KEGG   ENZYME: 2.7.11.15
Entry
EC 2.7.11.15                Enzyme                                 
Name
beta-adrenergic-receptor kinase;
ATP:beta-adrenergic-receptor phosphotransferase;
[beta-adrenergic-receptor] kinase;
beta-adrenergic receptor-specific kinase;
beta-AR kinase;
beta-ARK;
beta-ARK 1;
beta-ARK 2;
beta-receptor kinase;
GRK2;
GRK3;
beta-adrenergic-receptor kinase (phosphorylating);
beta2ARK;
betaARK1;
beta-adrenoceptor kinase;
beta-adrenoceptor kinase 1;
beta-adrenoceptor kinase 2;
ADRBK1;
BARK1;
adrenergic receptor kinase;
STK15
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:[beta-adrenergic receptor] phosphotransferase
Reaction(IUBMB)
ATP + [beta-adrenergic receptor] = ADP + phospho-[beta-adrenergic receptor] [RN:R03274]
Reaction(KEGG)
R03274
Substrate
ATP [CPD:C00002];
[beta-adrenergic receptor] [CPD:C01141]
Product
ADP [CPD:C00008];
phospho-beta-adrenergic receptor [CPD:C04141]
Comment
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
History
EC 2.7.11.15 created 1989 as EC 2.7.1.126, transferred 2005 to EC 2.7.11.15
Orthology
K00910  beta-adrenergic-receptor kinase
Genes
HSA156(GRK2) 157(GRK3)
PTR100614029(GRK3) 451363(GRK2)
PPS100984800(GRK3) 100991802(GRK2)
GGO101140574(GRK2) 101148325(GRK3)
PON100454669(GRK3) 100461893(GRK2)
NLE100582671(GRK3) 100604826(GRK2)
MCC714510(GRK3) 721754(GRK2)
MCF102141861(GRK2) 102141926(GRK3)
CSAB103219132(GRK2) 103223079(GRK3)
CATY105575649(ADRBK2) 105577363(ADRBK1)
PANU101003424(GRK3) 101017434(GRK2)
TGE112606411(GRK2) 112633452(GRK3)
RRO104664749(GRK2) 104671949(GRK3)
RBB108515962(GRK3) 108518610(GRK2)
TFN117080248(GRK2) 117096104(GRK3)
PTEH111522233(GRK2) 111525328(GRK3)
CJC100396838(GRK3)
SBQ101027803(ADRBK2) 101049133(ADRBK1)
CSYR103258733(GRK2) 103265957(GRK3)
MMUR105866915(GRK3) 105867521(GRK2)
OGA100943694(GRK2) 100966357(GRK3)
MMU110355(Grk2) 320129(Grk3)
MCAL110285277(Grk2) 110295078(Grk3)
MPAH110312827(Grk2) 110312920(Grk3)
RNO25238(Grk2) 25372(Grk3)
MCOC116068187(Grk3) 116103332(Grk2)
MUN110554001(Grk3) 110560356(Grk2)
CGE100761290 100762552(Grk2)
PLEU114684308(Grk3) 114685988(Grk2)
NGI103725575(Grk2) 103746714(Grk3)
HGL101708742(Grk3) 101708906(Grk2)
CPOC100730505(Grk3) 100732560(Grk2)
CCAN109684472 109690706(Grk2) 109701375(Grk3)
DORD105984177(Adrbk2) 105989215(Adrbk1)
DSP122097920(Grk3) 122104916(Grk2)
NCAR124960255 124990808
OCU100349708(GRK3) 103345045(GRK2)
OPI101524133(GRK2) 101526829(GRK3)
TUP102482004(GRK2) 102499442(GRK3)
CFA483701(GRK2) 486327(GRK3)
VVP112923199(GRK3) 112924194(GRK2)
VLG121471974(GRK2) 121475364(GRK3)
AML100469854(GRK2) 100475417(GRK3)
UMR103659256(GRK3) 103679607(GRK2)
UAH113244040(GRK2) 113244983(GRK3)
UAR123778398(GRK2) 123788122(GRK3)
ELK111149447 111160050
LLV125078662 125081722
MPUF101676854(ADRBK2) 101690956(ADRBK1)
ORO101384757(ADRBK1) 101385645(ADRBK2)
EJU114220504(GRK2) 114225191
ZCA113912434(GRK3) 113914853(GRK2)
MLX118016116(GRK2) 118018603(GRK3)
FCA101090393(GRK3) 101101082(GRK2)
PYU121022621(GRK3) 121023660(GRK2)
PBG122470448(GRK3) 122484042(GRK2)
PTG102957039(GRK3) 102970752(GRK2)
PPAD109246837(GRK2) 109253514(GRK3)
AJU106971185(GRK2) 106982294(GRK3)
HHV120227230(GRK3) 120233906(GRK2)
