Entry
Name
elongation factor 2 kinase;
Ca/CaM-kinase III;
calmodulin-dependent protein kinase III;
CaM kinase III;
eEF2 kinase;
eEF2K;
EF2K;
STK19
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[elongation factor 2] phosphotransferase
Reaction(IUBMB)
ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate
Substrate
ATP [CPD:
C00002 ];
[elongation factor 2]
Product
ADP [CPD:
C00008 ];
[elongation factor 2] phosphate
Comment
Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC
2.7.11.11 , cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+ [1,2].
History
EC 2.7.11.20 created 2005
Orthology
K08292 elongation factor 2 kinase
Genes
XLA : 108701597(eef2k.L) 108703159
SRX : 107745669 107753299(eef2k)
SANH : 107684750 107695560
SGH : 107569190(eef2k) 107596604
CAUA : 113056313 113111911
CGIB : 127969220 128024963
MASI : 127422914 127426961
SASA : 106589523 106609006(eef2k)
STRU : 115153576(eef2k) 115201312
OTW : 112233701(eef2k) 112258435
ONE : 115112931(eef2k) 115144169
SALP : 111967889 111978802
CCLU : 121547454 121576597
PSPA : 121300848 121330676
ARUT : 117418469 117431025(eef2k)
CSCU : 111614897 111622125 111634953
CEL : CELE_F42A10.4(efk-1)
CBR : CBG_21103(Cbr-efk-1)
BMY : BM_BM4019(Bma-efk-1)
HRO : HELRODRAFT_139735 HELRODRAFT_149307
SMM : Smp_072980 Smp_149500
SHX : MS3_00004500(EEF2K_3)
OVI : T265_02258 T265_04893
EPA : 110237033 110238318 110253820
AMIL : 114963728 114969541
DGT : 114520800 114539559 114541777 114543483 114544858
MORE : E1B28_008147 E1B28_012126
PGR : PGTG_04544 PGTG_09976 PGTG_17927
ACAN : ACA1_063130 ACA1_291770
SMIN : v1.2.015467.t1(symbB.v1.2.015467.t1)
PIF : PITG_00298 PITG_10239 PITG_15382
PSOJ : PHYSODRAFT_316115 PHYSODRAFT_324571 PHYSODRAFT_491619
SPAR : SPRG_01565 SPRG_06224
EHX : EMIHUDRAFT_231710 EMIHUDRAFT_237375 EMIHUDRAFT_95998
GTT : GUITHDRAFT_102348 GUITHDRAFT_105481 GUITHDRAFT_105739 GUITHDRAFT_116228 GUITHDRAFT_119862 GUITHDRAFT_120247 GUITHDRAFT_144911 GUITHDRAFT_147562
» show all
Taxonomy
Reference
Authors
Mitsui K, Brady M, Palfrey HC, Nairn AC.
Title
Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas.
Journal
J Biol Chem 268:13422-33 (1993)
Sequence
Reference
Authors
Hincke MT, Nairn AC.
Title
Phosphorylation of elongation factor 2 during Ca(2+)-mediated secretion from rat parotid acini.
Journal
Reference
Authors
Knebel A, Morrice N, Cohen P.
Title
A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.
Journal
Reference
Authors
Sans MD, Xie Q, Williams JA.
Title
Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini.
Journal
Reference
Authors
Browne GJ, Finn SG, Proud CG.
Title
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.
Journal
Sequence
Reference
Authors
Ryazanov AG.
Title
Elongation factor-2 kinase and its newly discovered relatives.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.11.20