KEGG   ENZYME: 2.7.11.2Help
Entry
EC 2.7.11.2                 Enzyme                                 

Name
[pyruvate dehydrogenase (acetyl-transferring)] kinase;
PDH kinase;
PDHK;
PDK;
PDK1;
PDK2;
PDK3;
PDK4;
pyruvate dehydrogenase kinase;
pyruvate dehydrogenase kinase (phosphorylating);
pyruvate dehydrogenase kinase activator protein;
STK1
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[pyruvate dehydrogenase (acetyl-transferring)] phosphotransferase
Reaction(IUBMB)
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate [RN:R03449]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
[pyruvate dehydrogenase (acetyl-transferring)] [CPD:C01256]
Product
ADP [CPD:C00008];
[pyruvate dehydrogenase (acetyl-transferring)] phosphate [CPD:C01293]
Comment
The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. Phosphorylation inactivates EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring).
History
EC 2.7.11.2 created 1978 as EC 2.7.1.99, transferred 2005 to EC 2.7.11.2
Orthology
K00898  pyruvate dehydrogenase kinase 2/3/4
K12077  pyruvate dehydrogenase kinase isoform 1
Genes
HSA: 5163(PDK1) 5164(PDK2) 5165(PDK3) 5166(PDK4)
PTR: 459743(PDK1) 468402(PDK2) 472448(PDK4) 740576(PDK3)
PPS: 100968174(PDK1) 100970620(PDK4) 100992308(PDK2) 100995647(PDK3)
GGO: 101129032(PDK2) 101143387(PDK3) 101149286(PDK4) 101150048(PDK1)
PON: 100174113(PDK2) 100435148(PDK4) 100442853(PDK1) 100462571(PDK3)
NLE: 100597085(PDK2) 100598085(PDK3) 100601990(PDK1) 100605243(PDK4)
MCC: 697772(PDK1) 698726(PDK4) 699394(PDK3) 704169(PDK2)
MCF: 101867293(PDK2) 102118837(PDK3) 102119067(PDK4) 102132161(PDK1)
CSAB: 103217325(PDK1) 103226523(PDK4) 103231727(PDK3) 103242950(PDK2)
RRO: 104654150(PDK3) 104656590(PDK4) 104673517(PDK1) 104680263(PDK2)
RBB: 108513535(PDK4) 108516442(PDK2) 108522274(PDK1) 108524111(PDK3)
CJC: 100386396(PDK2) 100388325(PDK3) 100402844(PDK1) 100407216(PDK4)
SBQ: 101037963(PDK1) 101038610(PDK3) 101048009(PDK2) 101049325(PDK4)
MMU: 18604(Pdk2) 228026(Pdk1) 236900(Pdk3) 27273(Pdk4)
RNO: 116551(Pdk1) 296849(Pdk3) 81530(Pdk2) 89813(Pdk4)
CGE: 100758762(Pdk2) 100763413(Pdk4) 100770270(Pdk3) 100774056(Pdk1)
NGI: 103725230(Pdk4) 103725376(Pdk3) 103728651 103738377(Pdk2) 103751806(Pdk1)
HGL: 101698433(Pdk4) 101699582(Pdk3) 101699994(Pdk2) 101705587(Pdk1)
CCAN: 109691403(Pdk2) 109697144(Pdk3) 109699522(Pdk1) 109701002(Pdk4)
OCU: 100348343(PDK2) 100351323(PDK1) 100351580(PDK4) 100352037(PDK3)
TUP: 102468786(PDK4) 102469133(PDK2) 102483149(PDK3) 102499515(PDK1)
CFA: 476828(PDK1) 480868(PDK3) 482310(PDK4) 491075(PDK2)
AML: 100464908(PDK4) 100466029(PDK3) 100476739(PDK2) 100483652(PDK1)
