KEGG   ENZYME: 2.7.11.16
Entry
EC 2.7.11.16                Enzyme                                 
Name
G-protein-coupled receptor kinase;
G protein-coupled receptor kinase;
GPCR kinase;
GPCRK;
GRK4;
GRK5;
GRK6;
STK16
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:[G-protein-coupled receptor] phosphotransferase
Reaction(IUBMB)
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate
Substrate
ATP [CPD:C00002];
[G-protein-coupled receptor]
Product
ADP [CPD:C00008];
[G-protein-coupled receptor] phosphate
Comment
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.15, beta-adrenergic-receptor kinase).
History
EC 2.7.11.16 created 2005
Orthology
K08291  G protein-coupled receptor kinase
Genes
HSA: 2868(GRK4) 2869(GRK5) 2870(GRK6)
PTR: 461082(GRK4) 466217(GRK5) 471760(GRK6)
PPS: 100972068(GRK6) 100972921(GRK4) 100975050(GRK5)
GGO: 101125204(GRK6) 101142802(GRK5) 101148767(GRK4)
PON: 100171722(GRK5) 100433745(GRK6) 100442141(GRK4)
PPYG: 129006083(GRK5) 129035783(GRK4) 129036312(GRK6)
NLE: 100592067(GRK6) 100593251(GRK5) 100595255(GRK4)
HMH: 116457082(GRK4) 116471889(GRK6) 116482945(GRK5)
SSYN: 129464401(GRK4) 129465343(GRK5) 129485978(GRK6)
MCC: 100427251(GRK5) 700000(GRK6) 720047(GRK4)
MCF: 102115240(GRK4) 102128844(GRK6) 102132362(GRK5)
MTHB: 126955566 126956333 126962667
MNI: 105467774(GRK5) 105483861(GRK4) 105484049(GRK6)
CSAB: 103216606(GRK5) 103245054(GRK6) 103246447(GRK4)
CATY: 105577971(GRK5) 105581727(GRK6) 105585464(GRK4)
PANU: 101000030(GRK6) 101001106(GRK4) 101025057(GRK5)
TGE: 112624597(GRK4) 112626333(GRK6) 112631680(GRK5)
MLEU: 105532692(GRK4) 105546705(GRK6) 105554561(GRK5)
RRO: 104672234(GRK5) 104678955(GRK4) 104680460(GRK6)
RBB: 108513853(GRK5) 108522739(GRK4) 108544772(GRK6)
TFN: 117065331(GRK6) 117065894(GRK5) 117085065(GRK4)
PTEH: 111521617(GRK6) 111539096(GRK4) 111550779(GRK5)
CANG: 105503381(GRK5) 105507028(GRK4) 105515133(GRK6)
CJC: 100400573(GRK5) 100403264(GRK6) 100403887(GRK4)
SBQ: 101030769(GRK6) 101037649(GRK5) 101054298(GRK4)
CIMI: 108289583(GRK5) 108292164(GRK6) 108293083(GRK4)
ANAN: 105714157(GRK5) 105726831(GRK6) 105727129(GRK4)
CSYR: 103258067(GRK4) 103269522(GRK6) 103275859(GRK5)
MMUR: 105856035(GRK4) 105857047(GRK5) 105883855(GRK6)
LCAT: 123621160 123622219(GRK4) 123623451(GRK6) 123650408(GRK5)
PCOQ: 105808707(GRK5) 105818890(GRK4) 105823509(GRK6)
OGA: 100946468(GRK4) 100954169(GRK6) 100956889(GRK5)
MMU: 14772(Grk4) 14773(Grk5) 26385(Grk6)
MCAL: 110285684(Grk5) 110294130(Grk4) 110307882(Grk6)
MPAH: 110326741(Grk5) 110330568(Grk4) 110333637(Grk6)
RNO: 59075(Grk5) 59076(Grk6) 59077(Grk4)
MCOC: 116070002(Grk4) 116082800(Grk6) 116104072(Grk5)
ANU: 117712968(Grk4) 117713692(Grk6) 117724937(Grk5)
MUN: 110549769(Grk6) 110552404(Grk4) 110566290(Grk5)
CGE: 100767022(Grk4) 100771151(Grk5) 103161260(Grk6)
MAUA: 101828206(Grk6) 101834234(Grk5) 101843576(Grk4)
PROB: 127229190(Grk6) 127233482(Grk5) 127233690(Grk4)
PLEU: 114686123(Grk5) 114689175(Grk6) 114694079(Grk4)
MORG: 121436435 121445804 121453371(Grk6) 121453996(Grk5) 121459367
MFOT: 126500758 126502745 126505573
AAMP: 119808870(Grk4) 119812381(Grk5) 119816894(Grk6)
NGI: 103729285(Grk5) 103732366(Grk6) 103741150(Grk4)
HGL: 101718249(Grk6) 101718850(Grk5) 101720649(Grk4) 101720846
CPOC: 100718627(Grk4) 100719009(Grk5) 100735666(Grk6)
CCAN: 109676704 109685731(Grk4) 109685760(Grk6) 109700825(Grk5)
DORD: 105985444(Grk6) 105989778(Grk5) 105991273(Grk4)
DSP: 122096515(Grk6) 122100679(Grk4) 122126856(Grk5)
PLOP: 125341987(Grk6) 125345996(Grk5) 125364441(Grk4)
NCAR: 124984553 124986734 124994901
