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Entry
EC 2.7.11.25                Enzyme                                 

Name
mitogen-activated protein kinase kinase kinase;
cMos;
cRaf;
MAPKKK;
MAP3K;
MAP kinase kinase kinase;
MEKK;
MEKK1;
MEKK2;
MEKK3;
MEK kinase;
Mil/Raf;
MLK-like mitogen-activated protein triple kinase;
MLTK;
MLTKa;
MLTKb;
REKS;
STK28
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (MAPKKKK-activated)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) but requires MAPKKKK for activation. Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway [2]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
History
EC 2.7.11.25 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K04415  mitogen-activated protein kinase kinase kinase 8
K04416  mitogen-activated protein kinase kinase kinase 1
K04417  mitogen-activated protein kinase kinase kinase 9
K04418  mitogen-activated protein kinase kinase kinase 10
K04419  mitogen-activated protein kinase kinase kinase 11
K04420  mitogen-activated protein kinase kinase kinase 2
K04421  mitogen-activated protein kinase kinase kinase 3
K04422  mitogen-activated protein kinase kinase kinase 13
K04423  mitogen-activated protein kinase kinase kinase 12
K04424  sterile alpha motif and leucine zipper containing kinase AZK
K04425  mitogen-activated protein kinase kinase kinase 6
K04426  mitogen-activated protein kinase kinase kinase 5
K04427  mitogen-activated protein kinase kinase kinase 7
K04428  mitogen-activated protein kinase kinase kinase 4
K04466  mitogen-activated protein kinase kinase kinase 14
K11228  mitogen-activated protein kinase kinase kinase
K11229  mitogen-activated protein kinase kinase kinase
K11230  mitogen-activated protein kinase kinase kinase
K13414  mitogen-activated protein kinase kinase kinase 1
K13986  mitogen-activated protein kinase kinase kinase 15
K17533  mitogen-activated protein kinase kinase kinase 19
K17534  mitogen-activated protein kinase kinase kinase MLK4
K20605  mitogen-activated protein kinase kinase kinase 2
K20606  mitogen-activated protein kinase kinase kinase ANP1
K20717  mitogen-activated protein kinase kinase kinase YODA
Genes
HSA: 10746(MAP3K2) 1326(MAP3K8) 389840(MAP3K15) 4214(MAP3K1) 4215(MAP3K3) 4216(MAP3K4) 4217(MAP3K5) 4293(MAP3K9) 4294(MAP3K10) 4296(MAP3K11) 51776(MAP3K20) 6885(MAP3K7) 7786(MAP3K12) 80122(MAP3K19) 84451(MAP3K21) 9020(MAP3K14) 9064(MAP3K6) 9175(MAP3K13)
PTR: 450384(MAP3K8) 451326(MAP3K11) 451940(MAP3K12) 454750(MAP3K14) 456674(MAP3K6) 459745(MAP3K20) 462888(MAP3K7) 463023(MAP3K5) 463119(MAP3K4) 465526(MAP3K15) 467498(MAP3K9) 468286(MAP3K3) 468880(MAP3K10) 469711(MAP3K21) 470547(MAP3K19) 471543(MAP3K1) 736244(MAP3K2) 737524(MAP3K13)
PPS: 100969705(MAP3K3) 100971946(MAP3K21) 100973371(MAP3K2) 100975785(MAP3K15) 100977883(MAP3K10) 100978161(MAP3K8) 100983287(MAP3K12) 100984930(MAP3K14) 100985472(MAP3K13) 100985853(MAP3K11) 100992106(MAP3K19) 100992712(MAP3K6) 100994192(MAP3K20) 100994796(MAP3K1)
GGO: 101128207(MAP3K13) 101130070(MAP3K21) 101132363(MAP3K19) 101133328(MAP3K8) 101136722(MAP3K1) 101137766(MAP3K6) 101147819(MAP3K14) 101148044(MAP3K3) 101148067(MAP3K10) 101148964(MAP3K11) 101149805(MAP3K2) 101154523(MAP3K20)
PON: 100171454(MAP3K7) 100172208(MAP3K12) 100172983(MAP3K13) 100433831(MAP3K9) 100436201(MAP3K14) 100440278(MAP3K20) 100442172(MAP3K4) 100444678(MAP3K3) 100445147(MAP3K6) 100448142(MAP3K19) 100450054(MAP3K2) 100450400(MAP3K21) 100450681(MAP3K10) 100452447(MAP3K15) 100453309(MAP3K1) 100456749(MAP3K11) 100458776(MAP3K5) 103889401(MAP3K8)
NLE: 100579516(MAP3K8) 100583302(MAP3K6) 100587341(MAP3K13) 100588522(MAP3K10) 100595740(MAP3K21) 100600394(MAP3K14) 100601763(MAP3K3) 100601802(MAP3K2) 100603568(MAP3K20) 100606554(MAP3K1)
