KEGG   ENZYME: 2.7.11.19
Entry
EC 2.7.11.19                Enzyme                                 

Name
phosphorylase kinase;
dephosphophosphorylase kinase;
glycogen phosphorylase kinase;
PHK;
phosphorylase b kinase;
phosphorylase B kinase;
phosphorylase kinase (phosphorylating);
STK17
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:phosphorylase-b phosphotransferase
Reaction(IUBMB)
2 ATP + phosphorylase b = 2 ADP + phosphorylase a [RN:R00076]
Reaction(KEGG)
R00076
Substrate
ATP [CPD:C00002];
phosphorylase b [CPD:C02308]
Product
ADP [CPD:C00008];
phosphorylase a [CPD:C02307]
Comment
Requires Ca2+ and calmodulin for activity. The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. The enzyme couples muscle contraction with energy production via glycogenolysis---glycolysis by catalysing the Ca2+-dependent phosphorylation and activation of glycogen phosphorylase b [5]. The gamma subunit of the tetrameric enzyme is the catalytic subunit.
History
EC 2.7.11.19 created 1961 as EC 2.7.1.38, transferred 2005 to EC 2.7.11.19
Orthology
K00871  phosphorylase kinase gamma subunit
Genes
HSA: 5260(PHKG1) 5261(PHKG2)
PTR: 741602(PHKG2) 746486(PHKG1)
PPS: 100983464(PHKG2) 100986631(PHKG1)
GGO: 101125302(PHKG2)
PON: 100453698(PHKG1) 100455717(PHKG2)
NLE: 100588039(PHKG2) 100594015 115830981(PHKG1)
MCC: 100423096(PHKG2) 703091(PHKG1)
MCF: 102125953(PHKG1) 102128006(PHKG2)
CSAB: 103226033(PHKG1) 103231924(PHKG2)
CATY: 105571983(PHKG1) 105599267(PHKG2)
PANU: 101017842(PHKG2) 101023830(PHKG1)
RRO: 104661547(PHKG2) 104675874(PHKG1)
RBB: 108526509(PHKG1) 108530886(PHKG2)
PTEH: 111525612(PHKG2) 111528016(PHKG1)
CJC: 100412760(PHKG2) 100414478(PHKG1)
SBQ: 101045885(PHKG2) 101048522(PHKG1)
MMUR: 105871018(PHKG1) 105871065(PHKG2)
MMU: 18682(Phkg1) 68961(Phkg2)
MCAL: 110294811(Phkg1) 110298655(Phkg2)
MPAH: 110312993(Phkg1) 110337850(Phkg2)
RNO: 140671(Phkg2) 29353(Phkg1)
MCOC: 116068481(Phkg1) 116103020(Phkg2)
MUN: 110547989(Phkg2) 110560975(Phkg1)
CGE: 100750910(Phkg2) 100754334(Phkg1)
PLEU: 114693674(Phkg1) 114704378(Phkg2)
NGI: 103726346(Phkg2) 103738953(Phkg1)
HGL: 101700591(Phkg2) 101707775(Phkg1)
CCAN: 109677759(Phkg1) 109682498(Phkg2)
OCU: 100009297(PHKG1) 100355661(PHKG2)
TUP: 102476302(PHKG1) 102480103(PHKG2) 102498323
CFA: 489784(PHKG1) 607275(PHKG2)
VVP: 112929247(PHKG2) 112934117(PHKG1)
VLG: 121487929(PHKG2) 121487998(PHKG1)
AML: 100477667(PHKG1) 100478501(PHKG2)
UMR: 103657874(PHKG2) 103670188(PHKG1)
UAH: 113267697(PHKG2) 113267739(PHKG1)
ORO: 101366392(PHKG1) 101373618(PHKG2)
MPUF: 101673513(PHKG1) 101682961(PHKG2)
EJU: 114214357(PHKG1) 114214412(PHKG2)
MLX: 117999543(PHKG1) 117999585(PHKG2)
FCA: 101081184(PHKG1) 101092572(PHKG2)
PYU: 121017789(PHKG1) 121022214(PHKG2)
PBG: 122471390(PHKG1) 122471437(PHKG2)
PTG: 102958678(PHKG2) 102965580(PHKG1)
PPAD: 109250661(PHKG1) 109258973(PHKG2)
AJU: 106972855(PHKG1) 106979102(PHKG2)
