KEGG   ENZYME: 2.7.11.14
Entry
EC 2.7.11.14                Enzyme                                 

Name
rhodopsin kinase;
cone opsin kinase;
G-protein-coupled receptor kinase 1;
GPCR kinase 1;
GRK1;
GRK7;
opsin kinase;
opsin kinase (phosphorylating);
rhodopsin kinase (phosphorylating);
RK;
STK14
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:rhodopsin phosphotransferase
Reaction(IUBMB)
ATP + rhodopsin = ADP + phosphorhodopsin [RN:R02903]
Reaction(KEGG)
R02903
Substrate
ATP [CPD:C00002];
rhodopsin [CPD:C00778]
Product
ADP [CPD:C00008];
phosphorhodopsin [CPD:C02456]
Comment
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the bleached or activated form of rhodopsin; also phosphorylates the beta-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.11.15, beta-adrenergic-receptor kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
History
EC 2.7.11.14 created 1989 as EC 2.7.1.125 (EC 2.7.1.97 created 1978, incorporated 1992), transferred 2005 to EC 2.7.11.14
Orthology
K00909  rhodopsin kinase
Genes
HSA: 131890(GRK7) 6011(GRK1)
PTR: 467338(GRK1) 470950(GRK7)
PPS: 100978320(GRK7) 100991375(GRK1)
GGO: 101142226(GRK1) 101142472(GRK7)
PON: 100446305(GRK7) 100460558(GRK1)
NLE: 100596640(GRK7)
MCC: 714916(GRK7) 715484(GRK1)
MCF: 102131074(GRK1) 102133613(GRK7)
CSAB: 103214852(GRK1) 103241564(GRK7)
CATY: 105584960(GRK1) 105586351(GRK7)
PANU: 100999299(GRK1) 101022757(GRK7)
RRO: 104671367(GRK1) 104674059(GRK7)
RBB: 108521833(GRK1) 108522348(GRK7)
TFN: 117063464(GRK1) 117084096(GRK7)
PTEH: 111526431(GRK7) 111546381(GRK1)
CJC: 100385178(GRK7) 100413609(GRK1)
SBQ: 101047234(GRK7) 101051604(GRK1)
MMUR: 105870048(GRK7) 105871942(GRK1)
MMU: 24013(Grk1)
MCAL: 110300107(Grk1)
MPAH: 110337043(Grk1)
RNO: 81760(Grk1)
MCOC: 116071162(Grk1)
CGE: 100750718(Grk1)
PLEU: 114701214(Grk1)
NGI: 103746297(Grk1)
HGL: 101697548(Grk1) 101726058(Grk7)
CPOC: 100731414(Grk1) 100735580(Grk7)
CCAN: 109686924(Grk1) 109699743(Grk7)
OCU: 100350579(GRK7)
OPI: 101519737(GRK7) 101526367(GRK1)
TUP: 102487091(GRK7)
CFA: 485557(GRK1) 485693(GRK7)
VVP: 112927444(GRK1) 112934966(GRK7)
VLG: 121477034(GRK1) 121478597(GRK7)
AML: 100464147(GRK7) 100479760(GRK1)
UMR: 103657516(GRK1) 103678440(GRK7)
UAH: 113247551(GRK1) 113254011(GRK7)
ORO: 101367921(GRK7) 101369670(GRK1)
MPUF: 101675318(GRK7) 101689672(GRK1)
EJU: 114196652(GRK1) 114205689(GRK7)
MLX: 118004615(GRK7) 118009109(GRK1)
FCA: 101089290(GRK7) 101092327(GRK1)
PYU: 121033757(GRK7) 121037672(GRK1)
PBG: 122485163(GRK1) 122491914(GRK7)
PTG: 102951583(GRK7) 102963599(GRK1)
PPAD: 109260221(GRK7) 109264025(GRK1)
AJU: 106981975(GRK7) 106986706(GRK1)
HHV: 120223471(GRK1) 120242660(GRK7)
BTA: 281457(GRK1) 281802(GRK7)
BOM: 102270913(GRK7) 102276250(GRK1)
BIU: 109564588(GRK7) 109567107(GRK1)
BBUB: 102389645(GRK7) 102404183(GRK1)
CHX: 102176894(GRK1) 102180541(GRK7)
OAS: 101106563(GRK7) 105606083(GRK1)
ODA: 120858114(GRK7) 120883389(GRK1)
CCAD: 122445344(GRK7) 122447426(GRK1)
SSC: 100620646(GRK1) 397114(GRK7)
CFR: 102513037(GRK7) 102520487(GRK1)
CBAI: 105066859(GRK7) 105066912(GRK1)
CDK: 105086344(GRK7) 105095499(GRK1)
BACU: 103002736(GRK1) 103013851(GRK7)
LVE: 103075679(GRK1) 103084736(GRK7)
OOR: 101275444(GRK1) 101277706(GRK7)