MCC: 100424131(MAP3K2) 693835(MAP3K9) 695958(MAP3K15) 696936(MAP3K8) 698274(MAP3K20) 700477(MAP3K10) 701085(MAP3K13) 703059(MAP3K12) 703101(MAP3K7) 710360(MAP3K4) 710979(MAP3K1) 711382(MAP3K5) 712728(MAP3K19) 712755(MAP3K21) 715911(MAP3K6) 716038(MAP3K11) 716258(MAP3K14) 717866(MAP3K3)
MCF: 102119428(MAP3K13) 102123041(MAP3K1) 102124252(MAP3K6) 102129741(MAP3K21) 102132095(MAP3K3) 102132262(MAP3K10) 102132599(MAP3K8) 102138136(MAP3K2) 102139881(MAP3K20) 102145584(MAP3K14)
CSAB: 103216879(MAP3K2) 103217331(MAP3K20) 103221113(MAP3K13) 103221701(MAP3K1) 103225290(MAP3K6) 103230770(MAP3K21) 103234697(MAP3K10) 103243225(MAP3K3) 103243289(MAP3K14) 103247459(MAP3K8)
RRO: 104657086(MAP3K1) 104657273(MAP3K8) 104662431(MAP3K2) 104672741(MAP3K13) 104673509(MAP3K20) 104675466(MAP3K3) 104675763(MAP3K6) 104676124(MAP3K10) 104678324(MAP3K21) 104678377(MAP3K14)
RBB: 108518196(MAP3K6) 108518539(MAP3K20) 108518979(MAP3K21) 108525357(MAP3K13) 108528065(MAP3K8) 108530959(MAP3K1) 108532216(MAP3K14) 108533000(MAP3K2) 108536280(MAP3K3) 108539086(MAP3K10)
CJC: 100385107(MAP3K8) 100389500(MAP3K1) 100395753(MAP3K13) 100395802(MAP3K10) 100396743(MAP3K21) 100401112(MAP3K14) 100401384(MAP3K20) 100404784(MAP3K6) 100406711(MAP3K2) 100409608(MAP3K3)
SBQ: 101035755(MAP3K3) 101035799(MAP3K2) 101038273(MAP3K6) 101038631(MAP3K10) 101043045 101043439 101044826(MAP3K14) 101046566(MAP3K8) 101049991(MAP3K13) 101052309 101054366(MAP3K1)
MMU: 22625(Map3k19) 234878(Map3k21) 26401(Map3k1) 26403(Map3k11) 26404(Map3k12) 26405(Map3k2) 26406(Map3k3) 26407(Map3k4) 26408(Map3k5) 26409(Map3k7) 26410(Map3k8) 269881(Map3k10) 270672(Map3k15) 338372(Map3k9) 53608(Map3k6) 53859(Map3k14) 65964(Map3k20) 71751(Map3k13)
MCAL: 110284809(Map3k8) 110285269(Map3k20) 110292889(Map3k6) 110298678(Map3k10) 110300557(Map3k21) 110304892(Map3k14) 110305762(Map3k3) 110307741(Map3k1) 110311270(Map3k13)
MPAH: 110318175(Map3k20) 110323270(Map3k6) 110327052(Map3k10) 110328949(Map3k1) 110329718(Map3k13) 110331495(Map3k3) 110332218(Map3k14) 110333248(Map3k8) 110337368(Map3k21)
RNO: 100910771 100912399 116596(Map3k8) 116667(Map3k1) 171492(Map3k2) 25579(Map3k12) 289001(Map3k19) 303604(Map3k3) 303823(Map3k13) 307950(Map3k21) 308106(Map3k4) 308463(Map3k10) 309168(Map3k11) 311743(Map3k20) 313022(Map3k6) 313121(Map3k7) 360640(Map3k14) 365057(Map3k5) 500690(Map3k9) 501558(Map3k15)
MUN: 110545661(Map3k14) 110546648(Map3k1) 110547048(Map3k3) 110552483(Map3k6) 110554363 110554364(Map3k20) 110556721(Map3k10) 110558401(Map3k8) 110561590(Map3k13)
CGE: 100753508(Map3k3) 100754991(Map3k13) 100759538(Map3k8) 100760135(Map3k6) 100762677(Map3k11) 100764739(Map3k19) 100766459(Map3k14) 100768062(Map3k10) 100769818(Map3k20) 100770540(Map3k1) 100771548(Map3k21) 100772559(Map3k2)
NGI: 103732132(Map3k2) 103732670(Map3k13) 103737078(Map3k6) 103738320(Map3k14) 103739909(Map3k1) 103743128(Map3k21) 103744757(Map3k3) 103747991(Map3k8) 103750755(Map3k10) 103751744(Map3k20)
HGL: 101697616(Map3k6) 101700680(Map3k13) 101703313(Map3k14) 101704125(Map3k21) 101704335(Map3k3) 101707762(Map3k20) 101710286(Map3k8) 101718471(Map3k10) 101718575(Map3k11) 101720769(Map3k1) 101725578(Map3k19) 101726195(Map3k2)
CCAN: 109687931 109688533(Map3k10) 109691665(Map3k14) 109695531(Map3k1) 109695913(Map3k8) 109696078(Map3k6) 109699113(Map3k2) 109699287(Map3k13) 109703189(Map3k3)
OCU: 100343069(MAP3K6) 100343621(MAP3K10) 100345602(MAP3K13) 100345607(MAP3K21) 100348484(MAP3K1) 100351032(MAP3K14) 100351826(MAP3K20) 100355324(MAP3K3) 100355566(MAP3K8) 100355693(MAP3K2)
TUP: 102471323(MAP3K10) 102477673(MAP3K3) 102478254(MAP3K13) 102479529(MAP3K21) 102483890(MAP3K1) 102485186(MAP3K2) 102493021(MAP3K8) 102500729(MAP3K14) 102501118(MAP3K20) 102503262(MAP3K6)
CFA: 100685499(MAP3K13) 100688368(MAP3K21) 102156745(MAP3K7) 476215(MAP3K5) 476262(MAP3K4) 478061(MAP3K1) 478802(MAP3K20) 480481(MAP3K3) 483732(MAP3K11) 483897(MAP3K19) 484504(MAP3K10) 487085(MAP3K8) 487345(MAP3K6) 490765(MAP3K9) 490926(MAP3K14) 491765(MAP3K15) 607170(MAP3K12) 612902(MAP3K2)