HHV: 120235665(PHKG1) 120242267(PHKG2)
BTA: 512670(PHKG2) 540682(PHKG1)
BOM: 102266225(PHKG1) 102279229(PHKG2)
BIU: 109578248(PHKG1) 109578294(PHKG2)
BBUB: 102408486(PHKG2) 102414182(PHKG1)
CHX: 100861337(PHKG2) 102185139(PHKG1)
OAS: 100217403(PHKG2) 101109323(PHKG1)
ODA: 120876938(PHKG2) 120877899(PHKG1)
CCAD: 122432793(PHKG1) 122433072(PHKG2)
SSC: 100310801(PHKG2) 397548(PHKG1)
CFR: 102509900(PHKG1) 102517940(PHKG2)
CBAI: 105082757(PHKG1) 105082793(PHKG2)
CDK: 105089705(PHKG1) 105102728(PHKG2)
BACU: 103011969(PHKG1) 103020540(PHKG2)
LVE: 103069260(PHKG1) 103082932(PHKG2)
OOR: 101270202(PHKG1) 101281573(PHKG2)
DLE: 111182088(PHKG1) 111182126(PHKG2)
PCAD: 102978084(PHKG2) 102982207(PHKG1)
ECB: 100061404(PHKG1) 100065274(PHKG2)
EPZ: 103547228(PHKG2) 103566047(PHKG1)
EAI: 106831860(PHKG1) 106831907(PHKG2)
MYB: 102249201(PHKG2) 102254502(PHKG1)
MYD: 102751284(PHKG2) 102760309(PHKG1)
MMYO: 118655777(PHKG2) 118656819(PHKG1)
MNA: 107524377(PHKG1) 107542003(PHKG2)
HAI: 109374179(PHKG2) 109376279(PHKG1)
DRO: 112304780(PHKG2) 112314866(PHKG1)
SHON: 118976256(PHKG1) 118997397
AJM: 119041148(PHKG2) 119055031(PHKG1)
MMF: 118641943(PHKG1) 118642446(PHKG2)
PALE: 102879938(PHKG1) 102882222(PHKG2)
PGIG: 120591810(PHKG1) 120620078(PHKG2)
RAY: 107503972(PHKG2) 107507449(PHKG1)
MJV: 108385379(PHKG2) 108405955(PHKG1)
TOD: 119241473(PHKG1) 119241726(PHKG2)
LAV: 100660711(PHKG2) 100663820(PHKG1)
MDO: 100012992(PHKG2) 100013442(PHKG1)
SHR: 100920220(PHKG1) 100927663(PHKG2)
PCW: 110221270(PHKG1) 110223219(PHKG2)
OAA: 100088260(PHKG1) 100093441(PHKG2)
GGA: 417543(PHKG1)
PCOC: 116228111(PHKG1)
MGP: 100546214(PHKG1)
CJO: 107322445(PHKG1)
NMEL: 110407838(PHKG1)
APLA: 101793068(PHKG1)
ACYG: 106041427(PHKG1)
TGU: 100221300(PHKG1)
LSR: 110482022(PHKG1)
SCAN: 103820093(PHKG1)
PMOA: 120507819(PHKG1)
GFR: 102038175(PHKG1)
FAB: 101811164(PHKG1)
PHI: 102104524(PHKG1)
PMAJ: 107212749(PHKG1)
CCAE: 111937725(PHKG1)
CCW: 104691086(PHKG1)
ETL: 114060505(PHKG1)
FPG: 101920077(PHKG1)
FCH: 102054686(PHKG1)
CLV: 102085380(PHKG1)
EGZ: 104131918(PHKG1)
NNI: 104016101(PHKG1)
ACUN: 113487119(PHKG1)
PADL: 103925605(PHKG1)
AROW: 112978577(PHKG1)
NPD: 112945399(PHKG1)
DNE: 112987390(PHKG1)
ASN: 102372756(PHKG1) 102380957(PHKG2)
AMJ: 102572090(PHKG2) 102574725(PHKG1)
CPOO: 109317058(PHKG1)
GGN: 109293440(PHKG1)
PSS: 102445349(PHKG2) 102455436(PHKG1)
CMY: 102934958(PHKG2) 102939493(PHKG1)
CPIC: 101932837(PHKG1) 101949847(PHKG2)
TST: 117867504(PHKG1) 117876272(PHKG2)
CABI: 116815071(PHKG2) 116821327(PHKG1)
ACS: 100557980(phkg2)
PVT: 110084500(PHKG1) 110090073(PHKG2)
PBI: 103061914(PHKG2) 103065315(PHKG1)
PMUR: 107287056(PHKG1) 107300286
TSR: 106552842(PHKG2)
PGUT: 117666808(PHKG2) 117667539(PHKG1)
PMUA: 114583711(PHKG2) 114585912(PHKG1)
ZVI: 118094673(PHKG2) 118097034(PHKG1)
GJA: 107111216(PHKG2) 107112491(PHKG1)
