grk1) 103026853 103037579 103038643
CMAO : 118797066(grk7a) 118798086(grk1a) 118814915(grk1b) 118818041(grk7b)
EEE : 113577359(grk1) 113591131(grk7)
TRU : 101061321 101064943(grk7) 101067484 101068104 105417278(grk1)
TNG : GSTEN00014998G001 GSTEN00017937G001 GSTEN00022127G001 GSTEN00025963G001
LCO : 104919936 104920904 104924175 104932094 104939392
NCC : 104945246(grk7) 104951937(grk1) 104963524
CGOB : 115017399 115018990 115022688 115026286 115028571(grk1)
ELY : 117251044 117251957(grk1a) 117260195(grk7b) 117264359(grk1b) 117271852(grk7a)
EFO : 125888516(grk7b) 125897899(grk1b) 125899870 125902548(grk7a) 125903072(grk1a)
PLEP : 121943559(grk7b) 121944433(grk1a) 121949224 121951688(grk7a) 121952621(grk1b)
SLUC : 116034025(grk1a) 116045586(grk7b) 116046308 116048811(grk7a) 116064963(grk1b)
ECRA : 117942450 117949361(grk1a) 117953357 117953810(grk7a) 117955931(grk1b)
ESP : 116686533 116697749 116699778 116700094(grk1) 116700619
PFLV : 114552888 114557878(grk1) 114564141 114565668(grk7) 114567085
GAT : 120816230(grk7a) 120823070(grk1b) 120824828(grk7b) 120834459 120835107(grk1a)
PPUG : 119209747(grk7a) 119211812(grk7b) 119215006(grk1b) 119229062
MSAM : 119882034 119883283 119889766(grk1a) 119894854(grk1b) 119903020(grk7a) 119904271 119916749
SCHU : 122878885(grk1a) 122879123(grk7b) 122885405 122887296(grk7a) 122888850(grk1b)
CUD : 121511285(grk1a) 121519004(grk1b) 121520522(grk7a) 121522129(grk7b) 121522730
ALAT : 119008726(grk7b) 119011558(grk7a) 119017713(grk1a) 119026482 119031236(grk1b)
MZE : 101466666 101476749 101482657(grk1) 101484663(grk7) 101487838 112435182
ONL : 100694101 100697786(grk1) 100702079 100702856(grk7) 100703644
OAU : 116312275(grk1a) 116316142 116328081(grk7a) 116330288(grk1b) 116330353(grk7b)
OLA : 100049187(grk7) 100529155(grk1) 100529159 101166975
OML : 112144202 112149333(grk7b) 112154953 112160365(grk1a)
XMA : 102220597(grk7) 102226240 102226317 102229735 102235499(grk1)
XCO : 114133576 114142614(grk1) 114145938(grk7) 114148517 114153804
XHE : 116708228 116718229(grk1) 116721581(grk7) 116723717 116728073
PRET : 103461969(grk1) 103474448 103475792 103479099(grk7) 103480054
PFOR : 103139383(grk1) 103140333 103145650 103146304 103149510(grk7)
PLAI : 106939930 106945712 106955376 106955619(grk1) 106964797(grk7)
PMEI : 106909264 106925192 106929962(grk7) 106930421(grk1) 106931527
GAF : 122832417(grk7b) 122840237 122840575(grk7a) 122844491(grk1a) 122845474(grk1b)
CVG : 107083475(grk7) 107088291(grk1) 107089964 107100598
CTUL : 119771834(grk7b) 119777003(grk7a) 119782679(grk1a) 119786381
GMU : 124866719(grk1a) 124869602(grk7a) 124871016 124883929(grk7b)
NFU : 107374459(grk7) 107380487 107381624(grk1) 107386487 107389806
KMR : 108232331 108240458(grk7b) 108244511(grk7a) 108245207(grk1b) 108250293(grk1a)
ALIM : 106513970(grk1) 106516359 106519820 106524389(grk7) 106528614
NWH : 119410507(grk7b) 119415033(grk7a) 119418899 119422566(grk1a)
AOCE : 111582442(grk1) 111582970 111585507(grk7) 111586019 111588513
MCEP : 125005513(grk1a) 125011205(grk7a) 125014068(grk7b) 125017168 125020769(grk1b)
CSEM : 103378577 103391687 103395691 103396114(grk7)
POV : 109624911(grk1) 109628460 109631195 109634471 109639381(grk7)
SSEN : 122765474 122772512(grk1a) 122773798(grk7b) 122777139(grk7a) 122777806(grk1b)
HHIP : 117754983 117757122(grk1a) 117773126(grk7b) 117774876(grk1b) 117778749(grk7a)
