KEGG ENZYME: 2.7.11.31

ENZYME: 2.7.11.31

Entry

EC 2.7.11.31                Enzyme

Name

[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase;
AMPK;
AMP-activated protein kinase;
HMG-CoA reductase kinase;
beta-hydroxy-beta-methylglutaryl-CoA reductase kinase;
[hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase;
3-hydroxy-3-methylglutaryl coenzyme A reductase kinase;
3-hydroxy-3-methylglutaryl-CoA reductase kinase;
hydroxymethylglutaryl coenzyme A reductase kinase;
hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating);
hydroxymethylglutaryl-CoA reductase kinase;
reductase kinase;
STK29

Class

Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases

Sysname

ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase

Reaction(IUBMB)

ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate [RN:R04555]

Reaction(KEGG)

R04555

Substrate

ATP [CPD:C00002];
[hydroxymethylglutaryl-CoA reductase (NADPH)] [CPD:C04632]

Product

ADP [CPD:C00008];
[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate [CPD:C04768]

Comment

The enzyme is activated by AMP. EC 1.1.1.34, hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC 6.4.1.2) and adipose hormone-sensitive lipase (EC 3.1.1.79) [5]. Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase [7]. GTP can act instead of ATP [4]

History

EC 2.7.11.31 created 1984 as EC 2.7.1.109, transferred 2005 to EC 2.7.11.31

Reference

1 [PMID:278983]

Authors

Beg ZH, Stonik JA, Brewer HB Jr.

Title

3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation.

Journal

Proc Natl Acad Sci U S A 75:3678-82 (1978)
DOI:10.1073/pnas.75.8.3678

Reference

2 [PMID:216867]

Authors

Gibson DM, Ingebritsen TS.

Title

Reversible modulation of liver hydroxymethylglutaryl CoA reductase.

Journal

Life Sci 23:2649-64 (1978)
DOI:10.1016/0024-3205(78)90644-6

Reference

3 [PMID:666819]

Authors

Ingebritsen TS, Lee HS, Parker RA, Gibson DM.

Title

Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation.

Journal

Biochem Biophys Res Commun 81:1268-77 (1978)
DOI:10.1016/0006-291X(78)91273-1

Reference

4 [PMID:3689494]

Authors

Ferrer A, Caelles C, Massot N, Hegardt FG.

Title

Allosteric activation of rat liver microsomal [hydroxymethylglutaryl-CoA reductase (NADPH)]kinase by nucleoside phosphates.

Journal

Biol Chem Hoppe Seyler 368:249-57 (1987)
DOI:10.1515/bchm3.1987.368.1.249

Reference

5 [PMID:7902296]

Authors

Weekes J, Ball KL, Caudwell FB, Hardie DG.

Title

Specificity determinants for the AMP-activated protein kinase and its plant homologue analysed using synthetic peptides.

Journal

FEBS Lett 334:335-9 (1993)
DOI:10.1016/0014-5793(93)80706-Z

Reference

6 [PMID:9857077]

Authors

Crute BE, Seefeld K, Gamble J, Kemp BE, Witters LA.

Title

Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase.

Journal

J Biol Chem 273:35347-54 (1998)
DOI:10.1074/jbc.273.52.35347

Sequence

[hsa:5562]

Reference

7 [PMID:10642499]

Authors

Stein SC, Woods A, Jones NA, Davison MD, Carling D.

Title

The regulation of AMP-activated protein kinase by phosphorylation.

Journal

Biochem J 345 Pt 3:437-43 (2000)

Other DBs

ExplorEnz - The Enzyme Database:

2.7.11.31

IUBMB Enzyme Nomenclature:

2.7.11.31

ExPASy - ENZYME nomenclature database:

2.7.11.31

BRENDA, the Enzyme Database:

2.7.11.31

CAS:	172522-01-9

DBGET integrated database retrieval system