XLA: 108708334(phkg1.L) 373780(phkg1.S) 496328(phkg2.L)
XTR: 448255(phkg1) 779740(phkg2)
NPR: 108799187(PHKG1) 108803931(PHKG2)
DRE: 393937(phkg2) 554046(phkg1b) 565379(phkg1a)
IPU: 108273676(phkg2) 108280550(phkg1)
PHYP: 113527058(phkg2) 113541799 113543328(phkg1)
EEE: 113573644(phkg1) 113583965(phkg2) 113584646
TRU: 101077385(phkg2) 101080204(phkg1)
LCO: 104923220(phkg2) 104936522(phkg1)
NCC: 104946331(phkg2) 104964917
CGOB: 115017640(phkg1) 115025091(phkg2)
ELY: 117246647(phkg2) 117260119(phkg1a)
PLEP: 121943338 121959332(phkg2)
SLUC: 116044288(phkg2) 116047992(phkg1a)
ECRA: 117937148(phkg2) 117942209(phkg1a)
PFLV: 114548023(phkg2) 114549461(phkg1)
GAT: 120819044(phkg2) 120835316
MSAM: 119882387 119915987(phkg2)
CUD: 121523885 121528945(phkg2)
MZE: 101469795(phkg1) 101485765(phkg2)
ONL: 100694651(phkg1) 100694837(phkg2)
OAU: 116316002 116319882(phkg2)
OLA: 101165598(phkg2) 101167060(phkg1)
OML: 112149621 112154320(phkg2)
XMA: 102229601(phkg2) 102233585(phkg1)
XCO: 114133398(phkg1) 114157788(phkg2)
XHE: 116708153(phkg1) 116727743(phkg2)
PRET: 103474557(phkg1) 103481060(phkg2)
CVG: 107088313(phkg1) 107089513
CTUL: 119782813 119793720(phkg2)
NFU: 107380364(phkg1) 107388054 107388073(phkg2)
KMR: 108237211(phkg2) 108246020(phkg1a)
ALIM: 106515467(phkg1) 106517365
AOCE: 111564740(phkg1) 111584911(phkg2)
CSEM: 103378132(phkg1) 103381724(phkg2)
POV: 109627136(phkg2) 109629980(phkg1)
LCF: 108886377(phkg1) 108886752(phkg2)
SDU: 111219834(phkg2) 111228039(phkg1)
SLAL: 111650931(phkg1) 111658612(phkg2)
XGL: 120791493 120794168(phkg2)
HCQ: 109525437(phkg1) 109530189(phkg2)
BPEC: 110154096 110159624(phkg2)
MALB: 109960264(phkg1) 109963558(phkg2)
OTW: 112223679 112265471(phkg1)
OMY: 110491588(phkg2) 110507716(phkg1a)
ELS: 105021305 105030287(phkg1)
SFM: 108922452(phkg1)
PKI: 111847182(phkg1)
AANG: 118220570(phkg2) 118235967
LOC: 102695754(phkg1)
PSPA: 121306827(phkg2) 121308581(phkg1b)
LCM: 102345800(PHKG1) 102362563
CMK: 103188445(phkg1)
BFO: 118426605
BBEL: 109466676
CIN: 100182979
SCLV: 120346799
SPU: 582497
APLC: 110980692
SKO: 102804634
DME: Dmel_CG1830(PhKgamma)
DER: 6551326
DSE: 6619897
DSI: Dsimw501_GD17041(Dsim_GD17041)
DAN: 6503515
DSR: 110184224
DPE: 6600411
DMN: 108153016
DWI: 6641221
DGR: 6566254
DAZ: 108618638
DNV: 108656298
DHE: 111605130
DVI: 6634800
CCAT: 101455500
MDE: 101900257
LCQ: 111686460
ACOZ: 120952908
AARA: 120908442
AAG: 5578562
CPII: 120420459
ACER: 107994806
BBIF: 117213926
BTER: 100644069
CCAL: 108628393
MGEN: 117227035
NMEA: 116429195
CGIG: 122400146
SOC: 105203941
MPHA: 105838151
AEC: 105144123
PBAR: 105434370
VEM: 105560950
HST: 105183521
DQU: 106749081
CFO: 105255564
FEX: 115246089
LHU: 105667336
PGC: 109856378
OBO: 105280515
PCF: 106790636
NVI: 100117602
CSOL: 105365361
MDL: 103571859
CCIN: 107268633
TCA: 655530
DPA: 109543742
ATD: 109600150
AGB: 108913185
LDC: 111502690
NVL: 108565553
PPYR: 116162573
