KEGG   ENZYME: 2.7.11.26Help
Entry
EC 2.7.11.26                Enzyme                                 

Name
tau-protein kinase;
ATP:tau-protein O-hosphotransferase;
brain protein kinase PK40erk;
cdk5/p20;
CDK5/p23;
glycogen synthase kinase-3beta;
GSK;
protein tau kinase;
STK31;
tau kinase;
[tau-protein] kinase;
tau-protein kinase I;
tau-protein kinase II;
tau-tubulin kinase;
TPK;
TPK I;
TPK II;
TTK
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[tau-protein] O-phosphotransferase
Reaction(IUBMB)
ATP + [tau-protein] = ADP + O-phospho-[tau-protein]
Reaction(KEGG)
(other) R03744
Show
Substrate
ATP [CPD:C00002];
tau-protein [CPD:C01867]
Product
ADP [CPD:C00008];
O-phospho-tau-protein [CPD:C03157]
Comment
Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
History
EC 2.7.11.26 created 1990 as EC 2.7.1.135, transferred 2005 to EC 2.7.11.27
Orthology
K03083  glycogen synthase kinase 3 beta
K05960  tau-protein kinase
K08815  tau tubulin kinase
K08822  glycogen synthase kinase 3 alpha
Genes
HSA: 146057(TTBK2) 2931(GSK3A) 2932(GSK3B) 84630(TTBK1)
PTR: 100616510(GSK3B) 453368(TTBK2) 456071(GSK3A) 463190(TTBK1)
PPS: 100978760(GSK3A)
GGO: 101141646(GSK3A)
PON: 100438000(TTBK1) 100444083(GSK3A) 100447772(GSK3B) 100452395(TTBK2)
NLE: 100601486(GSK3A)
MCC: 699913(TTBK1) 707037(GSK3A) 712249(TTBK2) 713114(GSK3B)
MCF: 101926713(GSK3A)
CSAB: 103234762(GSK3A)
RRO: 104658796(GSK3A)
RBB: 108513885(GSK3A)
CJC: 100414131(GSK3A)
SBQ: 101045033(GSK3A)
MMU: 106763(Ttbk1) 140810(Ttbk2) 56637(Gsk3b) 606496(Gsk3a)
MCAL: 110298326(Gsk3a)
MPAH: 110336376(Gsk3a)
RNO: 311349(Ttbk2) 316229(Ttbk1) 50686(Gsk3a) 84027(Gsk3b)
MUN: 110563908(Gsk3a)
CGE: 100757049(Gsk3a)
NGI: 103744603(Gsk3a)
HGL: 101717440(Gsk3a)
CCAN: 109691879(Gsk3a)
OCU: 100339192(GSK3A)
TUP: 102476261(GSK3A)
CFA: 100684678(TTBK1) 478575(GSK3B) 484476(GSK3A) 487520(TTBK2)
VVP: 112931560(GSK3A)
AML: 100475697(TTBK1) 100476187(TTBK2) 100478597(GSK3A) 100479224(GSK3B)
UMR: 103680179(GSK3A)
UAH: 113243514(GSK3A)
ORO: 101374811(GSK3A)
ELK: 111139521
FCA: 101084151(GSK3A)
PTG: 102954186(GSK3A)
PPAD: 109257965(GSK3A)
AJU: 106987692(GSK3A)
BTA: 536561(GSK3A) 541215(TTBK2) 786439(TTBK1) 790875(GSK3B)
BOM: 102273970(GSK3A)
BIU: 109571736(GSK3A)
BBUB: 102398502(GSK3A)
CHX: 102178478(GSK3A)
OAS: 101102753(GSK3A)
SSC: 100126852(GSK3B) 100155509(TTBK1) 100511488(TTBK2) 100515208(GSK3A)
CFR: 102505222(GSK3A) 102506445
CDK: 105090220(GSK3A)
BACU: 103016833(GSK3A)
LVE: 103071307(GSK3A)
OOR: 101281974(GSK3A)
DLE: 111180810(GSK3A)
PCAD: 102991994(GSK3A)
ECB: 100056539(TTBK2) 100061033(GSK3B) 100069693(GSK3A) 100147091(TTBK1)
EPZ: 103558829(GSK3A)
EAI: 106847952(GSK3A)
MYB: 102250707(GSK3A)
MYD: 102765679(GSK3A)
MNA: 107534159(GSK3A)
HAI: 109374469(GSK3A)
DRO: 112320087(GSK3A)
PALE: 102896740(GSK3A)
RAY: 107502598(GSK3A)
MJV: 108393369(GSK3A)
LAV: 100669169(GSK3A)
TMU: 101361052
MDO: 100010350(TTBK2) 100010778(TTBK1) 100012447(GSK3B)
PCW: 110219712(GSK3A)
OAA: 100084279(TTBK1) 100092089(GSK3B) 103169350(TTBK2) 114812208(GSK3A)
GGA: 416713(TTBK1) 418335(GSK3B) 423241(TTBK2)
TGU: 100220011(TTBK1) 100224604(GSK3B) 100232587(TTBK2)
ASN: 102375673(GSK3A)
AMJ: 102569716(GSK3A)