MMMA: 107138899(Grk4) 107144726(Grk6) 107152823(Grk5)
OCU: 100351551 100357639 103351438
OPI: 101521205(GRK4) 101521481(GRK6) 101524148(GRK5)
TUP: 102474598(GRK6) 102480420(GRK4) 102485965(GRK5)
GVR: 103589023(GRK6) 103594721(GRK4) 103604532(GRK5)
CFA: 100684653(GRK6) 479075(GRK4) 486915(GRK5)
CLUD: 112651973(GRK6) 112653961(GRK4) 112672418(GRK5)
VVP: 112916590(GRK5) 112920421(GRK4) 112925482(GRK6)
VLG: 121481324(GRK5) 121488264(GRK6) 121488859(GRK4)
NPO: 129509920(GRK6) 129510129(GRK4) 129523388(GRK5)
AML: 100466557(GRK4) 100478616(GRK6) 100480732(GRK5)
UMR: 103657694(GRK5) 103664442(GRK6) 103676663(GRK4)
UAH: 113245697(GRK4) 113251993(GRK5) 113264153(GRK6)
UAR: 123777841 123791288(GRK6) 123796011(GRK5)
ELK: 111140814 111144787 111148957
LLV: 125084243 125093485 125100066
MPUF: 101683582(GRK6) 101687496(GRK4) 101691123(GRK5)
MNP: 132003963(GRK4) 132016823(GRK5) 132028474(GRK6)
MLK: 131826899(GRK4) 131830625(GRK5) 131831978(GRK6)
NVS: 122892289(GRK6) 122901162(GRK5) 122919094(GRK4)
ORO: 101366445(GRK4) 101377206(GRK6) 101385208(GRK5)
EJU: 114198003(GRK4) 114208727(GRK6) 114223030(GRK5)
ZCA: 113918530(GRK5) 113924763(GRK4) 113929061(GRK6)
MLX: 118010768(GRK4) 118017323(GRK6) 118027000(GRK5)
NSU: 110569750(GRK4) 110588484(GRK6) 110589500(GRK5)
LWW: 102742180(GRK6) 102750357(GRK4)
FCA: 101086226(GRK4) 101087379(GRK6) 101089047(GRK5)
PYU: 121011732(GRK6) 121037297(GRK5) 121039056(GRK4)
PCOO: 112854769(GRK5) 112858238(GRK4) 112861006(GRK6)
PBG: 122479111(GRK4) 122489701(GRK6) 122493309(GRK5)
PVIV: 125147749(GRK5) 125159186(GRK4) 125169994(GRK6)
LRUF: 124507182 124519975 124522652
PTG: 102955344(GRK4) 102962153(GRK5) 102968971(GRK6)
PPAD: 109267583(GRK6) 109269752(GRK4) 109272977(GRK5)
PUC: 125923923 125933168 125934389
AJU: 106969373 106975413 106978855
HHV: 120231805(GRK4) 120235181(GRK5) 120236759(GRK6)
BTA: 281801(GRK5) 512489(GRK4) 521413(GRK6)
BOM: 102271649(GRK6) 102272970(GRK5) 102283303(GRK4)
BIU: 109553055(GRK5) 109560743(GRK4) 109561904(GRK6)
BBUB: 102389056(GRK5) 102389526(GRK4) 102412507(GRK6)
BBIS: 104993333(GRK6) 104994417(GRK4) 105002565(GRK5)
CHX: 102183500(GRK4) 102186301(GRK6) 102190578(GRK5)
OAS: 101107019(GRK6) 101107151(GRK5) 101120060 101122439(GRK4)
BTAX: 128049405(GRK4) 128050404(GRK6) 128067756(GRK5)
ODA: 120861817(GRK4) 120863852(GRK6) 120873864(GRK5)
CCAD: 122428099(GRK4) 122440033(GRK6) 122445871(GRK5)
MBEZ: 129535020 129555304(GRK5) 129558306(GRK6) 129561756(GRK4)
SSC: 100152937(GRK5) 100519668(GRK4) 110259389(GRK6)
CFR: 102518408(GRK5) 102522133(GRK4) 102524130(GRK6)
CBAI: 105062033(GRK6) 105072344(GRK4) 105080777(GRK5)
CDK: 105099593(GRK6) 105103924(GRK4) 105104188(GRK5)
VPC: 102528313(GRK6) 102533153(GRK5) 102539850(GRK4)
BACU: 103005786(GRK5) 103011898(GRK4) 103017883(GRK6)
BMUS: 118882721(GRK5) 118892251(GRK6) 118895252(GRK4)
LVE: 103071087(GRK5) 103082340(GRK6)
OOR: 101275494(GRK5) 101276909(GRK6)
DLE: 111169865(GRK6) 111172254(GRK5)
PCAD: 102979868 102988242(GRK4) 102988311(GRK6)
PSIU: 116741728(GRK5) 116750668(GRK6)
NASI: 112400058(GRK6) 112406916(GRK5)
ECB: 100053624(GRK4) 100065919(GRK5) 100068570(GRK6)
EPZ: 103539972(GRK6) 103554506(GRK5) 103558677(GRK4)
EAI: 106825835(GRK4) 106827137(GRK6) 106836364(GRK5)
MYB: 102246592(GRK5) 102255277(GRK6) 102260906(GRK4)
MYD: 102754944 102757801(GRK6) 102758601(GRK5) 102762532(GRK4)
MMYO: 118659264(GRK6) 118665906(GRK4) 118669688(GRK5)
MLF: 102418826(GRK4) 102423126(GRK6) 102428002(GRK5)
MDT: 132214401(GRK5) 132222117(GRK4) 132235575(GRK6)
PKL: 118707183(GRK4) 118710674(GRK6) 118719538(GRK5)
