KEGG   ENZYME: 2.7.11.26Help
Entry
EC 2.7.11.26                Enzyme                                 

Name
tau-protein kinase;
ATP:tau-protein O-hosphotransferase;
brain protein kinase PK40erk;
cdk5/p20;
CDK5/p23;
glycogen synthase kinase-3beta;
GSK;
protein tau kinase;
STK31;
tau kinase;
[tau-protein] kinase;
tau-protein kinase I;
tau-protein kinase II;
tau-tubulin kinase;
TPK;
TPK I;
TPK II;
TTK
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[tau-protein] O-phosphotransferase
Reaction(IUBMB)
ATP + [tau-protein] = ADP + O-phospho-[tau-protein]
Reaction(KEGG)
(other) R03744
Show
Substrate
ATP [CPD:C00002];
tau-protein [CPD:C01867]
Product
ADP [CPD:C00008];
O-phospho-tau-protein [CPD:C03157]
Comment
Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
History
EC 2.7.11.26 created 1990 as EC 2.7.1.135, transferred 2005 to EC 2.7.11.27
Orthology
K03083  glycogen synthase kinase 3 beta
K05960  tau-protein kinase
K08815  tau tubulin kinase
K08822  glycogen synthase kinase 3 alpha
Genes
HSA: 146057(TTBK2) 2931(GSK3A) 2932(GSK3B) 84630(TTBK1)
PTR: 100616510(GSK3B) 453368(TTBK2) 456071(GSK3A) 463190(TTBK1)
PPS: 100972306(GSK3B) 100978714(TTBK2) 100978760(GSK3A) 100987456(TTBK1)
GGO: 101124439(TTBK2) 101125534(GSK3B) 101134579(TTBK1) 101141646(GSK3A)
PON: 100438000(TTBK1) 100444083(GSK3A) 100447772(GSK3B) 100452395(TTBK2)
NLE: 100600490(TTBK2) 100601486(GSK3A) 100603779(TTBK1) 100606885(GSK3B)
MCC: 699913(TTBK1) 707037(GSK3A) 712249(TTBK2) 713114(GSK3B)
MCF: 101926713(GSK3A) 102121625(TTBK1) 102122682(TTBK2) 102133756(GSK3B)
CSAB: 103221469(TTBK1) 103228213(GSK3B) 103234762(GSK3A) 103245756(TTBK2)
RRO: 104658796(GSK3A) 104667343(TTBK1) 104678472(TTBK2) 104680990(GSK3B)
RBB: 108513885(GSK3A) 108519599(TTBK2) 108533470(TTBK1) 108541757(GSK3B)
CJC: 100387683(GSK3B) 100388003(TTBK2) 100402684(TTBK1) 100414131(GSK3A)
SBQ: 101031940(TTBK1) 101032416(TTBK2) 101045033(GSK3A) 101051107(GSK3B)
MMU: 106763(Ttbk1) 140810(Ttbk2) 56637(Gsk3b) 606496(Gsk3a)
RNO: 311349(Ttbk2) 316229(Ttbk1) 50686(Gsk3a) 84027(Gsk3b)
CGE: 100756759(Ttbk1) 100757049(Gsk3a) 100760865(Gsk3b) 100769455(Ttbk2)
NGI: 103730791(Ttbk1) 103741948(Gsk3b) 103744603(Gsk3a) 103744962(Ttbk2)
HGL: 101701301(Gsk3b) 101717285(Ttbk1) 101717440(Gsk3a) 101719202(Ttbk2)
CCAN: 109682183(Ttbk1) 109685333(Gsk3b) 109691879(Gsk3a) 109700056(Ttbk2)
OCU: 100338586(TTBK2) 100339192(GSK3A) 100348842(GSK3B) 100355205(TTBK1)
TUP: 102476038(GSK3B) 102476261(GSK3A) 102484027(TTBK1) 102498692(TTBK2)
CFA: 100684678(TTBK1) 478575(GSK3B) 484476(GSK3A) 487520(TTBK2)
AML: 100475697(TTBK1) 100476187(TTBK2) 100478597(GSK3A) 100479224(GSK3B)
UMR: 103664152(TTBK1) 103673413(TTBK2) 103678785(GSK3B) 103680179(GSK3A)
