KEGG   ENZYME: 2.7.11.2
Entry
EC 2.7.11.2                 Enzyme                                 

Name
[pyruvate dehydrogenase (acetyl-transferring)] kinase;
PDH kinase;
PDHK;
PDK;
PDK1;
PDK2;
PDK3;
PDK4;
pyruvate dehydrogenase kinase;
pyruvate dehydrogenase kinase (phosphorylating);
pyruvate dehydrogenase kinase activator protein;
STK1
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:[pyruvate dehydrogenase (acetyl-transferring)] phosphotransferase
Reaction(IUBMB)
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate [RN:R03449]
Reaction(KEGG)
R03449
Substrate
ATP [CPD:C00002];
[pyruvate dehydrogenase (acetyl-transferring)] [CPD:C01256]
Product
ADP [CPD:C00008];
[pyruvate dehydrogenase (acetyl-transferring)] phosphate [CPD:C01293]
Comment
The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. Phosphorylation inactivates EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring).
History
EC 2.7.11.2 created 1978 as EC 2.7.1.99, transferred 2005 to EC 2.7.11.2
Orthology
K00898  pyruvate dehydrogenase kinase 2/3/4
K12077  pyruvate dehydrogenase kinase isoform 1
Genes
HSA: 5163(PDK1) 5164(PDK2) 5165(PDK3) 5166(PDK4)
PTR: 459743(PDK1) 468402(PDK2) 472448(PDK4) 740576(PDK3)
PPS: 100968174(PDK1) 100970620(PDK4) 100992308(PDK2) 100995647(PDK3)
GGO: 101129032(PDK2) 101143387(PDK3) 101149286(PDK4) 101150048(PDK1)
PON: 100174113(PDK2) 100435148(PDK4) 100442853(PDK1) 100462571(PDK3)
NLE: 100597085(PDK2) 100598085(PDK3) 100601990(PDK1) 100605243(PDK4)
MCC: 697772(PDK1) 698726(PDK4) 699394(PDK3) 704169(PDK2)
MCF: 101867293(PDK2) 102118837(PDK3) 102119067(PDK4) 102132161(PDK1)
CSAB: 103217325(PDK1) 103226523(PDK4) 103231727(PDK3) 103242950(PDK2)
CATY: 105574610(PDK3) 105579448(PDK2) 105579807(PDK1) 105592197(PDK4)
PANU: 101000103(PDK4) 101003598(PDK2) 101007312(PDK3) 101026361(PDK1)
RRO: 104654150(PDK3) 104656590(PDK4) 104673517(PDK1) 104680263(PDK2)
RBB: 108513535(PDK4) 108516442(PDK2) 108522274(PDK1) 108524111(PDK3)
TFN: 117067209(PDK2) 117072465(PDK4) 117074293(PDK3) 117094853(PDK1)
CJC: 100386396(PDK2) 100388325(PDK3) 100402844(PDK1) 100407216(PDK4)
SBQ: 101037963(PDK1) 101038610(PDK3) 101048009(PDK2) 101049325(PDK4)
MMUR: 105867287(PDK4) 105880731(PDK1) 105882342(PDK3) 105885105(PDK2)
MMU: 18604(Pdk2) 228026(Pdk1) 236900(Pdk3) 27273(Pdk4)
MCAL: 110286641(Pdk3) 110296681(Pdk4) 110305050(Pdk2) 110312693(Pdk1)
MPAH: 110313531(Pdk3) 110317019(Pdk4) 110318417(Pdk1) 110331436(Pdk2)
RNO: 116551(Pdk1) 296849(Pdk3) 81530(Pdk2) 89813(Pdk4)
MCOC: 116078985(Pdk2) 116086802(Pdk3) 116090302(Pdk1) 116098549(Pdk4)
MUN: 110551207(Pdk2) 110559643(Pdk4) 110564184(Pdk3) 110565621(Pdk1)
CGE: 100751145 100758762(Pdk2) 100763413(Pdk4) 100770270(Pdk3) 100774056(Pdk1)
PLEU: 114692903(Pdk2) 114693453(Pdk4) 114701563(Pdk3) 114704478(Pdk1)
