| Entry |
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| Name |
[pyruvate dehydrogenase (acetyl-transferring)] kinase;
PDH kinase;
PDHK;
PDK;
PDK1;
PDK2;
PDK3;
PDK4;
pyruvate dehydrogenase kinase;
pyruvate dehydrogenase kinase (phosphorylating);
pyruvate dehydrogenase kinase activator protein;
STK1
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
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| Sysname |
ATP:[pyruvate dehydrogenase (acetyl-transferring)] phosphotransferase
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| Reaction(IUBMB) |
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate [RN: R03449]
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| Reaction(KEGG) |
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| Substrate |
ATP [CPD: C00002];
[pyruvate dehydrogenase (acetyl-transferring)] [CPD: C01256]
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| Product |
ADP [CPD: C00008];
[pyruvate dehydrogenase (acetyl-transferring)] phosphate [CPD: C01293]
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| Comment |
The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. Phosphorylation inactivates EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring).
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| History |
EC 2.7.11.2 created 1978 as EC 2.7.1.99, transferred 2005 to EC 2.7.11.2
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| Orthology |
| K00898 | pyruvate dehydrogenase kinase 2/3/4 |
| K12077 | pyruvate dehydrogenase kinase isoform 1 |
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| Genes |
» show all
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| Reference |
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| Authors |
Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ. |
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| Title |
-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart. |
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| Journal |
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| Reference |
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| Authors |
Reed LJ, Damuni Z, Merryfield ML. |
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| Title |
Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation. |
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| Journal |
Curr Top Cell Regul 27:41-9 (1985) |
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| Reference |
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| Authors |
Tovar-Mendez A, Hirani TA, Miernyk JA, Randall DD. |
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| Title |
Analysis of the catalytic mechanism of pyruvate dehydrogenase kinase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Bao H, Kasten SA, Yan X, Hiromasa Y, Roche TE. |
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| Title |
Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP. |
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| Journal |
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| Reference |
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| Authors |
Roche TE, Hiromasa Y, Turkan A, Gong X, Peng T, Yan X, Kasten SA, Bao H, Dong J. |
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| Title |
Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.11.2 |
| ExPASy - ENZYME nomenclature database: | 2.7.11.2 |
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