BTA282136(GRK3) 282682(GRK2)
BOM102286310(GRK2) 102288247(GRK3)
BIU109554452(GRK2) 109571286(GRK3)
BBUB102408612(GRK2) 102414435(GRK3)
CHX102180735(GRK2) 102185296(GRK3)
OAS101108265(GRK2) 101117366(GRK3)
ODA120871211(GRK3) 120874764(GRK2)
CCAD122421867(GRK3) 122430520(GRK2)
SSC100156449(GRK3) 100513842(GRK2)
CFR102505202(GRK3) 102523137(GRK2)
CBAI105066103(ADRBK2) 105070324(ADRBK1)
CDK105099520(GRK3) 105104436(GRK2)
VPC102536025(GRK3) 102543317(GRK2)
BACU103005732(GRK3) 103019615(GRK2)
LVE103073421(GRK3) 103076247(GRK2)
OOR101270842(ADRBK2) 101283682(ADRBK1)
DLE111162697(GRK3) 111183685(GRK2)
PCAD102978788(GRK3) 102996848(GRK2) 114485015
PSIU116738732(GRK3) 116757833(GRK2)
ECB100059001(GRK2) 100065495(GRK3) 111767400(GRK3)
EPZ103550032(GRK3) 103559830(GRK2)
EAI106833505(GRK2) 106841709(GRK3)
MYB102243341(GRK2) 102248143(GRK3)
MYD102761774(GRK3) 102764962(GRK2)
MMYO118665230(GRK2) 118678342(GRK3)
MLF102419138 102432583(GRK2) 102441969
MNA107533587(ADRBK1) 107533866(ADRBK2)
PKL118706968(GRK2) 118725511(GRK3)
HAI109384296(GRK2) 109394134(GRK3)
DRO112310529(GRK3) 112317213(GRK2)
SHON118991232(GRK3) 118991804(GRK2)
AJM119041860(GRK2) 119057439(GRK3)
PDIC114499827(GRK2) 114509548(GRK3)
PHAS123820806(GRK3) 123829489(GRK2)
MMF118627698(GRK2) 118639875(GRK3)
RFQ117017286(GRK3) 117030570(GRK2)
PALE102881239(GRK3) 102893733(GRK2)
PGIG120584771(GRK2) 120601990(GRK3)
PVP105301826(GRK3) 105309917(GRK2)
RAY107499745(ADRBK2) 107503771(ADRBK1)
MJV108387037(GRK3) 108393151(GRK2)
TOD119244788(GRK3) 119249919(GRK2)
SARA101548616(ADRBK1) 101549489(ADRBK2)
LAV100666578(GRK3) 100671884(GRK2)
TMU101346329 101357163
DNM101428937(GRK2) 101433169(GRK3)
MDO100009844(GRK3)
GAS123245282(GRK3) 123254338
SHR100913578(GRK3) 116420004(GRK2)
PCW110195409(GRK2) 110215258(GRK3)
OAA100078284(GRK3) 100090102(GRK2)
GGA416904(GRK3) 426000(GRK2)
PCOC116228526(GRK3) 116243006(GRK2)
MGP100541374(GRK3) 100545380(GRK2)
CJO107314190(GRK2) 107321443(GRK3)
NMEL110400830(GRK2) 110406207(GRK3)
APLA101801089(GRK2)
ACYG106029321(ADRBK1) 106031075(ADRBK2)
AFUL116489819(GRK2) 116495958(GRK3)
TGU100217970(GRK3) 100227701(GRK2)
LSR110478203(GRK3) 110484938(GRK2)
SCAN103818288(GRK3) 103822132(GRK2)
PMOA120499554(GRK2) 120509589(GRK3)
OTC121338834(GRK3) 121339908(GRK2)
PRUF121355192(GRK2) 121364845(GRK3)
GFR102032477(GRK2) 102036360(GRK3)
FAB101810197(GRK3) 101811193(GRK2)
PHI102108753(GRK3) 102114443(GRK2)
PMAJ107205270(GRK2) 107211779(GRK3)
CCAE111936727(GRK3) 111945589
CCW104688799(GRK3) 120410071(GRK2)
ETL114066071(GRK3) 114067868(GRK2)
ZAB102062501 102065350(GRK3)
FPG101911656(GRK2) 101916842(GRK3)
FCH102048951(GRK3) 102058946(GRK2)
CLV102092240(GRK2) 102096658(GRK3)
EGZ104128318(ADRBK2) 104129654
NNI104009467(ADRBK1) 104020459(ADRBK2)
ACUN113485979(GRK3)
TALA104367315(GRK3) 116965084(GRK2)
PADL103925680(ADRBK2)
ACHC115345756(GRK3) 115351926(GRK2)
AAM106492546(GRK3) 106493396
AROW112963364(GRK3) 112967069(GRK2)
NPD112945167(GRK3) 112954249(GRK2)
DNE112988615(GRK2) 112991748(GRK3)
ASN102367979(GRK2) 102378654(GRK3)
AMJ102563874(GRK2) 106737118(GRK3)
CPOO109312973(GRK3) 109324606(GRK2)
GGN109290257(GRK3)
PSS102443539(GRK2) 102454375
