KEGG ENZYME: 2.7.11.3

ENZYME: 2.7.11.3

Entry

EC 2.7.11.3                 Enzyme

Name

dephospho-[reductase kinase] kinase;
AMP-activated kinase;
AMP-activated protein kinase kinase;
hydroxymethylglutaryl coenzyme A reductase kinase kinase;
hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating);
reductase kinase;
reductase kinase kinase;
STK30

Class

Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases

Sysname

ATP:dephospho-{[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} phosphotransferase

Reaction(IUBMB)

ATP + dephospho-{[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} = ADP + {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} [RN:R04589]

Reaction(KEGG)

R04589

Substrate

ATP [CPD:C00002];
dephospho-{[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase}

Product

ADP [CPD:C00008];
{[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase}

Comment

The enzyme is activated by AMP and is specific for its substrate. Phosphorylates and activates EC 2.7.11.31, [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase, that has been inactivated by EC 3.1.3.16, protein-serine/threonine phosphatase.

History

EC 2.7.11.3 created 1984 as EC 2.7.1.110, transferred 2005 to EC 2.7.11.3

Reference

1 [PMID:291971]

Authors

Beg ZH, Stonik JA, Brewer HB Jr.

Title

Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Journal

Proc Natl Acad Sci U S A 76:4375-9 (1979)
DOI:10.1073/pnas.76.9.4375

Reference

2 [PMID:666819]

Authors

Ingebritsen TS, Lee HS, Parker RA, Gibson DM.

Title

Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation.

Journal

Biochem Biophys Res Commun 81:1268-77 (1978)
DOI:10.1016/0006-291X(78)91273-1

Reference

3 [PMID:3155737]

Authors

Beg ZH, Stonik JA, Brewer HB Jr.

Title

Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase.

Journal

J Biol Chem 260:1682-7 (1985)

Reference

4 [PMID:2369897]

Authors

Clarke PR, Hardie DG.

Title

Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver.

Journal

EMBO J 9:2439-46 (1990)
DOI:10.1002/j.1460-2075.1990.tb07420.x

Reference

5 [PMID:8415689]

Authors

Sato R, Goldstein JL, Brown MS.

Title

Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion.

Journal

Proc Natl Acad Sci U S A 90:9261-5 (1993)
DOI:10.1073/pnas.90.20.9261

Other DBs

ExplorEnz - The Enzyme Database:

2.7.11.3

IUBMB Enzyme Nomenclature:

2.7.11.3

ExPASy - ENZYME nomenclature database:

2.7.11.3

BRENDA, the Enzyme Database:

2.7.11.3

CAS:	72060-33-4

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
All databases (6)   

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