NGI: 103725230(Pdk4) 103725376(Pdk3) 103728651 103738377(Pdk2) 103751806(Pdk1)
HGL: 101698433(Pdk4) 101699582(Pdk3) 101699994(Pdk2) 101705587(Pdk1)
CCAN: 109691403(Pdk2) 109697144(Pdk3) 109699522(Pdk1) 109701002(Pdk4)
OCU: 100348343(PDK2) 100351323(PDK1) 100351580(PDK4) 100352037(PDK3)
TUP: 102468786(PDK4) 102469133(PDK2) 102483149(PDK3) 102499515(PDK1)
CFA: 476828(PDK1) 478801 482310(PDK4) 491075(PDK2)
VVP: 112916403(PDK1) 112917852(PDK2) 112919100(PDK3) 112923906(PDK4)
VLG: 121472624(PDK2) 121474516(PDK4) 121482752(PDK3) 121501706(PDK1)
AML: 100464908(PDK4) 100466029(PDK3) 100476739(PDK2) 100483652(PDK1)
UMR: 103658746(PDK4) 103659566(PDK1) 103660465(PDK2) 103668186(PDK3)
UAH: 113242221(PDK3) 113250772(PDK1) 113260367(PDK4) 113265612(PDK2)
ORO: 101362728(PDK3) 101367021(PDK2) 101370661(PDK4) 101383119(PDK1)
MPUF: 101683023(PDK1) 101684654(PDK2) 101685847(PDK4) 101689674(PDK3)
EJU: 114201172(PDK2) 114221329(PDK4) 114223594(PDK3) 114225916(PDK1)
FCA: 101092256(PDK4) 101092705(PDK1) 101095314(PDK3) 101100013(PDK2)
PTG: 102948846(PDK3) 102951784 102960301(PDK1) 102963206(PDK2) 102969030(PDK4)
PPAD: 109247310(PDK2) 109249360(PDK3) 109263716(PDK4) 109273020(PDK1)
AJU: 106970005(PDK4) 106985184(PDK2) 106986815(PDK3) 106987925(PDK1)
HHV: 120229146(PDK2) 120234392(PDK4) 120236402(PDK1) 120248768(PDK3)
BTA: 507367(PDK4) 510841(PDK3) 524075(PDK2) 528655(PDK1)
BOM: 102264999(PDK4) 102265648(PDK1) 102266253(PDK2) 102275065(PDK3)
BIU: 109555405(PDK3) 109558225(PDK4) 109566453(PDK1) 109573763(PDK2)
BBUB: 102390883(PDK2) 102394745(PDK3) 102413185(PDK4) 102416388(PDK1)
CHX: 102180838(PDK3) 102185217(PDK2) 102186251(PDK1) 102190015(PDK4)
OAS: 101108725(PDK3) 101108929(PDK2) 101113205(PDK1) 101117752(PDK4)
ODA: 120854929(PDK1) 120867335(PDK2) 120877971(PDK4) 120882623(PDK3)
SSC: 100153858(PDK3) 100286778(PDK4) 100286871(PDK1) 100516037(PDK2)
CFR: 102508070(PDK2) 102511071(PDK3) 102518730(PDK4) 102518782(PDK1)
CDK: 105088722(PDK4) 105091095(PDK1) 105103897(PDK3) 105104826(PDK2)
BACU: 103000815(PDK4) 103007993 103016999(PDK1) 103018751(PDK2)
LVE: 103072788(PDK2) 103073094(PDK4) 103073975(PDK3) 103078387(PDK1)
OOR: 101271748(PDK1) 101279937(PDK2) 101286339(PDK4) 101288876(PDK3)
DLE: 111166477(PDK2) 111167510(PDK3) 111172870(PDK1) 111181307(PDK4)
PCAD: 102979242(PDK4) 102982880(PDK2) 102983475(PDK3) 102993902(PDK1)
ECB: 100052078(PDK4) 100060791(PDK3) 100064091(PDK1) 100147514(PDK2)
EPZ: 103543124 103551054(PDK2) 103553122(PDK1) 103555010(PDK4)
EAI: 106824116(PDK3) 106826450(PDK2) 106834715(PDK1) 106838924(PDK4)
MYB: 102251531(PDK4) 102255458(PDK3) 102259213(PDK2) 102262215(PDK1)
MYD: 102767099(PDK1) 102774306(PDK3) 102775297(PDK2) 102775518(PDK4)
MMYO: 118653855(PDK3) 118661163(PDK1) 118666200(PDK4) 118671292(PDK2) 118671355
MNA: 107531030(PDK1) 107534264(PDK3) 107539176(PDK2) 107541747(PDK4)