VVP: 112910639(MAP3K14) 112916399(MAP3K20) 112920702(MAP3K3) 112921580(MAP3K8) 112926277(MAP3K13) 112927350(MAP3K21) 112928296(MAP3K10) 112931693(MAP3K6) 112935233(MAP3K1)
AML: 100465667(MAP3K4) 100466442(MAP3K1) 100466506(MAP3K7) 100467807(MAP3K13) 100469942(MAP3K12) 100472044(MAP3K9) 100472260(MAP3K14) 100473197(MAP3K10) 100475304(MAP3K5) 100475390(MAP3K21) 100475426(MAP3K2) 100475740(MAP3K3) 100479214(MAP3K6) 100479844(MAP3K20) 100480593(MAP3K8) 100480913(MAP3K11) 100483854(MAP3K19) 105241834(MAP3K15)
UMR: 103656496(MAP3K8) 103658571(MAP3K2) 103659570(MAP3K20) 103659895 103661092(MAP3K10) 103661981(MAP3K21) 103663891(MAP3K1) 103665628(MAP3K3) 103665883(MAP3K14) 103666761(MAP3K6) 103676070(MAP3K13)
UAH: 113243573(MAP3K10) 113244248(MAP3K8) 113250769(MAP3K20) 113254044(MAP3K13) 113255319(MAP3K1) 113259020(MAP3K21) 113265289(MAP3K3) 113265323(MAP3K14) 113268217(MAP3K6)
ORO: 101363246(MAP3K14) 101365627 101366511(MAP3K1) 101368270(MAP3K2) 101370047(MAP3K13) 101374941(MAP3K6) 101375291(MAP3K3) 101375908(MAP3K10) 101381295 101385184(MAP3K8)
FCA: 101081315(MAP3K6) 101083468(MAP3K14) 101083633(MAP3K3) 101087164(MAP3K12) 101087784(MAP3K21) 101089731(MAP3K10) 101089836(MAP3K15) 101090328(MAP3K1) 101090454(MAP3K19) 101090624(MAP3K8) 101093205(MAP3K13) 101094038(MAP3K20) 101096406(MAP3K2) 101098654(MAP3K11)
PTG: 102957925(MAP3K2) 102959520(MAP3K20) 102961042(MAP3K8) 102961509(MAP3K10) 102963818(MAP3K6) 102964388(MAP3K14) 102965107(MAP3K13) 102966576(MAP3K3) 102970826(MAP3K21) 102971191(MAP3K1)
PPAD: 109246346(MAP3K1) 109248910(MAP3K21) 109256635(MAP3K10) 109256795(MAP3K6) 109258173(MAP3K14) 109273104(MAP3K20) 109275247(MAP3K13) 109276338(MAP3K8) 109277107(MAP3K3)
AJU: 106966378(MAP3K2) 106967988(MAP3K13) 106975243(MAP3K1) 106977317(MAP3K8) 106977571(MAP3K6) 106978686(MAP3K3) 106979597(MAP3K10) 106981653(MAP3K21) 106987964(MAP3K20) 106988147(MAP3K14)
BTA: 504592(MAP3K2) 505369(MAP3K13) 505427(MAP3K12) 508367(MAP3K14) 508943(MAP3K3) 511779(MAP3K4) 514210(MAP3K11) 519251(MAP3K20) 523962(MAP3K1) 529146(MAP3K7) 529335(MAP3K15) 535622(MAP3K8) 537380(MAP3K5) 538340(MAP3K9) 538897(MAP3K19) 614598(MAP3K6) 616014(MAP3K21) 781037(MAP3K10)
BOM: 102264669(MAP3K6) 102267592(MAP3K1) 102268339(MAP3K14) 102273125(MAP3K2) 102274075(MAP3K21) 102274152(MAP3K10) 102275307(MAP3K3) 102278856(MAP3K8) 102285655(MAP3K13) 102288137(MAP3K20)
BIU: 109553877(MAP3K21) 109557274(MAP3K13) 109565311(MAP3K2) 109566425(MAP3K20) 109568007(MAP3K8) 109572644(MAP3K10) 109573153(MAP3K6) 109573385(MAP3K3) 109574056(MAP3K14) 109574889(MAP3K1)
BBUB: 102390268(MAP3K21) 102397755(MAP3K14) 102398186(MAP3K20) 102399287(MAP3K8) 102399327(MAP3K1) 102404285(MAP3K6) 102404576(MAP3K13) 102409579(MAP3K10) 102413611(MAP3K3)
CHX: 102173036(MAP3K3) 102175623(MAP3K2) 102178859(MAP3K13) 102183919(MAP3K20) 102186147(MAP3K10) 102186443(MAP3K6) 102187530(MAP3K1) 102188512(MAP3K8) 102189617(MAP3K14) 102191110(MAP3K21)
OAS: 101109858(MAP3K2) 101111776(MAP3K20) 101112260(MAP3K1) 101113737(MAP3K6) 101115427(MAP3K21) 101117036(MAP3K13) 101117094(MAP3K8) 101118723(MAP3K10) 101118799(MAP3K14) 101122537(MAP3K3)
SSC: 100135663(MAP3K7) 100152572(MAP3K20) 100154002(MAP3K21) 100154202(MAP3K4) 100155753(MAP3K9) 100511286(MAP3K19) 100512235(MAP3K6) 100513491(MAP3K3) 100515448(MAP3K13) 100517714(MAP3K12) 100520402(MAP3K14) 100521453(MAP3K10) 100621234(MAP3K2) 100622217(MAP3K8) 100622769(MAP3K5) 100736741(MAP3K11) 100739216(MAP3K15) 396617(MAP3K1)
CFR: 102504523(MAP3K14) 102505073(MAP3K2) 102505358(MAP3K1) 102505759(MAP3K3) 102506410(MAP3K13) 102509143(MAP3K10) 102518335(MAP3K8) 102518953(MAP3K6) 102520465(MAP3K20) 102523391(MAP3K21)