ORO: 101365718(GSK3B) 101374811(GSK3A) 101381066(TTBK2) 101382827(TTBK1)
FCA: 101081660(GSK3B) 101081810(TTBK2) 101084151(GSK3A) 101093857(TTBK1)
PTG: 102954186(GSK3A) 102958745(TTBK1) 102961382(GSK3B) 102966450(TTBK2)
AJU: 106968274(GSK3B) 106968498(TTBK2) 106973963(TTBK1) 106987692(GSK3A)
BTA: 536561(GSK3A) 541215(TTBK2) 786439(TTBK1) 790875(GSK3B)
BOM: 102271730(TTBK1) 102273970(GSK3A) 102275260(GSK3B) 102288406(TTBK2)
BIU: 109564995(TTBK2) 109571736(GSK3A) 109576573(TTBK1) 109578123(GSK3B) 109578227
PHD: 102321741(GSK3A) 102322657(TTBK1) 102333398(TTBK2) 102335629(GSK3B)
CHX: 102169294(TTBK2) 102176363(GSK3B) 102178314(TTBK1) 102178478(GSK3A)
OAS: 100169938(GSK3B) 101102753(GSK3A) 101111916(TTBK1) 101119052(TTBK2)
SSC: 100126852(GSK3B) 100155509(TTBK1) 100511488(TTBK2) 100515208(GSK3A)
CFR: 102504696(GSK3B) 102505222(GSK3A) 102506445 102510260(TTBK1) 102521295(TTBK2)
CDK: 105088618(TTBK1) 105090220(GSK3A) 105090321(GSK3B) 105101733(TTBK2)
BACU: 102997483(TTBK1) 102998893(GSK3B) 103002355(TTBK2) 103016833(GSK3A)
LVE: 103071307(GSK3A) 103074757(GSK3B) 103077272(TTBK1) 103085529(TTBK2)
OOR: 101279290(TTBK1) 101281974(GSK3A) 101283259(GSK3B) 101287145(TTBK2)
ECB: 100056539(TTBK2) 100061033(GSK3B) 100069693(GSK3A) 100147091(TTBK1)
EPZ: 103547424(GSK3B) 103548155(TTBK1) 103558829(GSK3A) 103563529(TTBK2)
EAI: 106828728(TTBK1) 106829188(GSK3B) 106841330(TTBK2) 106847952(GSK3A)
MYB: 102245889(TTBK1) 102248758(GSK3B) 102249480(TTBK2) 102250707(GSK3A)
MYD: 102751662(GSK3B) 102764322(TTBK1) 102765478(TTBK2) 102765679(GSK3A)
HAI: 109374469(GSK3A) 109382918(TTBK1) 109384053(TTBK2) 109388396(GSK3B)
PALE: 102882441(GSK3B) 102884617(TTBK2) 102895474(TTBK1) 102896740(GSK3A)
LAV: 100664225(TTBK1) 100669169(GSK3A) 100670366(TTBK2) 100675105(GSK3B)
MDO: 100010350(TTBK2) 100010778(TTBK1) 100012447(GSK3B)
SHR: 100920192(GSK3B) 100920380(GSK3A) 100925049(TTBK2) 100926406(TTBK1)
GGA: 416713(TTBK1) 418335(GSK3B) 423241(TTBK2)
MGP: 100540476 100545864(GSK3B) 100546498(TTBK2) 104909554(TTBK1)
CJO: 107310912(TTBK1) 107314898(TTBK2) 107319718(GSK3B)
APLA: 101791283(TTBK2) 101796937(TTBK1) 101802112(GSK3B)
ACYG: 106037022 106042797(TTBK2) 106044745(TTBK1) 106045720
TGU: 100220011(TTBK1) 100224604(GSK3B) 100232587(TTBK2)
GFR: 102034944(GSK3B) 102034952(TTBK1) 102041553(TTBK2)
FAB: 101807423(GSK3B) 101813154(TTBK1) 101813417(TTBK2)
PHI: 102105491(GSK3B) 102108325(TTBK2) 102110863(TTBK1)
PMAJ: 107201232(TTBK1) 107205227(GSK3B) 107205635(TTBK2)
CCW: 104683138(TTBK2) 104687192(GSK3B) 104696656(TTBK1)
FPG: 101921493(TTBK1) 101923550(TTBK2)
FCH: 102045699(TTBK1) 102054970(TTBK2) 102059271(GSK3B)