DLE: 111176312(GRK1) 111179161(GRK7)
PCAD: 102981560(GRK7) 102995100(GRK1)
PSIU: 116742978(GRK1) 116753389(GRK7)
ECB: 100062922(GRK7) 100069151(GRK1)
EPZ: 103549665(GRK1) 103557006(GRK7)
EAI: 106838155(GRK7) 106848207(GRK1)
MYB: 102242883(GRK7) 102257754(GRK1)
MYD: 102761230(GRK1) 102772275(GRK7)
MMYO: 118659646(GRK1) 118668108(GRK7)
MNA: 107534679(GRK7) 107536949(GRK1)
PKL: 118715742(GRK7) 118729139(GRK1)
HAI: 109383915(GRK1) 109384568(GRK7)
DRO: 112301054(GRK7) 112321528(GRK1)
SHON: 118984263(GRK1) 118990962(GRK7)
AJM: 119034610(GRK1) 119044790(GRK7)
PDIC: 114501325(GRK7) 114508889(GRK1)
MMF: 118622775(GRK1) 118633542(GRK7)
RFQ: 117021505(GRK1) 117036698(GRK7)
PALE: 102881273(GRK1) 102897090(GRK7)
PGIG: 120582158(GRK7) 120615632(GRK1)
RAY: 107509393(GRK7) 107514359(GRK1)
MJV: 108389875(GRK7) 108399960(GRK1)
TOD: 119257711(GRK7)
LAV: 100661845(GRK7) 100663708(GRK1)
MDO: 100013800(GRK7) 100016174(GRK1)
GAS: 123239804(GRK1) 123240191(GRK7)
SHR: 100914558(GRK1) 100931224(GRK7)
PCW: 110193377(GRK1) 110197221(GRK7)
OAA: 100078720(GRK1) 100078940(GRK7)
GGA: 395431(GRK1) 429125(GRK7)
PCOC: 116230895(GRK7) 116232969
MGP: 100540954(GRK7)
CJO: 107307752 107318088(GRK7)
NMEL: 110397747(GRK7)
APLA: 101796971(GRK7)
ACYG: 106036230(GRK7)
TGU: 100228229(GRK7)
LSR: 110467780(GRK1) 110473944(GRK7) 110480313
SCAN: 103815420(GRK7)
PMOA: 120507209(GRK1) 120508566(GRK7)
OTC: 121341101(GRK7) 121347835
PRUF: 121354065(GRK1) 121357933(GRK7)
GFR: 102042191(GRK7) 102043674(GRK1)
FAB: 101807639(GRK7)
PHI: 102101127(GRK1) 102108762(GRK7)
PMAJ: 107208859(GRK7)
CCAE: 111933517(GRK7)
CCW: 104693451(GRK7)
ETL: 114068734(GRK7)
FPG: 101912507(GRK7)
FCH: 102054411(GRK7)
CLV: 102097157(GRK7)
EGZ: 104127107(GRK7)
NNI: 104016390(GRK7)
ACUN: 113483518(GRK7)
PADL: 103917876(GRK7)
AAM: 106485856(GRK7)
AROW: 112976121(GRK7)
NPD: 112947895(GRK7)
DNE: 112984102(GRK7)
ASN: 102377543(GRK1) 102379208(GRK7)
AMJ: 102559313(GRK7) 102572840(GRK1)
CPOO: 109308597(GRK7)
GGN: 109288155(GRK7)
PSS: 102453105(GRK1) 102457262(GRK7)
CMY: 102935951(GRK7) 102942787(GRK1)
CPIC: 101943692(GRK7)
TST: 117882792(GRK7)
CABI: 116816433(GRK7) 116833195
ACS: 100557153(grk7) 100562054(grk1)
PVT: 110078433(GRK7) 110087761(GRK1)
SUND: 121926933(GRK7) 121933941(GRK1)
PBI: 103049908(GRK7)
PMUR: 107287767(GRK7)
TSR: 106541868(GRK7)
PGUT: 117678335(GRK7)
VKO: 123016680(GRK1) 123024774(GRK7)
PMUA: 114597833(GRK7) 114608093(GRK1)
ZVI: 118093643(GRK7) 118094752(GRK1)
GJA: 107112349(GRK7) 107121051(GRK1)
XLA: 100192358(grk7.L) 100192359(grk7.S) 443726(grk1.L) 733223(grk1.S)
XTR: 100145727(grk7) 100486335(grk1)
NPR: 108790153(GRK7) 108801185(GRK1)
DRE: 373871(grk7b) 550406(grk1b) 564152(grk1a) 566120(grk7a)
IPU: 108258333(grk1) 108260147 108280312(grk7)
PHYP: 113528872 113537539(grk1) 113546327(grk7)
EEE: 113577359(grk1) 113591131(grk7)
NCC: 104945246(grk7) 104951937(grk1) 104963524
ELY: 117251044 117251957(grk1a) 117260195(grk7b) 117264359(grk1b) 117271852(grk7a)
PLEP: 121943559(grk7b) 121944433(grk1a) 121949224 121951688(grk7a) 121952621(grk1b)
SLUC: 116034025(grk1a) 116045586(grk7b) 116046308 116048811(grk7a) 116064963(grk1b)
ECRA: 117942450 117949361(grk1a) 117953357 117953810(grk7a) 117955931(grk1b)