CDK: 105084487(MAP3K2) 105085862(MAP3K13) 105087133(MAP3K1) 105090412(MAP3K3) 105091098(MAP3K20) 105091198(MAP3K21) 105093336(MAP3K10) 105094405(MAP3K14) 105096296(MAP3K8) 105100707(MAP3K6)
BACU: 102999255(MAP3K3) 103001803(MAP3K21) 103002185(MAP3K1) 103005548(MAP3K10) 103010611(MAP3K8) 103015628(MAP3K6) 103015859(MAP3K14) 103017845(MAP3K2) 103018600(MAP3K20) 103020592(MAP3K13)
LVE: 103070441(MAP3K8) 103073201(MAP3K13) 103076636(MAP3K3) 103079692(MAP3K20) 103081325(MAP3K6) 103082490(MAP3K14) 103083140(MAP3K2) 103083385(MAP3K1) 103085713(MAP3K10) 103089656(MAP3K21)
OOR: 101269575(MAP3K8) 101270119(MAP3K14) 101270305(MAP3K2) 101271000(MAP3K6) 101272930 101273274(MAP3K10) 101273961(MAP3K3) 101278099(MAP3K13) 101285035 101288918(MAP3K1)
DLE: 111163411(MAP3K6) 111163906(MAP3K21) 111170190(MAP3K14) 111172872(MAP3K20) 111173071(MAP3K13) 111178133(MAP3K8) 111180858(MAP3K10) 111182605(MAP3K3) 111186550(MAP3K1)
PCAD: 102973167(MAP3K20) 102979076(MAP3K1) 102979560(MAP3K21) 102985093(MAP3K6) 102985586(MAP3K3) 102988471(MAP3K8) 102989373(MAP3K10) 102989494(MAP3K13) 102991269(MAP3K14)
ECB: 100050140(MAP3K14) 100050587(MAP3K19) 100050628(MAP3K2) 100053153(MAP3K20) 100054289(MAP3K9) 100057319(MAP3K11) 100058153(MAP3K4) 100058434(MAP3K15) 100059237(MAP3K13) 100059834(MAP3K21) 100061688(MAP3K1) 100063602(MAP3K8) 100064002(MAP3K12) 100064751(MAP3K3) 100065841(MAP3K7) 100070933(MAP3K6) 100073186(MAP3K5)
EPZ: 103541518(MAP3K8) 103548212(MAP3K1) 103549765(MAP3K3) 103550526(MAP3K6) 103554685(MAP3K14) 103555750(MAP3K21) 103559591(MAP3K20) 103560489(MAP3K10) 103562194(MAP3K2) 103564958(MAP3K13)
EAI: 106834092(MAP3K2) 106834499(MAP3K13) 106834739(MAP3K20) 106835525(MAP3K3) 106836478(MAP3K14) 106837968(MAP3K8) 106839092(MAP3K6) 106839676(MAP3K21) 106843249(MAP3K10) 106843371(MAP3K1)
MYB: 102239254(MAP3K13) 102240442(MAP3K10) 102242281(MAP3K6) 102242308(MAP3K3) 102245865(MAP3K2) 102248363(MAP3K8) 102258632(MAP3K1) 102259842(MAP3K21) 102262247(MAP3K14) 102263045(MAP3K20)
MYD: 102751509(MAP3K10) 102753581(MAP3K2) 102753720(MAP3K13) 102753749(MAP3K21) 102762787(MAP3K3) 102762988(MAP3K14) 102763786(MAP3K1) 102770852(MAP3K20) 102770934(MAP3K6) 102775461(MAP3K8)
MNA: 107524234 107524427(MAP3K8) 107527145(MAP3K1) 107527317(MAP3K13) 107528876(MAP3K14) 107530487(MAP3K3) 107531250 107534150(MAP3K10) 107541967(MAP3K6) 107546566
HAI: 109371277(MAP3K13) 109371823(MAP3K2) 109374860(MAP3K10) 109380266(MAP3K3) 109385705(MAP3K1) 109386678(MAP3K6) 109387711(MAP3K21) 109388741 109389111(MAP3K8) 109395015(MAP3K14)
DRO: 112298609(MAP3K14) 112299262(MAP3K6) 112305730(MAP3K20) 112306103(MAP3K21) 112308163(MAP3K13) 112315269(MAP3K1) 112316249(MAP3K3) 112316842(MAP3K8) 112320192(MAP3K10)
PALE: 102880315(MAP3K13) 102880422(MAP3K2) 102882855(MAP3K6) 102885138(MAP3K10) 102885530(MAP3K20) 102886741(MAP3K1) 102889570(MAP3K3) 102895694(MAP3K21) 102896654(MAP3K8) 102897751(MAP3K14)
RAY: 107501901(MAP3K3) 107503588(MAP3K6) 107505142 107508165(MAP3K14) 107518243(MAP3K13) 107518617(MAP3K1) 107518939(MAP3K8) 107520012 107521797(MAP3K10)
MJV: 108384016(MAP3K1) 108386996(MAP3K14) 108390480(MAP3K10) 108392181(MAP3K8) 108395540 108401834(MAP3K3) 108404979 108406519(MAP3K6) 108410204(MAP3K13)
LAV: 100655149(MAP3K1) 100660454(MAP3K20) 100661927(MAP3K14) 100662122(MAP3K3) 100662383(MAP3K8) 100665139(MAP3K2) 100673821(MAP3K10) 100673872(MAP3K21) 100674925(MAP3K6) 100677466(MAP3K13)
MDO: 100014185(MAP3K15) 100014282(MAP3K13) 100015818(MAP3K19) 100017378(MAP3K6) 100017495(MAP3K10) 100018494(MAP3K20) 100018684(MAP3K8) 100019975(MAP3K7) 100020082(MAP3K9) 100020668(MAP3K14) 100025970(MAP3K3) 100026735(MAP3K2) 100028987(MAP3K21) 100030111(MAP3K11) 100031527(MAP3K5) 100032065(MAP3K1) 100032495(MAP3K4)
SHR: 100913571(MAP3K1) 100913796(MAP3K13) 100916713(MAP3K2) 100918124(MAP3K14) 100924042(MAP3K21) 100925633(MAP3K8) 100927077(MAP3K6) 100932009(MAP3K10) 100932862(MAP3K15) 100932989(MAP3K11) 100933129(MAP3K19) 100933813(MAP3K20) 100933837(MAP3K3)