HSP : 118105738(grk7b) 118117245(grk7a) 118120497 118124592(grk1a) 124854839(grk1b)
LCF : 108872393 108883732(grk7a) 108888009(grk1a) 108893917 108901057
SDU : 111218234 111224088 111228824(grk7) 111234469 111238366(grk1)
SLAL : 111649981 111653922 111661292(grk7) 111662123 111668319(grk1)
XGL : 120791470(grk7b) 120792094(grk1a) 120798692(grk7a) 120801529 120802658(grk1b)
HCQ : 109512435 109520587(grk7) 109525534 109530609
SSCV : 125972604 125973903 125982095 125984424
BPEC : 110153385(grk7) 110158596 110172927(grk1) 110173179 110174329
MALB : 109959548 109964202(grk1) 109970577
BSPL : 114844245(grk7a) 114847253 114852208(grk1a) 114868379(grk7b) 114869241(grk1b)
SASA : 106568703 106574880 106580878 106586763(grk1) 106594304 106598174(grk7) 106612581
STRU : 115156610 115161277 115163207 115170129 115179507 115179509(grk1) 115206153
OTW : 112226505 112228188(grk1b) 112241568(grk1a) 112242275 112260240 112265313 112266899
OMY : 110503733 110507615 110509067 110514102 110516570 110520554(grk1a) 110530004 110534931(grk1b)
OGO : 123990448(grk1b) 123992889 124005875 124010016 124022054 124041027 124044207
ONE : 115103369 115113152(grk1) 115114103 115136915 115142151
SALP : 111949347 111949559 111956490 111979008 111979926
SNH : 120018298 120020070 120028702 120039481 120039482 120055470 120057993
CCLU : 121534934 121536557 121556788 121564553 121565135 121580623
ELS : 105012608 105016570 105020061(grk1) 105024979 105029565
SFM : 108918707 108926834(grk7) 108937888(grk1)
PKI : 111836639(grk7) 111850644 111855924(grk1)
AANG : 118214257(grk1a) 118223961(grk1b) 118230435(grk7a)
LOC : 102687717(grk1) 102691787 102693571(grk7)
PSPA : 121306522(grk1b) 121320885 121323128 121326626 121327712
ARUT : 117404472 117405397 117407213 117416921 117423614(grk7a) 117967983
PSEX : 120518528 120524242(grk1a) 120526460(grk1b)
LCM : 102348929(GRK7) 102357257(GRK1) 102362932
CMK : 103177456(grk1a) 103178747
CPLA : 122554880(grk1a) 122556222(grk7a)
» show all
Taxonomy
Reference
Authors
Benovic JL, Mayor F Jr, Somers RL, Caron MG, Lefkowitz RJ.
Title
Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase.
Journal
Reference
Authors
Shichi H, Somers RL.
Title
Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase.
Journal
J Biol Chem 253:7040-6 (1978)
Reference
Authors
Palczewski K, McDowell JH, Hargrave PA.
Title
Purification and characterization of rhodopsin kinase.
Journal
J Biol Chem 263:14067-73 (1988)
Reference
Authors
Weller M, Virmaux N, Mandel P.
Title
Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin.
Journal
Reference
Authors
Cha K, Bruel C, Inglese J, Khorana HG.
Title
Rhodopsin kinase: expression in baculovirus-infected insect cells, and characterization of post-translational modifications.
Journal
Reference
Authors
Khani SC, Abitbol M, Yamamoto S, Maravic-Magovcevic I, Dryja TP.
Title
Characterization and chromosomal localization of the gene for human rhodopsin kinase.
Journal
Sequence
Reference
Authors
Chen CK, Zhang K, Church-Kopish J, Huang W, Zhang H, Chen YJ, Frederick JM, Baehr W
Title
Characterization of human GRK7 as a potential cone opsin kinase.
Journal
Mol Vis 7:305-13 (2001)
Sequence
Reference
Authors
Willets JM, Challiss RA, Nahorski SR.
Title
Non-visual GRKs: are we seeing the whole picture?
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.11.14