KEGG   ENZYME: 2.7.11.14
Entry
EC 2.7.11.14                Enzyme                                 
Name
rhodopsin kinase;
cone opsin kinase;
G-protein-coupled receptor kinase 1;
GPCR kinase 1;
GRK1;
GRK7;
opsin kinase;
opsin kinase (phosphorylating);
rhodopsin kinase (phosphorylating);
RK;
STK14
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:rhodopsin phosphotransferase
Reaction(IUBMB)
ATP + rhodopsin = ADP + phosphorhodopsin [RN:R02903]
Reaction(KEGG)
R02903
Substrate
ATP [CPD:C00002];
rhodopsin [CPD:C00778]
Product
ADP [CPD:C00008];
phosphorhodopsin [CPD:C02456]
Comment
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the bleached or activated form of rhodopsin; also phosphorylates the beta-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.11.15, beta-adrenergic-receptor kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
History
EC 2.7.11.14 created 1989 as EC 2.7.1.125 (EC 2.7.1.97 created 1978, incorporated 1992), transferred 2005 to EC 2.7.11.14
Orthology
K00909  rhodopsin kinase
Genes
HSA131890(GRK7) 6011(GRK1)
PTR467338(GRK1) 470950(GRK7)
PPS100978320(GRK7) 100991375(GRK1)
GGO101142226(GRK1) 101142472(GRK7)
PON100446305(GRK7) 100460558(GRK1)
NLE100596640(GRK7)
MCC714916(GRK7) 715484(GRK1)
MCF102131074(GRK1) 102133613(GRK7)
CSAB103214852(GRK1) 103241564(GRK7)
CATY105584960(GRK1) 105586351(GRK7)
PANU100999299(GRK1) 101022757(GRK7)
TGE112611036(GRK1) 112619478(GRK7)
RRO104671367(GRK1) 104674059(GRK7)
RBB108521833(GRK1) 108522348(GRK7)
TFN117063464(GRK1) 117084096(GRK7)
PTEH111526431(GRK7) 111546381(GRK1)
CJC100385178(GRK7) 100413609(GRK1)
SBQ101047234(GRK7) 101051604(GRK1)
CSYR103268592(GRK7) 103271336(GRK1)
MMUR105870048(GRK7) 105871942(GRK1)
OGA100947659(GRK7) 100967035(GRK1)
MMU24013(Grk1)
MCAL110300107(Grk1)
MPAH110337043(Grk1)
RNO81760(Grk1)
MCOC116071162(Grk1)
MUN110558226 110558244
CGE100750718(Grk1)
PLEU114701214(Grk1)
NGI103746297(Grk1)
HGL101697548(Grk1) 101726058(Grk7)
CPOC100731414(Grk1) 100735580(Grk7)
CCAN109686924(Grk1) 109699743(Grk7)
DORD105990400(Grk1)
DSP122122879(Grk1)
NCAR124985824 124993483
OCU100350579(GRK7)
OPI101519737(GRK7) 101526367(GRK1)
TUP102487091(GRK7)
CFA485557(GRK1) 485693(GRK7)
VVP112927444(GRK1) 112934966(GRK7)
VLG121477034(GRK1) 121478597(GRK7)
AML100464147(GRK7) 100479760(GRK1)
UMR103657516(GRK1) 103678440(GRK7)
UAH113247551(GRK1) 113254011(GRK7)
UAR123776755(GRK1) 123788436(GRK7)
ELK111147107 111151154
LLV125094868 125098147
MPUF101675318(GRK7) 101689672(GRK1)
ORO101367921(GRK7) 101369670(GRK1)
EJU114196652(GRK1) 114205689(GRK7)
ZCA113918035(GRK7) 113920153(GRK1)
MLX118004615(GRK7) 118009109(GRK1)
FCA101089290(GRK7) 101092327(GRK1)
PYU121033757(GRK7) 121037672(GRK1)
PBG122485163(GRK1) 122491914(GRK7)
PTG102951583(GRK7) 102963599(GRK1)
PPAD109260221(GRK7) 109264025(GRK1)
AJU106981975(GRK7) 106986706(GRK1)
HHV120223471(GRK1) 120242660(GRK7)
BTA281457(GRK1) 281802(GRK7)
BOM102270913(GRK7) 102276250(GRK1)
BIU109564588(GRK7) 109567107(GRK1)
BBUB102389645(GRK7) 102404183(GRK1)
CHX102176894(GRK1) 102180541(GRK7)
OAS101106563(GRK7) 105606083(GRK1)
ODA120858114(GRK7) 120883389(GRK1)
CCAD122445344(GRK7) 122447426(GRK1)
SSC100620646(GRK1) 397114(GRK7)
CFR102513037(GRK7) 102520487(GRK1)
CBAI105066859(GRK7) 105066912(GRK1)
CDK105086344(GRK7) 105095499(GRK1)
VPC102524859(GRK7) 102526931(GRK1)
