[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase;
AMP-activated protein kinase;
HMG-CoA reductase kinase;
beta-hydroxy-beta-methylglutaryl-CoA reductase kinase;
[hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase;
3-hydroxy-3-methylglutaryl coenzyme A reductase kinase;
3-hydroxy-3-methylglutaryl-CoA reductase kinase;
hydroxymethylglutaryl coenzyme A reductase kinase;
hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating);
hydroxymethylglutaryl-CoA reductase kinase;
Transferring phosphorus-containing groups;
ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate [RN:
[hydroxymethylglutaryl-CoA reductase (NADPH)] [CPD:
[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate [CPD:
The enzyme is activated by AMP. EC
, hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC
) and adipose hormone-sensitive lipase (EC
) . Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase . GTP can act instead of ATP 
EC 22.214.171.124 created 1984 as EC 126.96.36.199, transferred 2005 to EC 188.8.131.52
Beg ZH, Stonik JA, Brewer HB Jr.
3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation.
Gibson DM, Ingebritsen TS.
Reversible modulation of liver hydroxymethylglutaryl CoA reductase.
Ingebritsen TS, Lee HS, Parker RA, Gibson DM.
Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation.
Ferrer A, Caelles C, Massot N, Hegardt FG.
Allosteric activation of rat liver microsomal [hydroxymethylglutaryl-CoA reductase (NADPH)]kinase by nucleoside phosphates.
Weekes J, Ball KL, Caudwell FB, Hardie DG.
Specificity determinants for the AMP-activated protein kinase and its plant homologue analysed using synthetic peptides.
Crute BE, Seefeld K, Gamble J, Kemp BE, Witters LA.
Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase.
Stein SC, Woods A, Jones NA, Davison MD, Carling D.
The regulation of AMP-activated protein kinase by phosphorylation.
Biochem J 345 Pt 3:437-43 (2000)
ExPASy - ENZYME nomenclature database: 184.108.40.206