UMR: 103658746(PDK4) 103659566(PDK1) 103660465(PDK2) 103668186(PDK3)
ORO: 101362728(PDK3) 101367021(PDK2) 101370661(PDK4) 101383119(PDK1)
FCA: 101092256(PDK4) 101092705(PDK1) 101095314(PDK3) 101100013(PDK2)
PTG: 102948846(PDK3) 102951784 102960301(PDK1) 102963206(PDK2) 102969030(PDK4)
AJU: 106970005(PDK4) 106985184(PDK2) 106986815(PDK3) 106987925(PDK1)
BTA: 507367(PDK4) 510841(PDK3) 524075(PDK2) 528655(PDK1)
BOM: 102264999(PDK4) 102265648(PDK1) 102266253(PDK2) 102275065(PDK3)
BIU: 109555405(PDK3) 109558225(PDK4) 109566453(PDK1) 109573763(PDK2)
PHD: 102327657(PDK4) 102329508(PDK2) 102337867(PDK3) 102339076(PDK1)
CHX: 102180838(PDK3) 102185217(PDK2) 102186251(PDK1) 102190015(PDK4)
OAS: 101108725(PDK3) 101108929(PDK2) 101113205(PDK1) 101117752(PDK4)
SSC: 100153858(PDK3) 100286778(PDK4) 100286871(PDK1) 100516037(PDK2)
CFR: 102508070(PDK2) 102511071(PDK3) 102518730(PDK4) 102518782(PDK1)
CDK: 105088722(PDK4) 105091095(PDK1) 105103897(PDK3) 105104826(PDK2)
BACU: 103000815(PDK4) 103007993 103016999(PDK1) 103018751(PDK2)
LVE: 103072788(PDK2) 103073094(PDK4) 103073975(PDK3) 103078387(PDK1)
OOR: 101271748(PDK1) 101279937(PDK2) 101286339(PDK4) 101288876(PDK3)
ECB: 100052078(PDK4) 100060791(PDK3) 100064091(PDK1) 100147514(PDK2)
EAI: 106824116(PDK3) 106826450(PDK2) 106834715(PDK1) 106838924(PDK4)
MYB: 102251531(PDK4) 102255458(PDK3) 102259213(PDK2) 102262215(PDK1)
MYD: 102767099(PDK1) 102774306(PDK3) 102775297(PDK2) 102775518(PDK4)
HAI: 109372242(PDK3) 109380767(PDK2) 109390399(PDK1) 109393138(PDK4)
RSS: 109445225(PDK1) 109446399(PDK4) 109451978(PDK2) 109461091(PDK3)
PALE: 102880150(PDK4) 102883688(PDK1) 102885302(PDK2) 102888523(PDK3)
LAV: 100655808(PDK1) 100670251 100671485(PDK3) 100674220(PDK4)
MDO: 100010271(PDK3) 100017644(PDK4) 100022514(PDK2) 100617164(PDK1)
SHR: 100924143(PDK2) 100924902(PDK3) 100932777(PDK1) 100934205(PDK4)
OAA: 100084173(PDK1) 100088087(PDK4)
GGA: 107050147(PDKI2) 418595(PDK3) 420570(PDK4) 425972(PDK1)
MGP: 100540747(PDK4) 100548787 100551417(PDK1)
CJO: 107309122(PDK4) 107316706(PDK1) 107325193(PDK3) 107325226(PDK2)
APLA: 101790921(PDK1) 101793451(PDK3) 101796141(PDK4)
ACYG: 106029999(PDK1) 106037540(PDK4) 106037792(PDK3)
TGU: 100218846(PDK1) 100226102(PDK3) 100230570(PDK4)
GFR: 102032982(PDK1) 102035869(PDK3) 102036508(PDK2) 102043114(PDK4)
FAB: 101810404(PDK4) 101812266(PDK2) 101812709(PDK1) 101819650(PDK3)
PHI: 102100647(PDK3) 102101703(PDK1) 102105276(PDK2) 102107706(PDK4)
PMAJ: 107198663(PDK2) 107200488(PDK4) 107204004(PDK3) 107207402(PDK1)
CCW: 104686204(PDK3) 104689332(PDK4) 104693871(PDK1)
FPG: 101913912(PDK4) 101915736(PDK2) 101921375(PDK3) 101925003(PDK1)
FCH: 102050815(PDK1) 102050926(PDK3) 102054883(PDK4) 102055203(PDK2)