EFUS: 103287374(GRK6) 103288601(GRK5) 103294565(GRK4)
MNA: 107524071(GRK4) 107529777(GRK6) 107532096(GRK5)
DRO: 112300283(GRK5) 112316718(GRK4) 112320363(GRK6)
SHON: 118987574(GRK4) 118996302(GRK5) 118999751(GRK6)
AJM: 119035145(GRK6) 119035473(GRK4) 119051889(GRK5)
PDIC: 114489914(GRK4) 114496447(GRK5) 114509375(GRK6)
PHAS: 123808059(GRK6) 123815942(GRK4) 123828954(GRK5)
MMF: 118632060(GRK5) 118638950(GRK4) 118643634(GRK6)
PPAM: 129066464(GRK6) 129077212(GRK5) 129077502(GRK4)
HAI: 109382992(GRK5) 109389794(GRK6) 109390911(GRK4)
RFQ: 117016850(GRK6) 117022130(GRK4) 117035983(GRK5)
PALE: 102877766(GRK5) 102881935(GRK6) 102893603(GRK4)
PGIG: 120582884(GRK4) 120608879(GRK5) 120616568(GRK6)
PVP: 105291448(GRK5) 105293506(GRK6) 105301218(GRK4)
RAY: 107509758(GRK5) 107517532(GRK6) 107517995(GRK4)
MJV: 108396051(GRK5) 108406370(GRK6)
TOD: 119233347(GRK5) 119236985(GRK6) 119261280(GRK4)
SARA: 101537836(GRK6) 101553961(GRK5) 101554686(GRK4)
SETR: 125994907(GRK5) 126011942(GRK6) 126032241(GRK4)
LAV: 100659746 100663377(GRK5) 100663381(GRK6) 100670615(GRK4)
TMU: 101341711 101350552 101361031
ETF: 101640122(GRK4) 101646929(GRK6) 101661483(GRK5)
DNM: 101420405(GRK4) 101434874(GRK5) 101444381(GRK6)
MDO: 100021366(GRK4) 100026232(GRK5) 100031943(GRK6)
GAS: 123235485(GRK6) 123238190(GRK5) 123253030(GRK4)
SHR: 100915281(GRK5) 100921906(GRK6) 100931079(GRK4)
AFZ: 127541253 127550285 127551629
PCW: 110209572(GRK5) 110212220(GRK4) 110216761(GRK6)
TVP: 118828281(GRK5) 118844092(GRK6) 118855410(GRK4)
OAA: 100074050(GRK4) 100084269(GRK5) 100084380(GRK6)
GGA: 416361(GRK6) 422879(GRK4) 423929(GRK5)
PCOC: 116225760(GRK4) 116231578(GRK5) 116232064(GRK6)
MGP: 100539666 100540688 100550765(GRK6)
CJO: 107314005(GRK4) 107316182(GRK5) 107320438(GRK6)
TPAI: 128077777(GRK5) 128080670(GRK4) 128081631(GRK6)
LMUT: 125692647(GRK4) 125692901(GRK5) 125700288(GRK6)
NMEL: 110398045(GRK4) 110399963(GRK5) 110405115(GRK6)
APLA: 101794252(GRK5) 101797744 101798639(GRK6) 101798987(GRK4)
ACYG: 106034651(GRK4) 106042780(GRK6) 106045200(GRK5)
CATA: 118248400(GRK4) 118248685(GRK5) 118254437(GRK6) 118256121
AFUL: 116488678(GRK4) 116491174(GRK5) 116494778(GRK6) 116499485
TGU: 100227306(GRK5) 100229994(GRK6) 100232432(GRK4)
LSR: 110469989(GRK5) 110470777(GRK6) 110481866(GRK4)
SCAN: 103814115(GRK5) 103817367(GRK6) 103823915(GRK4)
PMOA: 120498597(GRK6) 120502190(GRK5) 120509382(GRK4)
OTC: 121332424(GRK6) 121335097(GRK4) 121341858(GRK5)
PRUF: 121350222(GRK5) 121361349(GRK6) 121365873(GRK4)
GFR: 102035414(GRK5) 102036653(GRK4) 102041334(GRK6)
FAB: 101807573(GRK4) 101814948(GRK5) 101818256(GRK6)
OMA: 130252577(GRK4) 130254733(GRK5) 130258735(GRK6)
PHI: 102106169(GRK5) 102110063(GRK4) 102110395(GRK6)
PMAJ: 107202831(GRK4) 107206946(GRK5) 107210768(GRK6)
CCAE: 111928238(GRK4) 111930967(GRK5) 111935451(GRK6)
CCW: 104689515(GRK6) 104690771(GRK4) 104694850(GRK5)
CBRC: 103611459(GRK6) 103624019(GRK5) 103625625(GRK4)
ETL: 114060962(GRK5) 114061206(GRK4) 114066262(GRK6) 114066479
ZAB: 102064482(GRK6) 102069462(GRK5) 102073574(GRK4)
ZLE: 135446462(GRK4) 135449368(GRK5) 135453677(GRK6)
ACHL: 103797371 103798787(GRK5) 103799169(GRK6) 103800302(GRK4)
SVG: 106852994(GRK6) 106859484(GRK5) 106865301(GRK4)
MMEA: 130573099(GRK4) 130580780(GRK6) 130581245(GRK5)
HRT: 120752968(GRK4) 120755600(GRK5) 120759101(GRK6)
SATI: 136360285(GRK4) 136363987(GRK5) 136367588(GRK6)
FPG: 101911963(GRK6) 101912780(GRK4) 101916330(GRK5) 101919471
FCH: 102046997 102048279(GRK4) 102049406(GRK6) 102050182(GRK5)
CCRI: 104163284(GRK6) 104168375(GRK4)
NNT: 104399723(GRK4) 104412281(GRK6)