HAI: 109372242(PDK3) 109380767(PDK2) 109390399(PDK1) 109393138(PDK4)
DRO: 112305775(PDK1) 112313227(PDK3) 112316178(PDK2) 112319795(PDK4)
SHON: 118978115(PDK2) 118985702(PDK1) 118987339(PDK4) 118997065(PDK3)
AJM: 119047363(PDK4) 119047489(PDK3) 119052659(PDK2) 119053640(PDK1)
MMF: 118619928(PDK4) 118625263(PDK1) 118635080(PDK2) 118635694(PDK3)
PALE: 102880150(PDK4) 102883688(PDK1) 102885302(PDK2) 102888523(PDK3)
RAY: 107498344(PDK3) 107503332(PDK4) 107505192(PDK1) 107517591(PDK2)
MJV: 108385121(PDK2) 108390609(PDK3) 108391482(PDK1) 108406227(PDK4)
LAV: 100655808(PDK1) 100670251 100671485(PDK3) 100674220(PDK4)
MDO: 100010271(PDK3) 100017644(PDK4) 100022514(PDK2) 100029831 100617164(PDK1)
SHR: 100924143(PDK2) 100924902(PDK3) 100932777(PDK1) 100934205(PDK4)
PCW: 110210803(PDK3) 110211577(PDK1) 110215793(PDK2) 110217579(PDK4)
OAA: 100084173(PDK1) 100088087(PDK4) 100090199(PDK2) 103170840(PDK3)
GGA: 107050147(PDKI2) 418595(PDK3) 420570(PDK4) 425972(PDK1)
PCOC: 116232736(PDK3) 116232853(PDK1) 116233565(PDK2) 116243255(PDK4)
MGP: 100540747(PDK4) 100551417(PDK1) 104915378
CJO: 107309122(PDK4) 107316706(PDK1) 107325193(PDK3) 107325226(PDK2)
NMEL: 110394291(PDK4) 110400361(PDK1) 110404303(PDK3)
APLA: 101790921(PDK1) 101793451(PDK3) 101796141(PDK4) 113840021(PDK2)
ACYG: 106029999(PDK1) 106037540(PDK4) 106037792(PDK3)
TGU: 100218846(PDK1) 100226102(PDK3) 100230570(PDK4) 116806667(PDK2)
LSR: 110474730(PDK4) 110474799(PDK2) 110482900(PDK1) 110483254(PDK3)
PMOA: 120498173(PDK2) 120503424(PDK4) 120504686(PDK3) 120513475(PDK1)
GFR: 102032982(PDK1) 102035869(PDK3) 102036508(PDK2) 102043114(PDK4)
FAB: 101810404(PDK4) 101812266(PDK2) 101812709(PDK1) 101819650(PDK3)
PHI: 102100647(PDK3) 102101703(PDK1) 102105276(PDK2) 102107706(PDK4)
PMAJ: 107198663(PDK2) 107200488(PDK4) 107204004(PDK3) 107207402(PDK1)
CCAE: 111922906(PDK3) 111924238(PDK4) 111932081(PDK1) 111940029
CCW: 104686204(PDK3) 104689332(PDK4) 104693871(PDK1) 120411189(PDK2)
ETL: 114054918(PDK1) 114057650(PDK3) 114069034(PDK2) 114072967(PDK4)
FPG: 101913912(PDK4) 101915736(PDK2) 101921375(PDK3) 101925003(PDK1)
FCH: 102050815(PDK1) 102050926(PDK3) 102054883(PDK4) 102055203(PDK2)
CLV: 102092387(PDK2) 102093738(PDK3) 102097281(PDK4) 102098636(PDK1)
EGZ: 104123442(PDK3) 104128057(PDK1) 104129066(PDK4)
NNI: 104010002(PDK1) 104012302(PDK2) 104012823(PDK4) 104022502(PDK3)
ACUN: 113477053(PDK4) 113479913(PDK3) 113482065(PDK1)
PADL: 103914484(PDK3) 103922372(PDK4) 103924235(PDK1)
AAM: 106483564(PDK4) 106492245(PDK3) 106492763(PDK2) 106499285(PDK1)
ASN: 102370160(PDK4) 102375213(PDK2) 102384931(PDK1) 102385909(PDK3)
AMJ: 102560712(PDK2) 102565725(PDK1) 102576429(PDK3) 106736620(PDK4)
CPOO: 109305961(PDK3) 109309012(PDK4) 109318943(PDK2) 109322659(PDK1)