CMY102946005(GRK3) 102947181(GRK2)
CPIC101944586(GRK2) 101953922(GRK3)
TST117876033(GRK2) 117888032(GRK3)
CABI116818695(GRK3) 116833414(GRK2)
MRV120386194(GRK3) 120393445(GRK2)
ACS100555775(grk2) 103282961
PVT110083438(GRK3) 110085629(GRK2)
SUND121923548(GRK2)
PBI103064129(GRK2) 103066055(GRK3)
PMUR107287274(GRK3) 107296663(GRK2)
TSR106547124(ADRBK1) 106556848(ADRBK2)
PGUT117667175(GRK2) 117672298(GRK3)
VKO123027372(GRK2) 123028537(GRK3)
PMUA114582570 114601867(GRK2)
ZVI118090157(GRK2) 118094381(GRK3)
GJA107116822(GRK2) 107123215(GRK3)
STOW125426065(GRK2) 125442586(GRK3)
XLA108707086 108715724
XTR100379889(grk3)
NPR108790542
RTEM120937831(GRK3)
BBUF120988837(GRK3)
BGAR122924360(GRK3)
DRE569403(grk3)
SRX107741659 107758628
SANH107658541 107689528
SGH107567741 107588964
CCAR109067814 109093673 109097714
CAUA113054629 113110283
PPRM120482724(grk3)
MAMB125262386(grk3)
IPU108276813(grk3)
PHYP113544847(grk3)
SMEO124393295(grk3)
TFD113638351(grk3)
AMEX103046030
EEE113568347 113583216
TRU101073064(grk3)
TNGGSTEN00025383G001
LCO104934568(grk3)
ELY117269522(grk3)
SLUC116041782(grk3)
PFLV114570869(grk3)
PPUG119226472(grk3)
MSAM119914686(grk3)
CUD121524869(grk3)
MZE101476711(grk3)
ONL100707869(grk3)
OAU116329300(grk3)
OLA111948284(grk3)
OML112163042(grk3)
XMA102224709(grk3)
XCO114150251(grk3)
XHE116724737(grk3)
PRET103473184
PFOR103151765(adrbk2) 103156162
PLAI106955254(adrbk2) 106958266
PMEI106911922 106923393(adrbk2)
GAF122846969(grk3)
CVG107101402
CTUL119795954(grk3)
GMU124872423(grk3)
NFU107396329
KMR108245400(grk3)
ALIM106526089
NWH119424810(grk3)
AOCE111566117
CSEM103389928(grk3)
POV109626032(grk3)
SSEN122758514(grk3)
HHIP117771896(grk3)
LCF108895613(grk3)
SDU111224273(grk3)
SLAL111664712(grk3)
XGL120806051(grk3)
HCQ109527953(grk3)
BPEC110166677(grk3)
MALB109974750(grk3)
SASA106563006 106563091 106568375
OTW112230856 112237178(grk3)
OMY110512753 110523401(grk3)
OGO124006666 124049121
ONE115117262 115146893
SALP112070845
SNH120020946 120026183
ELS105015221(grk3)
SFM108930044
PKI111851486(grk3)
AANG118212322(grk3)
LOC102695299
PSPA121307722 121307723
ARUT117426618 117963071
LCM102362780(GRK2) 102365333(ADRBK2)
CMK103184070(grk3)
RTP109914938(grk3)
BFO118425552
BBEL109467794
CIN100184862
SCLV120343533
SPU100888242
APLC110987558
SKO100366720
DMEDmel_CG40129(Gprk1)
DER6541861
DSE6620153
DSIDsimw501_GD17695(Dsim_GD17695)
DYADyak_GE25059
DAN6497632
DSR110185369
DPE6602044
DMN117188156
DWI6640045
DGR6559369
DMODmoj_GI18854
DAZ108616079
DNV115564429
DHE111600089
DVI6635312
CCAT101454248
BOD118683218
MDE101896222
SCAC106083442
LCQ111677046
AGAAgaP_AGAP012026
ACOZ120954673
AARA120902452
AAG110681207 5568458
AALB109426380
CQUCpipJ_CPIJ004658
CPII120415167
AME413197
ACER107992508 108000044
ALAB122716961
BIM100748232
BBIF117207879
BVK117238306
BVAN117158816
BTER100651375
BPYO122570540
CCAL108621983
OBB114883156
MGEN117220029
NMEA116431916
CGIG122396225
SOC105194556
MPHA105832639
AEC105153411
ACEP105619512
PBAR105422796
VEM105564800
HST105181552
DQU106746819
CFO105258109
FEX115238912
LHU105678424
PGC109856349
OBO105276693
PCF106783861
PFUC122525965
VPS122632866
NVI100121113
CSOL105363982
TPRE106648977
MDL103575167