BACU103002736(GRK1) 103013851(GRK7)
LVE103075679(GRK1) 103084736(GRK7)
OOR101275444(GRK1) 101277706(GRK7)
DLE111176312(GRK1) 111179161(GRK7)
PCAD102981560(GRK7) 102995100(GRK1)
PSIU116742978(GRK1) 116753389(GRK7)
ECB100062922(GRK7) 100069151(GRK1)
EPZ103549665(GRK1) 103557006(GRK7)
EAI106838155(GRK7) 106848207(GRK1)
MYB102242883(GRK7) 102257754(GRK1)
MYD102761230(GRK1) 102772275(GRK7)
MMYO118659646(GRK1) 118668108(GRK7)
MLF102422335(GRK7) 102433720(GRK1)
MNA107534679(GRK7) 107536949(GRK1)
PKL118715742(GRK7) 118729139(GRK1)
HAI109383915(GRK1) 109384568(GRK7)
DRO112301054(GRK7) 112321528(GRK1)
SHON118984263(GRK1) 118990962(GRK7)
AJM119034610(GRK1) 119044790(GRK7)
PDIC114501325(GRK7) 114508889(GRK1)
PHAS123807779(GRK1) 123814319(GRK7)
MMF118622775(GRK1) 118633542(GRK7)
RFQ117021505(GRK1) 117036698(GRK7)
PALE102881273(GRK1) 102897090(GRK7)
PGIG120582158(GRK7) 120615632(GRK1)
PVP105290356(GRK7) 105305099(GRK1)
RAY107509393(GRK7) 107514359(GRK1)
MJV108389875(GRK7) 108399960(GRK1)
TOD119257711(GRK7)
SARA101549164(GRK7) 101552242(GRK1)
LAV100661845(GRK7) 100663708(GRK1)
TMU101343459 101351547
DNM101414151(GRK1)
MDO100013800(GRK7) 100016174(GRK1)
GAS123239804(GRK1) 123240191(GRK7)
SHR100914558(GRK1) 100931224(GRK7)
PCW110193377(GRK1) 110197221(GRK7)
OAA100078720(GRK1) 100078940(GRK7)
GGA395431(GRK1) 429125(GRK7)
PCOC116230895(GRK7) 116232969
MGP100540954(GRK7)
CJO107307752 107318088(GRK7)
NMEL110397747(GRK7)
APLA101796971(GRK7)
ACYG106036230(GRK7)
AFUL116492689(GRK7)
TGU100228229(GRK7)
LSR110467780(GRK1) 110473944(GRK7) 110480313
SCAN103815420(GRK7)
PMOA120507209(GRK1) 120508566(GRK7)
OTC121341101(GRK7) 121347835
PRUF121354065(GRK1) 121357933(GRK7)
GFR102042191(GRK7) 102043674(GRK1)
FAB101807639(GRK7)
PHI102101127(GRK1) 102108762(GRK7)
PMAJ107208859(GRK7)
CCAE111933517(GRK7)
CCW104693451(GRK7)
ETL114068734(GRK7)
ZAB102073648(GRK7)
FPG101912507(GRK7)
FCH102054411(GRK7)
CLV102097157(GRK7)
EGZ104127107(GRK7)
NNI104016390(GRK7)
ACUN113483518(GRK7)
TALA104367186(GRK7)
PADL103917876(GRK7)
ACHC115338260(GRK1) 115346977(GRK7)
AAM106485856(GRK7)
AROW112976121(GRK7)
NPD112947895(GRK7)
DNE112984102(GRK7)
ASN102377543(GRK1) 102379208(GRK7)
AMJ102559313(GRK7) 102572840(GRK1)
CPOO109308597(GRK7)
GGN109288155(GRK7)
PSS102453105(GRK1) 102457262(GRK7)
CMY102935951(GRK7) 102942787(GRK1)
CPIC101943692(GRK7)
TST117882792(GRK7)
CABI116816433(GRK7) 116833195
MRV120372669(GRK7) 120381865(GRK1)
ACS100557153(grk7) 100562054(grk1)
PVT110078433(GRK7) 110087761(GRK1)
SUND121926933(GRK7) 121933941(GRK1)
PBI103049908(GRK7)
PMUR107287767(GRK7)
TSR106541868(GRK7)
PGUT117678335(GRK7)
VKO123016680(GRK1) 123024774(GRK7)
PMUA114597833(GRK7) 114608093(GRK1)
ZVI118093643(GRK7) 118094752(GRK1)
GJA107112349(GRK7) 107121051(GRK1)
XLA100192358(grk7.L) 100192359(grk7.S) 443726(grk1.L) 733223(grk1.S)
XTR100145727(grk7) 100486335(grk1)
NPR108790153(GRK7) 108801185(GRK1)
RTEM120926396(GRK1) 120936453(GRK7)
BBUF120993480(GRK1) 120997623(GRK7)
BGAR122931459(GRK1) 122935590(GRK7)
DRE373871(grk7b) 550406(grk1b) 564152(grk1a) 566120(grk7a)
SRX107710616 107713316 107730351 107732950 107748333 107751068
SANH107654472(grk1) 107677726 107684366 107692039 107694475 107700560
SGH107553262 107563306 107563518 107571983(grk1) 107577152 107595985
CCAR109063155 109067355 109081031 109082762(grk1) 109090907 109109566 109110704 109112542