PCW: 110202681(MAP3K10) 110206150(MAP3K6) 110211269(MAP3K8) 110211581(MAP3K20) 110215703(MAP3K1) 110215732(MAP3K14) 110215942(MAP3K3) 110217833(MAP3K21) 110221295(MAP3K13)
OAA: 100076215(MAP3K8) 100076229(MAP3K7) 100076612(MAP3K1) 100076986(MAP3K13) 100081079(MAP3K5) 100081562(MAP3K4) 100083301 100083521(MAP3K15) 100084257(MAP3K20) 100085554(MAP3K14) 100086943(MAP3K9) 100087843(MAP3K2) 100088084(MAP3K6) 100089912(MAP3K19) 100092024(MAP3K3) 100092492(MAP3K12) 100092507(MAP3K10) 107547228(MAP3K11)
GGA: 100858193(MAP3K6) 101750513 418609(MAP3K15) 419954(MAP3K3) 419964(MAP3K14) 420419(MAPKKK3L) 420479(MAP3K8) 421579(MAP3K4) 421688(MAP3K5) 421808(MAP3K7) 424149(MAP3K20) 424225(MAP3K2) 424876(MAP3K13) 425792(MAP3K9) 427144(MAP3K1) 428586(MAP3K21) 429048(MAP3K19)
MGP: 100538760(MAP3K14) 100539648(MAP3K21) 100539749(MAP3K7) 100540233(MAP3K19) 100541097(MAP3K8) 100542691 100542719(MAP3K3) 100543830(MAP3K2) 100547994(MAP3K13) 100548383(MAP3K4) 100550623(MAP3K1) 100550901(MAP3K9) 100551250 104911778 104914275(MAP3K6)
CJO: 107306009(MAP3K1) 107308787 107308936(MAP3K8) 107311414(MAP3K21) 107316691(MAP3K20) 107316800(MAP3K2) 107317933(MAP3K13) 107324060(MAP3K6) 107325016(MAP3K14) 107325133(MAP3K3)
NMEL: 110387413(MAP3K6) 110388448(MAP3K14) 110388470(MAP3K3) 110390387(MAP3K1) 110393429(MAP3K8) 110394259 110395888(MAP3K21) 110399087(MAP3K13) 110399448(MAP3K20)
APLA: 101791236(MAP3K14) 101791769(MAP3K8) 101792050(MAP3K13) 101793656(MAP3K1) 101795869 101798043(MAP3K2) 101798142(MAP3K19) 101801284(MAP3K3) 101801810(MAP3K21) 101803181(MAP3K6) 101803306(MAP3K20)
ACYG: 106030002 106035615(MAP3K1) 106036842 106039243(MAP3K13) 106042681(MAP3K8) 106045922(MAP3K2) 106045975(MAP3K3) 106046936(MAP3K14) 106047891(MAP3K6) 106048621
TGU: 100217837(MAP3K14) 100219311(MAP3K15) 100219827(MAP3K2) 100221443(MAP3K7) 100223633(MAP3K3) 100224192(MAP3K5) 100225400(MAP3K13) 100225825(MAP3K1) 100226503 100228461(MAP3K20) 100228874(MAP3K21) 100229586(MAP3K9) 100229845(MAP3K4) 100230596(MAP3K8) 100232008(MAP3K19) 115491344
LSR: 110468877(MAP3K21) 110472556(MAP3K1) 110474076(MAP3K13) 110474827(MAP3K3) 110475629(MAP3K14) 110477339(MAP3K8) 110482911(MAP3K20) 110484542
SCAN: 103812700 103812752(MAP3K8) 103814440(MAP3K20) 103815669(MAP3K13) 103818563(MAP3K21) 103821035(MAP3K1) 103821648(MAP3K14) 103821658(MAP3K3)
GFR: 102032306(MAP3K3) 102033648(MAP3K2) 102033703(MAP3K20) 102035976(MAP3K8) 102038763(MAP3K14) 102040792(MAP3K13) 102041684(MAP3K21) 102044243 102044899(MAP3K1)
FAB: 101807669(MAP3K1) 101810116(MAP3K20) 101811653(MAP3K2) 101812912(MAP3K13) 101813386(MAP3K14) 101813992(MAP3K3) 101816945(MAP3K21) 101817004 101819414(MAP3K8)
PHI: 102102554(MAP3K20) 102103765(MAP3K1) 102106417(MAP3K21) 102108460 102112025(MAP3K13) 102112033(MAP3K3) 102113050(MAP3K2) 102113463(MAP3K14) 102114163(MAP3K8)
PMAJ: 107200237 107200816(MAP3K8) 107201984(MAP3K21) 107207509(MAP3K20) 107207590(MAP3K2) 107208746(MAP3K13) 107215258(MAP3K3) 107215307(MAP3K14) 107216401(MAP3K1)
CCAE: 111924099(MAP3K8) 111925531 111926874(MAP3K21) 111932076(MAP3K20) 111932210(MAP3K2) 111933696(MAP3K13) 111939927(MAP3K3) 111940095(MAP3K14) 111941445(MAP3K1)
CCW: 104684293(MAP3K21) 104686414 104686470(MAP3K8) 104686679(MAP3K1) 104693868(MAP3K20) 104693990(MAP3K2) 104696697(MAP3K13) 104698524(MAP3K14) 104698629(MAP3K3)
ETL: 114054812(MAP3K13) 114054911(MAP3K20) 114055129(MAP3K1) 114060299(MAP3K8) 114064004(MAP3K21) 114065134 114066926(MAP3K3) 114068663(MAP3K14)
FPG: 101910755(MAP3K20) 101911178(MAP3K1) 101911986(MAP3K6) 101912446(MAP3K3) 101914815(MAP3K21) 101916440(MAP3K13) 101919762(MAP3K14) 101921040(MAP3K8) 101921462(MAP3K2) 101923251
FCH: 102045898(MAP3K1) 102047801(MAP3K3) 102048630(MAP3K14) 102050351 102050412(MAP3K13) 102051326(MAP3K20) 102052421(MAP3K21) 102052668(MAP3K2) 102055830(MAP3K8) 102060113(MAP3K6)