GAT: 120816230(grk7a) 120823070(grk1b) 120824828(grk7b) 120834459 120835107(grk1a)
PPUG: 119209747(grk7a) 119211812(grk7b) 119215006(grk1b) 119229062
CUD: 121511285(grk1a) 121519004(grk1b) 121520522(grk7a) 121522129(grk7b) 121522730
OAU: 116312275(grk1a) 116316142 116328081(grk7a) 116330288(grk1b) 116330353(grk7b)
GAF: 122832417(grk7b) 122840237 122840575(grk7a) 122844491(grk1a) 122845474(grk1b)
CTUL: 119771834(grk7b) 119777003(grk7a) 119782679(grk1a) 119786381
KMR: 108232331 108240458(grk7b) 108244511(grk7a) 108245207(grk1b) 108250293(grk1a)
SSEN: 122765474 122772512(grk1a) 122773798(grk7b) 122777139(grk7a) 122777806(grk1b)
HHIP: 117754983 117757122(grk1a) 117773126(grk7b) 117774876(grk1b) 117778749(grk7a)
XGL: 120791470(grk7b) 120792094(grk1a) 120798692(grk7a) 120801529 120802658(grk1b)
SFM: 108918707 108926834(grk7) 108937888(grk1)
PKI: 111836639(grk7) 111850644 111855924(grk1)
AANG: 118214257(grk1a) 118223961(grk1b) 118230435(grk7a)
LOC: 102687717(grk1) 102691787 102693571(grk7)
LCM: 102348929(GRK7) 102357257(GRK1) 102362932
CMK: 103177456(grk1a) 103178747
RTP: 109917976(grk7)
 » show all
Reference
1  [PMID:3014340]
  Authors
Benovic JL, Mayor F Jr, Somers RL, Caron MG, Lefkowitz RJ.
  Title
Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase.
  Journal
Nature 321:869-72 (1986)
DOI:10.1038/321869a0
Reference
2  [PMID:690139]
  Authors
Shichi H, Somers RL.
  Title
Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase.
  Journal
J Biol Chem 253:7040-6 (1978)
Reference
3  [PMID:2844754]
  Authors
Palczewski K, McDowell JH, Hargrave PA.
  Title
Purification and characterization of rhodopsin kinase.
  Journal
J Biol Chem 263:14067-73 (1988)
Reference
4  [PMID:164024]
  Authors
Weller M, Virmaux N, Mandel P.
  Title
Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin.
  Journal
Proc Natl Acad Sci U S A 72:381-5 (1975)
DOI:10.1073/pnas.72.1.381
Reference
5  [PMID:9380677]
  Authors
Cha K, Bruel C, Inglese J, Khorana HG.
  Title
Rhodopsin kinase: expression in baculovirus-infected insect cells, and characterization of post-translational modifications.
  Journal
Proc Natl Acad Sci U S A 94:10577-82 (1997)
DOI:10.1073/pnas.94.20.10577
Reference
6  [PMID:8812493]
  Authors
Khani SC, Abitbol M, Yamamoto S, Maravic-Magovcevic I, Dryja TP.
  Title
Characterization and chromosomal localization of the gene for human rhodopsin kinase.
  Journal
Genomics 35:571-6 (1996)
DOI:10.1006/geno.1996.0399
  Sequence
[hsa:6011]
Reference
7  [PMID:11754336]
  Authors
Chen CK, Zhang K, Church-Kopish J, Huang W, Zhang H, Chen YJ, Frederick JM, Baehr W
  Title
Characterization of human GRK7 as a potential cone opsin kinase.
  Journal
Mol Vis 7:305-13 (2001)
  Sequence
[hsa:131890]
Reference
8  [PMID:14654303]
  Authors
Willets JM, Challiss RA, Nahorski SR.
  Title
Non-visual GRKs: are we seeing the whole picture?
  Journal
Trends Pharmacol Sci 24:626-33 (2003)
DOI:10.1016/j.tips.2003.10.003
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.14
IUBMB Enzyme Nomenclature: 2.7.11.14
ExPASy - ENZYME nomenclature database: 2.7.11.14
BRENDA, the Enzyme Database: 2.7.11.14
CAS: 54004-64-7

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