| Entry |
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| Name |
tau-protein kinase;
ATP:tau-protein O-hosphotransferase;
brain protein kinase PK40erk;
cdk5/p20;
CDK5/p23;
glycogen synthase kinase-3beta;
GSK;
protein tau kinase;
STK31;
tau kinase;
[tau-protein] kinase;
tau-protein kinase I;
tau-protein kinase II;
tau-tubulin kinase;
TPK;
TPK I;
TPK II;
TTK
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
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| Sysname |
ATP:[tau-protein] O-phosphotransferase
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| Reaction(IUBMB) |
ATP + [tau-protein] = ADP + O-phospho-[tau-protein]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
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| History |
EC 2.7.11.26 created 1990 as EC 2.7.1.135, transferred 2005 to EC 2.7.11.27
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| Orthology |
| K03083 | glycogen synthase kinase 3 beta |
| K08822 | glycogen synthase kinase 3 alpha |
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| Genes |
» show all
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| Reference |
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| Authors |
Ishiguro K, Ihara Y, Uchida T, Imahori K. |
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| Title |
A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau. |
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| Journal |
J Biochem (Tokyo) 104:319-21 (1988) |
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| Reference |
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| Authors |
Lund ET, McKenna R, Evans DB, Sharma SK, Mathews WR. |
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| Title |
Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry. |
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| Journal |
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| Reference |
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| Authors |
Michel G, Mercken M, Murayama M, Noguchi K, Ishiguro K, Imahori K, Takashima A. |
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| Title |
Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells. |
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| Journal |
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| Reference |
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| Authors |
Aoki M, Iwamoto-Sugai M, Sugiura I, Sasaki C, Hasegawa T, Okumura C, Sugio S, Kohno T, Matsuzaki T. |
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| Title |
Expression, purification and crystallization of human tau-protein kinase I/glycogen synthase kinase-3beta. |
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| Journal |
Acta Crystallogr D Biol Crystallogr 56 ( Pt 11):1464-5 (2000) |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.7.11.26 |
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