CGLO123265859
FAS105269996
DAM107040937
AGIF122848918
CCIN107271505
TCA654946
DPA109537817
SOY115887220
ATD109598675 109607670
CSET123316262
AGB108903923
LDC111505067
NVL108568789
APLN108732559
PPYR116179800
OTU111417188
BMOR101741546
BMAN114249881
MSEX115447635
DPLKGM_204545 KGM_212300A
BANY112051822
PMAC106717955
PPOT106108436
PXU106115946
PRAP110992337
ZCE119830779
HAW110372807
TNL113499032
SLIU111364977
OFU114364577
PXY105389442 105392068
API100166085
DNX107162156
AGS114126939
RMD113560481
BTAB109037372
DCI103519341
HHAL106685857
NLU111046871
PHUPhum_PHUM014910
FOC113204646
ZNE110841237
CSEC111871818
FCD110856660
DPXDAPPUDRAFT_194156(Grk2)
DMK116917985
PVM113809193
PJA122251215
HAME121855948
PCLA123766420
PTRU123503990
HAZT108664662
EAF111703766
LSM121131974
ISCIscW_ISCW009785
DSV119446021
RSAN119390439
RMP119171976
VDE111252280
VJA111266831
TUT107361145
DPTE113793852
DFR124500542
CSCU111628135
PTEP107446386
SDM118181383
CELCELE_W02B3.2(grk-2)
CBRCBG_15249(Cbr-grk-2)
BMYBM_BM7964(Bma-grk-2)
LOALOAG_06661
NAINECAME_16586
TSPTsp_00495
HROHELRODRAFT_75424
LGILOTGIDRAFT_144613
PCAN112562704
BGT106069803
GAE121369275
HRF124134938
HRJ124266637
CRG105319304
MYI110461337
PMAX117332490
MMER123533318
OBI106871981
OSN115224846
LAK106181894
SMMSmp_210820
OVIT265_09192
EGLEGR_01776 EGR_04327
NVE5506466
EPA110243336
ATEN116303328
ADF107338012
AMIL114960143
PDAM113665499
SPIS111345132
DGT114538288
XEN124434319
HMG100214170
TADTRIADDRAFT_59012
AQU100638292
MBRMONBRDRAFT_38629
SREPTSG_08590
PTIPHATRDRAFT_27639
FCYFRACYDRAFT_169425
TPSTHAPSDRAFT_15351
PIFPITG_16476
PSOJPHYSODRAFT_297885
EHXEMIHUDRAFT_234416 EMIHUDRAFT_428179 EMIHUDRAFT_444936 EMIHUDRAFT_466622
 » show all
Reference
1  [PMID:3036840]
  Authors
Benovic JL, Mayor F Jr, Staniszewski C, Lefkowitz RJ, Caron MG
  Title
Purification and characterization of the beta-adrenergic receptor kinase.
  Journal
J Biol Chem 262:9026-32 (1987)
Reference
2  [PMID:8394172]
  Authors
Kim CM, Dion SB, Onorato JJ, Benovic JL.
  Title
Expression and characterization of two beta-adrenergic receptor kinase isoforms using the baculovirus expression system.
  Journal
Receptor 3:39-55 (1993)
Reference
3  [PMID:9349395]
  Authors
Laugwitz KL, Kronsbein K, Schmitt M, Hoffmann K, Seyfarth M, Schomig A, Ungerer M.
  Title
Characterization and inhibition of beta-adrenergic receptor kinase in intact myocytes.
  Journal
Cardiovasc Res 35:324-33 (1997)
DOI:10.1016/s0008-6363(97)00102-8
Reference
4  [PMID:7559596]
  Authors
Ferguson SS, Menard L, Barak LS, Koch WJ, Colapietro AM, Caron MG.
  Title
Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1.
  Journal
J Biol Chem 270:24782-9 (1995)
DOI:10.1074/jbc.270.42.24782
Reference
5  [PMID:14654303]
  Authors
Willets JM, Challiss RA, Nahorski SR.
  Title
Non-visual GRKs: are we seeing the whole picture?
  Journal
Trends Pharmacol Sci 24:626-33 (2003)
DOI:10.1016/j.tips.2003.10.003
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.15
IUBMB Enzyme Nomenclature: 2.7.11.15
ExPASy - ENZYME nomenclature database: 2.7.11.15
BRENDA, the Enzyme Database: 2.7.11.15
CAS: 102925-39-3

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