KEGG ENZYME: 2.7.11.20

ENZYME: 2.7.11.20

Entry

EC 2.7.11.20 Enzyme

Name

elongation factor 2 kinase;
Ca/CaM-kinase III;
calmodulin-dependent protein kinase III;
CaM kinase III;
eEF2 kinase;
eEF2K;
EF2K;
STK19

Class

Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases

Sysname

ATP:[elongation factor 2] phosphotransferase

Reaction(IUBMB)

ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate

Substrate

ATP [CPD:C00002];
[elongation factor 2]

Product

ADP [CPD:C00008];
[elongation factor 2] phosphate

Comment

Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC 2.7.11.11, cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+ [1,2].

History

EC 2.7.11.20 created 2005

Orthology

K08292

elongation factor 2 kinase

Genes

HSA:	29904(EEF2K)

PTR:	454350(EEF2K)

PPS:	100974702(EEF2K)

GGO:	101135987(EEF2K)

PON:	100457763(EEF2K)

NLE:	100591954(EEF2K)

MCC:	698604(EEF2K)

MCF:	102136849(EEF2K)

CSAB:

103229593(EEF2K)

RRO:	104682093(EEF2K)

RBB:	108514252(EEF2K)

CJC:	100390187(EEF2K)

SBQ:	101029579(EEF2K)

MMU:	13631(Eef2k)

MCAL:

110297797(Eef2k)

MPAH:

110319766(Eef2k)

RNO:	25435(Eef2k)

MUN:	110547850(Eef2k)

CGE:	100765385(Eef2k)

NGI:	103742746(Eef2k)

HGL:	101709310(Eef2k)

CCAN:

109686284(Eef2k)

OCU:	100347896(EEF2K)

TUP:	102470788(EEF2K)

CFA:	479812(EEF2K)

VVP:	112908327(EEF2K)

AML:	100482707(EEF2K)

UMR:	103668877(EEF2K)

UAH:	113267554(EEF2K)

ORO:	101363112(EEF2K)

ELK:

111162285

FCA:	101101433(EEF2K)

PTG:	102960729(EEF2K)

PPAD:

109255570(EEF2K)

AJU:	106970506(EEF2K)

BTA:	521730(EEF2K)

BOM:	102283488(EEF2K)

BIU:	109578373(EEF2K)

BBUB:

102401523(EEF2K)

CHX:	102168229(EEF2K)

OAS:	101103447(EEF2K)

SSC:	100523723(EEF2K)

CFR:	102515399(EEF2K)

CDK:	105092290(EEF2K)

BACU:

102997361(EEF2K)

LVE:	103084838(EEF2K)

OOR:	101270520(EEF2K)

DLE:	111182260(EEF2K)

PCAD:

102988757(EEF2K)

ECB:	100058387(EEF2K)

EPZ:	103567577(EEF2K)

EAI:	106841742(EEF2K)

MYB:	102240849(EEF2K)

MYD:	102761531(EEF2K)

MNA:	107544796(EEF2K)

HAI:	109386570(EEF2K)

DRO:	112304898(EEF2K)

PALE:

102897678(EEF2K)

RAY:	107516081(EEF2K)

MJV:	108405166(EEF2K)

LAV:	100669506(EEF2K)

TMU:

101351746

MDO:	100019979(EEF2K)

SHR:	100917051(EEF2K)

PCW:	110193480(EEF2K)

OAA:	100077045(EEF2K)

GGA:	416619(EEF2K)

MGP:	100547079(EEF2K)

CJO:	107320867(EEF2K)

NMEL:

110406069(EEF2K)

APLA:

101798747(EEF2K)

ACYG:

106033497(EEF2K)

TGU:	100226037(EEF2K)

LSR:	110475534(EEF2K)

SCAN:

103817674(EEF2K)

GFR:	102034166(EEF2K)

FAB:	101818070(EEF2K)

PHI:	102109650(EEF2K)

PMAJ:

107211299(EEF2K)

CCAE:

111936015(EEF2K)

CCW:	104684860(EEF2K)

ETL:	114065918(EEF2K)

FPG:	101920273(EEF2K)

FCH:	102054348(EEF2K)

CLV:	102091136(EEF2K)

EGZ:	104135860(EEF2K)

NNI:	104015054(EEF2K)

ACUN:

113485855(EEF2K)

PADL:

103913492(EEF2K)

AAM:	106491361(EEF2K)

ASN:	102383218(EEF2K)

AMJ:	102562118(EEF2K)

PSS:	102444339(EEF2K)

CMY:	102948272(EEF2K)

CPIC:

101933737(EEF2K)

ACS:	100568209(eef2k)

PVT:	110082197(EEF2K)

PBI:	103061498(EEF2K)

PMUR:

107292088(EEF2K)

TSR:	106548029(EEF2K)

PMUA:

114584077(EEF2K)

GJA:	107123036(EEF2K)

XLA:	108701597 108703159

XTR:	100145184(eef2k)

NPR:	108796493(EEF2K)

DRE:	437013(eef2k)

SRX:	107745669 107753299(eef2k)

SANH:

107684750 107695560

SGH:	107569190(eef2k) 107596604

IPU:	108273921(eef2k)