PSS: 102463406
CMY: 102941443
CPIC: 101933208(GSK3A)
ACS: 100555307(gsk3a) 100564023(gsk3b)
PMUR: 107296360(GSK3A)
TSR: 106553381
PMUA: 114603375(GSK3A)
GJA: 107108859(GSK3A)
XLA: 100189575 108699183(ttbk2.L) 108699736(ttbk2.S) 108716561(ttbk1.L) 108717636(ttbk1.S) 398338(gsk3a.S) 399097(gsk3b.L) 779056
XTR: 100144645(gsk3a) 100489648(gsk3b) 780299(ttbk2)
NPR: 108785664(GSK3A)
DRE: 100000353(ttbk1b) 100331590(ttbk2a) 100332125(ttbk1a) 30654(gsk3ba) 30664(gsk3ab) 560194(gsk3aa) 569881(ttbk2b)
IPU: 108266398(gsk3a)
PHYP: 113542294(gsk3a)
AMEX: 103032471 103036469(gsk3a)
XMA: 102230000(gsk3a) 102236245
XCO: 114138946(gsk3a) 114155447
PRET: 103472964 103477940(gsk3a)
CVG: 107090180 107102327(gsk3a)
NFU: 107379512(gsk3a) 107394878
KMR: 108235549(gsk3a) 108249892
CSEM: 103387999(gsk3a) 103393872
MALB: 109966159(gsk3a)
SFM: 108922122(gsk3a)
PKI: 111842913(gsk3a)
LCM: 102349453(GSK3A)
CIN: 100176391 445595(gsk)
DME: Dmel_CG11533(Asator) Dmel_CG2621(sgg) Dmel_CG31003(gskt) Dmel_CG8201(par-1)
DSI: Dsimw501_GD11459(Dsim_GD11459)
DPE: 6598854
DAZ: 108609811
AAG: 5566167
TCA: 659527
CEL: CELE_C39H7.1(C39H7.1) CELE_C44H4.6(C44H4.6) CELE_F36H12.8(ttbk-2) CELE_K11C4.1(K11C4.1) CELE_R03D7.5(R03D7.5) CELE_R13H9.5(R13H9.5) CELE_R90.1(ttbk-7) CELE_Y18D10A.5(gsk-3) CELE_Y38H8A.3(Y38H8A.3)
SHX: MS3_09258
HMG: 100203080(GSK3) 100210998
ATH: AT1G09840(SK41) AT1G57870(SK42) AT5G14640(SK13)
PIC: PICST_77550(RIM11)
CAL: CAALFM_C204280WA(CaO19.792) CAALFM_C204290WA(RIM11)
NCR: NCU04185(prk-1)
SMP: SMAC_04408(putative rim11)
MGR: MGG_12122
ANI: AN6508.2
ANG: ANI_1_32134(An15g00170)
ABE: ARB_04291
TVE: TRV_06272
PTE: PTT_18800
SPO: SPAC1687.15(gsk3) SPBC8D2.01(gsk31)
CNE: CNB00720
CNB: CNBB4980
MGL: MGL_1055
DFA: DFA_10822
EHI: EHI_003900(370.t00002) EHI_121880(147.t00016)
TAN: TA02550
CPV: cgd4_240
TPS: THAPSDRAFT_38559(GSK-3)
 » show all
Taxonomy
Reference
1  [PMID:2467901]
  Authors
Ishiguro K, Ihara Y, Uchida T, Imahori K.
  Title
A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau.
  Journal
J Biochem (Tokyo) 104:319-21 (1988)
Reference
2  [PMID:11181841]
  Authors
Lund ET, McKenna R, Evans DB, Sharma SK, Mathews WR.
  Title
Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry.
  Journal
J Neurochem 76:1221-32 (2001)
DOI:10.1046/j.1471-4159.2001.00130.x
Reference
3  [PMID:9565682]
  Authors
Michel G, Mercken M, Murayama M, Noguchi K, Ishiguro K, Imahori K, Takashima A.
  Title
Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells.
  Journal
Biochim Biophys Acta 1380:177-82 (1998)
DOI:10.1016/S0304-4165(97)00139-6
Reference
4  [PMID:11053853]
  Authors
Aoki M, Iwamoto-Sugai M, Sugiura I, Sasaki C, Hasegawa T, Okumura C, Sugio S, Kohno T, Matsuzaki T.
  Title
Expression, purification and crystallization of human tau-protein kinase I/glycogen synthase kinase-3beta.
  Journal
Acta Crystallogr D Biol Crystallogr 56 ( Pt 11):1464-5 (2000)
DOI:10.1107/S0907444900010386
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.26
IUBMB Enzyme Nomenclature: 2.7.11.26
ExPASy - ENZYME nomenclature database: 2.7.11.26
BRENDA, the Enzyme Database: 2.7.11.26
CAS: 111694-09-8

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