SHAB: 115609059(GRK5) 115610831(GRK4) 115616073(GRK6)
ACUN: 113479265(GRK4) 113481464(GRK5) 113485270(GRK6)
TALA: 104363692(GRK4) 104367335(GRK6) 104369241(GRK5) 116965949
ACHC: 115334265(GRK6) 115339311(GRK4) 115347971(GRK5) 115350060
HALD: 104323528(GRK6)
HLE: 104828964 104830034(GRK5) 104838973(GRK6) 104841687(GRK4)
AGEN: 126042785 126050879 126051724 126053331
GCL: 127015567 127017646 127025288
CSTI: 104550319(GRK4) 104556642(GRK6) 104562804
LDI: 104340044(GRK4) 104340405(GRK6) 104346611(GRK5)
MNB: 103772065(GRK6)
DPUB: 104301285 104303930(GRK6) 104308847(GRK4) 104309123(GRK5)
AVIT: 104268380 104271664(GRK6) 104278223
BRHI: 104489562 104491208 104495486(GRK6)
EGZ: 104128614(GRK5) 104130186(GRK4) 104135895(GRK6)
NNI: 104016063 104018057(GRK4) 104018951(GRK6) 104022391(GRK5)
PCRI: 104035067(GRK6)
PCAO: 104044838(GRK6) 104049992(GRK4)
PADL: 103912228(GRK6) 103918548(GRK5) 103920932(GRK4)
AFOR: 103897764(GRK5) 103899707 103904046(GRK4) 103904327
FGA: 104069972(GRK4) 104073256(GRK6)
GSTE: 104255501(GRK6) 104259188(GRK4)
CLV: 102084153(GRK6) 102084308 102091969(GRK4) 102093957(GRK5)
MUI: 104536445(GRK5) 104545264(GRK4) 104545876(GRK6)
PGUU: 104458322(GRK6) 104462915(GRK4)
PLET: 104614300(GRK4) 104622495 104628822(GRK6)
EHS: 104508552(GRK5) 104509175(GRK4) 104514638(GRK6)
CMAC: 104474029(GRK6) 104478328
CUCA: 104062556(GRK4) 104065558(GRK6) 104067768(GRK5)
TEO: 104374735(GRK6) 104380223(GRK4) 104384347
BREG: 104629763(GRK4) 104638660(GRK6)
OHA: 104326337(GRK6) 104332356(GRK5) 104335200(GRK4)
ACAR: 104527390(GRK6) 104530185 104531788(GRK4)
CPEA: 104391041(GRK4) 104392569(GRK6) 104394385(GRK5)
CVF: 104283479(GRK5) 104285848 104291300(GRK4) 104293772(GRK6)
RTD: 128910033(GRK4) 128911855(GRK5) 128916177(GRK6) 128919645
AAM: 106489500(GRK5) 106489905(GRK6) 106498749(GRK4)
AROW: 112964781(GRK6) 112965452(LSM1) 112965530(GRK4) 112974152
NPD: 112943038(GRK4) 112954314(GRK6) 112957179(GRK5)
TGT: 104565802(GRK4) 104570202(GRK6) 104574824(GRK5)
DNE: 112988000(GRK5) 112990756(GRK4) 112991594 112996962(GRK6)
SCAM: 104138975(GRK6) 104140077(GRK5) 104151372(GRK4)
ASN: 102381837(GRK4) 102383862 102387634(GRK6) 102388176(GRK5)
AMJ: 102557717(GRK5) 102569938(GRK6) 102572009(GRK4) 102573177
CPOO: 109310248(GRK6) 109317420 109322299(GRK4) 109324155(GRK5)
GGN: 109287664(GRK5) 109289813(GRK6) 109295546 109304040(GRK4)
PSS: 102451200(GRK4) 102451544 102461436(GRK5)
CMY: 102936492(GRK4) 102943434(GRK5) 102944452(GRK6) 102948318
CCAY: 125626408 125636228(GRK4) 125639924(GRK5) 125641270(GRK6)
DCC: 119848808 119854568(GRK4) 119858855(GRK5) 119860223(GRK6)
CPIC: 101931530(GRK5) 101936310(LSM1) 101938937(GRK4) 101944859(GRK6)
TST: 117873014 117878096(GRK4) 117879774(GRK5) 117881831(GRK6)
CABI: 116821421 116825070(GRK5) 116825225(GRK4) 116833307(GRK6)
MRV: 120370306(GRK6) 120399467 120405942(GRK4) 120409578(GRK5)
ACS: 100554970 100564440(grk6) 100568068(grk5)
ASAO: 132769056(GRK6) 132771002(GRK5) 132782396
PVT: 110075170 110075316(GRK5) 110077405(GRK6)
SUND: 121922400(GRK6) 121926079(GRK5) 121933491
PBI: 103055580 103064613 103065042(GRK6)
PMUR: 107288606(GRK5) 107291402(GRK6) 107295358
CTIG: 120303440 120314049(GRK6) 120316538(GRK5)
TSR: 106540873(GRK6) 106547508
PGUT: 117677009 117678758(GRK5) 117679819(GRK6)
APRI: 131191357(GRK6) 131200960(GRK5) 131203695
PTEX: 113439143(GRK5) 113447215 113454998(GRK6)
NSS: 113413510(GRK5) 113414440 113415810(GRK6)
VKO: 123027071 123028251(GRK5) 123033978(GRK6)
PMUA: 114585237 114591452(GRK6) 114597434(GRK5)
PRAF: 128402504 128408074(GRK6) 128414181(GRK5)