CLV: 102085060(MAP3K3) 102085165(MAP3K20) 102087091(MAP3K8) 102088147 102088332(MAP3K14) 102089200(MAP3K21) 102091011(MAP3K13) 102092494(MAP3K2) 102097744(MAP3K1)
EGZ: 104128061 104130961 104131021 104131267(MAP3K13) 104132232(MAP3K14) 104133587(MAP3K8) 104133722(MAP3K2) 104134638(MAP3K3) 104134700(MAP3K1) 104134937(MAP3K6)
NNI: 104009891(MAP3K3) 104010005 104010621(MAP3K13) 104011958(MAP3K1) 104015344 104017829(MAP3K6) 104018900(MAP3K14) 104021753 104022250(MAP3K8)
ACUN: 113476643(MAP3K8) 113477214 113478674(MAP3K21) 113482184(MAP3K20) 113483720(MAP3K13) 113488380(MAP3K6) 113489126(MAP3K3) 113489146(MAP3K14) 113489657(MAP3K1)
PADL: 103913871(MAP3K3) 103916918(MAP3K13) 103918240(MAP3K8) 103919424(MAP3K1) 103921283 103921921(MAP3K14) 103924192 103924744
AAM: 106487372(MAP3K21) 106489958(MAP3K8) 106493178(MAP3K13) 106495649(MAP3K14) 106497426(MAP3K3) 106499249(MAP3K20) 106499278(MAP3K2)
ASN: 102368863 102374958(MAP3K3) 102375647(MAP3K20) 102376941(MAP3K1) 102379177(MAP3K6) 102379289 102380826(MAP3K21) 102381053(MAP3K13) 102387437(MAP3K8) 102388858(MAP3K14)
AMJ: 102559099(MAP3K21) 102560853(MAP3K6) 102562794(MAP3K1) 102566049(MAP3K13) 102566471(MAP3K8) 102568383(MAP3K20) 102572648 102574412(MAP3K2) 102575720(MAP3K14) 106736961(MAP3K3)
PSS: 102444358(MAP3K20) 102448094(MAP3K2) 102449623(MAP3K8) 102453748(MAP3K13) 102454634(MAP3K3) 102454880 102455384(MAP3K21) 102456989(MAP3K6) 102463619(MAP3K1) 102464024(MAP3K14)
CMY: 102930570(MAP3K3) 102931859 102933894(MAP3K6) 102936511(MAP3K8) 102936755(MAP3K21) 102938448(MAP3K1) 102939329(MAP3K13) 102939834(MAP3K14) 102941356(MAP3K2) 102941563(MAP3K20)
CPIC: 101932285(MAP3K14) 101933464(MAP3K1) 101934711(MAP3K2) 101939982(MAP3K13) 101940564(MAP3K20) 101941097(MAP3K8) 101942215(MAP3K6) 101948589 101950530(MAP3K10) 101951773(MAP3K21) 101953672(MAP3K3)
ACS: 100552553(map3k6) 100553164(map3k12) 100556486(map3k9) 100557698(map3k3) 100558170(map3k2) 100558270(map3k13) 100558842(map3k21) 100560190(map3k14) 100561745(map3k1) 100562159 100562883(map3k8) 100565973(map3k10) 100566960(map3k20) 100568169(map3k15)
PVT: 110075498(MAP3K21) 110075665(MAP3K10) 110075834(MAP3K13) 110080317(MAP3K3) 110081369(MAP3K14) 110082918(MAP3K8) 110085271(MAP3K2) 110085400(MAP3K1) 110085837 110088423(MAP3K6) 110088583(MAP3K20)
PBI: 103048285(MAP3K1) 103049938(MAP3K2) 103053098(MAP3K13) 103054161(MAP3K20) 103061668(MAP3K21) 103064348(MAP3K8) 103064885 103065661(MAP3K6) 103066049(MAP3K14) 103066986(MAP3K3) 112541949(MAP3K10)
PMUR: 107282828(MAP3K8) 107284356 107285893(MAP3K13) 107290426(MAP3K20) 107291593(MAP3K21) 107292307(MAP3K1) 107294312(MAP3K6) 107302364(MAP3K3) 107303029(MAP3K14)
TSR: 106540521(MAP3K3) 106540861(MAP3K1) 106541826 106542520(MAP3K14) 106544597(MAP3K13) 106545629 106546812 106548273(MAP3K6) 106548362(MAP3K8) 106554890
PMUA: 114581713(MAP3K3) 114581835(MAP3K14) 114594397(MAP3K21) 114597691(MAP3K13) 114601490(MAP3K6) 114603188(MAP3K10) 114606876(MAP3K20) 114606892(MAP3K1) 114607438 114607849(MAP3K8)
GJA: 107107052(MAP3K20) 107107352(MAP3K21) 107107364(MAP3K10) 107107910(MAP3K8) 107116392 107116647(MAP3K6) 107117807(MAP3K2) 107123377(MAP3K1) 107123584(MAP3K13) 107125527(MAP3K14)
XLA: 100113430(map3k12.S) 100126613(map3k4.S) 100337576(map3k12.L) 100337577(map3k13.S) 100337578(map3k13.L) 100381159(map3k9.L) 101027300 101027301 108699730(map3k9.S) 108700848(map3k14.L) 108701261(map3k2.L) 108701280(map3k19.L) 108701764 108702551(map3k14.S) 108702560 108702901(map3k2.S) 108702997 108704427(map3k1.S) 108708008 108708885 108717885 108718321(map3k1.L) 108718772(map3k8.L) 108719812 108719849(map3k8.S) 379399(map3k7.S) 398612(map3k10.L) 399459(map3k7.L) 734336(map3k3.L)