OTU: 111417464
BMOR: 101743489
BMAN: 114240512
MSEX: 115446834
BANY: 112049934
PPOT: 106109289
PXU: 106117943
PRAP: 110998330
ZCE: 119836322
HAW: 110380614
TNL: 113503033
PXY: 105380550
API: 100168501
DNX: 107163272
AGS: 114120380
RMD: 113549900
BTAB: 109036818
DCI: 103524519
CLEC: 106665838
HHAL: 106679629
NLU: 111045286
ZNE: 110830693
FCD: 110853985
DMK: 116931076
PVM: 113815105
HAME: 121853966
HAZT: 108672972
EAF: 111697010
DSV: 119446828
RSAN: 119389346
RMP: 119183669
VJA: 111259722
TUT: 107369709
DPTE: 113791735
PTEP: 107439334
SDM: 118205337
CEL: CELE_Y50D7A.3(Y50D7A.3)
CBR: CBG15712
BMY: BM_BM6708(Bm6708)
TSP: Tsp_00128
PCAN: 112561347
GAE: 121368874
CRG: 105317472
MYI: 110462867
PMAX: 117332829
OBI: 106871486
EGL: EGR_05948
NVE: 5516534
EPA: 110233083
ATEN: 116297762
ADF: 107344746
AMIL: 114960188
PDAM: 113665510
SPIS: 111344824
HMG: 100207615
AQU: 100641898
 » show all
Reference
1  [PMID:13315361]
  Authors
KREBS EG, FISCHER EH.
  Title
The phosphorylase b to a converting enzyme of rabbit skeletal muscle.
  Journal
Biochim Biophys Acta 20:150-7 (1956)
DOI:10.1016/0006-3002(56)90273-6
Reference
2  [PMID:13538949]
  Authors
KREBS EG, KENT AB, FISCHER EH.
  Title
The muscle phosphorylase b kinase reaction.
  Journal
J Biol Chem 231:73-83 (1958)
Reference
3  [PMID:13315351]
  Authors
RALL TW, WOSILAIT WD, SUTHERLAND EW.
  Title
The interconversion of phosphorylase a and phosphorylase b from dog heart muscle.
  Journal
Biochim Biophys Acta 20:69-76 (1956)
DOI:10.1016/0006-3002(56)90264-5
Reference
4  [PMID:4029141]
  Authors
Nikolaropoulos S, Sotiroudis TG.
  Title
Phosphorylase kinase from chicken gizzard. Partial purification and characterization.
  Journal
Eur J Biochem 151:467-73 (1985)
DOI:10.1111/j.1432-1033.1985.tb09125.x
Reference
5  [PMID:1931956]
  Authors
Farrar YJ, Carlson GM.
  Title
Kinetic characterization of the calmodulin-activated catalytic subunit of phosphorylase kinase.
  Journal
Biochemistry 30:10274-9 (1991)
DOI:10.1021/bi00106a027
Reference
6  [PMID:7673209]
  Authors
Dasgupta M, Blumenthal DK.
  Title
Characterization of the regulatory domain of the gamma-subunit of phosphorylase kinase. The two noncontiguous calmodulin-binding subdomains are also autoinhibitory.
  Journal
J Biol Chem 270:22283-9 (1995)
DOI:10.1074/jbc.270.38.22283
  Sequence
[ocu:100009297]
Reference
7  [PMID:9362479]
  Authors
Lowe ED, Noble ME, Skamnaki VT, Oikonomakos NG, Owen DJ, Johnson LN
  Title
The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.
  Journal
EMBO J 16:6646-58 (1997)
DOI:10.1093/emboj/16.22.6646
  Sequence
[ocu:100009297]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.19
IUBMB Enzyme Nomenclature: 2.7.11.19
ExPASy - ENZYME nomenclature database: 2.7.11.19
BRENDA, the Enzyme Database: 2.7.11.19
CAS: 9001-88-1

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