CLV: 102090893(GSK3B) 102093577(TTBK1) 102095941(TTBK2)
EGZ: 104126562(GSK3B) 104127558(TTBK2) 104128775(TTBK1)
AAM: 106494168(TTBK1) 106497256(GSK3B) 106498272(TTBK2)
ASN: 102373029(TTBK1) 102375673(GSK3A) 102375992(TTBK2) 102387985(GSK3B)
AMJ: 102568362(TTBK2) 102569716(GSK3A) 102574568(TTBK1) 106737044(GSK3B)
PSS: 102452191(TTBK2) 102453807(TTBK1) 102461748(GSK3B) 102463406(GSK3A)
CMY: 102935600(GSK3B) 102941443 102943063(TTBK1) 102945248(TTBK2)
CPIC: 101933208(GSK3A) 101933835(TTBK2) 101935079(GSK3B) 101940885(TTBK1) 101941447
ACS: 100555047(ttbk2) 100555307(gsk3a) 100560901(ttbk1) 100564023(gsk3b)
PVT: 110076947(GSK3B) 110078996(TTBK2) 110080746(TTBK1) 110086774(GSK3A)
PBI: 103051524(TTBK1) 103058366(TTBK2) 103066659(GSK3B)
GJA: 107108859(GSK3A) 107109342(GSK3B) 107110980(TTBK1) 107117892(TTBK2)
XLA: 100189575 108699183(ttbk2.L) 108699736(ttbk2.S) 108716561(ttbk1.L) 108717636(ttbk1.S) 398338(gsk3a.S) 399097(gsk3b.L) 779056
XTR: 100144645(gsk3a) 100489648(gsk3b) 780299(ttbk2)
NPR: 108793924(TTBK2) 108796464(TTBK1) 108801162(GSK3B)
DRE: 100000353(ttbk1b) 100331590(ttbk2a) 100332125(ttbk1a) 30654(gsk3b) 30664(gsk3ab) 560194(gsk3aa) 569881(ttbk2b)
XMA: 102219444(ttbk2) 102224919(gsk3b) 102227502(ttbk1) 102230000(gsk3a) 102231945 102236245
PRET: 103457432 103458398(ttbk2) 103459583(gsk3b) 103469629(ttbk1) 103472964 103477940(gsk3a)
NFU: 107377671 107379512(gsk3a) 107382291(ttbk1) 107389867(gsk3b) 107392092(ttbk2) 107394878
CSEM: 103380005(ttbk2) 103380920 103383360(ttbk1) 103387999(gsk3a) 103392124(gsk3b) 103393872
LCM: 102345091(TTBK2) 102349453(GSK3A) 102350787(GSK3B) 102366634(TTBK1)
CMK: 103177925(ttbk1) 103178472(ttbk2) 103180204(gsk3b)
CIN: 100176391 445595(gsk)
SPU: 582833 764638(gsk3b)
SKO: 100303595(gsk3b) 102806847
DME: Dmel_CG11533(Asator) Dmel_CG2621(sgg) Dmel_CG31003(gskt) Dmel_CG8201(par-1)
DSI: Dsimw501_GD11459(Dsim_GD11459) Dsimw501_GD21574(Dsim_GD21574) Dsimw501_GD24379(Dsim_GD24379)
AAG: 5566167
AME: 408976(sgg) 411575
TCA: 659527 664299(sgg)
CEL: CELE_C39H7.1(C39H7.1) CELE_C44H4.6(C44H4.6) CELE_F36H12.8(ttbk-2) CELE_K11C4.1(K11C4.1) CELE_R03D7.5(R03D7.5) CELE_R13H9.5(R13H9.5) CELE_R90.1(R90.1) CELE_Y18D10A.5(gsk-3) CELE_Y38H8A.3(Y38H8A.3)
HMG: 100203080(GSK3) 100210998
AQU: 100616537(Gsk3) 109584720
ATH: AT1G09840(SK41) AT1G57870(SK42) AT5G14640(SK13)
EGR: 104420009
CAM: 101499607
LJA: Lj0g3v0357589.1(Lj0g3v0357589.1) Lj6g3v2286310.1(Lj6g3v2286310.1) Lj6g3v2286310.2(Lj6g3v2286310.2)
ADU: 107482736
AIP: 107638504
LANG: 109345710
ZJU: 107412572
RCU: 8263267
DCR: 108208830
BVG: 104896931
SOE: 110797331
DOSA: Os01t0296100-01(Os01g0296100) Os03t0841800-01(Os03g0841800)
ATS: 109745525(LOC109745525) 109766472(LOC109766472)
