| Entry |
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| Name |
phosphorylase kinase;
dephosphophosphorylase kinase;
glycogen phosphorylase kinase;
PHK;
phosphorylase b kinase;
phosphorylase B kinase;
phosphorylase kinase (phosphorylating);
STK17
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
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| Sysname |
ATP:phosphorylase-b phosphotransferase
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| Reaction(IUBMB) |
2 ATP + phosphorylase b = 2 ADP + phosphorylase a [RN: R00076]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires Ca2+ and calmodulin for activity. The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. The enzyme couples muscle contraction with energy production via glycogenolysis---glycolysis by catalysing the Ca2+-dependent phosphorylation and activation of glycogen phosphorylase b [5]. The gamma subunit of the tetrameric enzyme is the catalytic subunit.
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| History |
EC 2.7.11.19 created 1961 as EC 2.7.1.38, transferred 2005 to EC 2.7.11.19
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| Orthology |
| K00871 | phosphorylase kinase gamma subunit |
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| Genes |
» show all
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| Reference |
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| Authors |
KREBS EG, FISCHER EH. |
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| Title |
The phosphorylase b to a converting enzyme of rabbit skeletal muscle. |
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| Journal |
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| Reference |
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| Authors |
KREBS EG, KENT AB, FISCHER EH. |
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| Title |
The muscle phosphorylase b kinase reaction. |
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| Journal |
J Biol Chem 231:73-83 (1958) |
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| Reference |
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| Authors |
RALL TW, WOSILAIT WD, SUTHERLAND EW. |
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| Title |
The interconversion of phosphorylase a and phosphorylase b from dog heart muscle. |
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| Journal |
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| Reference |
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| Authors |
Nikolaropoulos S, Sotiroudis TG. |
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| Title |
Phosphorylase kinase from chicken gizzard. Partial purification and characterization. |
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| Journal |
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| Reference |
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| Authors |
Farrar YJ, Carlson GM. |
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| Title |
Kinetic characterization of the calmodulin-activated catalytic subunit of phosphorylase kinase. |
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| Journal |
Biochemistry 30:10274-9 (1991) |
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| Reference |
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| Authors |
Dasgupta M, Blumenthal DK. |
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| Title |
Characterization of the regulatory domain of the gamma-subunit of phosphorylase kinase. The two noncontiguous calmodulin-binding subdomains are also autoinhibitory. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Lowe ED, Noble ME, Skamnaki VT, Oikonomakos NG, Owen DJ, Johnson LN. |
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| Title |
The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.7.11.19 |
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