GGN: 109291427(PDK4) 109301692(PDK1) 109302813(PDK3)
PSS: 102454133(PDK2) 102458098(PDK4) 102458322(PDK3) 102462980(PDK1)
CMY: 102930569(PDK4) 102931646(PDK3) 102934483(PDK2) 102942305(PDK1)
CPIC: 101939116(PDK4) 101939432(PDK1) 101947440(PDK3) 101948702(PDK2)
TST: 117868772(PDK3) 117869198(PDK2) 117872231(PDK4) 117884723(PDK1)
CABI: 116820150(PDK3) 116829232(PDK4) 116831478(PDK2) 116831976
ACS: 100555492(pdk1) 100560978(pdk4) 100562544(pdk3) 100565122(pdk2)
PVT: 110074717(PDK4) 110076723(PDK3) 110079134(PDK2) 110086017(PDK1)
PBI: 103048669(PDK2) 103052031(PDK4) 103052758(PDK1) 103063932(PDK3)
PMUR: 107282609(PDK2) 107283650(PDK4) 107291526(PDK1) 107298473(PDK3)
TSR: 106542459 106543989(PDK4) 106545023(PDK3) 106545193(PDK2)
PGUT: 117654883(PDK4) 117664511(PDK2) 117671546(PDK1) 117674927(PDK3)
PMUA: 114581688(PDK2) 114596206(PDK3) 114606930(PDK1) 114607069(PDK4)
ZVI: 118085064(PDK3) 118092009(PDK4) 118094214(PDK2) 118094675(PDK1)
GJA: 107107054(PDK1) 107112128 107112529(PDK2) 107114025(PDK3) 107118002(PDK4)
XLA: 108707984(pdk3.L) 108709313(pdk3.S) 379789(pdk4.L) 398840(pdk4.S) 432080(pdk1.L) 494745(pdk1.S)
XTR: 100135009(pdk3) 100497838(pdk1) 448511(pdk4)
NPR: 108790502(PDK4) 108790791(PDK3) 108800388(PDK1)
DRE: 393971(pdk2b) 555840(pdk1) 560068(pdk3a) 561007(pdk4) 794083(pdk2a)
ELY: 117247416(pdk2a) 117251613(pdk1) 117263920(pdk4) 117264726(pdk3a) 117268879
PLEP: 121948831(pdk1) 121956983 121957619(pdk4) 121960420(pdk3a) 121964955
SLUC: 116037946(pdk3a) 116048487(pdk1) 116061258(pdk2a) 116062847 116066907(pdk4)
GAT: 120811572(pdk3a) 120819247(pdk2a) 120826161(pdk4) 120828007 120834406(pdk1)
CUD: 121503371 121522539(pdk1) 121523956(pdk4) 121527199(pdk3a) 121528431(pdk2a)
MZE: 101472257 101479514(pdk3) 101482626(pdk1) 101483754(pdk4)
ONL: 100690776(pdk4) 100700648(pdk1) 100701650 100706734(pdk3)
OAU: 116319466(pdk4) 116323010(pdk1) 116328267(pdk3a) 116335611(pdk2a)
OLA: 101155612(pdk4) 101161766(pdk1) 101171116(pdk3) 101175202
OML: 112151208(pdk3a) 112154423(pdk2a) 112154859(pdk1) 112162963(pdk4)
XMA: 102220162(pdk4) 102223173 102228650(pdk3) 102235390(pdk1)
XCO: 114136739(pdk3) 114148095(pdk1) 114152118 114156304(pdk4)
XHE: 116711645(pdk3) 116723063(pdk1) 116727262 116731498(pdk4)
NFU: 107382959(pdk3) 107383300(pdk4) 107387611 107390016(pdk1)
KMR: 108239328(pdk4) 108240758(pdk1) 108243174(pdk3a) 108249334(pdk2a)
LCF: 108877204(pdk4) 108888700(pdk1) 108892051 108902052(pdk3)
SDU: 111218429(pdk1) 111219703 111223416(pdk4) 111237227(pdk3)
XGL: 120785908(pdk4) 120786116 120790240(pdk3a) 120794330(pdk2a) 120801399(pdk1)
LOC: 102689070(pdk1) 102689628 102689939(pdk4) 102694075(pdk3)
PSPA: 121301856 121302839(pdk3a) 121315036(pdk4) 121321396(pdk1) 121324237
LCM: 102347516(PDK2) 102354798(PDK3)
CMK: 103176918(pdk4) 103183848(pdk2) 103184837(pdk3)
BFO: 118403139