ZMA: 100273692 103655927 541696(pco107502b) 542518(gpm645)
EGU: 105036107
DCT: 110109893
AOF: 109827173
VCN: VOLCADRAFT_80100(gsk3)
MPP: MICPUCDRAFT_30445(GSK3)
PIC: PICST_77550(RIM11)
CAL: CAALFM_C204280WA(CaO19.792) CAALFM_C204290WA(RIM11)
CAUR: QG37_00924
SLB: AWJ20_1413(RIM11)
NCR: NCU04185(prk-1)
NTE: NEUTE1DRAFT115704(NEUTE1DRAFT_115704)
SMP: SMAC_04408(putative rim11)
MGR: MGG_12122
TRE: TRIREDRAFT_74400(gsk3)
MAW: MAC_05229
MAJ: MAA_07562
CMT: CCM_03795
MBE: MBM_03205
ANI: AN6508.2
ANG: ANI_1_32134(An15g00170)
ABE: ARB_04291
TVE: TRV_06272
PTE: PTT_18800
ZTR: MYCGRDRAFT_100881(GSK3)
PFJ: MYCFIDRAFT_50287(GSK3)
SPO: SPAC1687.15(gsk3) SPBC8D2.01(gsk31)
CNE: CNB00720
CNB: CNBB4980
ABP: AGABI1DRAFT111475(AGABI1DRAFT_111475)
ABV: AGABI2DRAFT190701(AGABI2DRAFT_190701)
MGL: MGL_1055
DFA: DFA_06870(gskA) DFA_08988(glkA) DFA_10822
EHI: EHI_003900(370.t00002) EHI_121880(147.t00016)
PYO: PY17X_0412900(PY01719) PY17X_1416200(PY06554)
PCB: PCHAS_041130(PC001308.02.0) PCHAS_141630(PC000418.03.0)
TAN: TA02550
CPV: cgd4_240
SMIN: v1.2.003582.t1(symbB.v1.2.003582.t1) v1.2.003582.t2(symbB.v1.2.003582.t2) v1.2.011523.t1(symbB.v1.2.011523.t1) v1.2.015655.t1(symbB.v1.2.015655.t1) v1.2.026205.t1(symbB.v1.2.026205.t1) v1.2.026205.t2(symbB.v1.2.026205.t2) v1.2.026205.t3(symbB.v1.2.026205.t3) v1.2.039074.t1(symbB.v1.2.039074.t1)
TPS: THAPSDRAFT_38559(GSK-3)
 » show all
Taxonomy
Reference
1  [PMID:2467901]
  Authors
Ishiguro K, Ihara Y, Uchida T, Imahori K.
  Title
A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau.
  Journal
J Biochem (Tokyo) 104:319-21 (1988)
Reference
2  [PMID:11181841]
  Authors
Lund ET, McKenna R, Evans DB, Sharma SK, Mathews WR.
  Title
Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry.
  Journal
J Neurochem 76:1221-32 (2001)
DOI:10.1046/j.1471-4159.2001.00130.x
Reference
3  [PMID:9565682]
  Authors
Michel G, Mercken M, Murayama M, Noguchi K, Ishiguro K, Imahori K, Takashima A.
  Title
Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells.
  Journal
Biochim Biophys Acta 1380:177-82 (1998)
DOI:10.1016/S0304-4165(97)00139-6
Reference
4  [PMID:11053853]
  Authors
Aoki M, Iwamoto-Sugai M, Sugiura I, Sasaki C, Hasegawa T, Okumura C, Sugio S, Kohno T, Matsuzaki T.
  Title
Expression, purification and crystallization of human tau-protein kinase I/glycogen synthase kinase-3beta.
  Journal
Acta Crystallogr D Biol Crystallogr 56 ( Pt 11):1464-5 (2000)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.26
IUBMB Enzyme Nomenclature: 2.7.11.26
ExPASy - ENZYME nomenclature database: 2.7.11.26
BRENDA, the Enzyme Database: 2.7.11.26
CAS: 111694-09-8

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