Entry |
|
Name |
elongation factor 2 kinase;
Ca/CaM-kinase III;
calmodulin-dependent protein kinase III;
CaM kinase III;
eEF2 kinase;
eEF2K;
EF2K;
STK19
|
Class |
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
|
Sysname |
ATP:[elongation factor 2] phosphotransferase
|
Reaction(IUBMB) |
ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate
|
Substrate |
ATP [CPD: C00002];
[elongation factor 2]
|
Product |
ADP [CPD: C00008];
[elongation factor 2] phosphate
|
Comment |
Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC 2.7.11.11, cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+ [1,2].
|
History |
EC 2.7.11.20 created 2005
|
Orthology |
K08292 | elongation factor 2 kinase |
|
Genes |
» show all
|
Reference |
|
Authors |
Mitsui K, Brady M, Palfrey HC, Nairn AC. |
Title |
Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas. |
Journal |
J Biol Chem 268:13422-33 (1993) |
Sequence |
|
Reference |
|
Authors |
Hincke MT, Nairn AC. |
Title |
Phosphorylation of elongation factor 2 during Ca(2+)-mediated secretion from rat parotid acini. |
Journal |
|
Reference |
|
Authors |
Knebel A, Morrice N, Cohen P. |
Title |
A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. |
Journal |
|
Reference |
|
Authors |
Sans MD, Xie Q, Williams JA. |
Title |
Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini. |
Journal |
|
Reference |
|
Authors |
Browne GJ, Finn SG, Proud CG. |
Title |
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Ryazanov AG. |
Title |
Elongation factor-2 kinase and its newly discovered relatives. |
Journal |
|
Other DBs |
ExPASy - ENZYME nomenclature database: | 2.7.11.20 |
|