ZVI: 118080514(GRK6) 118096617(GRK5) 118096815
HCG: 128333867 128346402(GRK6) 128350723(GRK5)
GJA: 107106728(GRK5) 107108166 107111541(GRK6)
STOW: 125429479(GRK6) 125437518(GRK5) 125442142
EMC: 129328191(GRK6) 129332694(GRK5) 129342267
XLA: 108696022(grk5.L) 108697324(grk5.S) 108711651(grk5l.L) 108712671(grk5l.S) 446831(grk4.L) 447337(grk6.S) 474158(grk4.S) 733256(grk6.L)
XTR: 100379796(grk6) 100497344 448587(grk4) 550070(grk5)
NPR: 108783744(GRK6) 108785832(GRK4) 108795411 108802218(GRK5)
RTEM: 120924396(GRK4) 120932212(GRK6) 120933190 120946779(GRK5)
BBUF: 120977531(GRK6) 120986257 120990393(GRK4)
BGAR: 122926368(GRK6) 122927323 122939586(GRK4)
MUO: 115461375(GRK4) 115469368 115469874(GRK5) 115476689(GRK6)
GSH: 117351802(GRK6) 117358867(GRK5) 117362604 117363107(GRK4)
DRE: 560761(grk4) 560806(grk5) 561288(grk6) 567452(grk5l)
SRX: 107707119 107723186 107725141 107733280 107751883 107756834 107758889
SANH: 107665967 107691567 107692618 107692774(grk6) 107697331 107702864 107704119
SGH: 107548280 107548972 107557931 107561710 107565039 107568601 107587195
CCAR: 109045840 109066536 109075598 109089862 109091197 109092812
CAUA: 113038360(grk6) 113044338 113051313 113070699 113089020 113102524 113107344 113110158
CGIB: 127948744 127963349 127966697 127977318 127985736 128018338 128021656
PTET: 122326877(grk6) 122333839(grk5) 122345704(grk4) 122350904(grk5l) 122350992
LROH: 127152267(grk6) 127163290(grk4) 127169339(grk5l) 127172196(grk5)
OMC: 131529333(grk6) 131540008(grk4) 131545927(grk5l) 131547833(grk5)
PPRM: 120474871(grk5l) 120478313(grk4) 120482238(grk6) 120482766(grk5)
RKG: 130075885(grk5) 130081971(grk5l) 130095540(grk6) 130097640(grk4)
MAMB: 125253374(grk6) 125262476(grk5) 125272460(grk4) 125279472(grk5l)
CIDE: 127503894 127512481 127516975 127520107
CERY: 137013310(grk6) 137027288(grk5l) 137029374(grk5) 137033176(grk4)
MASI: 127414641 127424483 127429009 127431022 127433076 127433961 127443985 127445233
TROS: 130546268(grk5) 130552796(grk4) 130568374(grk5l) 130570197(grk6)
TDW: 130407744(grk6) 130411616(grk5) 130439828(grk5l) 130440235(grk4)
MANU: 129414876(grk5l) 129423655(grk6) 129444872(grk4) 129446419(grk5)
IPU: 108265152(grk5l) 108277214(grk5) 108278711
IFU: 128607305(grk5l) 128620459(grk5) 128622177(grk6)
PHYP: 113541572(grk6) 113544728 113546069
SMEO: 124393286(grk5) 124397993(grk6) 124400282(grk5l)
TFD: 113638442(grk5) 113656830(grk5l) 113662442(grk6)
TVC: 132853333(grk5l) 132859617(grk6) 132863518(grk5)
TRN: 134318512(grk5l) 134330096(grk6) 134332127(grk5)
AMEX: 103027282(grk6) 103046047(grk5l)
CMAO: 118813052(grk5l) 118819929(grk6) 118824698(grk5)
EEE: 113571255(grk6) 113584115 113591386
CHAR: 105889975(grk5l) 105908523(grk4) 105911330(grk6) 105911747(grk5)
TRU: 101070620 101072843 101074586(grk6) 101074960(grk4) 115246487
TFS: 130517216(grk5) 130525216(grk5l) 130526677(grk4) 130537523(grk6)
TNG: GSTEN00014578G001 GSTEN00022638G001 GSTEN00025391G001
LCO: 104918943(grk6) 104921947(grk4) 104930665 104934131
NCC: 104946107(grk4) 104953072 104963411
TBEN: 117473164(grk5l) 117481436(grk4) 117490792(grk6)
CGOB: 115013191 115016729 115018681(grk6) 115020893
PGEO: 117440847 117451587(grk4) 117452316(grk5l) 117458434(grk6)
GACU: 117537309 117543903(grk5l) 117546078 117550627(grk6)
EMAC: 134864054(grk4) 134868083(grk5) 134871894(grk6) 134873653(grk5l)
ELY: 117246244(grk6) 117252435(grk5l) 117255160(grk4) 117269370(grk5)
EFO: 125884117(grk4) 125889948(grk5l) 125897898(grk6) 125905630(grk5)
PLEP: 121941873(grk4) 121944300(grk5l) 121952115(grk6) 121960128