XTR: 100101764(map3k7) 100488058(map3k10) 100488307(map3k12) 100488360(map3k22) 100488738(map3k19) 100488949(map3k9) 100489201(map3k14) 100490021(map3k3) 100490504(map3k1) 100493069(map3k8) 100493570(map3k2) 100493878(map3k13) 100495797(map3k20) 100497217(map3k4) 100497692(map3k5)
NPR: 108784622 108785393(MAP3K2) 108785983(MAP3K14) 108788845(MAP3K8) 108792018(MAP3K1) 108794093(MAP3K10) 108795599(MAP3K13) 108800631 108802493(MAP3K3)
DRE: 100004261(map3k14a) 100005496(si:ch211-1i11.3) 100334289(map3k15) 100334486(map3k1) 101886393 325488(map3k4) 404626(map3k12) 553788(map3k7) 555703(map3k5) 558321(map3k2) 559247(zak) 560211(map3k3) 560639(map3k9) 560932(map3k10) 561518(si:ch211-120p12.3) 563727(map3k8) 568412(si:ch211-45c16.2) 572217(map3k19) 795766
IPU: 108256020(map3k3) 108256334 108259239 108263591 108263809 108264755(map3k10) 108266646(map3k20) 108266772(map3k13) 108272715(map3k2) 108274187(map3k8) 108277254(map3k1)
PHYP: 113525868(map3k20) 113525928 113526695(map3k10) 113527715(map3k8) 113528261 113528353(map3k3) 113533797 113541066 113543563(map3k1) 113544164(map3k21)
AMEX: 103026704(map3k2) 103031259(map3k8) 103031546(map3k10) 103031965(map3k20) 103032151(map3k13) 103034596(map3k3) 103039485 103042517(map3k1) 103042822 103043321 103044968 103047161
TRU: 101061953 101063413(map3k13) 101064896(map3k20) 101067596 101068242(map3k10) 101068369 101069247(map3k8) 101069746(map3k2) 101070474 101072543(map3k3) 101074328(map3k19) 101075070(map3k21) 101079141
LCO: 104923921 104927785(map3k20) 104928818(map3k8) 104928841(map3k13) 104930222(map3k3) 104931530(map3k21) 104931623(map3k10) 104934606(map3k2) 104937092 104938682 109142828
ONL: 100689980(map3k21) 100692691(map3k3) 100695481(map3k20) 100695488 100704108(map3k10) 100707432 100710682(map3k8) 100711264 100711574(map3k13) 100712512
OLA: 101156127 101159779(map3k8) 101160297(map3k2) 101160858(map3k20) 101161665(map3k10) 101166009 101166422 101168074 101168084(map3k19) 101169290(map3k3) 101170310(map3k13) 101172131 101174595
XMA: 102217174 102220942(map3k13) 102222970(map3k10) 102224137 102228349 102228804(map3k20) 102232571(map3k2) 102234853(map3k3) 102235260(map3k8) 102235269 102235544
XCO: 114133159(map3k10) 114136809 114137073(map3k8) 114138146(map3k21) 114147068 114148301(map3k13) 114148676(map3k20) 114151841 114160172(map3k3) 114160257
KMR: 108230337 108237722 108239514 108239697(map3k20) 108240785(map3k13) 108240940(map3k10) 108245069 108246150(map3k14) 108247128(map3k8)
POV: 109629507(map3k8) 109629552 109629839 109630421(map3k10) 109630891(map3k21) 109631351(map3k20) 109631386(map3k13) 109633940 109633995(map3k3) 109638628 109645298
SDU: 111217593(map3k3) 111217746 111218353(map3k20) 111218550(map3k13) 111219576 111221016 111222725(map3k2) 111228231(map3k8) 111228953 111235336 111238128(map3k10)
HCQ: 109507895(map3k20) 109510165 109514181(map3k8) 109518541 109519328 109519483 109523279(map3k13) 109526404(map3k10) 109532434(map3k3)
BPEC: 110156771 110159957(map3k13) 110160986 110163573(map3k10) 110165688(map3k2) 110166574(map3k20) 110167886(map3k3) 110168889 110173386
MALB: 109955649(map3k2) 109957145(map3k13) 109958042(map3k20) 109960851 109961492 109962735 109963171(map3k3) 109964259 109969321 109974338(map3k10) 109974520(map3k8)
ELS: 105006267(map3k13) 105007215 105007693 105007974 105011943(map3k10) 105012974(map3k3) 105013210 105016206(map3k20) 105019416(map3k8) 105019952(map3k2) 105021218(map3k21) 105021721(map3k1)
LCM: 102347264 102350357 102350566(MAP3K2) 102351315(MAP3K14) 102353974(MAP3K3) 102355070(MAP3K1) 102364913(MAP3K20) 102367402(MAP3K13) 102367513(MAP3K8)
CMK: 103176455(map3k20) 103177870(map3k1) 103179260(map3k21) 103186428(map3k8) 103187711(map3k3) 103189809(map3k2) 103189852 103190243(map3k10) 103190572(map3k13)
DME: Dmel_CG18492(Tak1) Dmel_CG2272(slpr) Dmel_CG31421(Takl1) Dmel_CG4720(Ask1) Dmel_CG4803(Takl2) Dmel_CG7717(Mekk1) Dmel_CG8789(wnd)