CIN: 100185085
SCLV: 120342311
APLC: 110977370
SKO: 100375387
DME: Dmel_CG8808(Pdk)
DER: 6541111
DSE: 6608352
DSI: Dsimw501_GD10655(Dsim_GD10655)
DAN: 6495314
DSR: 110177125
DPE: 6592195
DWI: 6640984
DAZ: 108615926
DNV: 108653823
DHE: 111604602
DVI: 6636500
MDE: 101896544
LCQ: 111688894
ACOZ: 120960033
AARA: 120904951
AAG: 5569118
AME: 410424
ACER: 107998838
BIM: 100740637
BTER: 100651342
CCAL: 108633033
OBB: 114880709
MGEN: 117218847
NMEA: 116426865
SOC: 105196176
MPHA: 105840769
AEC: 105145793
ACEP: 105624222
PBAR: 105430164
VEM: 105567175
HST: 105184354
DQU: 106751135
CFO: 105254566
FEX: 115236023
LHU: 105667675
PGC: 109857987
OBO: 105278201
PCF: 106792239
NVI: 100122108
CSOL: 105361037
MDL: 103576368
TCA: 662090
DPA: 109543594
ATD: 109605857
AGB: 108904718
NVL: 108566338
APLN: 108741385
PPYR: 116176946
OTU: 111418780
BMOR: 100136898(Pdk)
BMAN: 114251157
MSEX: 115439768
BANY: 112054343
PMAC: 106715299
PPOT: 106101913
PXU: 106124323
PRAP: 110999946
ZCE: 119836410
HAW: 110379901
TNL: 113507471
PXY: 105398591
API: 100166307
DNX: 107164354
AGS: 114131694
RMD: 113555897
BTAB: 109033857
DCI: 103515710
CLEC: 106661526
NLU: 111046083
ZNE: 110830100
CSEC: 111874174
FCD: 110862532
PVM: 113820493
HAME: 121875703
DSV: 119456303
RMP: 119171878
VDE: 111253310
VJA: 111270221
TUT: 107364003
DPTE: 113797125
CSCU: 111618672
PTEP: 107446614
SDM: 118196190
CEL: CELE_ZK370.5(pdhk-2)
CBR: CBG06929(Cbr-pdhk-2)
BMY: BM_BM13766(Bma-pdhk-2)
PCAN: 112556504
BGT: 106059039
GAE: 121385433
CRG: 105337605
PMAX: 117314684
OBI: 106874800
LAK: 106151501
EGL: EGR_07392
NVE: 5514023
EPA: 110245620
ATEN: 116307513
ADF: 107338823
AMIL: 114965217
PDAM: 113686862
DGT: 114519114
HMG: 100211141
ATH: AT3G06483(PDK)
ALY: 9320654
CRB: 17891628
CPAP: 110808360
CIT: 102615178
PVY: 116144486
TCC: 18603766
DZI: 111306984
EGR: 104415295
APRC: 113874310
CAM: 101496392(Pdk) 101500787
LJA: Lj0g3v0267349.1(Lj0g3v0267349.1) Lj4g3v2249050.1(Lj4g3v2249050.1) Lj6g3v1126390.1(Lj6g3v1126390.1)
FVE: 101310404
RCN: 112198319
PPER: 18792242
PMUM: 103323292
PAVI: 110763836
PDUL: 117634649
ZJU: 107433361
MNT: 21407862
MCHA: 111009461
CMAX: 111479408
CMOS: 111457914
CPEP: 111791452
RCU: 8261345
JCU: 105643624
HBR: 110635268
MESC: 110611773
POP: 7496482
PEU: 105107180
PALZ: 118057332
QLO: 115994815
TWL: 120000101
INI: 109175738
ITR: 116002151
SIND: 105156800
EGT: 105960376
LSV: 111880400
CCAV: 112527429
BVG: 104889154
SOE: 110790972
NCOL: 116254246
DOSA: Os03t0370000-01(Os03g0370000) Os07t0637300-01(Os07g0637300)
ZMA: 100193944 103638995 541677(pdlk1) 542603(pdlk2)
EGU: 105061503
DCT: 110099184
PEQ: 110037896
ATR: 18430097
APRO: F751_4520
SCE: YGL059W(PKP2) YIL042C(PKP1)
KMX: KLMA_10248(PKP2) KLMA_20512(PKP1) KLMA_40335
NCS: NCAS_0A13390(NCAS0A13390) NCAS_0D03210(NCAS0D03210)