CAUA113044685 113045782 113083413 113084744(grk1) 113115522 113118830
IPU108258333(grk1a) 108260147(grk1b) 108280312(grk7a)
PHYP113528872 113537539(grk1) 113546327(grk7)
SMEO124378648(grk1a) 124402899(grk7a)
TFD113638503(grk7a) 113648879(grk1a)
AMEX103024262(grk1) 103026853 103037579 103038643
EEE113577359(grk1) 113591131(grk7)
TRU101061321 101064943(grk7) 101067484 101068104 105417278(grk1)
TNGGSTEN00014998G001 GSTEN00017937G001 GSTEN00022127G001 GSTEN00025963G001
LCO104919936 104920904 104924175 104932094 104939392
NCC104945246(grk7) 104951937(grk1) 104963524
CGOB115017399 115018990 115022688 115026286 115028571(grk1)
ELY117251044 117251957(grk1a) 117260195(grk7b) 117264359(grk1b) 117271852(grk7a)
PLEP121943559(grk7b) 121944433(grk1a) 121949224 121951688(grk7a) 121952621(grk1b)
SLUC116034025(grk1a) 116045586(grk7b) 116046308 116048811(grk7a) 116064963(grk1b)
ECRA117942450 117949361(grk1a) 117953357 117953810(grk7a) 117955931(grk1b)
PFLV114552888 114557878(grk1) 114564141 114565668(grk7) 114567085
GAT120816230(grk7a) 120823070(grk1b) 120824828(grk7b) 120834459 120835107(grk1a)
PPUG119209747(grk7a) 119211812(grk7b) 119215006(grk1b) 119229062
MSAM119882034 119883283 119889766(grk1a) 119894854(grk1b) 119903020(grk7a) 119904271 119916749
CUD121511285(grk1a) 121519004(grk1b) 121520522(grk7a) 121522129(grk7b) 121522730
MZE101466666 101476749 101482657(grk1) 101484663(grk7) 101487838 112435182
ONL100694101 100697786(grk1) 100702079 100702856(grk7) 100703644
OAU116312275(grk1a) 116316142 116328081(grk7a) 116330288(grk1b) 116330353(grk7b)
OLA100049187(grk7) 100529155(grk1) 100529159 101166975
OML112144202 112149333(grk7b) 112154953 112160365(grk1a)
XMA102220597(grk7) 102226240 102226317 102229735 102235499(grk1)
XCO114133576 114142614(grk1) 114145938(grk7) 114148517 114153804
XHE116708228 116718229(grk1) 116721581(grk7) 116723717 116728073
PRET103461969(grk1) 103474448 103475792 103479099(grk7) 103480054
PFOR103139383(grk1) 103140333 103145650 103146304 103149510(grk7)
PLAI106939930 106945712 106955376 106955619(grk1) 106964797(grk7)
PMEI106909264 106925192 106929962(grk7) 106930421(grk1) 106931527
GAF122832417(grk7b) 122840237 122840575(grk7a) 122844491(grk1a) 122845474(grk1b)
CVG107083475(grk7) 107088291(grk1) 107089964 107100598
CTUL119771834(grk7b) 119777003(grk7a) 119782679(grk1a) 119786381
GMU124866719(grk1a) 124869602(grk7a) 124871016 124883929(grk7b)
NFU107374459(grk7) 107380487 107381624(grk1) 107386487 107389806
KMR108232331 108240458(grk7b) 108244511(grk7a) 108245207(grk1b) 108250293(grk1a)
ALIM106513970(grk1) 106516359 106519820 106524389(grk7) 106528614
NWH119410507(grk7b) 119415033(grk7a) 119418899 119422566(grk1a)
AOCE111582442(grk1) 111582970 111585507(grk7) 111586019 111588513
CSEM103378577 103391687 103395691 103396114(grk7)
POV109624911(grk1) 109628460 109631195 109634471 109639381(grk7)
SSEN122765474 122772512(grk1a) 122773798(grk7b) 122777139(grk7a) 122777806(grk1b)
HHIP117754983 117757122(grk1a) 117773126(grk7b) 117774876(grk1b) 117778749(grk7a)
LCF108872393 108883732(grk7) 108888009(grk1) 108893917 108901057
SDU111218234 111224088 111228824(grk7) 111234469 111238366(grk1)
SLAL111649981 111653922 111661292(grk7) 111662123 111668319(grk1)