CLV: 102092387(PDK2) 102093738(PDK3) 102097281(PDK4) 102098636(PDK1)
EGZ: 104123442(PDK3) 104128057(PDK1) 104129066(PDK4) 104131408
AAM: 106483564(PDK4) 106492245(PDK3) 106492763(PDK2) 106499285(PDK1)
ASN: 102370160(PDK4) 102375213(PDK2) 102384931(PDK1) 102385909(PDK3)
AMJ: 102560712(PDK2) 102565725(PDK1) 102576429(PDK3) 106736620(PDK4)
PSS: 102454133(PDK2) 102458098(PDK4) 102458322(PDK3) 102462980(PDK1)
CMY: 102930569(PDK4) 102931646(PDK3) 102934483(PDK2) 102942305(PDK1)
CPIC: 101939116(PDK4) 101939432(PDK1) 101947440(PDK3) 101948702(PDK2)
ACS: 100555492(pdk1) 100560978(pdk4) 100562544(pdk3) 100565122(pdk2)
PVT: 110074717(PDK4) 110076723(PDK3) 110079134(PDK2) 110086017(PDK1)
PBI: 103048669(PDK2) 103052031(PDK4) 103052758(PDK1) 103063932(PDK3)
GJA: 107107054(PDK1) 107112128 107112529(PDK2) 107114025(PDK3) 107118002(PDK4)
XLA: 108707984 108709313 379789(pdk4.L) 398840(pdk4.S) 432080(pdk1.L) 494745
XTR: 100135009(pdk3) 100497838(pdk1) 448511(pdk4)
NPR: 108790502(PDK4) 108790791(PDK3) 108800388(PDK1)
DRE: 393971(pdk2b) 555840(pdk1) 560068(pdk3a) 561007(pdk4) 794083(pdk2a)
TRU: 101066123(pdk3) 101066998(pdk1) 101071739(pdk4) 101074391
MZE: 101472257 101479514(pdk3) 101482626(pdk1) 101483754(pdk4)
OLA: 101155612(pdk4) 101161766(pdk1) 101171116(pdk3) 101175202
XMA: 102220162(pdk4) 102223173 102228650(pdk3) 102235390(pdk1)
NFU: 107382959(pdk3) 107383300(pdk4) 107387611 107390016(pdk1)
LCF: 108877204(pdk4) 108888700(pdk1) 108892051 108902052(pdk3)
LCM: 102347516(PDK2) 102354798(PDK3)
CMK: 103176918(pdk4) 103183848(pdk2) 103184837(pdk3)
CIN: 100185085
SPU: 587933
APLC: 110977370
SKO: 100375387
DME: Dmel_CG8808(Pdk)
DSI: Dsimw501_GD10655(Dsim_GD10655)
MDE: 101896544
AAG: 5569118
AME: 410424(Pdk)
BIM: 100740637
BTER: 100651342
SOC: 105196176
AEC: 105145793
PBAR: 105430164
CFO: 105254566
LHU: 105667675
NVI: 100122108
DPA: 109543594
PMAC: 106715299
PRAP: 110999946
API: 100166307
DNX: 107164354
ZNE: 110830100
FCD: 110862532
TUT: 107364003
CEL: CELE_ZK370.5(pdhk-2)
CBR: CBG06929(Cbr-pdhk-2)
BMY: Bm1_30205
TSP: Tsp_01211
CRG: 105337605
OBI: 106874800
LAK: 106151501
ADF: 107338823
HMG: 100211141
ATH: AT3G06483(PDK)
CRB: 17891628
CPAP: 110808360
CIT: 102615178
TCC: 18603766
DZI: 111306984
EGR: 104415295
CAM: 101496392(Pdk) 101500787
LJA: Lj0g3v0267349.1(Lj0g3v0267349.1) Lj4g3v2249050.1(Lj4g3v2249050.1) Lj6g3v1126390.1(Lj6g3v1126390.1)
FVE: 101310404
PPER: 18792242
PMUM: 103323292
PAVI: 110763836
ZJU: 107433361
MCHA: 111009461
CMAX: 111479408
CMOS: 111457914
CPEP: 111791452
RCU: 8261345
JCU: 105643624
HBR: 110635268
POP: 7496482
INI: 109175738
SIND: 105156800
LSV: 111880400
BVG: 104889154