SLUC: 116039552(grk4) 116041785(grk5) 116055945(grk6) 116057255(grk5l)
ECRA: 117953498(grk4) 117955479(grk6) 117959151(grk5)
ESP: 116686201 116696467(grk4) 116701055(grk6)
PFLV: 114566729(grk6) 114566958(grk4) 114570552
GAT: 120822226(grk6) 120824978(grk4) 120830739(grk5l) 120831790
PPUG: 119215627(grk6) 119217487(grk4) 119225099(grk5l) 119226379(grk5)
AFB: 129095613(grk4) 129100809(grk5l) 129113200(grk6)
CLUM: 117733997(grk4) 117735986(grk5l) 117740641 117742305(grk6)
PSWI: 130189843(grk6) 130189926(grk4) 130197164(grk5l) 130205157
MSAM: 119891474(grk5l) 119895353(grk6) 119899651(grk4) 119914502(grk5)
SCHU: 122865623(grk5) 122873603(grk4) 122876622(grk5l) 122888407(grk6)
CUD: 121508850(grk4) 121509659(grk5l) 121518443(grk6) 121525085
ALAT: 119019961(grk5l) 119027002(grk4) 119030103(grk5) 119031021(grk6)
MZE: 101467438 101468334 101472775 101486524(grk6)
ONL: 100689749 100692015(grk6) 100696126 100703321
OAU: 116317448 116323757(grk5l) 116328486(grk6) 116331581(grk4)
OLA: 101160171 101162460 101166613(grk6) 101173769(grk4)
OML: 112139372(grk4) 112141415(grk6) 112148836(grk5l) 112162856
CSAI: 133447303(grk4) 133451608(grk5l) 133454629(grk5) 133460051(grk6)
XMA: 102223822 102226135(grk6) 102233865 102237931(grk4)
XCO: 114144411(grk4) 114148995 114153297(grk6) 114154950
XHE: 116719701(grk4) 116724739 116728561(grk6) 116729515
PRET: 103464439(grk4) 103470661 103473195 103476239(grk6)
PFOR: 103132125(grk4) 103146590 103147243(grk6) 103151736
PLAI: 106934434 106936718(grk6) 106948116 106963382
PMEI: 106904625 106906345(grk6) 106931005 106933814
GAF: 122819251 122828716(grk5l) 122829219(grk4) 122845373(grk6)
PPRL: 129366803(grk4) 129370644(grk6) 129372983(grk5l) 129379834(grk5)
CVG: 107092761 107093759(grk4) 107097517(grk6) 107102169
CTUL: 119784965(grk5l) 119790299(grk6) 119790902 119797993(grk4)
GMU: 124868115(grk4) 124872748 124876729(grk6) 124877732(grk5l)
NFU: 107387089(grk6) 107393217(grk4) 107393676 107395648
KMR: 108236374(grk4) 108236562(grk5l) 108242174(grk6) 108245374
ALIM: 106514672(grk6) 106516718 106524349(grk4) 106532121
NWH: 119414029(grk5l) 119420401(grk6) 119422355(grk4) 119424872
AOCE: 111567208(grk4) 111574425 111575037 111579089
MCEP: 124996282 125003763(grk4) 125011882(grk5l) 125020988(grk6)
CSEM: 103384199(grk4) 103389663 103395602(grk6) 103396909 103398033 103398938
POV: 109626034 109627610(grk4) 109641092 109642388(grk6)
SSEN: 122761348 122764743(grk5) 122769980(grk5l) 122770708(grk4) 122779532(grk6)
HHIP: 117762885(grk4) 117767301(grk5l) 117771903 117774383(grk6)
HSP: 118115094(grk5l) 118119444(grk4) 118122162(grk6) 118125916(grk5)
PPLT: 128424905(grk5) 128434206(grk4) 128438276(grk5l) 128456814(grk6)
SMAU: 118300670 118300884(grk6) 118311887(grk4) 118313611(grk5l)
LCF: 108875671 108878593(grk5l) 108885354 108895494(grk5)
SDU: 111217880(grk4) 111228851 111233077(grk6) 111239654
SLAL: 111644991 111659466 111664583(grk6) 111664624
XGL: 120800678(grk4) 120802985(grk6) 120805646(grk5l) 120806423(grk5)
HCQ: 109511636 109514519(grk6) 109525096 109527370
SSCV: 125969595 125979385 125982318 125994662
SBIA: 133490875 133491842(grk6) 133499551(grk5l) 133505911(grk4)
PEE: 133399697(grk5l) 133404099(grk4) 133413440 133416476(grk6)
PTAO: 133465201(grk5) 133467725(grk6) 133475580(grk5l) 133476362(grk4)
BPEC: 110156480(grk6) 110166672 110169810 110175665(grk4)
MALB: 109954945 109957868(grk4) 109968696(grk6) 109974760
BSPL: 114852428(grk4) 114862356(grk5l) 114866930(grk5) 114869448(grk6)
SJO: 128364499(grk5l) 128366675(grk4) 128371001(grk6) 128379906(grk5)
SASA: 106562980 106568006 106568462 106580577 106585171 106592297 106603485