DSI: Dsimw501_GD12264(Dsim_GD12264)
DSR: 110190250
DMN: 108151443
DAZ: 108612355
DNV: 108650988
DHE: 111605082
MDE: 101899738
LCQ: 111676608
AALB: 109425664
BIM: 100746449
BTER: 100644256
CCAL: 108625769
OBB: 114882625
SOC: 105198030
MPHA: 105828610
AEC: 105151574
ACEP: 105619459
PBAR: 105430207
VEM: 105567136
HST: 105188954
DQU: 106750938
CFO: 105258073
LHU: 105672726
PGC: 109863644
OBO: 105274700
PCF: 106791581
CSOL: 105360508
MDL: 103572708
TCA: 656961(Tak1) 661249 661365
DPA: 109541834
ATD: 109605479
NVL: 108556382
BMAN: 114246957
PMAC: 106717093
PRAP: 111003386
HAW: 110377574
TNL: 113499874
PXY: 105384868
DNX: 107173780
AGS: 114124283
RMD: 113551166
BTAB: 109043842
CLEC: 106663798
FCD: 110842400
TUT: 107371029
CEL: CELE_B0414.7(mtk-1) CELE_F33E2.2(dlk-1) CELE_F52F12.3(mom-4) CELE_F59A6.1(nsy-1) CELE_K11D12.10(mlk-1) CELE_R13F6.6(zak-1) CELE_Y105C5A.24(Y105C5A.24)
CBR: CBG02299(Cbr-nsy-1) CBG03852(Cbr-mom-4) CBG04061(Cbr-mtk-1) CBG08663(Cbr-mlk-1) CBG08707(Cbr-dlk-1) CBG16544(Cbr-zak-1)
TSP: Tsp_07016
SHX: MS3_10207
ATH: AT1G09000(NP1) AT1G53570(MAP3KA) AT1G54960(NP2) AT1G63700(YDA) AT4G08480(MAPKKK9) AT4G08500(MEKK1) AT5G11850
LJA: Lj0g3v0190659.1(Lj0g3v0190659.1) Lj0g3v0190659.2(Lj0g3v0190659.2) Lj1g3v1316910.1(Lj1g3v1316910.1) Lj1g3v1318210.1(Lj1g3v1318210.1) Lj1g3v1318220.1(Lj1g3v1318220.1) Lj2g3v0343910.1(Lj2g3v0343910.1) Lj3g3v0950630.1(Lj3g3v0950630.1) Lj4g3v2742830.1(Lj4g3v2742830.1) Lj4g3v2742850.1(Lj4g3v2742850.1) Lj6g3v1089020.2(Lj6g3v1089020.2)
DOSA: Os02t0220700-01(Os02g0220700) Os03t0262200-00(Os03g0262200) Os03t0703400-01(Os03g0703400) Os04t0559800-01(Os04g0559800) Os08t0421800-01(Os08g0421800) Os11t0207200-01(Os11g0207200)
ATS: 109750728(LOC109750728) 109758282(LOC109758282) 109765252(LOC109765252)
SCE: YCR073C(SSK22) YJL095W(BCK1) YLR362W(STE11) YNR031C(SSK2)
ERC: Ecym_2499
KMX: KLMA_70196(SSK2)
NCS: NCAS_0A05370(NCAS0A05370) NCAS_0D04600(NCAS0D04600)
NDI: NDAI_0I00340(NDAI0I00340)
TPF: TPHA_0M01840(TPHA0M01840)
TBL: TBLA_0I02400(TBLA0I02400)
TDL: TDEL_0A07560(TDEL0A07560)
KAF: KAFR_0C04590(KAFR0C04590) KAFR_0F04340(KAFR0F04340)
SLB: AWJ20_3718(SSK2)
NCR: NCU02234(mik-1) NCU03071(os-4) NCU06182(nrc-1)
NTE: NEUTE1DRAFT91407(NEUTE1DRAFT_91407)
SMP: SMAC_02801(putative os4)
SSCK: SPSK_05828
MAW: MAC_03196
MAJ: MAA_04290
CMT: CCM_02296
MBE: MBM_05856
ANG: ANI_1_450074(An08g03240) ANI_1_456154(An17g01280) ANI_1_938024(An02g06830)
ABE: ARB_02855
TVE: TRV_05548
PNO: SNOG_07196(SNOG_07195) SNOG_07664 SNOG_12215
PTE: PTT_19769
ZTR: MYCGRDRAFT_67344(MgSsk2)
SPO: SPAC1006.09(win1) SPAC1F3.02c(mkh1) SPAC9G1.02(wis4) SPBC1D7.05(byr2)
MRR: Moror_310
ABP: AGABI1DRAFT117102(AGABI1DRAFT_117102)
ABV: AGABI2DRAFT214884(AGABI2DRAFT_214884)
MRT: MRET_1340
DDI: DDB_G0281557(drkD)
DFA: DFA_02737(drkD)
 » show all
Taxonomy
Reference
1  [PMID:8940179]
  Authors
Wang XS, Diener K, Jannuzzi D, Trollinger D, Tan TH, Lichenstein H, Zukowski M, Yao Z.
  Title
Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.
  Journal
J Biol Chem 271:31607-11 (1996)
DOI:10.1074/jbc.271.49.31607
  Sequence
[hsa:4217]
Reference
2  [PMID:11042189]
  Authors
Gotoh I, Adachi M, Nishida E.
  Title
Identification and characterization of a novel MAP kinase kinase kinase, MLTK.
  Journal
J Biol Chem 276:4276-86 (2001)
DOI:10.1074/jbc.M008595200
  Sequence
[hsa:51776] [mmu:65964]
Reference
3  [PMID:8334704]
  Authors
Vojtek AB, Hollenberg SM, Cooper JA.
  Title
Mammalian Ras interacts directly with the serine/threonine kinase Raf.
  Journal
Cell 74:205-14 (1993)
DOI:10.1016/0092-8674(93)90307-C
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.25
IUBMB Enzyme Nomenclature: 2.7.11.25
ExPASy - ENZYME nomenclature database: 2.7.11.25
BRENDA, the Enzyme Database: 2.7.11.25
CAS: 146702-84-3

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