PHYP:

113527401(eef2k)

AMEX:

103031207(eef2k)

EEE:	113584628(eef2k)

TRU:	105419287(eef2k)

TNG:	GSTEN00006719G001

LCO:	104918854(eef2k)

MZE:	101477580(eef2k)

ONL:	100693329(eef2k)

OLA:	101158311(eef2k)

XMA:	102232849(eef2k)

XCO:	114152051(eef2k)

PRET:

103481520(eef2k)

CVG:	107089002(eef2k)

NFU:	107387735(eef2k)

KMR:	108248519(eef2k)

ALIM:

106516646(eef2k)

AOCE:

111585914(eef2k)

CSEM:

103381767(eef2k)

POV:	109642124(eef2k)

LCF:	108876059(eef2k)

SDU:	111219818(eef2k)

SLAL:

111673528(eef2k)

HCQ:	109527545(eef2k)

BPEC:

110166447(eef2k)

MALB:

109963045(eef2k)

SASA:

106589523 106609006(eef2k)

OTW:	112233701 112245973 112258435

SALP:

111967889 111978802

ELS:	105025068(eef2k)

SFM:	108940089(eef2k)

PKI:	111853860(eef2k)

LCM:	102345198(EEF2K)

CMK:	103178713(eef2k)

RTP:	109918128(eef2k)

BFO:

118429695

CIN:

100186164

SPU:	115918220 583067

APLC:

110981845

SKO:

100376880

DPX:	DAPPUDRAFT_299989

ISC:	IscW_ISCW010824

CSCU:

111614897 111622125 111634953

PTEP:

107456963

CEL:	CELE_F42A10.4(efk-1)

CBR:	CBG21103(Cbr-efk-1)

BMY:

Bm1_35010

LOA:	LOAG_04841

NAI:	NECAME_09662

TSP:

Tsp_07620

HRO:	HELRODRAFT_139735 HELRODRAFT_149307

LGI:	LOTGIDRAFT_232789

PCAN:

CRG:

MYI:

OBI:

LAK:	106160334 106161902

SMM:	Smp_072980 Smp_149500

SHX:

MS3_07859

OVI:	T265_02258 T265_04893

EGL:

EGR_01890

NVE:

5508438

EPA:	110237033 110238318 110253820

ADF:	107331965 107341939

AMIL:

114963728 114969541

PDAM:

113679883

SPIS:

111321883

DGT:	114520800 114539559 114541777 114543483 114544858

HMG:

100208670

TAD:	TRIADDRAFT_33592

AQU:

100639147

PGR:	PGTG_04544 PGTG_09976 PGTG_17927

MLR:	MELLADRAFT_95128

DPP:	DICPUDRAFT_83521

ACAN:

ACA1_063130 ACA1_291770

SMIN:

v1.2.015467.t1(symbB.v1.2.015467.t1)

PTI:	PHATRDRAFT_34488

FCY:	FRACYDRAFT_277313

TPS:	THAPSDRAFT_261433

AAF:	AURANDRAFT_61014

PIF:	PITG_00298 PITG_10239 PITG_15382

PSOJ:

PHYSODRAFT_316115 PHYSODRAFT_324571 PHYSODRAFT_491619

SPAR:

SPRG_01565 SPRG_06224

EHX:	EMIHUDRAFT_231710 EMIHUDRAFT_237375 EMIHUDRAFT_95998

GTT:	GUITHDRAFT_102348 GUITHDRAFT_105481 GUITHDRAFT_105739 GUITHDRAFT_116228 GUITHDRAFT_119862 GUITHDRAFT_120247 GUITHDRAFT_144911 GUITHDRAFT_147562

» show all

Reference

1 [PMID:8514778]

Authors

Mitsui K, Brady M, Palfrey HC, Nairn AC.

Title

Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas.

Journal

J Biol Chem 268:13422-33 (1993)

Sequence

[rno:25435]

Reference

2 [PMID:1372803]

Authors

Hincke MT, Nairn AC.

Title

Phosphorylation of elongation factor 2 during Ca(2+)-mediated secretion from rat parotid acini.

Journal

Biochem J 282 ( Pt 3):877-82 (1992)
DOI:10.1042/bj2820877

Reference

3 [PMID:11500363]

Authors

Knebel A, Morrice N, Cohen P.

Title

A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.

Journal

EMBO J 20:4360-9 (2001)
DOI:10.1093/emboj/20.16.4360

Reference

4 [PMID:15158453]

Authors

Sans MD, Xie Q, Williams JA.

Title

Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini.

Journal

Biochem Biophys Res Commun 319:144-51 (2004)
DOI:10.1016/j.bbrc.2004.04.164

Reference

5 [PMID:14709557]

Authors

Browne GJ, Finn SG, Proud CG.

Title

Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.

Journal

J Biol Chem 279:12220-31 (2004)
DOI:10.1074/jbc.M309773200

Sequence

[hsa:29904]

Reference

6 [PMID:11904175]

Authors

Ryazanov AG.

Title

Elongation factor-2 kinase and its newly discovered relatives.

Journal

FEBS Lett 514:26-9 (2002)
DOI:10.1016/S0014-5793(02)02299-8