SOE: 110790972
DOSA: Os03t0370000-01(Os03g0370000) Os07t0637300-01(Os07g0637300)
ATS: 109735306(LOC109735306) 109769724(LOC109769724)
EGU: 105061503
DCT: 110099184
ATR: 18430097
APRO: F751_4520
ERC: Ecym_2505
CAL: CAALFM_CR08860WA(PDK2)
CAUR: QG37_02778
SLB: AWJ20_864(PKP1)
NCR: NCU06760(stk-48)
NTE: NEUTE1DRAFT111129(NEUTE1DRAFT_111129)
MGR: MGG_07161
MAW: MAC_01792
MAJ: MAA_05401
CMT: CCM_01061
MBE: MBM_04625
ANI: AN6207.2
ANG: ANI_1_544024(An02g04000)
PBN: PADG_12250(PADG_07168)
ABE: ARB_00632
TVE: TRV_05098
PNO: SNOG_15668(SNOG_15666 SNOG_15667)
PTE: PTT_00963
SPO: SPAC644.11c(pkp1)
CNE: CNA00360
ABP: AGABI1DRAFT123518(AGABI1DRAFT_123518)
ABV: AGABI2DRAFT179568(AGABI2DRAFT_179568)
MGL: MGL_2833
SMIN: v1.2.006537.t1(symbB.v1.2.006537.t1) v1.2.009791.t1(symbB.v1.2.009791.t1) v1.2.017212.t1(symbB.v1.2.017212.t1) v1.2.019767.t1(symbB.v1.2.019767.t1) v1.2.020323.t1(symbB.v1.2.020323.t1) v1.2.020323.t2(symbB.v1.2.020323.t2) v1.2.027845.t1(symbB.v1.2.027845.t1) v1.2.027845.t2(symbB.v1.2.027845.t2) v1.2.033580.t1(symbB.v1.2.033580.t1) v1.2.033580.t2(symbB.v1.2.033580.t2) v1.2.036480.t1(symbB.v1.2.036480.t1) v1.2.036764.t1(symbB.v1.2.036764.t1) v1.2.039627.t1(symbB.v1.2.039627.t1)
 » show all
Taxonomy
Reference
1  [PMID:4401694]
  Authors
Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ.
  Title
-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart.
  Journal
Arch Biochem Biophys 148:327-42 (1972)
DOI:10.1016/0003-9861(72)90151-8
Reference
2  [PMID:3004826]
  Authors
Reed LJ, Damuni Z, Merryfield ML.
  Title
Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation.
  Journal
Curr Top Cell Regul 27:41-9 (1985)
Reference
3  [PMID:15629119]
  Authors
Tovar-Mendez A, Hirani TA, Miernyk JA, Randall DD.
  Title
Analysis of the catalytic mechanism of pyruvate dehydrogenase kinase.
  Journal
Arch Biochem Biophys 434:159-68 (2005)
DOI:10.1016/j.abb.2004.10.017
  Sequence
[ath:AT3G06483]
Reference
4  [PMID:15491151]
  Authors
Bao H, Kasten SA, Yan X, Hiromasa Y, Roche TE.
  Title
Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP.
  Journal
Biochemistry 43:13442-51 (2004)
DOI:10.1021/bi0494875
Reference
5  [PMID:12631265]
  Authors
Roche TE, Hiromasa Y, Turkan A, Gong X, Peng T, Yan X, Kasten SA, Bao H, Dong J.
  Title
Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1.
  Journal
Eur J Biochem 270:1050-6 (2003)
DOI:10.1046/j.1432-1033.2003.03468.x
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.2
IUBMB Enzyme Nomenclature: 2.7.11.2
ExPASy - ENZYME nomenclature database: 2.7.11.2
BRENDA, the Enzyme Database: 2.7.11.2
CAS: 9074-01-5

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