STRU: 115148821 115154290 115159791 115164213 115190924 115200427 115203866
OTW: 112222429 112228545 112230874 112248791 112257901 112262620 121844691
OMY: 110509607 110516120 110518749 110522817 110525940 110533606 110536318 110537519
OGO: 124000881(grk6) 124007058 124010947 124022347 124024363 124025852 124034101 124036540 124049136
ONE: 115101067 115105505 115111847 115120771 115135941 115140702
OKI: 109868816 109872941 109876808 109880100 109882842 109892772 109894940
OKE: 118373255 118378501 118385411 118387404 118391130 118393463 127929354
SALP: 111950365 111957863 111961796 111963860 111974314 111980885 112079466
SNH: 120021543 120025823 120030515 120044494(grk5l) 120057037(grk6) 120063387
CCLU: 121551943 121579409(grk6) 121581869 121582697 121585095 123484216(grk4)
ELS: 105011133(grk6) 105014098 105015238 105020825(grk4)
SFM: 108920065(grk6) 108923749 108925730(grk4) 108936160 108940333
PKI: 111847947 111853108(grk4) 111857546 111860778 111861162
AANG: 118206606(grk5l) 118212075 118228514 118231715 118235755(grk6)
LOC: 102684991(grk5) 102690196(grk6) 102696690 102696762(grk4)
PSPA: 121296931 121324752 121325075 121325156 121330478
ARUT: 117409448 117413199 117418215 117421430 117431448
PSEX: 120521554 120527805(grk4) 120538956(grk5l) 120543189(grk6)
LCM: 102345414(GRK5) 102358242 102359573(GRK6) 102364205(GRK4)
CMK: 103177327 103186330 103186576
RTP: 109917307(grk6) 109926488 109933260 109936422
CPLA: 122556709(grk4) 122556768 122561187
HOC: 132821827 132823348(grk6) 132826481
LERI: 129695387 129704020 129713318
PMRN: 116940731
LRJ: 133343556
BFO: 118414302
BBEL: 109475498
CIN: 100177731 100186924
SCLV: 120338834 120345691
SPU: 756375
LPIC: 129273379
APLC: 110988180
ARUN: 117294576
AJC: 117118831
SKO: 100374101(GRK5)
DME: Dmel_CG17998(Gprk2)
DER: 6554722
DSE: 6612984
DSI: Dsimw501_GD21578(Dsim_GD21578)
DYA: Dyak_GE10942
DAN: 6500568
DSR: 110191388
DPO: 4800727
DPE: 6598666
DMN: 108155750
DWI: 6649829
DGR: 6567694
DMO: Dmoj_GI22206
DAZ: 108608671
DNV: 108659601
DHE: 111597155
DVI: 6631057
CCAT: 101452366
BOD: 106621557
RZE: 108378516 108379863 108380743
AOQ: 129238140
TDA: 119678615
MDE: 101901760
SCAC: 106092777
LCQ: 111682859
LSQ: 119614028
GFS: 119638204
ECOE: 129943475
CLON: 129614484
HIS: 119652076
AGA: 1273941
ACOZ: 120961119
AARA: 120908350
AMER: 121601543
ASTE: 118502923
AFUN: 125760555
AMOU: 128310141
AALI: 118459971
AAG: 5567507
AALB: 109403598 109414765
ASUA: 134225416
CPII: 120425983
CNS: 116352119
BCOO: 119069204
AME: 410632
ACER: 107997984
ALAB: 122713776
ADR: 102673886
AFLR: 100870157
BIM: 100741600
BBIF: 117208080
BVK: 117240269
BVAN: 117164518
BTER: 100642779
BAFF: 126924118
BPYO: 122575605
BPAS: 132911823
FVI: 122538604
CCAL: 108630771
OBB: 114876758
OLG: 117604155
MGEN: 117219628
NMEA: 116424018
CGIG: 122405451
SOC: 105199349
MPHA: 105829530
AEC: 105146542
ACEP: 105624805
PBAR: 105433159
VEM: 105564122
HST: 105184862
DQU: 106749793
CFO: 105252842
FEX: 115239879
LHU: 105672492(Gprk2)
PGC: 109860236
OBO: 105275024
PCF: 106788165
PFUC: 122526475
VPS: 122632506
VCRB: 124422098
VVE: 124957546
NVI: 100122766
CSOL: 105363233
TPRE: 106660598
LHT: 122513113
LBD: 127276641
MDL: 103578293
CGLO: 123271771
FAS: 105267940
DAM: 107043961
AGIF: 122860994
CINS: 118065655
VCAN: 122406822
CCIN: 107263158
DSM: 124413955
NPT: 124222765
NFB: 124187188
NLO: 107221771
NVG: 124308466
AROA: 105688464
TCA: 656376
DPA: 109545471
AGRG: 126742206
ATD: 109594515
CSET: 123312937
AGB: 108906035
LDC: 111517172
DVV: 114330073
NVL: 108560187