NDI: NDAI_0A02650(NDAI0A02650) NDAI_0I01660(NDAI0I01660)
TPF: TPHA_0B02740(TPHA0B02740) TPHA_0J01760(TPHA0J01760)
TBL: TBLA_0B01550(TBLA0B01550) TBLA_0F02450(TBLA0F02450)
TDL: TDEL_0G03600(TDEL0G03600) TDEL_0H02230(TDEL0H02230)
KAF: KAFR_0A04690(KAFR0A04690) KAFR_0I01930(KAFR0I01930)
CAL: CAALFM_CR08860WA(PDK2)
SLB: AWJ20_2336(PKP2) AWJ20_864(PKP1)
NCR: NCU03796(stk-24) NCU06760(stk-48)
NTE: NEUTE1DRAFT111129(NEUTE1DRAFT_111129) NEUTE1DRAFT58210(NEUTE1DRAFT_58210)
MBE: MBM_04625
ANG: ANI_1_544024(An02g04000) ANI_1_682084(An09g05460)
PBN: PADG_07553 PADG_12250(PADG_07168)
PNO: SNOG_10913 SNOG_15668(SNOG_15666 SNOG_15667)
SPO: SPAC644.11c(pkp1)
TASA: A1Q1_01815
ABP: AGABI1DRAFT123518(AGABI1DRAFT_123518) AGABI1DRAFT72910(AGABI1DRAFT_72910)
ABV: AGABI2DRAFT179568(AGABI2DRAFT_179568) AGABI2DRAFT203285(AGABI2DRAFT_203285)
SMIN: v1.2.006537.t1(symbB.v1.2.006537.t1) v1.2.009791.t1(symbB.v1.2.009791.t1) v1.2.017212.t1(symbB.v1.2.017212.t1) v1.2.019767.t1(symbB.v1.2.019767.t1) v1.2.020323.t1(symbB.v1.2.020323.t1) v1.2.020323.t2(symbB.v1.2.020323.t2) v1.2.027845.t1(symbB.v1.2.027845.t1) v1.2.027845.t2(symbB.v1.2.027845.t2) v1.2.033580.t1(symbB.v1.2.033580.t1) v1.2.033580.t2(symbB.v1.2.033580.t2) v1.2.036480.t1(symbB.v1.2.036480.t1) v1.2.036764.t1(symbB.v1.2.036764.t1) v1.2.039627.t1(symbB.v1.2.039627.t1)
 » show all
Reference
1  [PMID:4401694]
  Authors
Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ.
  Title
-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart.
  Journal
Arch Biochem Biophys 148:327-42 (1972)
DOI:10.1016/0003-9861(72)90151-8
Reference
2  [PMID:3004826]
  Authors
Reed LJ, Damuni Z, Merryfield ML.
  Title
Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation.
  Journal
Curr Top Cell Regul 27:41-9 (1985)
DOI:10.1016/b978-0-12-152827-0.50011-6
Reference
3  [PMID:15629119]
  Authors
Tovar-Mendez A, Hirani TA, Miernyk JA, Randall DD.
  Title
Analysis of the catalytic mechanism of pyruvate dehydrogenase kinase.
  Journal
Arch Biochem Biophys 434:159-68 (2005)
DOI:10.1016/j.abb.2004.10.017
  Sequence
[ath:AT3G06483]
Reference
4  [PMID:15491151]
  Authors
Bao H, Kasten SA, Yan X, Hiromasa Y, Roche TE.
  Title
Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP.
  Journal
Biochemistry 43:13442-51 (2004)
DOI:10.1021/bi0494875
Reference
5  [PMID:12631265]
  Authors
Roche TE, Hiromasa Y, Turkan A, Gong X, Peng T, Yan X, Kasten SA, Bao H, Dong J.
  Title
Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1.
  Journal
Eur J Biochem 270:1050-6 (2003)
DOI:10.1046/j.1432-1033.2003.03468.x
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.2
IUBMB Enzyme Nomenclature: 2.7.11.2
ExPASy - ENZYME nomenclature database: 2.7.11.2
BRENDA, the Enzyme Database: 2.7.11.2
CAS: 9074-01-5

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