XGL120791470(grk7b) 120792094(grk1a) 120798692(grk7a) 120801529 120802658(grk1b)
HCQ109512435 109520587(grk7) 109525534 109530609
BPEC110153385(grk7) 110158596 110172927(grk1) 110173179 110174329
MALB109959548 109964202(grk1) 109970577
SASA106568703 106574880 106580878 106586763(grk1) 106594304 106598174(grk7) 106612581
OTW112226505 112228188(grk1b) 112241568(grk1a) 112242275 112260240 112265313 112266899
OMY110503733 110507615 110509067 110514102 110516570 110520554(grk1a) 110530004 110534931(grk1b)
OGO123990448(grk1b) 123992889 124005875 124010016 124022054 124041027 124044207
ONE115103369 115113152(grk1) 115114103 115136915 115142151
SALP111949347 111949559 111956490 111979008 111979926
SNH120018298 120020070 120028702 120039481 120039482 120055470 120057993
ELS105012608 105016570 105020061(grk1) 105024979 105029565
SFM108918707 108926834(grk7) 108937888(grk1)
PKI111836639(grk7) 111850644 111855924(grk1)
AANG118214257(grk1a) 118223961(grk1b) 118230435(grk7a)
LOC102687717(grk1) 102691787 102693571(grk7)
PSPA121306522(grk1b) 121320885 121323128 121326626 121327712
ARUT117404472 117405397 117407213 117416921 117423614(grk7a) 117967983
LCM102348929(GRK7) 102357257(GRK1) 102362932
CMK103177456(grk1a) 103178747
RTP109917976(grk7)
 » show all
Reference
1  [PMID:3014340]
  Authors
Benovic JL, Mayor F Jr, Somers RL, Caron MG, Lefkowitz RJ.
  Title
Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase.
  Journal
Nature 321:869-72 (1986)
DOI:10.1038/321869a0
Reference
2  [PMID:690139]
  Authors
Shichi H, Somers RL.
  Title
Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase.
  Journal
J Biol Chem 253:7040-6 (1978)
Reference
3  [PMID:2844754]
  Authors
Palczewski K, McDowell JH, Hargrave PA.
  Title
Purification and characterization of rhodopsin kinase.
  Journal
J Biol Chem 263:14067-73 (1988)
Reference
4  [PMID:164024]
  Authors
Weller M, Virmaux N, Mandel P.
  Title
Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin.
  Journal
Proc Natl Acad Sci U S A 72:381-5 (1975)
DOI:10.1073/pnas.72.1.381
Reference
5  [PMID:9380677]
  Authors
Cha K, Bruel C, Inglese J, Khorana HG.
  Title
Rhodopsin kinase: expression in baculovirus-infected insect cells, and characterization of post-translational modifications.
  Journal
Proc Natl Acad Sci U S A 94:10577-82 (1997)
DOI:10.1073/pnas.94.20.10577
Reference
6  [PMID:8812493]
  Authors
Khani SC, Abitbol M, Yamamoto S, Maravic-Magovcevic I, Dryja TP.
  Title
Characterization and chromosomal localization of the gene for human rhodopsin kinase.
  Journal
Genomics 35:571-6 (1996)
DOI:10.1006/geno.1996.0399
  Sequence
[hsa:6011]
Reference
7  [PMID:11754336]
  Authors
Chen CK, Zhang K, Church-Kopish J, Huang W, Zhang H, Chen YJ, Frederick JM, Baehr W
  Title
Characterization of human GRK7 as a potential cone opsin kinase.
  Journal
Mol Vis 7:305-13 (2001)
  Sequence
[hsa:131890]
Reference
8  [PMID:14654303]
  Authors
Willets JM, Challiss RA, Nahorski SR.
  Title
Non-visual GRKs: are we seeing the whole picture?
  Journal
Trends Pharmacol Sci 24:626-33 (2003)
DOI:10.1016/j.tips.2003.10.003
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.14
IUBMB Enzyme Nomenclature: 2.7.11.14
ExPASy - ENZYME nomenclature database: 2.7.11.14
BRENDA, the Enzyme Database: 2.7.11.14
CAS: 54004-64-7

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