DCOR: 135803836(Gprk2)
APLN: 108745270
PPYR: 116176350
OTU: 111427048
BMOR: 101747093
BMAN: 114241498
MSEX: 115447089
MJU: 123877788
NIQ: 126778130
VCD: 124539684
MCIX: 123664931
PPOT: 106105858
PXU: 106116076
PRAP: 110998692
PBX: 123706817
PNAP: 125063208
ZCE: 119837743
CCRC: 123702881
LSIN: 126972383
AAGE: 121737650
HAW: 110377080(Gprk2)
HZE: 124641780
TNL: 113495152
SLIU: 111357062
OFU: 114355400
ATRA: 106140129
GMW: 113514241
PXY: 105394381
PGW: 126376972
LGLY: 125238325
CFEL: 113369919
CCRN: 123305693
API: 100165035
DNX: 107168275
AGS: 114127518
RMD: 113555217
ACOO: 126843537
DVT: 126901427
BTAB: 109038990
DCI: 103515681
CLEC: 106662266
HHAL: 106684277(Gprk2)
NLU: 111045485
HVI: 124359216
MQU: 128984948
PHU: Phum_PHUM066650
FOC: 113202394
TPAL: 117652969
ZNE: 110837064
CSEC: 111873812
SGRE: 126356366
BROR: 134536467
IEL: 124153968
FCD: 110858013
DPX: DAPPUDRAFT_127071(Grk1)
DMK: 116926511
DPZ: 124315236
PVM: 113817454
PJA: 122253585
PCHN: 125031874
PMOO: 119593577
HAME: 121869335
PCLA: 123770830
CQD: 128690594
PTRU: 123498888
ESN: 127002581
MNZ: 135200237
HAZT: 108670457 108671622
EAF: 111704102
LSM: 121119742
TCF: 131877478
PPOI: 119099347
ISC: 8051643
DSV: 119461403
RSAN: 119379036
RMP: 119175982
VDE: 111252092
VJA: 111268895 111271941
TUT: 107369896
DPTE: 113795012
DFR: 124491192
CSCU: 111612737
CVS: 136968186(Gprk2)
PTEP: 107452617
ABRU: 129960189
UDV: 129231316
SDM: 118187228
LPOL: 106462979 106473076
CEL: CELE_F19C6.1(grk-1)
CBR: CBG_01947(Cbr-grk-1)
CRQ: GCK72_023503
NAI: NECAME_08066
LOA: LOAG_09581 LOAG_13169
HRO: HELRODRAFT_100074
LGI: LOTGIDRAFT_117728
PVUL: 126815097
PCAN: 112564568
BGT: 106074042
GAE: 121384544
HRF: 124146082
HRJ: 124282849
CRG: 105324517
CANU: 128180065
CVN: 111135594
OED: 125660388
MYI: 110451725
PMAX: 117339870
MCAF: 127735134
MMER: 123547084
RPHI: 132716367
DPOL: 127858435
MAEA: 128210368
OBI: 106876126
OSN: 115215078
LJP: 135466414
LAK: 106178688
SMM: Smp_123640
SHX: MS3_00005588(GRK6_1)
OVI: T265_00665
EGL: EGR_02568
LLON: 135488925
NVE: 5519770
EPA: 110245004
ATEN: 116288429
ADF: 107338742
AMIL: 114958128
PDAM: 113682745
SPIS: 111331987
DGT: 114515746
XEN: 124444838
HMG: 100197054
HSY: 130644920
RES: 135695820
TAD: TRIADDRAFT_28308
AQU: 100637826
 » show all
Reference
1  [PMID:8288567]
  Authors
Kunapuli P, Onorato JJ, Hosey MM, Benovic JL.
  Title
Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5.
  Journal
J Biol Chem 269:1099-105 (1994)
  Sequence
[hsa:2869]
Reference
2  [PMID:8120045]
  Authors
Premont RT, Koch WJ, Inglese J, Lefkowitz RJ.
  Title
Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.
  Journal
J Biol Chem 269:6832-41 (1994)
  Sequence
[bta:281801]
Reference
3  [PMID:14654303]
  Authors
Willets JM, Challiss RA, Nahorski SR.
  Title
Non-visual GRKs: are we seeing the whole picture?
  Journal
Trends Pharmacol Sci 24:626-33 (2003)
DOI:10.1016/j.tips.2003.10.003
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.16
IUBMB Enzyme Nomenclature: 2.7.11.16
ExPASy - ENZYME nomenclature database: 2.7.11.16
BRENDA, the Enzyme Database: 2.7.11.16

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Gene (4058)   
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   RefGene (1864)   
Protein sequence (134)   
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   PDBSTR (14)   
   PMD (1)   
DNA sequence (104)   
   RefSeq(nuc) (51)   
   GenBank (49)   
   EMBL (4)   
3D Structure (8)   
   PDB (8)   
Protein domain (11)   
   InterPro (11)   
All databases (4315)   

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