KEGG   ENZYME: 2.7.11.28Help
Entry
EC 2.7.11.28                Enzyme                                 

Name
tropomyosin kinase;
tropomyosin kinase (phosphorylating);
STK
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:tropomyosin O-phosphotransferase
Reaction(IUBMB)
ATP + tropomyosin = ADP + O-phosphotropomyosin [RN:R02980]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
tropomyosin [CPD:C00839]
Product
ADP [CPD:C00008];
O-phosphotropomyosin [CPD:C03016]
Comment
The enzyme phosphorylates casein equally well, and histone and phosvitin to a lesser extent. The acceptor is a serine residue in the protein.
History
EC 2.7.11.28 created 1990 as EC 2.7.1.132, transferred 2005 to EC 2.7.11.28
Reference
1  [PMID:3593768]
  Authors
deBelle I, Mak AS.
  Title
Isolation and characterization of tropomyosin kinase from chicken embryo.
  Journal
Biochim Biophys Acta 925:17-26 (1987)
DOI:10.1016/0304-4165(87)90143-7
Reference
2  [PMID:6325440]
  Authors
Montgomery K, Mak AS.
  Title
In vitro phosphorylation of tropomyosin by a kinase from chicken embryo.
  Journal
J Biol Chem 259:5555-60 (1984)
Reference
3  [PMID:3166994]
  Authors
Watson MH, Taneja AK, Hodges RS, Mak AS.
  Title
Phosphorylation of alpha alpha- and beta beta-tropomyosin and synthetic peptide analogues.
  Journal
Biochemistry 27:4506-12 (1988)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.28
IUBMB Enzyme Nomenclature: 2.7.11.28
ExPASy - ENZYME nomenclature database: 2.7.11.28
BRENDA, the Enzyme Database: 2.7.11.28
CAS: 90804-56-1

DBGET integrated database retrieval system